메뉴 건너뛰기




Volumn 40, Issue 8, 2011, Pages 1276-1282

Co-expression of mesothelin and CA125 correlates with unfavorable patient outcome in pancreatic ductal adenocarcinoma

Author keywords

CA125; co expression of mesothelin and CA125; mesothelin; pancreatic ductal adenocarcinoma

Indexed keywords

CA 125 ANTIGEN; MESOTHELIN;

EID: 80054861821     PISSN: 08853177     EISSN: 15364828     Source Type: Journal    
DOI: 10.1097/MPA.0b013e318221bed8     Document Type: Conference Paper
Times cited : (77)

References (43)
  • 2
    • 12144288807 scopus 로고    scopus 로고
    • Pancreatic Cancer Registry in Japan: 20 years of experience
    • Matsuno S, Egawa S, Fukuyama S, et al. Pancreatic Cancer Registry in Japan: 20 years of experience. Pancreas. 2004;28:219-230.
    • (2004) Pancreas. , vol.28 , pp. 219-230
    • Matsuno, S.1    Egawa, S.2    Fukuyama, S.3
  • 3
    • 0028985078 scopus 로고
    • Treatment and survival in 13,560 patients with pancreatic cancer, and incidence of the disease, in the West Midlands: An epidemiological study
    • Bramhall SR, Allum WH, Jones AG, et al. Treatment and survival in 13,560 patients with pancreatic cancer, and incidence of the disease, in the West Midlands: An epidemiological study. Br J Surg. 1995;82:111-115.
    • (1995) Br J Surg. , vol.82 , pp. 111-115
    • Bramhall, S.R.1    Allum, W.H.2    Jones, A.G.3
  • 4
    • 0034767957 scopus 로고    scopus 로고
    • Cancer burden in the year 2000. The global picture
    • Parkin DM, Bray FI, Devesa SS. Cancer burden in the year 2000. The global picture. Eur J Cancer. 2001;37(suppl 8):S4YS66.
    • (2001) Eur J Cancer. , vol.37 , Issue.SUPPL. 8
    • Parkin, D.M.1    Bray, F.I.2    Devesa, S.S.3
  • 5
    • 0030069718 scopus 로고    scopus 로고
    • Molecular cloning of mesothelin, a differentiation antigen present on mesothelium, mesotheliomas, and ovarian cancers
    • Chang K, Pastan I. Molecular cloning of mesothelin, a differentiation antigen present on mesothelium, mesotheliomas, and ovarian cancers. Proc Natl Acad Sci U S A. 1996;93:136-140.
    • (1996) Proc Natl Acad Sci U S A. , vol.93 , pp. 136-140
    • Chang, K.1    Pastan, I.2
  • 6
    • 0026503664 scopus 로고
    • Isolation and characterization of a monoclonal antibody, K1, reactive with ovarian cancers and normal mesothelium
    • Chang K, Pastan I, Willingham MC. Isolation and characterization of a monoclonal antibody, K1, reactive with ovarian cancers and normal mesothelium. Int J Cancer. 1992;50:373-381.
    • (1992) Int J Cancer. , vol.50 , pp. 373-381
    • Chang, K.1    Pastan, I.2    Willingham, M.C.3
  • 7
    • 0035674996 scopus 로고    scopus 로고
    • Mesothelin is overexpressed in the vast majority of ductal adenocarcinomas of the pancreas: Identification of a new pancreatic cancer marker by serial analysis of gene expression (SAGE
    • Argani P, Iacobuzio-Donahue C, Ryu B, et al. Mesothelin is overexpressed in the vast majority of ductal adenocarcinomas of the pancreas: Identification of a new pancreatic cancer marker by serial analysis of gene expression (SAGE). Clin Cancer Res. 2001;7:3862-3868.
    • (2001) Clin Cancer Res. , vol.7 , pp. 3862-3868
    • Argani, P.1    Iacobuzio-Donahue, C.2    Ryu, B.3
  • 9
    • 0037341494 scopus 로고    scopus 로고
    • Value of mesothelin immunostaining in the diagnosis of mesothelioma
    • Ordonez NG. Value of mesothelin immunostaining in the diagnosis of mesothelioma. Mod Pathol. 2003;16:192-197.
    • (2003) Mod Pathol. , vol.16 , pp. 192-197
    • Ordonez, N.G.1
  • 10
    • 0142169984 scopus 로고    scopus 로고
    • Application of mesothelin immunostaining in tumor diagnosis
    • Ordonez NG. Application of mesothelin immunostaining in tumor diagnosis. Am J Surg Pathol. 2003;27:1418-1428.
    • (2003) Am J Surg Pathol. , vol.27 , pp. 1418-1428
    • Ordonez, N.G.1
  • 11
    • 39749173738 scopus 로고    scopus 로고
    • Mesothelin is a malignant factor and therapeutic vaccine target for pancreatic cancer
    • Li M, Bharadwaj U, Zhang R, et al. Mesothelin is a malignant factor and therapeutic vaccine target for pancreatic cancer. Mol Cancer Ther. 2008;7:286-296.
    • (2008) Mol Cancer Ther. , vol.7 , pp. 286-296
    • Li, M.1    Bharadwaj, U.2    Zhang, R.3
  • 12
    • 32944468551 scopus 로고    scopus 로고
    • Diffuse mesothelin expression correlates with prolonged patient survival in ovarian serous carcinoma
    • Yen MJ, Hsu CY, Mao TL, et al. Diffuse mesothelin expression correlates with prolonged patient survival in ovarian serous carcinoma. Clin Cancer Res. 2006;12:827-831.
    • (2006) Clin Cancer Res. , vol.12 , pp. 827-831
    • Yen, M.J.1    Hsu, C.Y.2    Mao, T.L.3
  • 13
    • 63949085839 scopus 로고    scopus 로고
    • High mesothelin correlates with chemoresistance and poor survival in epithelial ovarian carcinoma
    • Cheng WF, Huang CY, Chang MC, et al. High mesothelin correlates with chemoresistance and poor survival in epithelial ovarian carcinoma. Br J Cancer. 2009;100:1144-1153.
    • (2009) Br J Cancer. , vol.100 , pp. 1144-1153
    • Cheng, W.F.1    Huang, C.Y.2    Chang, M.C.3
  • 14
    • 28444437055 scopus 로고    scopus 로고
    • Mesothelin is overexpressed in pancreaticobiliary adenocarcinomas but not in normal pancreas and chronic pancreatitis
    • Hassan R, Laszik ZG, Lerner M, et al. Mesothelin is overexpressed in pancreaticobiliary adenocarcinomas but not in normal pancreas and chronic pancreatitis. Am J Clin Pathol. 2005;124:838-845.
    • (2005) Am J Clin Pathol. , vol.124 , pp. 838-845
    • Hassan, R.1    Laszik, Z.G.2    Lerner, M.3
  • 15
    • 12144288836 scopus 로고    scopus 로고
    • Analysis of novel tumor markers in pancreatic and biliary carcinomas using tissue microarrays
    • Swierczynski SL, Maitra A, Abraham SC, et al. Analysis of novel tumor markers in pancreatic and biliary carcinomas using tissue microarrays. Hum Pathol. 2004;35:357-366.
    • (2004) Hum Pathol. , vol.35 , pp. 357-366
    • Swierczynski, S.L.1    Maitra, A.2    Abraham, S.C.3
  • 16
    • 0019790278 scopus 로고
    • Reactivity of a monoclonal antibody with human ovarian carcinoma
    • Bast RC Jr, Feeney M, Lazarus H, et al. Reactivity of a monoclonal antibody with human ovarian carcinoma. J Clin Invest. 1981;68:1331-1337.
    • (1981) J Clin Invest. , vol.68 , pp. 1331-1337
    • Bast Jr., R.C.1    Feeney, M.2    Lazarus, H.3
  • 17
    • 0021053493 scopus 로고
    • Tissue distribution of a coelomic-epithelium-related antigen recognized by the monoclonal antibody OC125
    • Kabawat SE, Bast RC Jr, Bhan AK, et al. Tissue distribution of a coelomic-epithelium-related antigen recognized by the monoclonal antibody OC125. Int J Gynecol Pathol. 1983;2:275-285.
    • (1983) Int J Gynecol Pathol. , vol.2 , pp. 275-285
    • Kabawat, S.E.1    Bast Jr., R.C.2    Bhan, A.K.3
  • 18
    • 0031034824 scopus 로고    scopus 로고
    • Immunohistochemical phenotype of malignant mesothelioma: Predictive value of CA125 and HBME-1 expression
    • Bateman AC, al-Talib RK, Newman T, et al. Immunohistochemical phenotype of malignant mesothelioma: Predictive value of CA125 and HBME-1 expression. Histopathology. 1997;30:49-56.
    • (1997) Histopathology. , vol.30 , pp. 49-56
    • Bateman, A.C.1    Al-Talib, R.K.2    Newman, T.3
  • 19
    • 0023583596 scopus 로고
    • CA 125 in the serum and tissue of patients with gynecological disease
    • Fuith LC, Daxenbichler G, Dapunt O. CA 125 in the serum and tissue of patients with gynecological disease. Arch Gynecol Obstet. 1987;241:157-164.
    • (1987) Arch Gynecol Obstet. , vol.241 , pp. 157-164
    • Fuith, L.C.1    Daxenbichler, G.2    Dapunt, O.3
  • 20
    • 33847112141 scopus 로고    scopus 로고
    • Immunohistochemical marker panels for distinguishing between epithelioid mesothelioma and lung adenocarcinoma
    • Kushitani K, Takeshima Y, Amatya VJ, et al. Immunohistochemical marker panels for distinguishing between epithelioid mesothelioma and lung adenocarcinoma. Pathol Int. 2007;57:190-199.
    • (2007) Pathol Int. , vol.57 , pp. 190-199
    • Kushitani, K.1    Takeshima, Y.2    Amatya, V.J.3
  • 21
    • 33846634622 scopus 로고    scopus 로고
    • Circulating CA125 in patients with peritoneal mesothelioma treated with cytoreductive surgery and intraperitoneal hyperthermic perfusion
    • Baratti D, Kusamura S, Martinetti A, et al. Circulating CA125 in patients with peritoneal mesothelioma treated with cytoreductive surgery and intraperitoneal hyperthermic perfusion. Ann Surg Oncol. 2007;14:500-508.
    • (2007) Ann Surg Oncol. , vol.14 , pp. 500-508
    • Baratti, D.1    Kusamura, S.2    Martinetti, A.3
  • 22
    • 30744470421 scopus 로고    scopus 로고
    • New tumor markers: CA125 and beyond
    • Bast RC Jr, Badgwell D, Lu Z, et al. New tumor markers: CA125 and beyond. Int J Gynecol Cancer. 2005;15(suppl 3):274-281.
    • (2005) Int J Gynecol Cancer. , vol.15 , Issue.SUPPL. 3 , pp. 274-281
    • Bast Jr., R.C.1    Badgwell, D.2    Lu, Z.3
  • 23
    • 0029655359 scopus 로고    scopus 로고
    • Importance of serum CA 125 levels in malignant peritoneal mesothelioma
    • Simsek H, Kadayifci A, Okan E. Importance of serum CA 125 levels in malignant peritoneal mesothelioma. Tumour Biol. 1996;17:1-4.
    • (1996) Tumour Biol. , vol.17 , pp. 1-4
    • Simsek, H.1    Kadayifci, A.2    Okan, E.3
  • 24
    • 0036560755 scopus 로고    scopus 로고
    • The CA 125 gene: A newly discovered extension of the glycosylated N-terminal domain doubles the size of this extracellular superstructure
    • O'Brien TJ, Beard JB, Underwood LJ, et al. The CA 125 gene: A newly discovered extension of the glycosylated N-terminal domain doubles the size of this extracellular superstructure. Tumour Biol. 2002;23:154-169.
    • (2002) Tumour Biol. , vol.23 , pp. 154-169
    • O'Brien, T.J.1    Beard, J.B.2    Underwood, L.J.3
  • 25
    • 0035920171 scopus 로고    scopus 로고
    • Molecular cloning of the CA125 ovarian cancer antigen: Identification as a new mucin, MUC16
    • Yin BW, Lloyd KO. Molecular cloning of the CA125 ovarian cancer antigen: Identification as a new mucin, MUC16. J Biol Chem. 2001;276:27371-27375.
    • (2001) J Biol Chem. , vol.276 , pp. 27371-27375
    • Yin, B.W.1    Lloyd, K.O.2
  • 26
    • 33750998782 scopus 로고    scopus 로고
    • Mesothelin-MUC16 binding is a high affinity N-glycan dependent interaction that facilitates peritoneal metastasis of ovarian tumors
    • Gubbels JA, Belisle J, Onda M, et al. Mesothelin-MUC16 binding is a high affinity, N-glycan dependent interaction that facilitates peritoneal metastasis of ovarian tumors. Mol Cancer. 2006;5:50.
    • (2006) Mol Cancer. , vol.5 , pp. 50
    • Gubbels, J.A.1    Belisle, J.2    Onda, M.3
  • 27
    • 63649151399 scopus 로고    scopus 로고
    • A binding domain on mesothelin for CA125/MUC16
    • Kaneko O, Gong L, Zhang J, et al. A binding domain on mesothelin for CA125/MUC16. J Biol Chem. 2009;284:3739-3749.
    • (2009) J Biol Chem. , vol.284 , pp. 3739-3749
    • Kaneko, O.1    Gong, L.2    Zhang, J.3
  • 28
    • 1542365125 scopus 로고    scopus 로고
    • Binding of ovarian cancer antigen CA125/MUC16 to mesothelin mediates cell adhesion
    • Rump A, Morikawa Y, Tanaka M, et al. Binding of ovarian cancer antigen CA125/MUC16 to mesothelin mediates cell adhesion. J Biol Chem. 2004;279:9190-9198.
    • (2004) J Biol Chem. , vol.279 , pp. 9190-9198
    • Rump, A.1    Morikawa, Y.2    Tanaka, M.3
  • 30
    • 56449108335 scopus 로고    scopus 로고
    • Mesothelin-induced pancreatic cancer cell proliferation involves alteration of cyclin E via activation of signal transducer and activator of transcription protein 3
    • Bharadwaj U, Li M, Chen C, et al. Mesothelin-induced pancreatic cancer cell proliferation involves alteration of cyclin E via activation of signal transducer and activator of transcription protein 3. Mol Cancer Res. 2008;6:1755-1765.
    • (2008) Mol Cancer Res. , vol.6 , pp. 1755-1765
    • Bharadwaj, U.1    Li, M.2    Chen, C.3
  • 31
    • 73149108613 scopus 로고    scopus 로고
    • Mesothelin inhibits paclitaxel-induced apoptosis through the PI3K pathway
    • Chang MC, Chen CA, Hsieh CY, et al. Mesothelin inhibits paclitaxel-induced apoptosis through the PI3K pathway. Biochem J. 2009;424:449-458.
    • (2009) Biochem J. , vol.424 , pp. 449-458
    • Chang, M.C.1    Chen, C.A.2    Hsieh, C.Y.3
  • 32
    • 77952551039 scopus 로고    scopus 로고
    • Inhibition of mesothelinYCA-125 interaction in patients with mesothelioma by the anti-mesothelin monoclonal antibody MORAb-009: Implications for cancer therapy
    • Hassan R, Schweizer C, Lu KF, et al. Inhibition of mesothelinYCA-125 interaction in patients with mesothelioma by the anti-mesothelin monoclonal antibody MORAb-009: Implications for cancer therapy. Lung Cancer. 2010;68:455-459.
    • (2010) Lung Cancer. , vol.68 , pp. 455-459
    • Hassan, R.1    Schweizer, C.2    Lu, K.F.3
  • 33
    • 37449006756 scopus 로고    scopus 로고
    • Preclinical evaluation of MORAb-009, a chimeric antibody targeting tumor-associated mesothelin
    • Hassan R, Ebel W, Routhier EL, et al. Preclinical evaluation of MORAb-009, a chimeric antibody targeting tumor-associated mesothelin. Cancer Immun. 2007;7:20.
    • (2007) Cancer Immun. , vol.7 , pp. 20
    • Hassan, R.1    Ebel, W.2    Routhier, E.L.3
  • 34
    • 79952479229 scopus 로고    scopus 로고
    • A novel high-affinity human monoclonal antibody to mesothelin
    • Ho M, Feng M, Fisher RJ, et al. A novel high-affinity human monoclonal antibody to mesothelin. Int J Cancer. 2011;128:2020-2030.
    • (2011) Int J Cancer. , vol.128 , pp. 2020-2030
    • Ho, M.1    Feng, M.2    Fisher, R.J.3
  • 35
    • 6044241807 scopus 로고    scopus 로고
    • The correlation between cytoplasmic overexpression of epidermal growth factor receptor and tumor aggressiveness: Poor prognosis in patients with pancreatic ductal adenocarcinoma
    • Ueda S, Ogata S, Tsuda H, et al. The correlation between cytoplasmic overexpression of epidermal growth factor receptor and tumor aggressiveness: Poor prognosis in patients with pancreatic ductal adenocarcinoma. Pancreas. 2004;29:e1Ye8.
    • (2004) Pancreas. , vol.29
    • Ueda, S.1    Ogata, S.2    Tsuda, H.3
  • 36
    • 24144457548 scopus 로고    scopus 로고
    • Assessment of HER-2 status in pancreatic adenocarcinoma: Correlation of immunohistochemistry, quantitative real-time RT-PCR, and FISH with aneuploidy and survival
    • Saxby AJ, Nielsen A, Scarlett CJ, et al. Assessment of HER-2 status in pancreatic adenocarcinoma: Correlation of immunohistochemistry, quantitative real-time RT-PCR, and FISH with aneuploidy and survival. Am J Surg Pathol. 2005;29:1125-1134.
    • (2005) Am J Surg Pathol. , vol.29 , pp. 1125-1134
    • Saxby, A.J.1    Nielsen, A.2    Scarlett, C.J.3
  • 37
    • 32944478346 scopus 로고    scopus 로고
    • Phase II trial of bevacizumab plus gemcitabine in patients with advanced pancreatic cancer
    • Kindler HL, Friberg G, Singh DA, et al. Phase II trial of bevacizumab plus gemcitabine in patients with advanced pancreatic cancer. J Clin Oncol. 2005;23:8033-8040.
    • (2005) J Clin Oncol. , vol.23 , pp. 8033-8040
    • Kindler, H.L.1    Friberg, G.2    Singh, D.A.3
  • 38
    • 34249933404 scopus 로고    scopus 로고
    • Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: A phase III trial of the National Cancer Institute of Canada Clinical Trials Group
    • Moore MJ, Goldstein D, Hamm J, et al. Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: A phase III trial of the National Cancer Institute of Canada Clinical Trials Group. J Clin Oncol. 2007;25:1960-1966.
    • (2007) J Clin Oncol. , vol.25 , pp. 1960-1966
    • Moore, M.J.1    Goldstein, D.2    Hamm, J.3
  • 39
    • 3042621639 scopus 로고    scopus 로고
    • Mesothelin: A new target for immunotherapy
    • Hassan R, Bera T, Pastan I. Mesothelin: A new target for immunotherapy. Clin Cancer Res. 2004;10:3937-3942.
    • (2004) Clin Cancer Res. , vol.10 , pp. 3937-3942
    • Hassan, R.1    Bera, T.2    Pastan, I.3
  • 40
    • 37249025607 scopus 로고    scopus 로고
    • Anti-mesothelin immunotoxin SS1P in combination with gemcitabine results in increased activity against mesothelin-expressing tumor xenografts
    • Hassan R, Broaddus VC,Wilson S, et al. Anti-mesothelin immunotoxin SS1P in combination with gemcitabine results in increased activity against mesothelin-expressing tumor xenografts. Clin Cancer Res. 2007;13:7166-7171.
    • (2007) Clin Cancer Res. , vol.13 , pp. 7166-7171
    • Hassan, R.1    Broaddus, V.C.2    Wilson, S.3
  • 41
    • 34548858453 scopus 로고    scopus 로고
    • Phase i study of SS1P, a recombinant anti-mesothelin immunotoxin given as a bolus I.V. infusion to patients with mesothelin-expressing mesothelioma, ovarian, and pancreatic cancers
    • Hassan R, Bullock S, Premkumar A, et al. Phase I study of SS1P, a recombinant anti-mesothelin immunotoxin given as a bolus I.V. infusion to patients with mesothelin-expressing mesothelioma, ovarian, and pancreatic cancers. Clin Cancer Res. 2007;13:5144-5149.
    • (2007) Clin Cancer Res. , vol.13 , pp. 5144-5149
    • Hassan, R.1    Bullock, S.2    Premkumar, A.3
  • 42
    • 37249038187 scopus 로고    scopus 로고
    • Mesothelin targeted cancer immunotherapy
    • Hassan R, Ho M. Mesothelin targeted cancer immunotherapy. Eur J Cancer. 2008;44:46-53.
    • (2008) Eur J Cancer. , vol.44 , pp. 46-53
    • Hassan, R.1    Ho, M.2
  • 43
    • 77957263361 scopus 로고    scopus 로고
    • Antitumor activity of anti-C-ERC/mesothelin monoclonal antibody in vivo
    • Inami K, Abe M, Takeda K, et al. Antitumor activity of anti-C-ERC/mesothelin monoclonal antibody in vivo. Cancer Sci. 2010;101:969-974.
    • (2010) Cancer Sci. , vol.101 , pp. 969-974
    • Inami, K.1    Abe, M.2    Takeda, K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.