MAp19, the alternative splice product of the MASP2 gene

Journal of Immunological Methods

Volumn 373, Issue 1-2, 2011, Pages 89-101

  Degn, Søren E ^a   Thiel, Steffen ^a   Nielsen, Ole ^b   Hansen, Annette G ^a   Steffensen, Rudi ^c   Jensenius, Jens C ^a  

^a AARHUS UNIVERSITY   (Denmark)

^b ODENSE UNIVERSITY HOSPITAL   (Denmark)

^c AALBORG UNIVERSITY HOSPITAL   (Denmark)

Author keywords

Complement; Lectin pathway; Mannan binding lectin; MAp19; MASP 2; SMAP

Indexed keywords

AMINO ACID; BCG VACCINE; FICOLIN; GENE PRODUCT; H FICOLIN; L FICOLIN; LECTIN; M FICOLIN; MANNAN BINDING LECTIN; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY MAP19; MONOCLONAL ANTIBODY MASP2; PATTERN RECOGNITION MOLECULE; PATTERN RECOGNITION RECEPTOR; RECOMBINANT MANNAN BINDING LECTIN; RECOMBINANT MAP19; RECOMBINANT MASP 3; RECOMBINANT PROTEIN; SERINE PROTEINASE; UNCLASSIFIED DRUG;

ALTERNATIVE RNA SPLICING; AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIBODY BLOOD LEVEL; ANTIBODY PRODUCTION; ANTIBODY SPECIFICITY; ANTIBODY URINE LEVEL; ARTICLE; CATALYSIS; COMPLEMENT ACTIVATION; CONTROLLED STUDY; GEL PERMEATION CHROMATOGRAPHY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOASSAY; IMMUNOHISTOCHEMISTRY; LIVER CELL; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; PROTEIN URINE LEVEL; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TISSUE DISTRIBUTION;

ALTERNATIVE SPLICING; ANIMALS; ANTIBODIES, MONOCLONAL; ANTIBODY AFFINITY; BLOTTING, WESTERN; CYTOPLASM; GENE EXPRESSION PROFILING; HEK293 CELLS; HEPATOCYTES; HUMANS; HYBRIDOMAS; IMMUNOHISTOCHEMISTRY; KIDNEY; LECTINS; MACROPHAGES, ALVEOLAR; MANNOSE-BINDING LECTIN; MANNOSE-BINDING PROTEIN-ASSOCIATED SERINE PROTEASES; MICE; PROTEIN BINDING; PROTEIN ISOFORMS; RATS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

RATTUS;

EID: 80054845610     PISSN: 00221759     EISSN: 18727905     Source Type: Journal    
DOI: 10.1016/j.jim.2011.08.006     Document Type: Article

References (34)

1. Aregger F., Pilop C., Uehlinger D.E., Brunisholz R., Carrel T.P., Frey F.J., Frey B.M. Urinary proteomics before and after extracorporeal circulation in patients with and without acute kidney injury. J. Thorac. Cardiovasc. Surg. 2010, 139:692.
2. Chen C.B., Wallis R. Stoichiometry of complexes between mannose-binding protein and its associated serine proteases. Defining functional units for complement activation. J. Biol. Chem. 2001, 276:25894.
3. Cseh S., Vera L., Matsushita M., Fujita T., Arlaud G.J., Thielens N.M. Characterization of the interaction between L-ficolin/p35 and mannan-binding lectin-associated serine proteases-1 and -2. J. Immunol. 2002, 169:5735.
4. Dahl M.R., Thiel S., Matsushita M., Fujita T., Willis A.C., Christensen T., Vorup-Jensen T., Jensenius J.C. MASP-3 and its association with distinct complexes of the mannan-binding lectin complement activation pathway. Immunity 2001, 15:127.
5. Degn S.E., Hansen A.G., Steffensen R., Jacobsen C., Jensenius J.C., Thiel S. MAp44, a human protein associated with pattern recognition molecules of the complement system and regulating the lectin pathway of complement activation. J. Immunol. 2009, 183:7371.
6. Degn S.E., Jensen L., Gál P., Dobó J., Holmvad S.H., Jensenius J.C., Thiel S. Biological variations of MASP-3 and MAp44, two splice products of the MASP1 gene involved in regulation of the complement system. J. Immunol. Meth. 2010, 361:37.
7. Degn S.E., Andersen S.H., Jensen L., Thiel S., Jensenius J.C. Assay interference caused by antibodies reacting with rat kappa light-chain in human sera. J. Immunol. Methods 2011, 372:204.
8. Dodds A.W. Small-scale preparation of complement components C3 and C4. Meth. Enzymol. 1993, 223:46.
9. Frederiksen P.D., Thiel S., Larsen C.B., Jensenius J.C. M-ficolin, an innate immune defence molecule, binds patterns of acetyl groups and activates complement. Scand. J. Immunol. 2005, 62:462.
10. Gregory L.A., Thielens N.M., Matsushita M., Sorensen R., Arlaud G.J., Fontecilla-Camps J.C., Gaboriaud C. The X-ray structure of human mannan-binding lectin-associated protein 19 (MAp19) and its interaction site with mannan-binding lectin and L-ficolin. J. Biol. Chem. 2004, 279:29391.
11. Iwaki D., Kanno K., Takahashi M., Endo Y., Lynch N.J., Schwaeble W.J., Matsushita M., Okabe M., Fujita T. Small mannose-binding lectin-associated protein plays a regulatory role in the lectin complement pathway. J. Immunol. 2006, 177:8626.
12. Jensenius J.C., Jensen P.H., McGuire K., Larsen J.L., Thiel S. Recombinant mannan-binding lectin (MBL) for therapy. Biochem. Soc. Trans. 2003, 31:763.
13. Kang I., Kim J.I., Chang S.G., Lee S.J., Choi S.L., Ha J., Kim S.S. Mannan-binding lectin (MBL)-associated plasma protein present in human urine inhibits calcium oxalate crystal growth. FEBS Lett. 1999, 462:89.
14. Kearney J.F., Radbruch A., Liesegang B., Rajewsky K. A new mouse myeloma cell line that has lost immunoglobulin expression but permits the construction of antibody-secreting hybrid cell lines. J. Immunol. 1979, 123:1548.
15. Kohler G., Milstein C. Continuous cultures of fused cells secreting antibody of predefined specificity. Nature 1975, 256:495.
16. Krarup A., Thiel S., Hansen A., Fujita T., Jensenius J.C. L-ficolin is a pattern recognition molecule specific for acetyl groups. J. Biol. Chem. 2004, 279:47513.
17. Liu J.L., Cao C., Ma Q.J. Study on interaction between SARS-CoV N and MAP19. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2009, 25:777.
18. Matsushita M., Thiel S., Jensenius J.C., Terai I., Fujita T. Proteolytic activities of two types of mannose-binding lectin-associated serine protease. J. Immunol. 2000, 165:2637.
19. Møller-Kristensen M., Jensenius J.C., Jensen L., Thielens N., Rossi V., Arlaud G., Thiel S. Levels of mannan-binding lectin-associated serine protease-2 in healthy individuals. J. Immunol. Meth. 2003, 282:159.
20. Musante L., Candiano G., Bruschi M., Zennaro C., Carraro M., Artero M., Giuffrida M.G., Conti A., Santucci A., Ghiggeri G.M. Characterization of plasma factors that alter the permeability to albumin within isolated glomeruli. Proteomics 2002, 2:197.
21. Nakajima T., Ballou C.E. Characterization of the carbohydrate fragments obtained from Saccharomyces cerevisiae mannan by alkaline degradation. J. Biol. Chem. 1974, 249:7679.
22. Petersen S.V., Thiel S., Jensen L., Steffensen R., Jensenius J.C. An assay for the mannan-binding lectin pathway of complement activation. J. Immunol. Meth. 2001, 257:107.
23. Schwaeble W., Dahl M.R., Thiel S., Stover C., Jensenius J.C. The mannan-binding lectin-associated serine proteases (MASPs) and MAp19: four components of the lectin pathway activation complex encoded by two genes. Immunobiology 2002, 205:455.
24. Seyfarth J., Garred P., Madsen H.O. Extra-hepatic transcription of the human mannose-binding lectin gene (mbl2) and the MBL-associated serine protease 1-3 genes. Mol. Immunol. 2006, 43:962.
25. Stover C.M., Thiel S., Lynch N.J., Schwaeble W.J. The rat and mouse homologues of MASP-2 and MAp19, components of the lectin activation pathway of complement. J. Immunol. 1999, 163:6848.
26. Stover C.M., Thiel S., Thelen M., Lynch N.J., Vorup-Jensen T., Jensenius J.C., Schwaeble W.J. Two constituents of the initiation complex of the mannan-binding lectin activation pathway of complement are encoded by a single structural gene. J. Immunol. 1999, 162:3481.
27. Stover C.M., Lynch N.J., Hanson S.J., Windbichler M., Gregory S.G., Schwaeble W.J. Organization of the MASP2 locus and its expression profile in mouse and rat. Mamm. Genome 2004, 15:887.
28. Takahashi M., Endo Y., Fujita T., Matsushita M. A truncated form of mannose-binding lectin-associated serine protease (MASP)-2 expressed by alternative polyadenylation is a component of the lectin complement pathway. Int. Immunol. 1999, 11:859.
29. Thiel S. Complement activating soluble pattern recognition molecules with collagen-like regions, mannan-binding lectin, ficolins and associated proteins. Mol. Immunol. 2007, 44:3875.
30. Thiel S., Vorup-Jensen T., Stover C.M., Schwaeble W., Laursen S.B., Poulsen K., Willis A.C., Eggleton P., Hansen S., Holmskov U., Reid K.B., Jensenius J.C. A second serine protease associated with mannan-binding lectin that activates complement. Nature 1997, 386:506.
31. Thiel S., Petersen S.V., Vorup-Jensen T., Matsushita M., Fujita T., Stover C.M., Schwaeble W.J., Jensenius J.C. Interaction of C1q and mannan-binding lectin (MBL) with C1r, C1s, MBL-associated serine proteases 1 and 2, and the MBL-associated protein MAp19. J. Immunol. 2000, 165:878.
32. Thielens N.M., Cseh S., Thiel S., Vorup-Jensen T., Rossi V., Jensenius J.C., Arlaud G.J. Interaction properties of human mannan-binding lectin (MBL)-associated serine proteases-1 and -2, MBL-associated protein 19, and MBL. J. Immunol. 2001, 166:5068.
33. Thongboonkerd V., McLeish K.R., Arthur J.M., Klein J.B. Proteomic analysis of normal human urinary proteins isolated by acetone precipitation or ultracentrifugation. Kidney Int. 2002, 62:1461.
34. Ytting H., Christensen I.J., Thiel S., Jensenius J.C., Svendsen M.N., Nielsen L., Lottenburger T., Nielsen H.J. Biological variation in circulating levels of mannan-binding lectin (MBL) and MBL-associated serine protease-2 and the influence of age, gender and physical exercise. Scand. J. Immunol. 2007, 66:458.