Monitoring nonadherence and acute rejection with variation in blood immunosuppressant levels in pediatric renal transplantation

Transplantation

Volumn 92, Issue 8, 2011, Pages 918-922

  Hsiau, Margaret ^a   Fernandez, Hilda E ^a   Gjertson, David ^b   Ettenger, Robert B ^a   Tsai, Eileen W ^a  

^a MATTEL CHILDREN S HOSPITAL   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Immunosuppressant adherence; Mycophenolate mofetil; Pediatric kidney transplantation; Tacrolimus; Trough level; Variability

Indexed keywords

DACLIZUMAB; IMMUNOSUPPRESSIVE AGENT; MYCOPHENOLIC ACID; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; STEROID; TACROLIMUS;

ACUTE GRAFT REJECTION; ADOLESCENT; ADULT; ARTICLE; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; FEMALE; HUMAN; KIDNEY BIOPSY; KIDNEY GRAFT REJECTION; KIDNEY TRANSPLANTATION; MALE; PATIENT COMPLIANCE; POSTOPERATIVE PERIOD; PRESCHOOL CHILD; PRIORITY JOURNAL; RECEIVER OPERATING CHARACTERISTIC; RISK FACTOR; SCHOOL CHILD;

ACUTE DISEASE; ADOLESCENT; ADULT; CHILD; CHILD, PRESCHOOL; FEMALE; GRAFT REJECTION; HUMANS; IMMUNOSUPPRESSIVE AGENTS; INFANT; KIDNEY TRANSPLANTATION; MALE; MEDICATION ADHERENCE; MYCOPHENOLIC ACID; TACROLIMUS;

EID: 80054761726     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/TP.0b013e31822dc34f     Document Type: Article

References (14)

1. Smith JM, Ho PL, McDonald RA. Renal transplant outcomes in adolescents: A report of the North American Pediatric Renal Transplant Cooperative Study. Pediatr Transplant 2002; 6: 493.
2. Cecka JM, Gjertson DW, Terasaki PI. Pediatric renal transplantation: A review of the UNOS data. United Network for Organ Sharing. Pediatr Transplant 1997; 1: 55.
3. Gerson AC, Stablein D, Fivush BA, et al. Physician identified nonadherence associated graft failure: A retrospective cohort analysis of NAPRTCS Data 1988-2006. Poster presentation, PAS Annual Meeting 2007; Toronto, Canada.
4. Chisholm-Burns MA, Spivey CA, Rehfeld R, et al. Immunosuppressant therapy adherence and graft failure among pediatric renal transplant recipients. Am J Transplant 2009; 9: 2497.
5. Rianthavorn P, Ettenger R. Medication non-adherence in the adolescent renal transplant recipient: A clinician's viewpoint. Pediatr Transplant 2005; 9: 398.
6. Shemesh E, Shneider BL, Savitzky JK, et al. Medication adherence in pediatric and adolescent liver transplant recipients. Pediatrics 2004; 113: 825.
7. Stuber M, Shemesh E, Seacord D, et al. Evaluating non-adherence to immunosuppressant medications in pediatric liver transplant recipients. Pediatr Transplant 2008; 12: 284.
8. Pollock-BarZiv SM, Finkelstein Y, Manlhiot C, et al. Variability in tacrolimus blood levels increases the risk of late rejection and graft loss after solid organ transplantation in older children. Pediatr Transplant 2010; 14: 968.
9. Ettenger RB, Rosenthal JT, Marik JL, et al. Improved cadaveric renal transplant outcome in children. Pediatr Nephrol 1991; 5: 137.
10. De Geest S, Abraham I, Moons P, et al. Late acute rejection and subclinical noncompliance with cyclosporine therapy in heart transplant recipients. J Heart Lung Transplant 1998; 17: 854.
11. Feldman H, Hackett M, Bilder W, et al. Potential utility of electronic drug compliance monitoring in measures of adverse outcomes associated with immunosuppressive agents. Pharmacoepidemiol Drug Saf 1999; 8: 1.
12. Shaw C, Korecka M, Brayman L. Pharmacokinetic-pharmacodynamic relationship for mycophenolic acid in renal transplant patients. Graft 1994; 2: 597.
13. Bullingham RE, Nicholls AJ, Kamm BR. Clinical pharmacokinetics of mycophenolate mofetil. Clin Pharmacokinet 1998; 34: 429.
14. Schwartz GJ, Haycock GB, EdelmannCMJr., et al. A simple estimate of glomerular filtration rate in children derived from body length and plasma creatinine. Pediatrics 1976; 58: 259.