Acute systemic inflammation induced by influenza A (H1N1) vaccination causes a deterioration in endothelial function in HIV-infected patients

HIV Medicine

Volumn 12, Issue 10, 2011, Pages 594-601

  Vlachopoulos, C ^a   Xaplanteris, P ^a   Sambatakou, H ^a   Mariolis, E ^a   Bratsas, A ^a   Christoforatou, E ^a   Miliou, A ^a   Aznaouridis, K ^a   Stefanadis, C ^a  

^a HIPPOKRATION HOSPITAL   (Greece)

Author keywords

Endothelial function; H1N1 subtype; HIV; Influenza A virus; Influenza vaccines

Indexed keywords

INFLUENZA VACCINE;

ACUTE SYSTEMIC INFLAMMATION; ADULT; ARTICLE; CARDIOVASCULAR EFFECT; CARDIOVASCULAR FUNCTION; CLINICAL ARTICLE; COHORT ANALYSIS; CONTROLLED STUDY; DETERIORATION; DOUBLE BLIND PROCEDURE; DRUG INDUCED DISEASE; ENDOTHELIAL DYSFUNCTION; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INFLUENZA A (H1N1); INFLUENZA VACCINATION; LEUKOCYTE COUNT; MALE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL;

ADULT; AIDS-RELATED OPPORTUNISTIC INFECTIONS; CD4 LYMPHOCYTE COUNT; DOUBLE-BLIND METHOD; ENDOTHELIUM, VASCULAR; FOLLOW-UP STUDIES; HIV INFECTIONS; HUMANS; INFLUENZA A VIRUS, H1N1 SUBTYPE; INFLUENZA VACCINES; INFLUENZA, HUMAN; INTERCELLULAR ADHESION MOLECULE-1; MALE;

EID: 80054837147     PISSN: 14642662     EISSN: 14681293     Source Type: Journal    
DOI: 10.1111/j.1468-1293.2011.00935.x     Document Type: Article

References (42)

1. Charatan F. WHO raises flu pandemic alert to level 5. BMJ 2009; 338: b1821.
2. Chlibek R, Anca I, Andre F et al. Central European Vaccination Advisory Group (CEVAG) guidance statement on recommendations for 2009 pandemic influenza A (H1N1) vaccination. Vaccine 2010; 28: 3758-3766.
3. WHO. WHO recommendations for the post-pandemic period. Pandemic (H1N1) 2009 briefing note 23. Available at.
4. Zhu FC, Wang H, Fang HH et al. A novel influenza A (H1N1) vaccine in various age groups. N Engl J Med 2009; 361: 2414-2423.
5. Hingorani AD, Cross J, Kharbanda RK et al. Acute systemic inflammation impairs endothelium-dependent dilatation in humans. Circulation 2000; 102: 994-999.
6. Vlachopoulos C, Dima I, Aznaouridis K et al. Acute systemic inflammation increases arterial stiffness and decreases wave reflections in healthy individuals. Circulation 2005; 112: 2193-2200.
7. Liuba P, Aburawi EH, Pesonen E et al. Residual adverse changes in arterial endothelial function and LDL oxidation after a mild systemic inflammation induced by influenza vaccination. Ann Med 2007; 39: 392-399.
8. Inaba Y, Chen JA, Bergmann SR. Prediction of future cardiovascular outcomes by flow-mediated vasodilatation of brachial artery: a meta-analysis. Int J Cardiovasc Imaging 2010; 26: 631-640.
9. Hulten E, Mitchell J, Scally J, Gibbs B, Villines TC. HIV positivity, protease inhibitor exposure and subclinical atherosclerosis: a systematic review and meta-analysis of observational studies. Heart 2009; 95: 1826-1835.
10. Sudano I, Spieker LE, Noll G, Corti R, Weber R, Luscher TF. Cardiovascular disease in HIV infection. Am Heart J 2006; 151: 1147-1155.
11. Schillaci G, Pucci G, De Socio GV. HIV infection and antiretroviral treatment: a "two-hit" model for arterial stiffness? Am J Hypertens 2009; 22: 817-818.
12. Lekakis J, Tsiodras S, Ikonomidis I et al. HIV-positive patients treated with protease inhibitors have vascular changes resembling those observed in atherosclerotic cardiovascular disease. Clin Sci (Lond) 2008; 115: 189-196.
13. Schillaci G, De Socio GV, Pirro M et al. Impact of treatment with protease inhibitors on aortic stiffness in adult patients with human immunodeficiency virus infection. Arterioscler Thromb Vasc Biol 2005; 25: 2381-2385.
14. Vlachopoulos C, Aznaouridis K, Dagre A et al. Protective effect of atorvastatin on acute systemic inflammation-induced endothelial dysfunction in hypercholesterolaemic subjects. Eur Heart J 2007; 28: 2102-2109.
15. Thijssen DH, Black MA, Pyke KE et al. Assessment of flow mediated dilation (FMD) in humans: a methodological and technical guideline. Am J Physiol Heart Circ Physiol 2011; 300: H2-12.
16. Yeboah J, Folsom AR, Burke GL et al. Predictive value of brachial flow-mediated dilation for incident cardiovascular events in a population-based study: the multi-ethnic study of atherosclerosis. Circulation 2009; 120: 502-509.
17. Francisci D, Giannini S, Baldelli F et al. HIV type 1 infection, and not short-term HAART, induces endothelial dysfunction. AIDS 2009; 23: 589-596.
18. Solages A, Vita JA, Thornton DJ et al. Endothelial function in HIV-infected persons. Clin Infect Dis 2006; 42: 1325-1332.
19. Flammer AJ, Vo NT, Ledergerber B et al. Effect of atazanavir versus other protease inhibitor-containing antiretroviral therapy on endothelial function in HIV-infected persons: randomised controlled trial. Heart 2009; 95: 385-390.
20. Charakida M, Donald AE, Green H et al. Early structural and functional changes of the vasculature in HIV-infected children: impact of disease and antiretroviral therapy. Circulation 2005; 112: 103-109.
21. Woo KS, Chook P, Yu CW et al. Effects of diet and exercise on obesity-related vascular dysfunction in children. Circulation 2004; 109: 1981-1986.
22. Overton ET. An overview of vaccinations in HIV. Curr HIV/AIDS Rep 2007; 4: 105-113.
23. Siriwardena AN, Gwini SM, Coupland CA. Influenza vaccination, pneumococcal vaccination and risk of acute myocardial infarction: matched case-control study. CMAJ 2010; 182: 1617-1623.
24. Tseng HF, Slezak JM, Quinn VP, Sy LS, Van den Eeden SK, Jacobsen SJ. Pneumococcal vaccination and risk of acute myocardial infarction and stroke in men. JAMA 2010; 303: 1699-1706.
25. Warren-Gash C, Smeeth L, Hayward AC. Influenza as a trigger for acute myocardial infarction or death from cardiovascular disease: a systematic review. Lancet Infect Dis 2009; 9: 601-610.
26. Dvorakova A, Poledne R. Influenza - a trigger for acute myocardial infarction. Atherosclerosis 2004; 172: 391.
27. Lippi G, Franchini M, Favaloro EJ. Influenza and cardiovascular disease: does swine-origin, 2009 H1N1 flu virus represent a risk factor, an acute trigger, or both? Semin Thromb Hemost 2010; 36: 49-58.
28. Gwini SM, Coupland CA, Siriwardena AN. The effect of influenza vaccination on risk of acute myocardial infarction: self-controlled case-series study. Vaccine 2011; 29: 1145-1149.
29. Naghavi M, Barlas Z, Siadaty S, Naguib S, Madjid M, Casscells W. Association of influenza vaccination and reduced risk of recurrent myocardial infarction. Circulation 2000; 102: 3039-3045.
30. Anema A, Mills E, Montaner J, Brownstein JS, Cooper C. Efficacy of influenza vaccination in HIV-positive patients: a systematic review and meta-analysis. HIV Med 2008; 9: 57-61.
31. Libby P, Ridker PM, Hansson GK. Inflammation in atherosclerosis: from pathophysiology to practice. J Am Coll Cardiol 2009; 54: 2129-2138.
32. Mauriello A, Sangiorgi G, Fratoni S et al. Diffuse and active inflammation occurs in both vulnerable and stable plaques of the entire coronary tree: a histopathologic study of patients dying of acute myocardial infarction. J Am Coll Cardiol 2005; 45: 1585-1593.
33. Baker J, Quick H, Hullsiek KH et al. Interleukin-6 and d-dimer levels are associated with vascular dysfunction in patients with untreated HIV infection. HIV Med 2010; 11: 608-609.
34. Kuller LH, Tracy R, Belloso W et al. Inflammatory and coagulation biomarkers and mortality in patients with HIV infection. PLoS Med 2008; 5: e203.
35. Hetherington SV, Quie PG. Human polymorphonuclear leukocytes of the bone marrow, circulation, and marginated pool: function and granule protein content. Am J Hematol 1985; 20: 235-246.
36. Blann AD, Ridker PM, Lip GY. Inflammation, cell adhesion molecules, and stroke: tools in pathophysiology and epidemiology? Stroke 2002; 33: 2141-2143.
37. Pradhan AD, Rifai N, Ridker PM. Soluble intercellular adhesion molecule-1, soluble vascular adhesion molecule-1, and the development of symptomatic peripheral arterial disease in men. Circulation 2002; 106: 820-825.
38. Ridker PM, Hennekens CH, Roitman-Johnson B, Stampfer MJ, Allen J. Plasma concentration of soluble intercellular adhesion molecule 1 and risks of future myocardial infarction in apparently healthy men. Lancet 1998; 351: 88-92.
39. Maple C, Kirk G, McLaren M, Veale D, Belch JJ. A circadian variation exists for soluble levels of intercellular adhesion molecule-1 and E-selectin in healthy volunteers. Clin Sci (London) 1998; 94: 537-540.
40. Kaufmann P, Demel U, Tilz GP, Krejs GJ. Time course of plasma soluble intercellular adhesion molecule-1 (sICAM-1) is related to severity of acute pancreatitis. Hepatogastroenterology 1999; 46: 2565-2571.
41. Tebas P, Frank I, Lewis M et al. Poor immunogenicity of the H1N1 2009 vaccine in well controlled HIV-infected individuals. AIDS 2010; 24: 2187-2192.
42. Phillips AN, Carr A, Neuhaus J et al. Interruption of antiretroviral therapy and risk of cardiovascular disease in persons with HIV-1 infection: exploratory analyses from the SMART trial. Antivir Ther 2008; 13: 177-187.