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Volumn 18, Issue 6, 2011, Pages 388-394

Prevention and treatment of acute myeloid leukemia relapse after allogeneic stem cell transplantation

Author keywords

acute myeloid leukemia; allogeneic stem cell transplantation; prevention; relapse

Indexed keywords

AZACITIDINE; CD135 ANTIGEN; HLA A ANTIGEN; MOLECULAR MARKER; PEPTIDE VACCINE; SORAFENIB; WT1 PROTEIN;

EID: 80054759339     PISSN: 10656251     EISSN: 15317048     Source Type: Journal    
DOI: 10.1097/MOH.0b013e32834b6158     Document Type: Review
Times cited : (38)

References (63)
  • 1
    • 48849095824 scopus 로고    scopus 로고
    • Allogeneic stem cell transplantation in acute myeloid leukemia in first or subsequent remission: Weighing prognostic markers predicting relapse and risk factors for nonrelapse mortality
    • Meijer E, Cornelissen JJ. Allogeneic stem cell transplantation in acute myeloid leukemia in first or subsequent remission: Weighing prognostic markers predicting relapse and risk factors for nonrelapse mortality. Semin Oncol 2008; 35:449-457.
    • (2008) Semin Oncol , vol.35 , pp. 449-457
    • Meijer, E.1    Cornelissen, J.J.2
  • 2
    • 0027940491 scopus 로고
    • Leukemia relapse after allogeneic bone marrow transplantation: A review
    • Giralt SA, Champlin RE. Leukemia relapse after allogeneic bone marrow transplantation: A review. Blood 1994; 84:3603-3612. (Pubitemid 24362455)
    • (1994) Blood , vol.84 , Issue.11 , pp. 3603-3612
    • Giralt, S.A.1    Champlin, R.E.2
  • 3
    • 34548693215 scopus 로고    scopus 로고
    • Outcomes among Patients with Recurrent High-Risk Hematologic Malignancies after Allogeneic Hematopoietic Cell Transplantation
    • DOI 10.1016/j.bbmt.2007.06.007, PII S1083879107003175
    • Mielcarek M, Storer BE, Flowers ME, et al. Outcomes among patients with recurrent high-risk hematologic malignancies after allogeneic hematopoietic cell transplantation. Biol Blood Marrow Transplant 2007; 13:1160-1168. (Pubitemid 47413010)
    • (2007) Biology of Blood and Marrow Transplantation , vol.13 , Issue.10 , pp. 1160-1168
    • Mielcarek, M.1    Storer, B.E.2    Flowers, M.E.D.3    Storb, R.4    Sandmaier, B.M.5    Martin, P.J.6
  • 8
    • 57649155053 scopus 로고    scopus 로고
    • Quantitative assessment of WT1 gene expression after allogeneic stem cell transplantation is a useful tool for monitoring minimal residual disease in acute myeloid leukemia
    • Candoni A, Tiribelli M, Toffoletti E, et al. Quantitative assessment of WT1 gene expression after allogeneic stem cell transplantation is a useful tool for monitoring minimal residual disease in acute myeloid leukemia. Eur J Haematol 2009; 82:61-68.
    • (2009) Eur J Haematol , vol.82 , pp. 61-68
    • Candoni, A.1    Tiribelli, M.2    Toffoletti, E.3
  • 9
    • 57549101876 scopus 로고    scopus 로고
    • Quantitative monitoring of NPM1 mutations provides a valid minimal residual disease parameter following allogeneic stem cell transplantation
    • Bacher U, Badbaran A, Fehse B, et al. Quantitative monitoring of NPM1 mutations provides a valid minimal residual disease parameter following allogeneic stem cell transplantation. Exp Hematol 2009; 37:135-142.
    • (2009) Exp Hematol , vol.37 , pp. 135-142
    • Bacher, U.1    Badbaran, A.2    Fehse, B.3
  • 10
    • 79953090055 scopus 로고    scopus 로고
    • Towards individualized follow-up in adult acute myeloid leukemia in remission
    • Hokland P, Ommen HB. Towards individualized follow-up in adult acute myeloid leukemia in remission. Blood 2011; 117:2577-2584.
    • (2011) Blood , vol.117 , pp. 2577-2584
    • Hokland, P.1    Ommen, H.B.2
  • 11
    • 34247640052 scopus 로고    scopus 로고
    • Clinical implications of minimal residual disease monitoring by quantitative polymerase chain reaction in acute myeloid leukemia patients bearing nucleophosmin (NPM1) mutations
    • Chou WC, Tang JL, Wu SJ, et al. Clinical implications of minimal residual disease monitoring by quantitative polymerase chain reaction in acute myeloid leukemia patients bearing nucleophosmin (NPM1) mutations. Leukemia 2007; 21:998-1004.
    • (2007) Leukemia , vol.21 , pp. 998-1004
    • Chou, W.C.1    Tang, J.L.2    Wu, S.J.3
  • 13
    • 0038040665 scopus 로고    scopus 로고
    • Detection of minimal residual disease in hematologic malignancies by real-time quantitative PCR: Principles, approaches, and laboratory aspects
    • DOI 10.1038/sj.leu.2402922
    • van der Velden VH, Hochhaus A, Cazzaniga G, et al. Detection of minimal residual disease in hematologic malignancies by real-time quantitative PCR: Principles, approaches, and laboratory aspects. Leukemia 2003; 17:1013-1034. (Pubitemid 36722231)
    • (2003) Leukemia , vol.17 , Issue.6 , pp. 1013-1034
    • Van Der Velden, V.H.J.1    Hochhaus, A.2    Cazzaniga, G.3    Szczepanski, T.4    Gabert, J.5    Van Dongen, J.J.M.6
  • 14
    • 7744244145 scopus 로고    scopus 로고
    • Stability of leukemia-associated aberrant immunophenotypes in patients with acute myeloid leukemia between diagnosis and relapse: Comparison with cytomorphologic, cytogenetic, and molecular genetic findings
    • DOI 10.1002/cyto.b.20025
    • Voskova D, Schoch C, Schnittger S, et al. Stability of leukemia-associated aberrant immunophenotypes in patients with acute myeloid leukemia between diagnosis and relapse: Comparison with cytomorphologic, cytogenetic, and molecular genetic findings. Cytometry B Clin Cytom 2004; 62:25-38. (Pubitemid 39463698)
    • (2004) Cytometry Part B - Clinical Cytometry , vol.62 , Issue.1 , pp. 25-38
    • Voskova, D.1    Schoch, C.2    Schnittger, S.3    Hiddemann, W.4    Haferlach, T.5    Kern, W.6
  • 17
    • 79952439621 scopus 로고    scopus 로고
    • Monitoring of WT1 expression in PB and CD34(+) donor chimerism of BM predicts early relapse in AML and MDS patients after hematopoietic cell transplantation with reduced-intensity conditioning
    • In this study, monitoring of WT1 expression and CD34(+) donor chimerism predicted relapse of AML and MDS after RIC-HC.T.
    • Lange T, Hubmann M, Burkhardt R, et al. Monitoring of WT1 expression in PB and CD34(+) donor chimerism of BM predicts early relapse in AML and MDS patients after hematopoietic cell transplantation with reduced-intensity conditioning. Leukemia 2011; 25:498-505. In this study, monitoring of WT1 expression and CD34(+) donor chimerism predicted relapse of AML and MDS after RIC-HCT.
    • (2011) Leukemia , vol.25 , pp. 498-505
    • Lange, T.1    Hubmann, M.2    Burkhardt, R.3
  • 18
    • 33746163435 scopus 로고    scopus 로고
    • Chimerism and transplant-related diagnostics
    • DOI 10.1038/sj.leu.2404268, PII 2404268
    • Muller-Berat N, Lion T. Chimerism and transplant-related diagnostics. Leukemia 2006; 20: 1358-1360. (Pubitemid 44084047)
    • (2006) Leukemia , vol.20 , Issue.8 , pp. 1358-1360
    • Muller-Berat, N.1    Lion, T.2
  • 19
    • 33847306904 scopus 로고    scopus 로고
    • Chimerism analysis within 6 months of allogeneic stem cell transplantation predicts relapse in acute myeloid leukemia
    • DOI 10.1038/sj.bmt.1705582, PII 1705582
    • Huisman C, de Weger RA, de Vries L, et al. Chimerism analysis within 6 months of allogeneic stem cell transplantation predicts relapse in acute myeloid leukemia. Bone Marrow Transplant 2007; 39:285-291. (Pubitemid 46322635)
    • (2007) Bone Marrow Transplantation , vol.39 , Issue.5 , pp. 285-291
    • Huisman, C.1    De Weger, R.A.2    De Vries, L.3    Tilanus, M.G.J.4    Verdonck, L.F.5
  • 20
    • 78549285253 scopus 로고    scopus 로고
    • Chimerism studies with quantitative real-time PCR in stem cell recipients with acute myeloid leukemia
    • Wiedemann B, Klyuchnikov E, Kroger N, et al. Chimerism studies with quantitative real-time PCR in stem cell recipients with acute myeloid leukemia. Exp Hematol 2010; 38:1261-1271.
    • (2010) Exp Hematol , vol.38 , pp. 1261-1271
    • Wiedemann, B.1    Klyuchnikov, E.2    Kroger, N.3
  • 21
    • 77953587073 scopus 로고    scopus 로고
    • NCI first international workshop on the biology, prevention, and treatment of relapse after allogeneic hematopoietic stem cell transplantation: Report from the committee on the epidemiology and natural history of relapse following allogeneic cell transplantation
    • Pavletic SZ, Kumar S, Mohty M, et al. NCI First International Workshop on the Biology, Prevention, and Treatment of Relapse after Allogeneic Hematopoietic Stem Cell Transplantation: Report from the Committee on the Epidemiology and Natural History of Relapse following Allogeneic Cell Transplantation. Biol Blood Marrow Transplant 2010; 16:871-890.
    • (2010) Biol Blood Marrow Transplant , vol.16 , pp. 871-890
    • Pavletic, S.Z.1    Kumar, S.2    Mohty, M.3
  • 22
    • 79952757082 scopus 로고    scopus 로고
    • Impact of pretransplantation minimal residual disease, as detected by multiparametric flow cytometry, on outcome of myeloablative hematopoietic cell transplantation for acute myeloid leukemia
    • In this study, pre-HCT MRD based on MFC was associated with increased risk of relapse and death after myeloablative HCT for AML in CR1, even after controlling for other risk factors
    • Walter RB, Gooley TA, Wood BL, et al. Impact of pretransplantation minimal residual disease, as detected by multiparametric flow cytometry, on outcome of myeloablative hematopoietic cell transplantation for acute myeloid leukemia. J Clin Oncol 2011; 29:1190-1197. In this study, pre-HCT MRD based on MFC was associated with increased risk of relapse and death after myeloablative HCT for AML in CR1, even after controlling for other risk factors.
    • (2011) J Clin Oncol , vol.29 , pp. 1190-1197
    • Walter, R.B.1    Gooley, T.A.2    Wood, B.L.3
  • 23
    • 80051560743 scopus 로고    scopus 로고
    • Early human cytomegalovirus replication after transplant is associated with a decreased relapse risk: Evidence for a putative virus-versus-leukemia effect in AML patients
    • Elmaagacli AH, Steckel NK, Koldehoff M, et al. Early human cytomegalovirus replication after transplant is associated with a decreased relapse risk: Evidence for a putative virus-versus-leukemia effect in AML patients. Blood 2011; 118:1402-1412.
    • (2011) Blood , vol.118 , pp. 1402-1412
    • Elmaagacli, A.H.1    Steckel, N.K.2    Koldehoff, M.3
  • 25
    • 0028820386 scopus 로고
    • Reconstitution of cellular immunity against cytomegalovirus in recipients of allogeneic bone marrow by transfer of T-cell clones from the donor
    • Walter EA, Greenberg PD, Gilbert MJ, et al. Reconstitution of cellular immunity against cytomegalovirus in recipients of allogeneic bone marrow by transfer of T-cell clones from the donor. N Engl J Med 1995; 333:1038-1044.
    • (1995) N Engl J Med , vol.333 , pp. 1038-1044
    • Walter, E.A.1    Greenberg, P.D.2    Gilbert, M.J.3
  • 26
    • 77951257237 scopus 로고    scopus 로고
    • Therapy of relapsed leukemia after allogeneic hematopoietic cell transplantation with T cells specific for minor histocompatibility antigens
    • In this study, adoptive transfer of donor T cells that recognize recipient mHAgs was used to prevent or to treat leukemic relapse after allo-HCT in seven patients. Adoptively transferred CTLs persisted in the blood up to 21 days after infusion, and five patients achieved complete but transient remissions after therapy
    • Warren EH, Fujii N, Akatsuka Y, et al. Therapy of relapsed leukemia after allogeneic hematopoietic cell transplantation with T cells specific for minor histocompatibility antigens. Blood 2010; 115:3869-3878. In this study, adoptive transfer of donor T cells that recognize recipient mHAgs was used to prevent or to treat leukemic relapse after allo-HCT in seven patients. Adoptively transferred CTLs persisted in the blood up to 21 days after infusion, and five patients achieved complete but transient remissions after therapy.
    • (2010) Blood , vol.115 , pp. 3869-3878
    • Warren, E.H.1    Fujii, N.2    Akatsuka, Y.3
  • 27
    • 33845991508 scopus 로고    scopus 로고
    • Cancer vaccines for patients with acute myeloid leukemia - Definition of leukemia-associated antigens and current clinical protocols targeting these antigens
    • Greiner J, Dohner H, Schmitt M. Cancer vaccines for patients with acute myeloid leukemia: Definition of leukemia-associated antigens and current clinical protocols targeting these antigens. Haematologica 2006; 91:1653-1661. (Pubitemid 46039635)
    • (2006) Haematologica , vol.91 , Issue.12 , pp. 1653-1661
    • Greiner, J.1    Dohner, H.2    Schmitt, M.3
  • 28
    • 0035806246 scopus 로고    scopus 로고
    • + T cells at the levels of T cell repertoire and presentation of viral antigens
    • DOI 10.1084/jem.193.11.1319
    • Chen W, Norbury CC, Cho Y, et al. Immunoproteasomes shape immunodominance hierarchies of antiviral CD8(+) T cells at the levels of T cell repertoire and presentation of viral antigens. J Exp Med 2001; 193:1319-1326. (Pubitemid 32524782)
    • (2001) Journal of Experimental Medicine , vol.193 , Issue.11 , pp. 1319-1326
    • Chen, W.1    Norbury, C.C.2    Cho, Y.3    Yewdell, J.W.4    Bennink, J.R.5
  • 29
    • 77956955626 scopus 로고    scopus 로고
    • WT1 peptide vaccine induces reduction in minimal residual disease in an imatinib-treated CML patient
    • Oji Y, Oka Y, Nishida S, et al. WT1 peptide vaccine induces reduction in minimal residual disease in an imatinib-treated CML patient. Eur J Haematol 2010; 85:358-360.
    • (2010) Eur J Haematol , vol.85 , pp. 358-360
    • Oji, Y.1    Oka, Y.2    Nishida, S.3
  • 30
    • 79951779813 scopus 로고    scopus 로고
    • Vaccines as consolidation therapy for myeloid leukemia
    • Alatrash G, Molldrem JJ. Vaccines as consolidation therapy for myeloid leukemia. Expert Rev Hematol 2011; 4:37-50.
    • (2011) Expert Rev Hematol , vol.4 , pp. 37-50
    • Alatrash, G.1    Molldrem, J.J.2
  • 31
    • 79955966609 scopus 로고    scopus 로고
    • An anti-PR1/HLA-A2 T-cell receptor-like antibody mediates complement-dependent cytotoxicity against acute myeloid leukemia progenitor cells
    • Sergeeva A, Alatrash G, He H, et al. An anti-PR1/HLA-A2 T-cell receptor-like antibody mediates complement-dependent cytotoxicity against acute myeloid leukemia progenitor cells. Blood 2011; 117:4262-4272.
    • (2011) Blood , vol.117 , pp. 4262-4272
    • Sergeeva, A.1    Alatrash, G.2    He, H.3
  • 32
    • 38049188363 scopus 로고    scopus 로고
    • Leukemia-associated antigen-specific T-cell responses following combined PR1 and WT1 peptide vaccination in patients with myeloid malignancies
    • Rezvani K, Yong AS, Mielke S, et al. Leukemia-associated antigen-specific T-cell responses following combined PR1 and WT1 peptide vaccination in patients with myeloid malignancies. Blood 2008; 111:236-242.
    • (2008) Blood , vol.111 , pp. 236-242
    • Rezvani, K.1    Yong, A.S.2    Mielke, S.3
  • 34
    • 0021160287 scopus 로고
    • 5-Aza-2'-deoxycytidine induces terminal differentiation of leukemic blasts from patients with acute myeloid leukemias
    • Pinto A, Attadia V, Fusco A, et al. 5-Aza-2'-deoxycytidine induces terminal differentiation of leukemic blasts from patients with acute myeloid leukemias. Blood 1984; 64:922-929.
    • (1984) Blood , vol.64 , pp. 922-929
    • Pinto, A.1    Attadia, V.2    Fusco, A.3
  • 36
    • 77956924038 scopus 로고    scopus 로고
    • Induction of a CD8+ T-cell response to the MAGE cancer testis antigen by combined treatment with azacitidine and sodium valproate in patients with acute myeloid leukemia and myelodysplasia
    • Goodyear O, Agathanggelou A, Novitzky-Basso I, et al. Induction of a CD8+ T-cell response to the MAGE cancer testis antigen by combined treatment with azacitidine and sodium valproate in patients with acute myeloid leukemia and myelodysplasia. Blood 2010; 116:1908-1918.
    • (2010) Blood , vol.116 , pp. 1908-1918
    • Goodyear, O.1    Agathanggelou, A.2    Novitzky-Basso, I.3
  • 37
    • 65649120045 scopus 로고    scopus 로고
    • Low-dose azacitidine after allogeneic stem cell transplantation for acute leukemia
    • Jabbour E, Giralt S, Kantarjian H, et al. Low-dose azacitidine after allogeneic stem cell transplantation for acute leukemia. Cancer 2009; 115:1899-1905.
    • (2009) Cancer , vol.115 , pp. 1899-1905
    • Jabbour, E.1    Giralt, S.2    Kantarjian, H.3
  • 38
    • 77950614210 scopus 로고    scopus 로고
    • Efficacy of a 3-day, low-dose treatment with 5-azacytidine followed by donor lymphocyte infusions in older patients with acute myeloid leukemia or chronic myelomonocytic leukemia relapsed after allografting
    • Lubbert M, Bertz H, Wasch R, et al. Efficacy of a 3-day, low-dose treatment with 5-azacytidine followed by donor lymphocyte infusions in older patients with acute myeloid leukemia or chronic myelomonocytic leukemia relapsed after allografting. Bone Marrow Transplant 2010; 45:627-632.
    • (2010) Bone Marrow Transplant , vol.45 , pp. 627-632
    • Lubbert, M.1    Bertz, H.2    Wasch, R.3
  • 39
    • 79954573454 scopus 로고    scopus 로고
    • 5-azacytidine as salvage treatment in relapsed myeloid tumors after allogeneic bone marrow transplantation
    • Bolanos-Meade J, Smith BD, Gore SD, et al. 5-azacytidine as salvage treatment in relapsed myeloid tumors after allogeneic bone marrow transplantation. Biol Blood Marrow Transplant 2011; 17:754-758.
    • (2011) Biol Blood Marrow Transplant , vol.17 , pp. 754-758
    • Bolanos-Meade, J.1    Smith, B.D.2    Gore, S.D.3
  • 40
    • 27744451026 scopus 로고    scopus 로고
    • No evidence that FLT3 status should be considered as an indicator for transplantation in acute myeloid leukemia (AML): An analysis of 1135 patients, excluding acute promyelocytic leukemia, from the UK MRCAML10 and 12 trials
    • DOI 10.1182/blood-2005-03-1323
    • Gale RE, Hills R, Kottaridis PD, et al. No evidence that FLT3 status should be considered as an indicator for transplantation in acute myeloid leukemia (AML): An analysis of 1135 patients, excluding acute promyelocytic leukemia, from the UK MRC AML10 and 12 trials. Blood 2005; 106:3658-3665. (Pubitemid 41609208)
    • (2005) Blood , vol.106 , Issue.10 , pp. 3658-3665
    • Gale, R.E.1    Hills, R.2    Kottaridis, P.D.3    Srirangan, S.4    Wheatley, K.5    Burnett, A.K.6    Linch, D.C.7
  • 42
    • 69249221392 scopus 로고    scopus 로고
    • Compassionate use of sorafenib in FLT3-ITD-positive acute myeloid leukemia: Sustained regression before and after allogeneic stem cell transplantation
    • Metzelder S, Wang Y, Wollmer E, et al. Compassionate use of sorafenib in FLT3-ITD-positive acute myeloid leukemia: Sustained regression before and after allogeneic stem cell transplantation. Blood 2009; 113:6567-6571.
    • (2009) Blood , vol.113 , pp. 6567-6571
    • Metzelder, S.1    Wang, Y.2    Wollmer, E.3
  • 43
    • 80054771760 scopus 로고    scopus 로고
    • Treatment of FLT3-ITD positive acute myeloid leukemia relapsing after allogeneic hematopoietic stem cell transplantation with sorafenib
    • [Epub ahead of print]
    • Sharma MR, Ravandi F, Bayraktar UD, et al. Treatment of FLT3-ITD positive acute myeloid leukemia relapsing after allogeneic hematopoietic stem cell transplantation with sorafenib. Biol Blood Marrow Transplant 2011 [Epub ahead of print].
    • (2011) Biol Blood Marrow Transplant
    • Sharma, M.R.1    Ravandi, F.2    Bayraktar, U.D.3
  • 44
    • 58149178882 scopus 로고    scopus 로고
    • Outcome of second allogeneic transplants using reduced-intensity conditioning following relapse of haematological malignancy after an initial allogeneic transplant
    • Shaw BE, Mufti GJ, Mackinnon S, et al. Outcome of second allogeneic transplants using reduced-intensity conditioning following relapse of haematological malignancy after an initial allogeneic transplant. Bone Marrow Transplant 2008; 42:783-789.
    • (2008) Bone Marrow Transplant , vol.42 , pp. 783-789
    • Shaw, B.E.1    Mufti, G.J.2    Mackinnon, S.3
  • 45
    • 16644379996 scopus 로고    scopus 로고
    • Higher mortality after allogeneic peripheral-blood transplantation compared with bone marrow in children and adolescents: The histocompatibility and alternate stem cell source working committee of the International Bone Marrow Transplant Registry
    • DOI 10.1200/JCO.2004.02.189
    • Eapen M, Horowitz MM, Klein JP, et al. Higher mortality after allogeneic peripheral-blood transplantation compared with bone marrow in children and adolescents: The Histocompatibility and Alternate Stem Cell Source Working Committee of the International Bone Marrow Transplant Registry. J Clin Oncol 2004; 22:4872-4880. (Pubitemid 46638610)
    • (2004) Journal of Clinical Oncology , vol.22 , Issue.24 , pp. 4872-4880
    • Eapen, M.1    Horowitz, M.M.2    Klein, J.P.3    Champlin, R.E.4    Loberiza Jr., F.R.5    Ringden, O.6    Wagner, J.E.7
  • 48
    • 34247853271 scopus 로고    scopus 로고
    • Impact of natural killer cell dose and donor killer-cell immunoglobulin-like receptor (KIR) genotype on outcome following human leucocyte antigen-identical haematopoietic stem cell transplantation
    • DOI 10.1111/j.1365-2249.2007.03360.x
    • Clausen J, Wolf D, Petzer AL, et al. Impact of natural killer cell dose and donor killer-cell immunoglobulin-like receptor (KIR) genotype on outcome following human leucocyte antigen-identical haematopoietic stem cell transplantation. Clin Exp Immunol 2007; 148:520-528. (Pubitemid 46701023)
    • (2007) Clinical and Experimental Immunology , vol.148 , Issue.3 , pp. 520-528
    • Clausen, J.1    Wolf, D.2    Petzer, A.L.3    Gunsilius, E.4    Schumacher, P.5    Kircher, B.6    Gastl, G.7    Nachbaur, D.8
  • 49
    • 60249098439 scopus 로고    scopus 로고
    • Donors with group B KIR haplotypes improve relapse-free survival after unrelated hematopoietic cell transplantation for acute myelogenous leukemia
    • Cooley S, Trachtenberg E, Bergemann TL, et al. Donors with group B KIR haplotypes improve relapse-free survival after unrelated hematopoietic cell transplantation for acute myelogenous leukemia. Blood 2009; 113:726-732.
    • (2009) Blood , vol.113 , pp. 726-732
    • Cooley, S.1    Trachtenberg, E.2    Bergemann, T.L.3
  • 50
    • 63749126940 scopus 로고    scopus 로고
    • What is the role for donor natural killer cells after nonmyeloablative conditioning?
    • Baron F, Petersdorf EW, Gooley T, et al. What is the role for donor natural killer cells after nonmyeloablative conditioning? Biol Blood Marrow Transplant 2009; 15:580-588.
    • (2009) Biol Blood Marrow Transplant , vol.15 , pp. 580-588
    • Baron, F.1    Petersdorf, E.W.2    Gooley, T.3
  • 51
    • 58849140610 scopus 로고    scopus 로고
    • Clinical-grade purification of natural killer cells in haploidentical hematopoietic stem cell transplantation
    • Meyer-Monard S, Passweg J, Siegler U, et al. Clinical-grade purification of natural killer cells in haploidentical hematopoietic stem cell transplantation. Transfusion 2009; 49:362-371.
    • (2009) Transfusion , vol.49 , pp. 362-371
    • Meyer-Monard, S.1    Passweg, J.2    Siegler, U.3
  • 52
    • 20144388509 scopus 로고    scopus 로고
    • Successful adoptive transfer and in vivo expansion of human haploidentical NK cells in patients with cancer
    • Miller JS, Soignier Y, Panoskaltsis-Mortari A, et al. Successful adoptive transfer and in vivo expansion of human haploidentical NK cells in patients with cancer. Blood 2005; 105:3051-3057.
    • (2005) Blood , vol.105 , pp. 3051-3057
    • Miller, J.S.1    Soignier, Y.2    Panoskaltsis-Mortari, A.3
  • 53
    • 68049132603 scopus 로고    scopus 로고
    • Clinical-grade ex vivo-expanded human natural killer cells up-regulate activating receptors and death receptor ligands and have enhanced cytolytic activity against tumor cells
    • Berg M, Lundqvist A, McCoy P Jr., et al. Clinical-grade ex vivo-expanded human natural killer cells up-regulate activating receptors and death receptor ligands and have enhanced cytolytic activity against tumor cells. Cytotherapy 2009; 11:341-355.
    • (2009) Cytotherapy , vol.11 , pp. 341-355
    • Berg, M.1    Lundqvist, A.2    McCoy Jr., P.3
  • 54
    • 65949111530 scopus 로고    scopus 로고
    • Expansion of highly cytotoxic human natural killer cells for cancer cell therapy
    • Fujisaki H, Kakuda H, Shimasaki N, et al. Expansion of highly cytotoxic human natural killer cells for cancer cell therapy. Cancer Res 2009; 69:4010-4017.
    • (2009) Cancer Res , vol.69 , pp. 4010-4017
    • Fujisaki, H.1    Kakuda, H.2    Shimasaki, N.3
  • 55
    • 79952039394 scopus 로고    scopus 로고
    • Minimal residual disease (MRD) based preemptive 5-azacytidine treatment can prevent or delay imminent relapse in patients with high-risk MDS or AML after allogeneic HSCT: Results of the 'RELAZA' trial
    • Platzbecker U, Wermke M, Radke J, et al. Minimal residual disease (MRD) based preemptive 5-azacytidine treatment can prevent or delay imminent relapse in patients with high-risk MDS or AML after allogeneic HSCT: Results of the 'RELAZA' trial. Blood 2010; 116:679.
    • (2010) Blood , vol.116 , pp. 679
    • Platzbecker, U.1    Wermke, M.2    Radke, J.3
  • 56
    • 78649601394 scopus 로고    scopus 로고
    • Maintenance therapy with low-dose azacitidine after allogeneic hematopoietic stem cell transplantation for recurrent acute myelogenous leukemia or myelodysplastic syndrome: A dose and schedule finding study
    • This phase I study showed that azacitidine at 32 mg/m2 given for 5 days is well tolerated and can be administered after allogeneic transplant for at least four cycles to heavily pretreated AML/MDS patients. The trial also suggested that this treatment may prolong event-free and overall survival, and that more cycles may be associated with greater benefit
    • de Lima M, Giralt S, Thall PF, et al. Maintenance therapy with low-dose azacitidine after allogeneic hematopoietic stem cell transplantation for recurrent acute myelogenous leukemia or myelodysplastic syndrome: A dose and schedule finding study. Cancer 2010; 116:5420-5431. This phase I study showed that azacitidine at 32 mg/m2 given for 5 days is well tolerated and can be administered after allogeneic transplant for at least four cycles to heavily pretreated AML/MDS patients. The trial also suggested that this treatment may prolong event-free and overall survival, and that more cycles may be associated with greater benefit.
    • (2010) Cancer , vol.116 , pp. 5420-5431
    • De Lima, M.1    Giralt, S.2    Thall, P.F.3
  • 58
    • 77957950672 scopus 로고    scopus 로고
    • Toxic effects of sorafenib when given early after allogeneic hematopoietic stem cell transplantation
    • Yokoyama H, Lundqvist A, Su S, et al. Toxic effects of sorafenib when given early after allogeneic hematopoietic stem cell transplantation. Blood 2010; 116:2858-2859.
    • (2010) Blood , vol.116 , pp. 2858-2859
    • Yokoyama, H.1    Lundqvist, A.2    Su, S.3
  • 59
    • 79953073247 scopus 로고    scopus 로고
    • FLT3 ligand impedes the efficacy of FLT3 inhibitors in vitro and in vivo
    • Sato T, Yang X, Knapper S, et al. FLT3 ligand impedes the efficacy of FLT3 inhibitors in vitro and in vivo. Blood 2011; 117:3286-3293.
    • (2011) Blood , vol.117 , pp. 3286-3293
    • Sato, T.1    Yang, X.2    Knapper, S.3
  • 60
    • 79953124734 scopus 로고    scopus 로고
    • Results from a randomized trial of salvage chemotherapy followed by lestaurtinib for patients with FLT3 mutant AML in first relapse
    • Levis M, Ravandi F, Wang ES, et al. Results from a randomized trial of salvage chemotherapy followed by lestaurtinib for patients with FLT3 mutant AML in first relapse. Blood 2011; 117:3294-3301.
    • (2011) Blood , vol.117 , pp. 3294-3301
    • Levis, M.1    Ravandi, F.2    Wang, E.S.3
  • 61
    • 79956017109 scopus 로고    scopus 로고
    • Clofarabine +/- fludarabine with once daily i.v. busulfan as pretransplant conditioning therapy for advanced myeloid leukemia and MDS
    • Andersson BS, Valdez BC, de Lima M, et al. Clofarabine +/- fludarabine with once daily i.v. busulfan as pretransplant conditioning therapy for advanced myeloid leukemia and MDS. Biol Blood Marrow Transplant 2011; 17:893-900.
    • (2011) Biol Blood Marrow Transplant , vol.17 , pp. 893-900
    • Andersson, B.S.1    Valdez, B.C.2    De Lima, M.3
  • 62
    • 78650972375 scopus 로고    scopus 로고
    • Phase 1/2 trial of total marrow and lymph node irradiation to augment reduced-intensity transplantation for advanced hematologic malignancies
    • The regimen was well tolerated well with 1-year event-free survival of 65% suggesting that addition of total marrow and lymph node irradiation to RIC could be an alternative in patients who otherwise would not be eligible for RI.C.
    • Rosenthal J, Wong J, Stein A, et al. Phase 1/2 trial of total marrow and lymph node irradiation to augment reduced-intensity transplantation for advanced hematologic malignancies. Blood 2011; 117:309-315. The regimen was well tolerated well with 1-year event-free survival of 65% suggesting that addition of total marrow and lymph node irradiation to RIC could be an alternative in patients who otherwise would not be eligible for RIC.
    • (2011) Blood , vol.117 , pp. 309-315
    • Rosenthal, J.1    Wong, J.2    Stein, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.