Identification and SAR of selective inducible nitric oxide synthase (iNOS) dimerization inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 22, 2011, Pages 6888-6894

  Gahman, Timothy C ^a   Herbert, Mark R ^a   Lang, Henk ^a   Thayer, Angie ^a   Symons, Kent T ^a   Nguyen, Phan Manh ^a   Massari, Mark E ^a   Dozier, Sara ^a   Zhang, Yan ^a   Sablad, Marciano ^a   Rao, Tadimeti S ^a   Noble, Stewart A ^a   Shiau, Andrew K ^a   Hassig, Christian A ^a  

^a Kalypsys Inc   (United States)

Author keywords

Dimerization inhibitor; iNOS; Tactile allodynia

Indexed keywords

ANALGESIC AGENT; IMIDAZOLE DERIVATIVE; INDUCIBLE NITRIC OXIDE SYNTHASE; INDUCIBLE NITRIC OXIDE SYNTHASE DIMERIZATION INHIBITOR; NITRIC OXIDE SYNTHASE INHIBITOR; UNCLASSIFIED DRUG;

ALLODYNIA; ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; DIMERIZATION; DOSE RESPONSE; FEMALE; HYPERALGESIA; INFLAMMATION; NERVE LIGATION; NEUROPATHIC PAIN; NONHUMAN; PAIN; POSTOPERATIVE PAIN; RAT; SPINAL NERVE; STRUCTURE ACTIVITY RELATION;

ANIMALS; ENZYME INHIBITORS; FEMALE; HUMANS; HYPERALGESIA; IMIDAZOLES; NITRIC OXIDE SYNTHASE TYPE II; PAIN; PROTEIN MULTIMERIZATION; RATS; RATS, INBRED LEW;

EID: 80054752516     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.08.112     Document Type: Article

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