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Volumn 31, Issue 10, 2011, Pages 3289-3299

Polo-like kinase 1 inhibition as a new therapeutic modality in therapy of cholangiocarcinoma

Author keywords

5 fluorouracil; BI 2536; Cholangiocarcinoma; Gemcitabine; Polo like kinase 1

Indexed keywords

4 (8 CYCLOPENTYL 7 ETHYL 5,6,7,8 TETRAHYDRO 5 METHYL 6 OXO 2 PTERIDINYLAMINO) 3 METHOXY N (1 METHYL 4 PIPERIDINYL)BENZAMIDE; FLUOROURACIL; GEMCITABINE; HISTONE H3; MESSENGER RNA; NVP AEW 541; POLO LIKE KINASE 1; PROTEIN KINASE B; PROTEIN P42; PROTEIN P44;

EID: 80054753124     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (18)

References (47)
  • 2
    • 0032535244 scopus 로고    scopus 로고
    • Polo-like kinases: A team that plays throughout mitosis
    • Glover DM, Hagan IM and Tavares AA: Polo-like kinases: a team that plays throughout mitosis. Genes Dev 12: 3777-3787, 1998. (Pubitemid 29024839)
    • (1998) Genes and Development , vol.12 , Issue.24 , pp. 3777-3787
    • Glover, D.M.1    Hagan, I.M.2    Tavares, A.A.M.3
  • 3
    • 68049112546 scopus 로고    scopus 로고
    • Polo-like kinase (PLK) inhibitors in preclinical and early clinical development in oncology
    • Schoffski P: Polo-like kinase (PLK) inhibitors in preclinical and early clinical development in oncology. Oncologist 14: 559-570, 2009.
    • (2009) Oncologist , vol.14 , pp. 559-570
    • Schoffski, P.1
  • 5
    • 76649103697 scopus 로고    scopus 로고
    • Treatment of biliary tract cancer with NVP-AEW541: Mechanisms of action and resistance
    • Wolf S, Lorenz J, Mossner J and Wiedmann M: Treatment of biliary tract cancer with NVP-AEW541: mechanisms of action and resistance. World J Gastroenterol 16: 156-166, 2010.
    • (2010) World J Gastroenterol , vol.16 , pp. 156-166
    • Wolf, S.1    Lorenz, J.2    Mossner, J.3    Wiedmann, M.4
  • 6
    • 0027523131 scopus 로고
    • Cultured human gallbladder epithelia: Methods and partial characterization of a carcinoma-derived model
    • Purdum PP, 3rd, Ulissi A, Hylemon PB, Shiffman ML and Moore EW: Cultured human gallbladder epithelia. Methods and partial characterization of a carcinoma-derived model. Lab Invest 68: 345-353, 1993. (Pubitemid 23097656)
    • (1993) Laboratory Investigation , vol.68 , Issue.3 , pp. 345-353
    • Purdum III, P.P.1    Ulissi, A.2    Hylemon, P.B.3    Shiffman, M.L.4    Moore, E.W.5
  • 7
    • 0021874928 scopus 로고
    • Biliary adenocarcinoma. Characterisation of three new human tumor cell lines
    • DOI 10.1016/S0168-8278(85)80002-7
    • Knuth A, Gabbert H, Dippold W, Klein O, Sachsse W, Bitter-Suermann D, Prellwitz W and Meyer zum Buschenfelde KH: Biliary adenocarcinoma. Characterisation of three new human tumor cell lines. J Hepatol 1: 579-596, 1985. (Pubitemid 15015131)
    • (1985) Journal of Hepatology , vol.1 , Issue.6 , pp. 579-596
    • Knuth, A.1    Gabbert, H.2    Dippold, W.3
  • 9
    • 0023761438 scopus 로고
    • Establishment and characterization of a cell line from a human cholangiocellular carcinoma
    • (Berl)
    • Kusaka Y, Tokiwa T and Sato J: Establishment and characterization of a cell line from a human cholangiocellular carcinoma. Res Exp Med (Berl) 188: 367-375, 1988.
    • (1988) Res Exp Med , vol.188 , pp. 367-375
    • Kusaka, Y.1    Tokiwa, T.2    Sato, J.3
  • 12
    • 0023388991 scopus 로고
    • International Conference on Tumor Necrosis Factor and Related Cytotoxins. September 14-18, 1987, Heidelberg, Federal Republic of Germany
    • Abstracts.
    • International Conference on Tumor Necrosis Factor and Related Cytotoxins. September 14-18, 1987, Heidelberg, Federal Republic of Germany. Abstracts. Immunobiology 175: 1-143, 1987.
    • (1987) Immunobiology , vol.175 , pp. 1-143
  • 14
    • 0036581160 scopus 로고    scopus 로고
    • Relative expression software tool (REST) for group-wise comparison and statistical analysis of relative expression results in real-time PCR
    • Pfaffl MW, Horgan GW and Dempfle L: Relative expression software tool (REST) for group-wise comparison and statistical analysis of relative expression results in real-time PCR. Nucleic Acids Res 30: e36, 2002.
    • (2002) Nucleic Acids Res , vol.30
    • Pfaffl, M.W.1    Horgan, G.W.2    Dempfle, L.3
  • 15
    • 0019750732 scopus 로고
    • Criteria for analyzing interactions between biologically active agents
    • Berenbaum MC: Criteria for analyzing interactions between biologically active agents. Adv Cancer Res 35: 269-335, 1981.
    • (1981) Adv Cancer Res , vol.35 , pp. 269-335
    • Berenbaum, M.C.1
  • 18
    • 77954711656 scopus 로고    scopus 로고
    • Molecular targeted therapy of biliary tract cancer - Results of the first clinical studies
    • Wiedmann MW and Mossner J: Molecular targeted therapy of biliary tract cancer - results of the first clinical studies. Curr Drug Targets 11: 834-850, 2010.
    • (2010) Curr Drug Targets , vol.11 , pp. 834-850
    • Wiedmann, M.W.1    Mossner, J.2
  • 19
    • 33644767315 scopus 로고    scopus 로고
    • Normal cells, but not cancer cells, survive severe Plk1 depletion
    • DOI 10.1128/MCB.26.6.2093-2108.2006
    • Liu X, Lei M and Erikson RL: Normal cells, but not cancer cells, survive severe Plk1 depletion. Mol Cell Biol 26: 2093-2108, 2006. (Pubitemid 43346913)
    • (2006) Molecular and Cellular Biology , vol.26 , Issue.6 , pp. 2093-2108
    • Liu, X.1    Lei, M.2    Erikson, R.L.3
  • 21
    • 62449333305 scopus 로고    scopus 로고
    • Identification of Polo-like kinase 1 as a potential therapeutic target in anaplastic thyroid carcinoma
    • Nappi TC, Salerno P, Zitzelsberger H, Carlomagno F, Salvatore G and Santoro M: Identification of Polo-like kinase 1 as a potential therapeutic target in anaplastic thyroid carcinoma. Cancer Res 69: 1916-1923, 2009.
    • (2009) Cancer Res , vol.69 , pp. 1916-1923
    • Nappi, T.C.1    Salerno, P.2    Zitzelsberger, H.3    Carlomagno, F.4    Salvatore, G.5    Santoro, M.6
  • 22
    • 70149106223 scopus 로고    scopus 로고
    • Polo-like kinase 1 is overexpressed in acute myeloid leukemia and its inhibition preferentially targets the proliferation of leukemic cells
    • Renner AG, Dos Santos C, Recher C, Bailly C, Creancier L, Kruczynski A, Payrastre B and Manenti S: Polo-like kinase 1 is overexpressed in acute myeloid leukemia and its inhibition preferentially targets the proliferation of leukemic cells. Blood 114: 659-662, 2009.
    • (2009) Blood , vol.114 , pp. 659-662
    • Renner, A.G.1    Dos Santos, C.2    Recher, C.3    Bailly, C.4    Creancier, L.5    Kruczynski, A.6    Payrastre, B.7    Manenti, S.8
  • 26
    • 33845624084 scopus 로고    scopus 로고
    • Polo-like kinase 1: Target and regulator of transcriptional control
    • Martin BT and Strebhardt K: Polo-like kinase 1: target and regulator of transcriptional control. Cell Cycle 5: 2881-2885, 2006. (Pubitemid 44953940)
    • (2006) Cell Cycle , vol.5 , Issue.24 , pp. 2881-2885
    • Martin, B.T.1    Strebhardt, K.2
  • 28
    • 7544231164 scopus 로고    scopus 로고
    • The mouse Forkhead Box m1 transcription factor is essential for hepatoblast mitosis and development of intrahepatic bile ducts and vessels during liver morphogenesis
    • DOI 10.1016/j.ydbio.2004.08.022, PII S0012160604005767
    • Krupczak-Hollis K, Wang X, Kalinichenko VV, Gusarova GA, Wang IC, Dennewitz MB, Yoder HM, Kiyokawa H, Kaestner KH and Costa RH: The mouse Forkhead Box ml transcription factor is essential for hepatoblast mitosis and development of intrahepatic bile ducts and vessels during liver morphogenesis. Dev Biol 276: 74-88, 2004. (Pubitemid 39452847)
    • (2004) Developmental Biology , vol.276 , Issue.1 , pp. 74-88
    • Krupczak-Hollis, K.1    Wang, X.2    Kalinichenko, V.V.3    Gusarova, G.A.4    Wang, I.-C.5    Dennewitz, M.B.6    Yoder, H.M.7    Kiyokawa, H.8    Kaestner, K.H.9    Costa, R.H.10
  • 29
    • 51049093989 scopus 로고    scopus 로고
    • Plk1-dependent phosphorylation of FOXMl regulates a transcriptional programme required for mitotic progression
    • Fu Z, Malureanu L, Huang J, Wang W, Li H, van Deursen JM, Tindall DJ and Chen J: Plk1-dependent phosphorylation of FOXMl regulates a transcriptional programme required for mitotic progression. Nat Cell Biol 10: 1076-1082, 2008.
    • (2008) Nat Cell Biol , vol.10 , pp. 1076-1082
    • Fu, Z.1    Malureanu, L.2    Huang, J.3    Wang, W.4    Li, H.5    Van Deursen, J.M.6    Tindall, D.J.7    Chen, J.8
  • 34
    • 68049095649 scopus 로고    scopus 로고
    • A phase I dose escalation trial of BI 2536, a novel Plk1 inhibitor, with standard dose pemetrexed in previously treated advanced or metastatic non-small cell lung cancer (NSCLC)
    • abstract 8115
    • Ellis P, Chu Q, Leighl N, Laurie S, Trommeshauser D, Hanft G, Munzert G and Gyorffy S: A phase I dose escalation trial of BI 2536, a novel Plk1 inhibitor, with standard dose pemetrexed in previously treated advanced or metastatic non-small cell lung cancer (NSCLC). J Clin Oncol 26: abstract 8115, 2008.
    • (2008) J Clin Oncol , vol.26
    • Ellis, P.1    Chu, Q.2    Leighl, N.3    Laurie, S.4    Trommeshauser, D.5    Hanft, G.6    Munzert, G.7    Gyorffy, S.8
  • 35
    • 59349121035 scopus 로고    scopus 로고
    • An open label phase II trial of BI 2536, a novel Plk1 inhibitor, in patients with metastatic hormone-refractory prostate cancer (HRPC)
    • abstract 14547
    • Pandha H, Protheroe A, Wylie J, Parker C, Chambers J, Bell S and Munzert G: An open label phase II trial of BI 2536, a novel Plk1 inhibitor, in patients with metastatic hormone-refractory prostate cancer (HRPC). J Clin Oncol 26: abstract 14547, 2008.
    • (2008) J Clin Oncol , vol.26
    • Pandha, H.1    Protheroe, A.2    Wylie, J.3    Parker, C.4    Chambers, J.5    Bell, S.6    Munzert, G.7
  • 36
    • 80054744283 scopus 로고    scopus 로고
    • A randomized phase II trial of the novel Polo-like kinase 1 inhibitor BI 2536 in chemonaïve patients with unresectable advanced pancreatic cancer: A study in cooperation with the CESAR network of investigators
    • (abstract)
    • Mross K, Dittrich C, Aulitzky W, Strumberg D, Schütte J, Schmid R, Hollerbach S, Merger M, Munzert G and Scheulen M: A randomized phase II trial of the novel Polo-like kinase 1 inhibitor BI 2536 in chemonaïve patients with unresectable advanced pancreatic cancer: a study in cooperation with the CESAR network of investigators. Ann Oncol 19: 163 (abstract), 2008.
    • (2008) Ann Oncol , vol.19 , pp. 163
    • Mross, K.1    Dittrich, C.2    Aulitzky, W.3    Strumberg, D.4    Schütte, J.5    Schmid, R.6    Hollerbach, S.7    Merger, M.8    Munzert, G.9    Scheulen, M.10
  • 37
    • 77954423900 scopus 로고    scopus 로고
    • The efficacy and safety of BI 2536, a novel PLKl inhibitor, in patients with stage IIIB/IV non-small cell lung cancer who had relapsed after, or failed, chemotherapy: Results from an open-label, randomized phase II clinical trial
    • Sebastian M, Reck M, Waller CF, Kortsik C, Frickhofen N, Schuler M, Fritsch H, Gaschler-Markefski B, Hanft G, Munzert G and von Pawel J: The efficacy and safety of BI 2536, a novel PLKl inhibitor, in patients with stage IIIB/IV non-small cell lung cancer who had relapsed after, or failed, chemotherapy: results from an open-label, randomized phase II clinical trial. J Thorac Oncol 5: 1060-1067, 2010.
    • (2010) J Thorac Oncol , vol.5 , pp. 1060-1067
    • Sebastian, M.1    Reck, M.2    Waller, C.F.3    Kortsik, C.4    Frickhofen, N.5    Schuler, M.6    Fritsch, H.7    Gaschler-Markefski, B.8    Hanft, G.9    Munzert, G.10    Von Pawel, J.11
  • 38
    • 77955714290 scopus 로고    scopus 로고
    • Multicentric parallel phase II trial of the polo-like kinase 1 inhibitor BI 2536 in patients with advanced head and neck cancer, breast cancer, ovarian cancer, soft tissue sarcoma and melanoma. The first protocol of the European Organization for Research and Treatment of Cancer (EORTC) Network of Core Institutes (NOCI)
    • Schoffski P, Blay JY, De Greve J, Brain E, Machiels JP, Soria JC, Sleijfer S, Wolter P, Ray-Coquard I, Fontaine C, Munzert G, Fritsch H, Hanft G, Aerts C, Rapion J, Allgeier A, Bogaerts J and Lacombe D: Multicentric parallel phase II trial of the polo-like kinase 1 inhibitor BI 2536 in patients with advanced head and neck cancer, breast cancer, ovarian cancer, soft tissue sarcoma and melanoma. The first protocol of the European Organization for Research and Treatment of Cancer (EORTC) Network Of Core Institutes (NOCI). Eur J Cancer 46: 2206-2215, 2010.
    • (2010) Eur J Cancer , vol.46 , pp. 2206-2215
    • Schoffski, P.1    Blay, J.Y.2    De Greve, J.3    Brain, E.4    Machiels, J.P.5    Soria, J.C.6    Sleijfer, S.7    Wolter, P.8    Ray-Coquard, I.9    Fontaine, C.10    Munzert, G.11    Fritsch, H.12    Hanft, G.13    Aerts, C.14    Rapion, J.15    Allgeier, A.16    Bogaerts, J.17    Lacombe, D.18
  • 39
    • 33947387077 scopus 로고    scopus 로고
    • Chemotherapy in advanced biliary tract carcinoma: A pooled analysis of clinical trials
    • DOI 10.1038/sj.bjc.6603648, PII 6603648
    • Eckel F and Schmid RM: Chemotherapy in advanced biliary tract carcinoma: a pooled analysis of clinical trials. Br J Cancer 96: 896-902, 2007. (Pubitemid 46452283)
    • (2007) British Journal of Cancer , vol.96 , Issue.6 , pp. 896-902
    • Eckel, F.1    Schmid, R.M.2
  • 40
    • 23644446486 scopus 로고    scopus 로고
    • The insulin-like growth factor-I receptor as a target for cancer therapy
    • Baserga R: The insulin-like growth factor-I receptor as a target for cancer therapy. Expert Opin Ther Targets 9: 753-768, 2005.
    • (2005) Expert Opin Ther Targets , vol.9 , pp. 753-768
    • Baserga, R.1
  • 41
    • 33846807433 scopus 로고    scopus 로고
    • Disrupting insulin-like growth factor signaling as a potential cancer therapy
    • DOI 10.1158/1535-7163.MCT-06-0080
    • Sachdev D and Yee D: Disrupting insulin-like growth factor signaling as a potential cancer therapy. Mo Cancer Ther 6: 1-12, 2007. (Pubitemid 46206663)
    • (2007) Molecular Cancer Therapeutics , vol.6 , Issue.1 , pp. 1-12
    • Sachdev, D.1    Yee, D.2
  • 42
    • 22044434446 scopus 로고    scopus 로고
    • Role of insulin-like growth factor I receptor signalling in cancer
    • DOI 10.1038/sj.bjc.6602627
    • Larsson O, Girnita A and Girnita L: Role of insulin-like growth factor 1 receptor signalling in cancer. Br J Cancer 92: 2097-2101, 2005. (Pubitemid 40966242)
    • (2005) British Journal of Cancer , vol.92 , Issue.12 , pp. 2097-2101
    • Larsson, O.1    Girnita, A.2    Girnita, L.3
  • 44
    • 0042926509 scopus 로고    scopus 로고
    • Regulation of hypoxia-inducible factor-1alpha, vascular endothelial growth factor, and angiogenesis by an insulin-like growth factor-I receptor autocrine loop in human pancreatic cancer
    • Stoeltzing O, Liu W, Reinmuth N, Fan F, Parikh AA, Bucana CD, Evans DB, Semenza GL and Ellis LM: Regulation of hypoxia-inducible factor-1alpha, vascular endothelial growth factor, and angiogenesis by an insulin-like growth factor-I receptor autocrine loop in human pancreatic cancer. Am J Pathol 163: 1001-1011, 2003. (Pubitemid 37040136)
    • (2003) American Journal of Pathology , vol.163 , Issue.3 , pp. 1001-1011
    • Stoeltzing, O.1    Liu, W.2    Reinmuth, N.3    Fan, F.4    Parikh, A.A.5    Bucana, C.D.6    Evans, D.B.7    Semenza, G.L.8    Ellis, L.M.9
  • 45
    • 0030006574 scopus 로고    scopus 로고
    • Enhanced expression of vascular endothelial growth factor in human SaOS-2 osteoblast-like cells and murine osteoblasts induced by insulin-like growth factor I
    • DOI 10.1210/en.137.6.2262
    • Goad DL, Rubin J, Wang H, Tashjian AH Jr. and Patterson C: Enhanced expression of vascular endothelial growth factor in human SaOS-2 osteoblast-like cells and murine osteoblasts induced by insulin-like growth factor I. Endocrinology 137: 2262-2268, 1996. (Pubitemid 26155757)
    • (1996) Endocrinology , vol.137 , Issue.6 , pp. 2262-2268
    • Goad, D.L.1    Rubin, J.2    Wang, H.3    Tashjian Jr., A.H.4    Patterson, C.5
  • 46
    • 33344467985 scopus 로고    scopus 로고
    • Targeting insulin-like growth factor pathways
    • Yee D: Targeting insulin-like growth factor pathways. Br J Cancer 94: 465-468, 2006.
    • (2006) Br J Cancer , vol.94 , pp. 465-468
    • Yee, D.1


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