Effect of CEP-751 (KT-6587) on neuroblastoma xenografts expressing TrkB

Medical and Pediatric Oncology

Volumn 36, Issue 1, 2001, Pages 181-184

  Manzke, Oliver ^a   Russello, Orsolina ^a   Leenen, Christiane ^a   Diehl, Volker ^a   Bohlen, Heribert ^a   Berthold, Frank ^a  

^a UNIVERSITY OF COLOGNE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; CEP 751; MESSENGER RNA;

ANTINEOPLASTIC ACTIVITY; CANCER GRAFT; CANCER INHIBITION; CONFERENCE PAPER; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME INHIBITION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; NEUROBLASTOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ASSAY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR GROWTH; XENOGRAFT;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; BRAIN-DERIVED NEUROTROPHIC FACTOR; CARBAZOLES; ENZYME ACTIVATION; ENZYME INHIBITORS; FEMALE; HUMANS; IN SITU NICK-END LABELING; MICE; MICE, NUDE; NEOPLASM PROTEINS; NEUROBLASTOMA; PHOSPHORYLATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; RECEPTOR, TRKB; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANSFECTION; TUMOR CELLS, CULTURED; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 0035165355     PISSN: 00981532     EISSN: None     Source Type: Journal    
DOI: 10.1002/1096-911X(20010101)36:1<181::AID-MPO1043>3.0.CO;2-Q     Document Type: Conference Paper

References (5)

1. Inhibition of human neuroblastoma (NBL cell lines in vitro and in vivo by CEP-751
2. CEP-751 inhibits Trk receptor tyrosine kinase activity in vitro and exhibits anti-tumor activity
3. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation
4. Cell cycle independent death of prostate adenocarcinoma is induced by the Trk kyrosine kinase inhibitor CEP-751 (KT-6587)
5. The effect of CEP-751 (KT-6587) on human neuroblastoma and medulloblastoma cell lines in vitro and in vivo