C-122, a novel antagonist of serotonin receptor 5-HT 2B, prevents monocrotaline-induced pulmonary arterial hypertension in rats

European Journal of Pharmacology

Volumn 670, Issue 1, 2011, Pages 195-203

  Zopf, David A ^a   Neves, Liomar A A Das ^b   Nikula, Kristen J ^c   Huang, Jinbao ^b   Senese, Peter B ^b   Gralinski, Michael R ^b  

^a Corridor Pharmaceuticals Inc ^*  (United States)

^b CorDynamics Inc ^*  (United States)

^c Seventh Wave Laboratories LLC   (United States)

Author keywords

Antiproliferative; Hemodynamics; Pulmonary arterial hypertension; Rat monocrotaline model; Serotonin antagonist; Vascular remodeling

Indexed keywords

2 AMINO N [2 [4 [3 (2 TRIFLUOROMETHYLPHENOTHIAZIN 10 YL)PROPYL]PIPERAZIN 1 YL]ETHYL]ACETAMIDE; DOPAMINE RECEPTOR; GLYCOPROTEIN P; HISTAMINE H1 RECEPTOR; MONOCROTALINE; SEROTONIN 2B RECEPTOR; SEROTONIN ANTAGONIST; UNCLASSIFIED DRUG;

ADULT ANIMAL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIHYPERTENSIVE ACTIVITY; AREA UNDER THE CURVE; ARTERIOLE; ARTICLE; CONTROLLED STUDY; DISTRIBUTION VOLUME; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG DISTRIBUTION; DRUG PROTEIN BINDING; DRUG RECEPTOR BINDING; HEART; HEART RIGHT VENTRICLE HYPERTROPHY; HISTOPATHOLOGY; LUNG ARTERY; LUNG FIBROSIS; LUNG HEMODYNAMICS; LUNG PARENCHYMA; MALE; NONHUMAN; PRIORITY JOURNAL; PULMONARY HYPERTENSION; RAT; SINGLE DRUG DOSE;

ANIMALS; ARTERIOLES; BIOLOGICAL TRANSPORT; BLOOD PROTEINS; HEART VENTRICLES; HEMODYNAMICS; HYPERTENSION, PULMONARY; HYPERTROPHY; MALE; MONOCROTALINE; P-GLYCOPROTEINS; PHENOTHIAZINES; PIPERAZINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, SEROTONIN, 5-HT2B; SEROTONIN 5-HT2 RECEPTOR ANTAGONISTS;

EID: 80054747799     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2011.08.015     Document Type: Article

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