-
1
-
-
2342471392
-
Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
-
10.1056/NEJMoa040938, 15118073
-
Lynch TJ, Bell DW, Sordella R, Gurubhagavatula S, Okimoto RA, Brannigan BW, Harris PL, Haserlat SM, Supko JG, Haluska FG, et al. Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N Engl J Med 2004, 350(21):2129-2139. 10.1056/NEJMoa040938, 15118073.
-
(2004)
N Engl J Med
, vol.350
, Issue.21
, pp. 2129-2139
-
-
Lynch, T.J.1
Bell, D.W.2
Sordella, R.3
Gurubhagavatula, S.4
Okimoto, R.A.5
Brannigan, B.W.6
Harris, P.L.7
Haserlat, S.M.8
Supko, J.G.9
Haluska, F.G.10
-
2
-
-
14644445166
-
Epidermal growth factor receptor signaling in colorectal cancer: preclinical data and therapeutic perspectives
-
10.1093/annonc/mdi057, 15668269
-
Spano JP, Fagard R, Soria JC, Rixe O, Khayat D, Milano G. Epidermal growth factor receptor signaling in colorectal cancer: preclinical data and therapeutic perspectives. Ann Oncol 2005, 16(2):189-194. 10.1093/annonc/mdi057, 15668269.
-
(2005)
Ann Oncol
, vol.16
, Issue.2
, pp. 189-194
-
-
Spano, J.P.1
Fagard, R.2
Soria, J.C.3
Rixe, O.4
Khayat, D.5
Milano, G.6
-
3
-
-
3242720345
-
Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer
-
10.1056/NEJMoa033025, 15269313
-
Cunningham D, Humblet Y, Siena S, Khayat D, Bleiberg H, Santoro A, Bets D, Mueser M, Harstrick A, Verslype C, et al. Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer. N Engl J Med 2004, 351(4):337-345. 10.1056/NEJMoa033025, 15269313.
-
(2004)
N Engl J Med
, vol.351
, Issue.4
, pp. 337-345
-
-
Cunningham, D.1
Humblet, Y.2
Siena, S.3
Khayat, D.4
Bleiberg, H.5
Santoro, A.6
Bets, D.7
Mueser, M.8
Harstrick, A.9
Verslype, C.10
-
4
-
-
34147103678
-
Open-label phase III trial of panitumumab plus best supportive care compared with best supportive care alone in patients with chemotherapy-refractory metastatic colorectal cancer
-
10.1200/JCO.2006.08.1620, 17470858
-
Van Cutsem E, Peeters M, Siena S, Humblet Y, Hendlisz A, Neyns B, Canon JL, Van Laethem JL, Maurel J, Richardson G, et al. Open-label phase III trial of panitumumab plus best supportive care compared with best supportive care alone in patients with chemotherapy-refractory metastatic colorectal cancer. J Clin Oncol 2007, 25(13):1658-1664. 10.1200/JCO.2006.08.1620, 17470858.
-
(2007)
J Clin Oncol
, vol.25
, Issue.13
, pp. 1658-1664
-
-
Van Cutsem, E.1
Peeters, M.2
Siena, S.3
Humblet, Y.4
Hendlisz, A.5
Neyns, B.6
Canon, J.L.7
Van Laethem, J.L.8
Maurel, J.9
Richardson, G.10
-
5
-
-
63849088630
-
Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer
-
10.1056/NEJMoa0805019, 19339720
-
Van Cutsem E, Kohne CH, Hitre E, Zaluski J, Chang Chien CR, Makhson A, D'Haens G, Pinter T, Lim R, Bodoky G, et al. Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer. N Engl J Med 2009, 360(14):1408-1417. 10.1056/NEJMoa0805019, 19339720.
-
(2009)
N Engl J Med
, vol.360
, Issue.14
, pp. 1408-1417
-
-
Van Cutsem, E.1
Kohne, C.H.2
Hitre, E.3
Zaluski, J.4
Chang Chien, C.R.5
Makhson, A.6
D'Haens, G.7
Pinter, T.8
Lim, R.9
Bodoky, G.10
-
6
-
-
40149088765
-
KRAS wild-type state predicts survival and is associated to early radiological response in metastatic colorectal cancer treated with cetuximab
-
De Roock W, Piessevaux H, De Schutter J, Janssens M, De Hertogh G, Personeni N, Biesmans B, Van Laethem JL, Peeters M, Humblet Y, et al. KRAS wild-type state predicts survival and is associated to early radiological response in metastatic colorectal cancer treated with cetuximab. Ann Oncol 2008, 19(3):508-515.
-
(2008)
Ann Oncol
, vol.19
, Issue.3
, pp. 508-515
-
-
De Roock, W.1
Piessevaux, H.2
De Schutter, J.3
Janssens, M.4
De Hertogh, G.5
Personeni, N.6
Biesmans, B.7
Van Laethem, J.L.8
Peeters, M.9
Humblet, Y.10
-
7
-
-
34047248571
-
Oncogenic activation of the RAS/RAF signaling pathway impairs the response of metastatic colorectal cancers to anti-epidermal growth factor receptor antibody therapies
-
10.1158/0008-5472.CAN-06-4158, 17363584
-
Benvenuti S, Sartore-Bianchi A, Di Nicolantonio F, Zanon C, Moroni M, Veronese S, Siena S, Bardelli A. Oncogenic activation of the RAS/RAF signaling pathway impairs the response of metastatic colorectal cancers to anti-epidermal growth factor receptor antibody therapies. Cancer Res 2007, 67(6):2643-2648. 10.1158/0008-5472.CAN-06-4158, 17363584.
-
(2007)
Cancer Res
, vol.67
, Issue.6
, pp. 2643-2648
-
-
Benvenuti, S.1
Sartore-Bianchi, A.2
Di Nicolantonio, F.3
Zanon, C.4
Moroni, M.5
Veronese, S.6
Siena, S.7
Bardelli, A.8
-
8
-
-
77955277111
-
Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: a retrospective consortium analysis
-
10.1016/S1470-2045(10)70130-3, 20619739
-
De Roock W, Claes B, Bernasconi D, De Schutter J, Biesmans B, Fountzilas G, Kalogeras KT, Kotoula V, Papamichael D, Laurent-Puig P, et al. Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: a retrospective consortium analysis. Lancet Oncol 2010, 11(8):753-762. 10.1016/S1470-2045(10)70130-3, 20619739.
-
(2010)
Lancet Oncol
, vol.11
, Issue.8
, pp. 753-762
-
-
De Roock, W.1
Claes, B.2
Bernasconi, D.3
De Schutter, J.4
Biesmans, B.5
Fountzilas, G.6
Kalogeras, K.T.7
Kotoula, V.8
Papamichael, D.9
Laurent-Puig, P.10
-
9
-
-
79953121335
-
EGFR related mutational status and association to clinical outcome of third-line cetuximab-irinotecan in metastatic colorectal cancer
-
10.1186/1471-2407-11-107, 3073939, 21439039
-
Spindler KL, Pallisgaard N, Lindebjerg J, Frifeldt SK, Jakobsen A. EGFR related mutational status and association to clinical outcome of third-line cetuximab-irinotecan in metastatic colorectal cancer. BMC Cancer 2011, 11:107. 10.1186/1471-2407-11-107, 3073939, 21439039.
-
(2011)
BMC Cancer
, vol.11
, pp. 107
-
-
Spindler, K.L.1
Pallisgaard, N.2
Lindebjerg, J.3
Frifeldt, S.K.4
Jakobsen, A.5
-
10
-
-
34548258303
-
Epidermal growth factor receptor gene copy number and clinical outcome of metastatic colorectal cancer treated with panitumumab
-
10.1200/JCO.2007.11.5956, 17664472
-
Sartore-Bianchi A, Moroni M, Veronese S, Carnaghi C, Bajetta E, Luppi G, Sobrero A, Barone C, Cascinu S, Colucci G, et al. Epidermal growth factor receptor gene copy number and clinical outcome of metastatic colorectal cancer treated with panitumumab. J Clin Oncol 2007, 25(22):3238-3245. 10.1200/JCO.2007.11.5956, 17664472.
-
(2007)
J Clin Oncol
, vol.25
, Issue.22
, pp. 3238-3245
-
-
Sartore-Bianchi, A.1
Moroni, M.2
Veronese, S.3
Carnaghi, C.4
Bajetta, E.5
Luppi, G.6
Sobrero, A.7
Barone, C.8
Cascinu, S.9
Colucci, G.10
-
11
-
-
2342624080
-
EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy
-
10.1126/science.1099314, 15118125
-
Paez JG, Janne PA, Lee JC, Tracy S, Greulich H, Gabriel S, Herman P, Kaye FJ, Lindeman N, Boggon TJ, et al. EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy. Science 2004, 304(5676):1497-1500. 10.1126/science.1099314, 15118125.
-
(2004)
Science
, vol.304
, Issue.5676
, pp. 1497-1500
-
-
Paez, J.G.1
Janne, P.A.2
Lee, J.C.3
Tracy, S.4
Greulich, H.5
Gabriel, S.6
Herman, P.7
Kaye, F.J.8
Lindeman, N.9
Boggon, T.J.10
-
12
-
-
17844362179
-
Gene copy number for epidermal growth factor receptor (EGFR) and clinical response to antiEGFR treatment in colorectal cancer: a cohort study
-
10.1016/S1470-2045(05)70102-9, 15863375
-
Moroni M, Veronese S, Benvenuti S, Marrapese G, Sartore-Bianchi A, Di Nicolantonio F, Gambacorta M, Siena S, Bardelli A. Gene copy number for epidermal growth factor receptor (EGFR) and clinical response to antiEGFR treatment in colorectal cancer: a cohort study. Lancet Oncol 2005, 6(5):279-286. 10.1016/S1470-2045(05)70102-9, 15863375.
-
(2005)
Lancet Oncol
, vol.6
, Issue.5
, pp. 279-286
-
-
Moroni, M.1
Veronese, S.2
Benvenuti, S.3
Marrapese, G.4
Sartore-Bianchi, A.5
Di Nicolantonio, F.6
Gambacorta, M.7
Siena, S.8
Bardelli, A.9
-
13
-
-
14644406844
-
Somatic mutations of epidermal growth factor receptor in colorectal carcinoma
-
10.1158/1078-0432.CCR-04-1894, 15746034
-
Nagahara H, Mimori K, Ohta M, Utsunomiya T, Inoue H, Barnard GF, Ohira M, Hirakawa K, Mori M. Somatic mutations of epidermal growth factor receptor in colorectal carcinoma. Clin Cancer Res 2005, 11(4):1368-1371. 10.1158/1078-0432.CCR-04-1894, 15746034.
-
(2005)
Clin Cancer Res
, vol.11
, Issue.4
, pp. 1368-1371
-
-
Nagahara, H.1
Mimori, K.2
Ohta, M.3
Utsunomiya, T.4
Inoue, H.5
Barnard, G.F.6
Ohira, M.7
Hirakawa, K.8
Mori, M.9
-
14
-
-
77950936173
-
Mutations in epidermal growth factor receptor and K-ras in Chinese patients with colorectal cancer
-
2848222, 20184776
-
Yunxia Z, Jun C, Guanshan Z, Yachao L, Xueke Z, Jin L. Mutations in epidermal growth factor receptor and K-ras in Chinese patients with colorectal cancer. BMC Med Genet 2010, 11:34. 2848222, 20184776.
-
(2010)
BMC Med Genet
, vol.11
, pp. 34
-
-
Yunxia, Z.1
Jun, C.2
Guanshan, Z.3
Yachao, L.4
Xueke, Z.5
Jin, L.6
-
15
-
-
19944422060
-
Somatic mutations of EGFR in colorectal cancers and glioblastomas
-
10.1056/NEJM200412303512724, 15625347
-
Barber TD, Vogelstein B, Kinzler KW, Velculescu VE. Somatic mutations of EGFR in colorectal cancers and glioblastomas. N Engl J Med 2004, 351(27):2883. 10.1056/NEJM200412303512724, 15625347.
-
(2004)
N Engl J Med
, vol.351
, Issue.27
, pp. 2883
-
-
Barber, T.D.1
Vogelstein, B.2
Kinzler, K.W.3
Velculescu, V.E.4
-
16
-
-
20044364940
-
Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers
-
10.1093/jnci/dji055, 15741570
-
Shigematsu H, Lin L, Takahashi T, Nomura M, Suzuki M, Wistuba II, Fong KM, Lee H, Toyooka S, Shimizu N, et al. Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers. J Natl Cancer Inst 2005, 97(5):339-346. 10.1093/jnci/dji055, 15741570.
-
(2005)
J Natl Cancer Inst
, vol.97
, Issue.5
, pp. 339-346
-
-
Shigematsu, H.1
Lin, L.2
Takahashi, T.3
Nomura, M.4
Suzuki, M.5
Wistuba, I.I.6
Fong, K.M.7
Lee, H.8
Toyooka, S.9
Shimizu, N.10
-
17
-
-
54949085398
-
K-ras mutations and benefit from cetuximab in advanced colorectal cancer
-
10.1056/NEJMoa0804385, 18946061
-
Karapetis CS, Khambata-Ford S, Jonker DJ, O'Callaghan CJ, Tu D, Tebbutt NC, Simes RJ, Chalchal H, Shapiro JD, Robitaille S, et al. K-ras mutations and benefit from cetuximab in advanced colorectal cancer. N Engl J Med 2008, 359(17):1757-1765. 10.1056/NEJMoa0804385, 18946061.
-
(2008)
N Engl J Med
, vol.359
, Issue.17
, pp. 1757-1765
-
-
Karapetis, C.S.1
Khambata-Ford, S.2
Jonker, D.J.3
O'Callaghan, C.J.4
Tu, D.5
Tebbutt, N.C.6
Simes, R.J.7
Chalchal, H.8
Shapiro, J.D.9
Robitaille, S.10
-
18
-
-
41549097718
-
EGFR FISH assay predicts for response to cetuximab in chemotherapy refractory colorectal cancer patients
-
Cappuzzo F, Finocchiaro G, Rossi E, Janne PA, Carnaghi C, Calandri C, Bencardino K, Ligorio C, Ciardiello F, Pressiani T, et al. EGFR FISH assay predicts for response to cetuximab in chemotherapy refractory colorectal cancer patients. Ann Oncol 2008, 19(4):717-723.
-
(2008)
Ann Oncol
, vol.19
, Issue.4
, pp. 717-723
-
-
Cappuzzo, F.1
Finocchiaro, G.2
Rossi, E.3
Janne, P.A.4
Carnaghi, C.5
Calandri, C.6
Bencardino, K.7
Ligorio, C.8
Ciardiello, F.9
Pressiani, T.10
-
19
-
-
35348908314
-
PTEN loss of expression predicts cetuximab efficacy in metastatic colorectal cancer patients
-
10.1038/sj.bjc.6604009, 2360431, 17940504
-
Frattini M, Saletti P, Romagnani E, Martin V, Molinari F, Ghisletta M, Camponovo A, Etienne LL, Cavalli F, Mazzucchelli L. PTEN loss of expression predicts cetuximab efficacy in metastatic colorectal cancer patients. Br J Cancer 2007, 97(8):1139-1145. 10.1038/sj.bjc.6604009, 2360431, 17940504.
-
(2007)
Br J Cancer
, vol.97
, Issue.8
, pp. 1139-1145
-
-
Frattini, M.1
Saletti, P.2
Romagnani, E.3
Martin, V.4
Molinari, F.5
Ghisletta, M.6
Camponovo, A.7
Etienne, L.L.8
Cavalli, F.9
Mazzucchelli, L.10
-
20
-
-
53249123419
-
Clinical usefulness of EGFR gene copy number as a predictive marker in colorectal cancer patients treated with cetuximab: a fluorescent in situ hybridization study
-
10.1158/1078-0432.CCR-08-0449, 18794099
-
Personeni N, Fieuws S, Piessevaux H, De Hertogh G, De Schutter J, Biesmans B, De Roock W, Capoen A, Debiec-Rychter M, Van Laethem JL, et al. Clinical usefulness of EGFR gene copy number as a predictive marker in colorectal cancer patients treated with cetuximab: a fluorescent in situ hybridization study. Clin Cancer Res 2008, 14(18):5869-5876. 10.1158/1078-0432.CCR-08-0449, 18794099.
-
(2008)
Clin Cancer Res
, vol.14
, Issue.18
, pp. 5869-5876
-
-
Personeni, N.1
Fieuws, S.2
Piessevaux, H.3
De Hertogh, G.4
De Schutter, J.5
Biesmans, B.6
De Roock, W.7
Capoen, A.8
Debiec-Rychter, M.9
Van Laethem, J.L.10
-
21
-
-
10844231985
-
Mutations of the epidermal growth factor receptor gene in lung cancer: biological and clinical implications
-
10.1158/0008-5472.CAN-04-2818, 15604253
-
Kosaka T, Yatabe Y, Endoh H, Kuwano H, Takahashi T, Mitsudomi T. Mutations of the epidermal growth factor receptor gene in lung cancer: biological and clinical implications. Cancer Res 2004, 64(24):8919-8923. 10.1158/0008-5472.CAN-04-2818, 15604253.
-
(2004)
Cancer Res
, vol.64
, Issue.24
, pp. 8919-8923
-
-
Kosaka, T.1
Yatabe, Y.2
Endoh, H.3
Kuwano, H.4
Takahashi, T.5
Mitsudomi, T.6
-
22
-
-
33744551470
-
Novel mutations of epidermal growth factor receptor in localized prostate cancer
-
10.2741/1986, 16720329
-
Douglas DA, Zhong H, Ro JY, Oddoux C, Berger AD, Pincus MR, Satagopan JM, Gerald WL, Scher HI, Lee P, et al. Novel mutations of epidermal growth factor receptor in localized prostate cancer. Front Biosci 2006, 11:2518-2525. 10.2741/1986, 16720329.
-
(2006)
Front Biosci
, vol.11
, pp. 2518-2525
-
-
Douglas, D.A.1
Zhong, H.2
Ro, J.Y.3
Oddoux, C.4
Berger, A.D.5
Pincus, M.R.6
Satagopan, J.M.7
Gerald, W.L.8
Scher, H.I.9
Lee, P.10
-
23
-
-
27244451321
-
Epidermal growth factor receptor gene mutations and increased copy numbers predict gefitinib sensitivity in patients with recurrent non-small-cell lung cancer
-
10.1200/JCO.2005.01.0793, 15998907
-
Takano T, Ohe Y, Sakamoto H, Tsuta K, Matsuno Y, Tateishi U, Yamamoto S, Nokihara H, Yamamoto N, Sekine I, et al. Epidermal growth factor receptor gene mutations and increased copy numbers predict gefitinib sensitivity in patients with recurrent non-small-cell lung cancer. J Clin Oncol 2005, 23(28):6829-6837. 10.1200/JCO.2005.01.0793, 15998907.
-
(2005)
J Clin Oncol
, vol.23
, Issue.28
, pp. 6829-6837
-
-
Takano, T.1
Ohe, Y.2
Sakamoto, H.3
Tsuta, K.4
Matsuno, Y.5
Tateishi, U.6
Yamamoto, S.7
Nokihara, H.8
Yamamoto, N.9
Sekine, I.10
-
24
-
-
33646154001
-
Detection of EGFR- and HER2-activating mutations in squamous cell carcinoma involving the head and neck
-
10.1038/modpathol.3800552, 16547470
-
Willmore-Payne C, Holden JA, Layfield LJ. Detection of EGFR- and HER2-activating mutations in squamous cell carcinoma involving the head and neck. Mod Pathol 2006, 19(5):634-640. 10.1038/modpathol.3800552, 16547470.
-
(2006)
Mod Pathol
, vol.19
, Issue.5
, pp. 634-640
-
-
Willmore-Payne, C.1
Holden, J.A.2
Layfield, L.J.3
|