Assay interference caused by antibodies reacting with rat kappa light-chain in human sera

Journal of Immunological Methods

Volumn 372, Issue 1-2, 2011, Pages 204-208

  Degn, Søren E ^a   Andersen, Stig Henrik ^a   Jensen, Lisbeth ^a   Thiel, Steffen ^a   Jensenius, Jens C ^a  

^a AARHUS UNIVERSITY   (Denmark)

Author keywords

ELISA; Heterophilic antibody; Interference; MAp19; Solid phase assay; TRIFMA

Indexed keywords

BUFFER; FOOD ANTIGEN; IMMUNOGLOBULIN ANTIBODY; IMMUNOGLOBULIN G; IMMUNOGLOBULIN KAPPA CHAIN; IMMUNOGLOBULIN KAPPA CHAIN ANTIBODY; IMMUNOGLOBULIN M; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY P19; UNCLASSIFIED DRUG;

ANTIBODY BLOOD LEVEL; ARTICLE; BLOOD DONOR; BLOOD SAMPLING; CAUCASIAN; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; PRIORITY JOURNAL;

ANIMALS; BLOOD DONORS; COHORT STUDIES; CROSS REACTIONS; DENMARK; ENZYME-LINKED IMMUNOSORBENT ASSAY; FALSE POSITIVE REACTIONS; HUMANS; IMMUNOGLOBULIN G; IMMUNOGLOBULIN KAPPA-CHAINS; MANNOSE-BINDING PROTEIN-ASSOCIATED SERINE PROTEASES; RATS;

RATTUS;

EID: 80052471159     PISSN: 00221759     EISSN: 18727905     Source Type: Journal    
DOI: 10.1016/j.jim.2011.06.030     Document Type: Article

References (24)

1. Andersen D.C., Koch C., Jensen C.H., Skjodt K., Brandt J., Teisner B. High prevalence of human anti-bovine IgG antibodies as the major cause of false positive reactions in two-site immunoassays based on monoclonal antibodies. J. Immunoassay Immunochem. 2004, 25:17.
2. Bjerner J., Børmer O.P., Nustad K. The war on heterophilic antibody interference. Clin. Chem. 2005, 51:9.
3. Bjerner J., Olsen K.H., Børmer O.P., Nustad K. Human heterophilic antibodies display specificity for murine IgG subclasses. Clin. Biochem. 2005, 38:465.
4. Butler J.E. Characteristics of bovine immunoglobulins and related molecules. Review of the bovine immunoglobulins. J. Dairy Sci. 1971, 54:1315.
5. Degn S.E., Jensen L., Gál P., Dobó J., Holmvad S.H., Jensenius J.C., Thiel S. Biological variations of MASP-3 and MAp44, two splice products of the MASP1 gene involved in regulation of the complement system. J. Immunol. Methods 2010, 361:37.
6. Engvall E., Perlmann P. Enzyme-linked immunosorbent assay (ELISA). Quantitative assay of immunoglobulin G. Immunochemistry 1971, 8:871.
7. Harlow E., Lane D. Antibodies - A Laboratory Manual 1988, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York.
8. Hennig C., Rink L., Fagin U., Jabs W.J., Kirchner H. The influence of naturally occurring heterophilic anti-immunoglobulin antibodies on direct measurement of serum proteins using sandwich ELISAs. J. Immunol. Methods 2000, 235:71.
9. Husby S., Oxelius V.A., Teisner B., Jensenius J.C., Svehag S.E. Humoral immunity to dietary antigens in healthy adults. Occurrence, isotype and IgG subclass distribution of serum antibodies to protein antigens. Int. Arch. Allergy Appl. Immunol. 1985, 77:416.
10. Kaplan I.V., Levinson S.S. When is a heterophile antibody not a heterophile antibody? When it is an antibody against a specific immunogen. Clin. Chem. 1999, 45:616.
11. Koshida S., Asanuma K., Kuribayashi K., Goto M., Tsuji N., Kobayashi D., Tanaka M., Watanabe N. Prevalence of human anti-mouse antibodies (HAMAs) in routine examinations. Clin. Chim. Acta 2010, 411:391.
12. Kricka L.J. Human anti-animal antibody interferences in immunological assays. Clin. Chem. 1999, 45:942.
13. Kuen L.S., Ming C.H., Fan Y.S. Background noise in ELISA procedures. Influence of the pH of the coating buffer and correlations with serum IgM concentration. J. Immunol. Methods 1993, 163:277.
14. Naot Y., Barnett E.V., Remington J.S. Method for avoiding false-positive results occurring in immunoglobulin M enzyme-linked immunosorbent assays due to presence of both rheumatoid factor and antinuclear antibodies. J. Clin. Microbiol. 1981, 14:73.
15. Nilsson R., Sjögren H.O. Antigen-independent binding of rat immunoglobulins in a radioimmunoassay. Solutions to an unusual background problem. J. Immunol. Methods 1984, 66:17.
16. Park A., Edwards M., Donaldson M., Ghatei M., Meeran K. Lesson of the week: interfering antibodies affecting immunoassays in woman with pet rabbits. BMJ 2003, 326:541.
17. Rose H.M., Ragan C., et al. Differential agglutination of normal and sensitized sheep erythrocytes by sera of patients with rheumatoid arthritis. Proc. Soc. Exp. Biol. Med. 1948, 68:1.
18. Sawyer M., Osburn B.I., Knight H.D., Kendrick J.W. A quantitative serologic assay for diagnosing congenital infections of cattle. Am. J. Vet. Res. 1973, 34:1281.
19. Todd D.J., Knowlton N., Amato M., Frank M.B., Schur P.H., Izmailova E.S., Roubenoff R., Shadick N.A., Weinblatt M.E., Centola M., Lee D.M. Erroneous augmentation of multiplex assay measurements in patients with rheumatoid arthritis due to heterophilic binding by serum rheumatoid factor. Arthritis Rheum. 2011, 63:894.
20. Van Weemen B.K., Schuurs A.H. Immunoassay using antigen-enzyme conjugates. FEBS Lett. 1971, 15:232.
21. Waaler E. On the occurrence of a factor in human serum activating the specific agglutintion of sheep blood corpuscles. 1939. APMIS 2007, 115:422. discussion 439.
22. Welch M.J., Fong S., Vaughan J., Carson D. Increased frequency of rheumatoid factor precursor B lymphocytes after immunization of normal adults with tetanus toxoid. Clin. Exp. Immunol. 1983, 51:299.
23. Williams M.R., Maxwell D.A., Spooner R.L. Quantitative studies on bovine immunoglobulins, normal plasma levels of IgG2, IgG1, IgM and IgA. Res. Vet. Sci. 1975, 18:314.
24. Ytting H., Christensen I.J., Thiel S., Jensenius J.C., Svendsen M.N., Nielsen L., Lottenburger T., Nielsen H.J. Biological variation in circulating levels of mannan-binding lectin (MBL) and MBL-associated serine protease-2 and the influence of age, gender and physical exercise. Scand. J. Immunol. 2007, 66:458.