Diagnostic value of urine sTREM-1 for sepsis and relevant acute kidney injuries: A prospective study

Critical Care

Volumn 15, Issue 5, 2011, Pages

  Su, Long xiang ^a,b   Feng, Lin ^a   Zhang, Jie ^a   Xiao, Yong jiu ^a   Jia, Yan hong ^a   Yan, Peng ^a   Feng, Dan ^a   Xie, Li xin ^a  

^a CHINESE PLA GENERAL HOSPITAL   (China)

^b NANKAI UNIVERSITY   (China)

Author keywords

Acute kidney injury (AKI); Prognosis; Sensitivity; Sepsis; Severity; Soluble triggering receptor expressed on myeloid cells 1(sTREM 1); Specificity; Urine

Indexed keywords

C REACTIVE PROTEIN; CREATININE; PROCALCITONIN; SOLUBLE TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELL 1 PROTEIN; TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS 1; UNCLASSIFIED DRUG; BIOLOGICAL MARKER; IMMUNOGLOBULIN RECEPTOR; MEMBRANE PROTEIN; TREM1 PROTEIN, HUMAN;

ACUTE KIDNEY FAILURE; ADULT; ARTICLE; CREATININE BLOOD LEVEL; CREATININE CLEARANCE; DIAGNOSTIC VALUE; DISEASE SEVERITY; FEMALE; HOSPITAL ADMISSION; HUMAN; INTENSIVE CARE UNIT; LEUKOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROGNOSIS; PROSPECTIVE STUDY; SEPSIS; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME; UREA NITROGEN BLOOD LEVEL; URINE; URINE VOLUME; AGED; HOSPITALIZATION; MIDDLE AGED; SENSITIVITY AND SPECIFICITY;

ACUTE KIDNEY INJURY; ADULT; AGED; BIOLOGICAL MARKERS; FEMALE; HUMANS; MALE; MEMBRANE GLYCOPROTEINS; MIDDLE AGED; PROGNOSIS; PROSPECTIVE STUDIES; RECEPTORS, IMMUNOLOGIC; SENSITIVITY AND SPECIFICITY; SEPSIS; SEVERITY OF ILLNESS INDEX;

EID: 80054821049     PISSN: 13648535     EISSN: 1466609X     Source Type: Journal    
DOI: 10.1186/cc10508     Document Type: Article

References (36)

1. Martin GS, Mannino DM, Eaton S, Moss M. The epidemiology of sepsis in the United States from 1979 through 2000. N Engl J Med 2003, 348:1546-1554. 10.1056/NEJMoa022139, 12700374.
2. Vincent JL, Nelson DR, Williams MD. Is worsening multiple organ failure the cause of death in patients with severe sepsis?. Crit Care Med 2011, 39:1050-1055. 10.1097/CCM.0b013e31820eda29, 21317650.
3. Hoste EA, Clermont G, Kersten A, Venkataraman R, Angus DC, De Bacquer D, Kellum JA. RIFLE criteria for acute kidney injury are associated with hospital mortality in critically ill patients: a cohort analysis. Crit Care 2006, 10:R73. 10.1186/cc4915, 1550961, 16696865.
4. Steinvall I, Bak Z, Sjoberg F. Acute kidney injury is common, parallels organ dysfunction or failure, and carries appreciable mortality in patients with major burns: a prospective exploratory cohort study. Crit Care 2008, 12:R124. 10.1186/cc7032, 2592761, 18847465.
5. Lameire N, Van Biesen W, Vanholder R. Acute renal failure. Lancet 2005, 365:417-430.
6. Otero RM, Nguyen HB, Huang DT, Gaieski DF, Goyal M, Gunnerson KJ, Trzeciak S, Sherwin R, Holthaus CV, Osborn T, Rivers EP. Early goal-directed therapy in severe sepsis and septic shock revisited: concepts, controversies, and contemporary findings. Chest 2006, 130:1579-1595. 10.1378/chest.130.5.1579, 17099041.
7. Bouchon A, Facchetti F, Weigand MA, Colonna M. TREM-1 amplifies inflammation and is a crucial mediator of septic shock. Nature 2001, 410:1103-1107. 10.1038/35074114, 11323674.
8. Gibot S, Kolopp-Sarda MN, Bene MC, Cravoisy A, Levy B, Faure GC, Bollaert PE. Plasma level of a triggering receptor expressed on myeloid cells-1: its diagnostic accuracy in patients with suspected sepsis. Ann Intern Med 2004, 141:9-15.
9. Gibot S, Cravoisy A, Levy B, Bene MC, Faure G, Bollaert PE. Soluble triggering receptor expressed on myeloid cells and the diagnosis of pneumonia. N Engl J Med 2004, 350:451-458. 10.1056/NEJMoa031544, 14749453.
10. Liu CL, Hsieh WY, Wu CL, Kuo HT, Lu YT. Triggering receptor expressed on myeloid cells-1 in pleural effusions: a marker of inflammatory disease. Respir Med 2007, 101:903-909. 10.1016/j.rmed.2006.09.021, 17097866.
11. Collins CE, La DT, Yang HT, Massin F, Gibot S, Faure G, Stohl W. Elevated synovial expression of triggering receptor expressed on myeloid cells 1 in patients with septic arthritis or rheumatoid arthritis. Ann Rheum Dis 2009, 68:1768-1774. 10.1136/ard.2008.089557, 19054829.
12. Determann RM, Weisfelt M, de Gans J, van der Ende A, Schultz MJ, van de Beek D. Soluble triggering receptor expressed on myeloid cells 1: a biomarker for bacterial meningitis. Intensive Care Med 2006, 32:1243-1247. 10.1007/s00134-006-0240-4, 16786330.
13. Kusanovic JP, Romero R, Chaiworapongsa T, Mittal P, Mazaki-Tovi S, Vaisbuch E, Erez O, Gotsch F, Than NG, Edwin SS, Pacora P, Jodicke C, Yeo L, Hassan SS. Amniotic fluid sTREM-1 in normal pregnancy, spontaneous parturition at term and preterm, and intra-amniotic infection/inflammation. J Matern Fetal Neonatal Med 2010, 23:34-47.
14. Determann RM, van Till JW, van Ruler O, van Veen SQ, Schultz MJ, Boermeester MA. sTREM-1 is a potential useful biomarker for exclusion of ongoing infection in patients with secondary peritonitis. Cytokine 2009, 46:36-42. 10.1016/j.cyto.2008.12.006, 19251433.
15. Gibot S, Kolopp-Sarda MN, Bene MC, Bollaert PE, Lozniewski A, Mory F, Levy B, Faure GC. A soluble form of the triggering receptor expressed on myeloid cells-1 modulates the inflammatory response in murine sepsis. J Exp Med 2004, 200:1419-1426. 10.1084/jem.20040708, 2211948, 15557347.
16. Dimopoulou I, Orfanos SE, Pelekanou A, Kotanidou A, Livaditi O, Augustatou C, Zervou M, Douka E, Theodorakopoulou M, Karagianni V, Douzinas E, Armaganidis A, Giamarellos-Bourboulis EJ. Serum of patients with septic shock stimulates the expression of Trem-1 on U937 monocytes. Inflamm Res 2009, 58:127-132. 10.1007/s00011-008-7039-4, 19109693.
17. Zhang J, She D, Feng D, Jia Y, Xie L. Dynamic changes of serum soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) reflect sepsis severity and can predict prognosis: a prospective study. BMC Infect Dis 2011, 11:53. 10.1186/1471-2334-11-53, 3056794, 21356122.
18. Gibot S, Cravoisy A, Kolopp-Sarda MN, Bene MC, Faure G, Bollaert PE, Levy B. Time-course of sTREM (soluble triggering receptor expressed on myeloid cells)-1, procalcitonin, and C-reactive protein plasma concentrations during sepsis. Crit Care Med 2005, 33:792-796. 10.1097/01.CCM.0000159089.16462.4A, 15818107.
19. Friedewald JJ, Rabb H. Inflammatory cells in ischemic acute renal failure. Kidney Int 2004, 66:486-491. 10.1111/j.1523-1755.2004.761_3.x, 15253694.
20. Bonventre JV, Zuk A. Ischemic acute renal failure: an inflammatory disease?. Kidney Int 2004, 66:480-485. 10.1111/j.1523-1755.2004.761_2.x, 15253693.
21. Schrier RW. Pathophysiology of ischemic acute renal injury. Diseases of the Kidney and Urinary Tract 2007, 2. Philadelphia, PA, USA: Lippincott Williams & Wilkins, 8.
22. Schrier RW. ARF: pathogenesis, diagnosis andmanagement. Renal and Electrolyte Disorders 2003, Philadelphia, PA, USA: Lippincott Williams & Wilkins, 6.
23. Kinsey GR, Li L, Okusa MD. Inflammation in acute kidney injury. Nephron Exp Nephrol 2008, 109:e102-107. 10.1159/000142934, 2614446, 18802372.
24. Akcay A, Nguyen Q, Edelstein CL. Mediators of inflammation in acute kidney injury. Mediators Inflamm 2009, 2009:137072. 2825552, 20182538.
25. Bone RC, Balk RA, Cerra FB, Dellinger RP, Fein AM, Knaus WA, Schein RM, Sibbald WJ. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine. Chest 1992, 101:1644-1655. 10.1378/chest.101.6.1644, 1303622.
26. Levy MM, Fink MP, Marshall JC, Abraham E, Angus D, Cook D, Cohen J, Opal SM, Vincent JL, Ramsay G. 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Crit Care Med 2003, 31:1250-1256. 10.1097/01.CCM.0000050454.01978.3B, 12682500.
27. Mehta RL, Kellum JA, Shah SV, Molitoris BA, Ronco C, Warnock DG, Levin A. Acute Kidney Injury Network: report of an initiative to improve outcomes in acute kidney injury. Crit Care 2007, 11:R31. 10.1186/cc5713, 2206446, 17331245.
28. Uchino S, Kellum JA, Bellomo R, Doig GS, Morimatsu H, Morgera S, Schetz M, Tan I, Bouman C, Macedo E, Gibney N, Tolwani A, Ronco C, . Beginning and Ending Supportive Therapy for the Kidney (BEST Kidney) Investigators Acute renal failure in critically ill patients: a multinational, multicenter study. JAMA 2005, 294:813-818. 10.1001/jama.294.7.813, 16106006, Beginning and Ending Supportive Therapy for the Kidney (BEST Kidney) Investigators.
29. Zhang B, Ramesh G, Uematsu S, Akira S, Reeves WB. TLR4 signaling mediates inflammation and tissue injury in nephrotoxicity. J Am Soc Nephrol 2008, 19:923-932. 10.1681/ASN.2007090982, 2386719, 18256356.
30. Goncalves GM, Zamboni DS, Camara NO. The role of innate immunity in septic acute kidney injuries. Shock 2010, 34(Suppl 1):22-26. 10.1097/SHK.0b013e3181e7e69e, 20523275.
31. Ishikawa K, May CN, Gobe G, Langenberg C, Bellomo R. Pathophysiology of septic acute kidney injury: a different view of tubular injury. Contrib Nephrol 2010, 165:18-27.
32. El-Achkar TM, Hosein M, Dagher PC. Pathways of renal injury in systemic gram-negative sepsis. Eur J Clin Invest 2008, 38(Suppl 2):39-44.
33. Colonna M. TREMs in the immune system and beyond. Nat Rev Immunol 2003, 3:445-453. 10.1038/nri1106, 12776204.
34. Ornatowska M, Azim AC, Wang X, Christman JW, Xiao L, Joo M, Sadikot RT. Functional genomics of silencing TREM-1 on TLR4 signaling in macrophages. Am J Physiol Lung Cell Mol Physiol 2007, 293:L1377-1384. 10.1152/ajplung.00140.2007, 17905855.
35. Gomez-Pina V, Soares-Schanoski A, Rodriguez-Rojas A, Del Fresno C, Garcia F, Vallejo-Cremades MT, Fernandez-Ruiz I, Arnalich F, Fuentes-Prior P, Lopez-Collazo E. Metalloproteinases shed TREM-1 ectodomain from lipopolysaccharide-stimulated human monocytes. J Immunol 2007, 179:4065-4073.
36. Determann RM, Schultz MJ, Geerlings SE. Soluble triggering receptor expressed on myeloid cells-1 is not a sufficient biological marker for infection of the urinary tract. J Infect 2007, 54:e249-250. 10.1016/j.jinf.2007.01.010, 17343917.