Discovery of a novel series of cyclic urea as potent CCR5 antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 21, 2011, Pages 6381-6385

  Duan, Maosheng ^a   Kazmierski, Wieslaw M ^a   Tallant, Matt ^a   Jun, Jung Ho ^a   Edelstein, Mark ^a   Ferris, Rob ^a   Todd, Dan ^a   Wheelan, Pat ^a   Xiong, Zhiping ^a  

^a GLAXOSMITHKLINE   (United States)

Author keywords

Antagonist; CCR5; Chemokine; Cyclic urea; HIV 1; Pharmacokinetics

Indexed keywords

ANTIVIRUS AGENT; CHEMOKINE RECEPTOR CCR5 ANTAGONIST; UREA DERIVATIVE;

ANIMAL EXPERIMENT; ANTIVIRAL ACTIVITY; ARTICLE; CYTOTOXICITY; DRUG HALF LIFE; DRUG SYNTHESIS; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; NONHUMAN; RAT;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 80054788314     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.08.096     Document Type: Article

References (7)

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4. Kazmierski, W. M.; Chong, P. Y.; Duan, M. PCT Int. Appl., WO 2009058919, 2009.
5. Muniz-Medina, V.; Jones, S.; Maglich, J.; Galardi, C.; Hollinggswirth, R.; Kazmierski, W.; Ferris, R.; Edelstein, M.; Chiswell, K.; Kenakin, T. Mol. Pharmacol. 2009, 75, 490.
6. Kazmierski, W. M.; Chong, P. Y.; Duan, M. PCT Int. Appl., WO 2009058921, 2009.
7. After this work was completed, we became aware of related work: Zhou, Y.; Bourque, E.; Zhu, Y.; McEachern, E. J.; Harwig, C.; Skerlj, R. T.; Bridger, G. J.; Li, T.-S.; Metz, M. WO 200702237.