The therapeutic potential of Berberis darwinii Stem-bark: Quantification of berberine and in vitro evidence for Alzheimer's disease therapy

Natural Product Communications

Volumn 6, Issue 8, 2011, Pages 1089-1090

  Habtemariam, Solomon ^a  

^a UNIVERSITY OF GREENWICH   (United Kingdom)

Author keywords

Acetylcholinesterase; Alzheimer's disease; Berberidaceae; Berberine; Berberis darwinii

Indexed keywords

ACETYLCHOLINESTERASE; BERBERINE; BERBERIS DARWINII EXTRACT; METHANOL; PHYSOSTIGMINE; PLANT EXTRACT; UNCLASSIFIED DRUG; CHOLINESTERASE INHIBITOR;

ALZHEIMER DISEASE; ARTICLE; BARK; BERBERIDACEAE; BERBERIS DARWINII; ENZYME INHIBITION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IC 50; IN VITRO STUDY; NONHUMAN; PLANT STEM; QUANTITATIVE ANALYSIS; BERBERIS; CHEMISTRY;

BERBERIDACEAE; BERBERIS DARWINII;

ALZHEIMER DISEASE; BERBERINE; BERBERIS; CHOLINESTERASE INHIBITORS; PLANT BARK; PLANT STEMS;

EID: 80054777175     PISSN: 1934578X     EISSN: 15559475     Source Type: Journal    
DOI: None     Document Type: Article

References (12)

1. (a) Tang J, Feng Y, Tsao S, Wang N, Curtain R, Wang Y. (2009) Berberine and Coptidis rhizoma as novel antineoplastic agents: A review of traditional use and biomedical investigations. Journal of Ethnopharmacology, 126, 5-17;
2. (b) Zhou X-Q, Zeng X-N, Kong, H, Sun XL. (2008) Neuroprotective effects of berberine on stroke models in vitro and in vivo. Neuroscience Letters, 447, 31- 36;
3. (c) Klein WL. (2002) Aβ toxicity in Alzheimer's disease: globular oligomers (ADDLs) as new vaccine and drug targets. Neurochemistry International, 41, 345-352;
4. (d) Asai M, Iwata N, Yoshikawa A, Aizaki Y, Ishiura S, Saido TC, Maruyama K. (2007) Berberine alters the processing of Alzheimer's amyloid precursor protein to decrease Aβ secretion. Biochemical and Biophysical Research Communication, 52, 498-502;
5. (e) Racchi M, Mazzucchelli M, Porrello E, Lanni C, Govoni S. (2004) Acetylcholinesterase inhibitors: novel activities of old molecules. Pharmacological Research, 50, 441-445,
6. (f) Huang L, Luo Z, He F, Lu J, Li X.(2010) Synthesis and biological evaluation of a new series of berberine derivatives as dual inhibitors of acetylcholinesterase and butyrylcholinesterase. Bioorganic & Medicinal Chemistry Letters, 18, 4475-4484.
7. (a) Wikipedia: http://en.wikipedia.org/wiki/Berberis-darwinii#cite-note-0 Accessed - February 2011;
8. (b) Cromwell BT. (1933) Experiments on the origin and function of berberine in Berberis Darwinii. Biochemical Journal, 27, 860-872.
9. Douglas JA, Follett JM, Parmenter GA, Sansom CE, Perry NB, Littler RA. (2010) Seasonal variation of biomass and bioactive alkaloid content of goldenseal, Hydrastis canadensis. Fitoterapia, 81, 925-928;
10. (c) Douglas JA, Follett JM, Parmenter GA, Sansom CE, Perry NB, Littler RA. (2010) Seasonal variation of biomass and bioactive alkaloid content of goldenseal, Hydrastis canadensis. Fitoterapia, 81, 925-928;
11. (d) Chen J, Wang F, Liu J, Lee FS-C, Wang X, Yang H. (2008) Analysis of alkaloids in Coptis chinensis Franch by accelerated solvent extraction combined with ultra performance liquid chromatographic analysis with photodiode array and tandem mass spectrometry detections. Analytica Chimica Acta, 613, 184-195;
12. (e) Ellman GL, Courtney KD, Andres V, Featherstone RM. (1961) A new and rapid colourimetric determination of acetylcholinesterase activity. Biochemical Pharmacology, 7, 88-95.