Streptococcus pneumoniae serotype 9A isolates contain diverse mutations to wcjE that result in variable expression of serotype 9v-specific epitope

Journal of Infectious Diseases

Volumn 204, Issue 10, 2011, Pages 1585-1595

  Calix, Juan J ^a   Oliver, Melissa B ^a   Sherwood, Logan K ^c   Beall, Bernard W ^c   Hollingshead, Susan K ^a   Nahm, Moon H ^b  

^a University of Alabama at Birmingham   (United States)

^b UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^c CENTERS FOR DISEASE CONTROL AND PREVENTION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EPITOPE;

BACTERIAL GENE; BACTERIAL STRAIN; BACTERIUM ISOLATE; CONFERENCE PAPER; CONTROLLED STUDY; FLOW CYTOMETRY; GENE EXPRESSION; GENE FREQUENCY; GENE INACTIVATION; GENE LOCUS; GENE MUTATION; GENE SEQUENCE; GENETIC HETEROGENEITY; GENETIC RECOMBINATION; GENETIC VARIABILITY; IMMUNOREACTIVITY; NONHUMAN; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SEQUENCE ALIGNMENT; SEQUENCE ANALYSIS; SEROTYPE; STREPTOCOCCUS PNEUMONIAE; WCJE GENE;

ACETYLTRANSFERASES; BACTERIAL CAPSULES; BASE SEQUENCE; DNA, BACTERIAL; EPITOPE MAPPING; GENES, BACTERIAL; MOLECULAR SEQUENCE DATA; MUTATION; POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS, DNA; SEROTYPING; STREPTOCOCCUS PNEUMONIAE;

EID: 80054757043     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1093/infdis/jir593     Document Type: Conference Paper

References (24)

1. Hyams C, Camberlein E, Cohen JM, Bax K, Brown JS. The Streptococcus pneumoniae capsule inhibits complement activity and neutrophil phagocytosis by multiple mechanisms. Infect Immun 2010; 78:704-15.
2. Bratcher PE, Kim KH, Kang JH, Hong JY, Nahm MH. Identification of natural pneumococcal isolates expressing serotype 6D by genetic, biochemical, and serological characterization. Microbiology 2010; 156:555-60.
3. Calix JJ, Nahm MH. A new pneumococcal serotype, 11E, has variably inactivated wcjE gene. J Infect Dis 2010; 202:29-38.
4. Park IH, Pritchard DG, Cartee R, Brandao A, BrandileoneMC, Nahm MH. Discovery of a new capsular serotype (6C) within serogroup 6 of Streptococcus pneumoniae. J ClinMicrobiol 2007; 45:1225-33. (Pubitemid 46626489)
5. Trzcinski K, Thompson CM, Lipsitch M. Construction of otherwise isogenic serotype 6B, 7F, 14, and 19F capsular variants of Streptococcus pneumoniae strain TIGR4. Appl Environ Microbiol 2003; 69: 7364-70. (Pubitemid 38585389)
6. Jones C, Lemercinier X. Full NMR assignment and revised structure for the capsular polysaccharide from Streptococcus pneumoniae type 15B. Carbohydr Res 2005; 340:403-9. (Pubitemid 40186767)
7. van Selm S, van Cann LM, Kolkman MA, van der Zeijst BA, van Putten JP. Genetic basis for the structural difference between Streptococcus pneumoniae serotype 15B and 15C capsular polysaccharides. Infect Immun 2003; 71:6192-8. (Pubitemid 37337674)
8. Venkateswaran PS, Stanton N, Austrian R. Type variation of strains of Streptococcus pneumoniae in capsular serogroup 15. J Infect Dis 1983; 147:1041-54. (Pubitemid 13068350)
9. van Selm S, Kolkman MA, van der Zeijst BA, Zwaagstra KA, Gaastra W, van Putten JP. Organization and characterization of the capsule biosynthesis locus of Streptococcus pneumoniae serotype 9V. Microbiology 2002; 148:1747-55. (Pubitemid 34679028)
10. Bentley SD, Aanensen DM, Mavroidi A, et al. Genetic analysis of the capsular biosynthetic locus from all 90 pneumococcal serotypes. PLoS Genet 2006; 2:e31.
11. Rutherford TJ, Jones C, Davies DB, Elliott AC. Location and quantitation of the sites of O-acetylation on the capsular polysaccharide from Streptococcus pneumoniae type 9V by 1H-n.m.r. spectroscopy: comparison with type 9A. Carbohydr Res 1991; 218:175-84.
12. Calix JJ, Nahm MH, Zartler ER. Elucidation of structural and antigenic properties of pneumococcal serotype 11A, 11B, 11C, and 11F polysaccharide capsules. J Bacteriol 2011. In press.
13. Sung CK, Li H, Claverys JP, Morrison DA. An rpsL cassette, janus, for gene replacement through negative selection in Streptococcus pneumoniae. Appl Environ Microbiol 2001; 67:5190-6. (Pubitemid 33701288)
14. Lin J, Kaltoft MS, Brandao AP, et al. Validation of a multiplex pneumococcal serotyping assay with clinical samples. J Clin Microbiol 2006; 44:383-8. (Pubitemid 43222227)
15. Theilacker C, Coleman FT, Mueschenborn S, Llosa N, Grout M, Pier GB. Construction and characterization of a Pseudomonas aeruginosa mucoid exopolysaccharide-alginate conjugate vaccine. Infect Immun 2003; 71:3875-84. (Pubitemid 36763514)
16. Fattom AI, Sarwar J, Basham L, Ennifar S, Naso R. Antigenic determinants of Staphylococcus aureus type 5 and type 8 capsular polysaccharide vaccines. Infect Immun 1998; 66:4588-92. (Pubitemid 28453057)
17. Berry DS, Lynn F, Lee CH, Frasch CE, Bash MC. Effect of O acetylation of Neisseria meningitidis serogroup A capsular polysaccharide on development of functional immune responses. Infect Immun 2002; 70: 3707-13. (Pubitemid 34666010)
18. McNeely TB, Staub JM, Rusk CM, Blum MJ, Donnelly JJ. Antibody responses to capsular polysaccharide backbone and O-acetate side groups of Streptococcus pneumoniae type 9V in humans and rhesus macaques. Infect Immun 1998; 66:3705-10. (Pubitemid 28347827)
19. Harboe ZB, Thomsen RW, Riis A, et al. Pneumococcal serotypes and mortality following invasive pneumococcal disease: A population-based cohort study. PLoS Med 2009; 6:e1000081.
20. Levin BR, Bull JJ. Short-sighted evolution and the virulence of pathogenic microorganisms. Trends Microbiol 1994; 2:76-81. (Pubitemid 24072104)
21. Farabaugh PJ. Programmed translational frameshifting. Microbiol Rev 1996; 60:103-34. (Pubitemid 26087764)
22. Richter SS, Heilmann KP, Dohrn CL, Riahi F, Beekmann SE, Doern GV. Changing epidemiology of antimicrobial-resistant Streptococcus pneumoniae in the United States, 2004-2005. Clin Infect Dis 2009; 48:e23-33.
23. Huang SS, Hinrichsen VL, Stevenson AE, et al. Continued impact of pneumococcal conjugate vaccine on carriage in young children. Pediatrics 2009; 124:e1-11.
24. Gonzalez BE, Hulten KG, Lamberth L, Kaplan SL, Mason EO Jr. Streptococcus pneumoniae serogroups 15 and 33: an increasing cause of pneumococcal infections in children in the United States after the introduction of the pneumococcal 7-valent conjugate vaccine. Pediatr Infect Dis J 2006; 25:301-5.