TB/AIDS Coinfection: An Integrated Clinical and Research Response

AIDS and Tuberculosis: A Deadly Liaison

Volumn , Issue , 2009, Pages 209-252

  Goldfeld, Anne E ^a,b,c   Corbett, Elizabeth L ^d,e  

^a HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^b CENTER FOR BLOOD RESEARCH   (United States)

^c Cambodian Health Committee   (Cambodia)

^d LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

^e MALAWI LIVERPOOL WELLCOME TRUST CLINICAL RESEARCH PROGRAMME   (Malawi)

Author keywords

Basic research; Epidemiology; Integrated approach; Integration of services; TB HIV coinfection; Treatment

Indexed keywords

EID: 80054722512     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9783527627905.ch9     Document Type: Chapter

References (151)

1. Lucas, S.B., Hounnou, A., Peacock, C., Beaumel, A., Djomand, G., N'Gbichi, J.M., Yeboue, K., Honde, M., Diomande, M., Giordano, C., Doorly, R., Brattegaard, K., Kestens, L., Smithwick, R.W., Kadio, A., Ezani, N., Yapi, A. and De Cock, K.M. (1993) The mortality and pathology of HIV infection in a west African city. AIDS, 7, 1569-1579.
2. Nelson, A.M., Perriens, J.H., Kapita, B., Okonda, L., Lusamuno, N., Kalengayi, M.R., Angritt, P., Quinn, T.C. and Mullick, F.G. (1993) A clinical and pathological comparison of the WHO and CDC case definitions for AIDS in Kinshasa, Zaire: is passive surveillance valid? AIDS, 7, 1241-1245.
3. Rana, F.S., Hawken, M.P., Mwachari, C., Bhatt, S.M., Abdullah, F., Ng'ang'a, L.W., Power, C., Githui, W.A., Porter, J.D. and Lucas, S.B. (2000)Autopsy study ofHIV-1-positive and HIV-1-negative adult medical patients in Nairobi, Kenya. J. Acquir. Immune. Defic. Syndr., 24, 23-29.
4. Corbett, E.L.,Watt, C.J.,Walker, N.,Maher, D., Lazzari, S.,Williams, B.G., Raviglione, M.C. and Dye, C. (2003) The growing burden of tuberculosis: global trends and interactions with the HIV epidemic. Arch. Intern. Med., 163, 1009-1021.
5. Corbett, E.L., Marston, B., Churchyard, G.J. and De Cock, K.M. (2006) Tuberculosis in sub-Saharan Africa: opportunities, challenges and change in the era of antiretroviral treatment. Lancet, 367, 926-937.
6. Mann, J., Snider, D.E. Jr, Francis, H., Quinn, T.C., Colebunders, R.L., Piot, P., Curran, J.W., Nzilambi, N., Bosenge, N., Malonga, M. et al. (1986) Association between HTLV-III/LAV infection and tuberculosis in Zaire. JAMA, 256, 346.
7. Pape, J.W., Liautaud, B., Thomas, F., Mathurin, J.R., St Amand, M.M., Boncy, M., Pean, V., Pamphile, M., Laroche, A.C. and Johnson, W.D. Jr (1983) Characteristics of the acquired immunodeficiency syndrome (AIDS) in Haiti. N. Engl. J. Med., 309, 945-950.
8. Goldfeld, A.E., Ranjbar, S. and Tsitsikov, E.N. (2008) Tuberculosis/ Human immunodeficiency virus coinfection and the host immune response, in Handbook of Tuberculosis: Immunology and Cell Biology (eds S.H.E. Kaufman and W.J., Britton), Wiley-VCH, Weinheim, p. 432.
9. De Cock, K.M. and Chaisson, R.E. (1999) Will DOTS do it? A reappraisal of tuberculosis control in countries with high rates of HIV infection. Int. J. Tuberc. Lung Dis., 3, 457-465.
10. Wells, C.D., Cegielski, J.P., Nelson, L.J., Laserson, K.F., Holtz, T.H., Finlay, A., Castro, K.G. and Weyer, K. (2007) HIV infection and multidrug-resistant tuberculosis: the perfect storm. J. Infect. Dis., 196 (Suppl. 1), S86-S107.
11. Bock, N.N., Jensen, P.A., Miller, B. and Nardell, E. (2007) Tuberculosis infection control in resource-limited settings in the era of expanding HIVcare and treatment. J. Infect. Dis., 196 (Suppl. 1), S108-S113.
12. Gandhi, N.R., Moll, A., Sturm, A.W., Pawinski, R., Govender, T., Lalloo, U., Zeller, K., Andrews, J. and Friedland, G. (2006) Extensively drug-resistant tuberculosis as a cause of death in patients co-infected with tuberculosis andHIVin a rural area of South Africa. Lancet, 368, 1575-1580.
13. Young, D.B., Perkins, M.D., Duncan, K. and Barry, C.E. III (2008) Confronting the scientific obstacles to global control of tuberculosis. J. Clin. Invest., 118, 1255-1265.
14. Blanc, F.X.,Havlir, D.V., Onyebujoh, P.C., Thim, S., Goldfeld, A.E. and Delfraissy, J.F. (2007) Treatment strategies for HIVinfected patients with tuberculosis: ongoing and planned clinical trials. J. Infect. Dis., 196 (Suppl. 1), S46-S51.
15. Onyebujoh, P.C., Ribeiro, I. and Whalen, C.C. (2007) Treatment options for HIVassociated tuberculosis. J. Infect. Dis., 196 (Suppl. 1), S35-S45.
16. Taylor, Z., Nolan, C.M. and Blumberg, H.M. (2005) Controlling tuberculosis in the United States. Recommendations from the American Thoracic Society, CDC, and the Infectious Diseases Society of America. MMWR Recomm. Rep., 54, 1-81.
17. WorldHealth Organization (2008) Global Tuberculosis Control: Surveillance, Planning, Financing, WHO, Geneva.
18. Dye, C., Scheele, S., Dolin, P., Pathania, V. and Raviglione, M.C. (1999) Consensus statement. Global burden of tuberculosis: estimated incidence, prevalence, and mortality by country. WHO Global Surveillance and Monitoring Project. JAMA, 282, 677-686.
19. Corbett, E.L., Charalambous, S., Fielding, K., Clayton, T.,Hayes, R.J., De Cock, K.M. and Churchyard, G.J. (2003) Stable incidence rates of tuberculosis (TB) among human immunodeficiency virus (HIV)-negative South African gold miners during a decade of epidemic HIV-associated TB. J. Infect. Dis., 188, 1156-1163.
20. Corbett, E.L., Bandason, T., Cheung, Y.B., Munyati, S., Godfrey-Faussett, P., Hayes, R., Churchyard, G., Butterworth, A. and Mason, P. (2007) Epidemiology of tuberculosis in a high HIV prevalence population provided with enhanced diagnosis of symptomatic disease. PLoS Med., 4, e22.
21. Siriarayapon, P., Yanai, H., Glynn, J.R., Yanpaisarn, S. and Uthaivoravit,W. (2002) The evolving epidemiology of HIV infection and tuberculosis in northern Thailand. J. Acquir. Immune. Defic. Syndr., 31, 80-89.
22. Glynn, J.R.,Murray, J., Bester, A., Nelson, G., Shearer, S. and Sonnenberg, P. (2008) Effects of duration of HIV infection and secondary tuberculosis transmission on tuberculosis incidence in the South African gold mines. AIDS, 22, 1859-1867.
23. National Center for Tuberculosis and Leprosy (2001) National Health Policies and Strategies for Tuberculosis Control in the Kingdom of Cambodia 2001-2005, Kingdom of Cambodia, Ministry of Health, National Center, for Tuberculosis and Leprosy Control (CENAT), Phnom Penh, Cambodia, p. 8.
24. Dehne, K.L., Pokrovskiy, V., Kobyshcha, Y. and Schwartlander, B. (2000) Update on the epidemics of HIV and other sexually transmitted infections in the newly independent states of the former Soviet Union. AIDS, 14 (Suppl. 3), S75-S84.
25. Portu, J.J., Aldamiz-Etxebarria, M., Agud, J.M., Arevalo, J.M., Almaraz, M.J. and Ayensa, C. (2002) Tuberculin skin testing in intravenous drug users: differences between HIV-seropositive and HIVseronegative subjects. Addict. Biol., 7, 235-241.
26. TheWHOIUATLD global project on antituberculosis drug resistance surveillance (2008) Anti-Tuberculosis Drug Resistance in theWorld: 4th Global Report,WorldHealth Organization, Geneva.
27. Vynnycky, E., Glynn, J.R., Crampin, A.C., Mwaungulu, F., White, R. and Fine, P.E. (2004) The impact of the HIVepidemic on pulmonary tuberculosis in Karonga district, Malawi: analyses of the evolving relative risk of tuberculosis associated with HIV infection. TSRU Progress Report.
28. Woldehanna, S. and Volmink, J. (2004) Treatment of latent tuberculosis infection in HIV infected persons. Cochrane Database Syst. Rev., CD000171.
29. Lawn, S.D., Badri, M. andWood, R. (2005) Tuberculosis among HIV-infected patients receiving HAART: long term incidence and risk factors in a South African cohort. AIDS, 19, 2109-2116.
30. Williams, B.G. and Dye, C. (2003) Antiretroviral therapy for TB control in the era of HIV/AIDS. Science, 301, 1535-1537.
31. Badri, M., Wilson, D. andWood, R. (2002) Effect of highly active antiretroviral therapy on incidence of tuberculosis in South Africa: a cohort study. Lancet, 359, 2059-2064.
32. Girardi, E., Antonucci, G., Vanacore, P., Libanore, M., Errante, I., Mattelli, A., Ippolito, G. and GISTA-SIMIT (Gruppo Italiano di Studio Tubercolosi e AIDS -Italian Society of Infectious Diseases) (2000) Impact of combination antiretroviral therapy on the risk of tuberculosis among persons with HIV infection. AIDS, 14, 1985-1991.
33. Jones, J.L., Hanson, D.L., Dworkin, M.S., De Cock, K.M. and The Adult/Adolescent Spectrum of HIV Disease Group. (2000) HIV associated TB in the era of HAART. Int. J. Tuberc. Lung Dis., 4, 1026-1031.
34. Santoro-Lopes, G., de Pinho, A.M., Harrison, L.H. and Schechter, M. (2002) Reduced risk of tuberculosis among Brazilian patients with advanced human immunodeficiency virus infection treated with highly active antiretroviral therapy. Clin. Infect. Dis., 34, 543-546.
35. Lawn, S.D.,Wilkinson, R.J., Lipman, M.C. and Wood, R. (2008) Immune reconstitution and "unmasking" of tuberculosis during antiretroviral therapy. Am. J.Respir.Crit.CareMed., 177, 680-685.
36. Lawn, S.D. and Wood, R. (2007) When should antiretroviral treatment be started in patients with HIV-associated tuberculosis in South Africa? S. Afr. Med. J., 97, 412, 414-415.
37. Lawn, S.D., Bekker, L.G. and Wood, R. (2005) How effectively does HAART restore immune responses to Mycobacterium tuberculosis? Implications for tuberculosis control. AIDS, 19, 1113-1124.
38. Corbett, E.L., Currie, C., Churchyard, G.J. and Williams, B.G. (2002) Strategies for reducing the burden of TB infection and disease in high HIV prevalence populations: modelling the impact of active case finding, antiretrovirals and preventive therapy. XIV International AIDS Conference, Barcelona, Spain.
39. Korenromp,E.L.,Scano,F.,Williams,B.G., Dye, C. and Nunn, P. (2003) Effects of human immunodeficiency virus infection on recurrence of tuberculosis after rifampin-based treatment: an analytical review. Clin. Infect. Dis., 37, 101-112.
40. Seyler, C., Toure, S., Messou, E., Bonard, D., Gabillard, D. and Anglaret, X. (2005) Risk factors for active tuberculosis following antiretroviral treatment initiation in Abidjan. Am. J. Respir. Crit. Care Med., 172, 123-127.
41. Churchyard, G.J., Fielding, K., Charalambous, S., Day, J.H., Corbett, E.L.,Hayes, R.J., Chaisson, R.E., De Cock, K.M., Samb, B. and Grant, A.D. (2003) Efficacy of secondary isoniazid preventive therapy among HIV-infected Southern Africans: time to change policy?AIDS, 17, 2063-2070.
42. Rieder, H.L. (1999) Infection with tubercle bacilli, in Epidemiologic Basis of Tuberculosis Control, IUATLD, Paris, pp. 17-26.
43. Corbett, E.L., Muzangwa, J., Chaka, K., Dauya, E., Cheung, Y.B., Munyati, S.S., Reid, A., Hakim, J., Chandiwana, S., Mason, P.R., Butterworth, A.E. and Houston, S. (2007) Nursing and community rates of Mycobacterium tuberculosis infection among students in Harare, Zimbabwe. Clin. Infect. Dis., 44, 317-323.
44. Galgalo, T., Dalal, S., Cain, K.P., Oeltmann, J., Tetteh, C., Kamau, J.G., Njenga, M.K., Breiman, R.F., Chakaya, J.M., Irimu, H.M., Miller, B., De Cock, K.M., Bock, N.N. and Ijaz, K. (2008) Tuberculosis risk among staff of a large public hospital in Kenya. Int. J. Tuberc. Lung Dis., 12, 949-954.
45. Gagneux, S. and Small, P.M. (2007) Global phylogeography of Mycobacterium tuberculosis and implications for tuberculosis product development. Lancet Infect. Dis., 7, 328-337.
46. Cowley, D., Govender, D., February, B., Wolfe, M., Steyn, L., Evans, J., Wilkinson, R.J. and Nicol, M.P. (2008) Recent and rapid emergence of WBeijing strain of M. tuberculosis in Cape Town, South Africa. Clin. Infect. Dis., 47, 1252-1259.
47. Strauss, O.J., Warren, R.M., Jordaan, A., Streicher, E.M., Hanekom, M., Falmer, A.A., Albert, H., Trollip, A., Hoosain, E., van Helden, P.D. and Victor, T.C. (2008) Spread of a low-fitness drug-resistant Mycobacterium tuberculosis strain in a setting of high human immunodeficiency virus prevalence. J. Clin. Microbiol., 46, 1514-1516.
48. Brindle, R.J., Nunn, P.P., Githui, W., Allen, B.W., Gathua, S. and Waiyaki, P. (1993) Quantitative bacillary response to treatment in HIV-associated pulmonary tuberculosis. Am. Rev. Respir. Dis., 147, 958-961.
49. Escombe, A.R., Moore, D.A., Gilman, R.H., Pan, W., Navincopa, M., Ticona, E., Martinez, C., Caviedes, L., Sheen, P., Gonzalez, A., Noakes, C.J., Friedland, J.S. and Evans, C.A. (2008) The infectiousness of tuberculosis patients coinfected with HIV. PLoS Med., 5, e188.
50. Borgdorff, M.W. (2004) New measurable indicator for tuberculosis case detection. Emerg. Infect. Dis., 10, 1523-1528.
51. Fennelly, K.P.,Martyny, J.W., Fulton, K.E., Orme, I.M., Cave, D.M. and Heifets, L.B. (2004) Cough-generated aerosols of Mycobacterium tuberculosis: a new method to study infectiousness. Am. J. Respir. Crit. Care Med., 169, 604-609.
52. Corbett, E.L., Charalambous, S., Moloi, V.M., Fielding, K., Grant, A.D., Dye, C., De Cock, K.M., Hayes, R.J., Williams, B.G. and Churchyard, G.J. (2004)Human immunodeficiency virus and the prevalence of undiagnosed tuberculosis in African gold miners. Am. J. Respir. Crit. Care Med., 170, 673-679.
53. Corbett, E.L., Bandason, T., Dauya, E., Makamure, B., Cheung, Y.B., Mtero-Munyati, S., Matambo, R., Godfrey-Faussett, P., Hayes, R., Churchyard, G.J. andMason, P.R. (2005) HIVinfection and the duration and control of prevalent tuberculosis disease in Harare, Zimbabwe. TSRU Progress Report, pp. 28-39.
54. Godfrey-Faussett, P., Sonnenberg, P., Shearer, S.C., Bruce, M.C., Mee, C., Morris, L. and Murray, J. (2000) Tuberculosis control and molecular epidemiology in a South African goldmining community. Lancet, 356, 1066-1071.
55. Valway, S.E., Sanchez, M.P., Shinnick, T.F., Orme, I., Agerton, T., Hoy, D., Jones, J.S.,Westmoreland, H. and Onorato, I.M. (1998) An outbreak involving extensive transmission of a virulent strain of Mycobacterium tuberculosis. N. Engl. J. Med., 338, 633-639.
56. den Boon, S., White, N.W., van Lill, S.W., Borgdorff, M.W.,Verver, S., Lombard,C.J., Bateman, E.D., Irusen, E., Enarson, D.A. and Beyers, N. (2006) An evaluation of symptomandchest radiographicscreening in tuberculosis prevalence surveys. Int. J. Tuberc. Lung Dis., 10, 876-882.
57. Wood, R., Middelkoop, K., Myer, L., Grant, A.D., Whitelaw, A., Lawn, S.D., Kaplan, G., Huebner, R., McIntyre, J. and Bekker, L.G. (2007) Undiagnosed tuberculosis in a community with high HIV prevalence: implications for tuberculosis control. Am. J. Respir. Crit. Care Med., 175, 87-93.
58. Frieden, T.R., Fujiwara, P.I., Washko, R.M. and Hamburg, M.A. (1995) Tuberculosis in New York City -turning the tide. N. Engl. J. Med., 333, 229-233.
59. Escombe, A.R., Oeser, C., Gilman, R.H., Navincopa, M., Ticona, E., Martinez, C., Caviedes, L., Sheen, P., Gonzalez, A., Noakes, C., Moore, D.A., Friedland, J.S. and Evans, C.A. (2007) The detection of airborne transmission of tuberculosis from HIV-infected patients, using an in vivo air sampling model. Clin. Infect. Dis., 44, 1349-1357.
60. Dye, C. (2009) Doomsday postponed? Preventing and reversing epidemics of drug-resistant tuberculosis. Nat. Rev. Microbiol., 7, 81-87.
61. UNAIDS (2002) Report on the global HIV/AIDS epidemic, 2002.
62. Esparza, J. and Bhamarapravati, N. (2000) Accelerating the development and future availability of HIV-1 vaccines: why, when, where, and how? Lancet, 355, 2061.
63. Montano, M.A., Nixon, C.P. and Essex, M. (1998) Dysregulation through the NFkappaB enhancer and TATA box of the human immunodeficiency virus type 1 subtype E promoter. J. Virol., 72, 8446-8452.
64. Montano, M.A., Novitsky, V.A., Blackard, J.T., Cho, N.L., Katzenstein, D.A. and Essex, M. (1997) Divergent transcriptional regulation among expanding human immunodeficiency virus type 1 subtypes. J. Virol., 71, 8657-8665.
65. Lemieux, A.M., Pare, M.E., Audet, B., Legault, E., Lefort, S., Boucher, N., Landry, S., van Opijnen, T., Berkhout, B., Naghavi, M.H., Tremblay, M.J. and Barbeau, B. (2004) T-cell activation leads to poor activation of the HIV-1 clade E long terminal repeat and weak association of nuclear factor-kappaB and NFAT with its enhancer region. J. Biol. Chem., 279, 52949-52960.
66. Verhoef, K., Sanders, R.W., Fontaine, V., Kitajima, S. and Berkhout, B. (1999) Evolution of the human immunodeficiency virus type 1 long terminal repeat promoter by conversion of an NF-kappaB enhancer element into a GABP binding site. J. Virol., 73, 1331-1340.
67. Ranjbar, S., Rajsbaum, R. and Goldfeld, A.E. (2006) Transactivator of transcription from HIV type 1 subtype E selectively inhibits TNF gene expression via interference with chromatin remodeling of the TNF locus. J. Immunol., 176, 4182-4190.
68. Ranjbar, S., Tsytsykova, A.V., Lee, S.K., Rajsbaum, R., Falvo, J.V., Lieberman, J., Shankar, P. and Goldfeld, A.E. (2006) NFAT5 regulates HIV-1 in primary monocytes via a highly conserved long terminal repeat site. PLoS Pathog., 2, e130.
69. Manca, C., Tsenova, L., Barry, C.E. 3rd, Bergtold, A., Freeman, S., Haslett, P.A., Musser, J.M., Freedman, V.H. and Kaplan, G. (1999) Mycobacterium tuberculosis CDC1551 induces a more vigorous host response in vivo and in vitro, but is not more virulent than other clinical isolates. J. Immunol., 162, 6740-6746.
70. Reed, M.B., Domenech, P.,Manca, C., Su, H., Barczak, A.K., Kreiswirth, B.N., Kaplan, G. and Barry, C.E. 3rd (2004) A glycolipid of hypervirulent tuberculosis strains that inhibits the innate immune response. Nature, 431, 84-87.
71. Ranjbar, S., Boshoff, H.I., Mulder, A., Siddiqi, N., Rubin, E.J. and Goldfeld, A.E. (2008) HIV-1 replication is differentially regulated by distinct clinical strains of Mycobacterium tuberculosis. U.S.-Japan Cooperative Medical Sciences Program Forty-Third Tuberculosis and Leprosy Research Conference. National Institute of Allergy and Infectious Diseases, National Institutes ofHealth, Department of Health and Human Services, Baltimore, Maryland.
72. Ranjbar, S. (2008) HIV-1 replication is differentially regulated by different clinical strains of Mycobacterium tuberculosis, inHIVPathogenesis,Keystone Symposia, Banff, Alberta, Canada.
73. Ranjbar, S., Boshoff, H.I., Mulder, A., Siddiqi, N., Rubin, E.J. and Goldfeld, A.E. HIV-1 replication is differentially regulated by distinct clinical strains of Mycobacterium tuberculosis. PLoS One (submitted).
74. Lama, J. and Planelles, V. (2007) Host factors influencing susceptibility to HIV infection and AIDS progression. Retrovirology, 4, 52.
75. Deeks, S.G. and Walker, B.D. (2007) Human immunodeficiency virus controllers: mechanisms of durable virus control in the absence of antiretroviral therapy. Immunity, 27, 406-416.
76. Delgado, J.C., Baena, A., Thim, S. and Goldfeld, A.E. (2006) Aspartic acid homozygosity at codon 57 of HLA-DQ beta is associated with susceptibility to pulmonary tuberculosis in Cambodia. J. Immunol., 176, 1090-1097.
77. Boussiotis, V.A., Tsai, E.Y., Yunis, E.J., Thim, S., Delgado, J.C., Dascher, C.C., Berezovskaya, A., Rousset, D., Reynes, J.M. and Goldfeld, A.E. (2000) IL-10-producing T cells suppress immune responses in anergic tuberculosis patients. J. Clin. Invest., 105, 1317-1325.
78. Delgado, J.C.,Tsai,E.Y., Thim, S., Baena, A., Boussiotis, V.A., Reynes, J.M., Sath, S., Grosjean, P., Yunis, E.J. andGoldfeld, A.E. (2002) Antigen-specific and persistent tuberculin anergy in a cohort of pulmonary tuberculosis patients from rural Cambodia. Proc. Natl Acad. Sci. USA, 99, 7576-7581.
79. Ranjbar, S., Ly, N., Thim, S., Reynes, J.M. and Goldfeld, A.E. (2004) Mycobacterium tuberculosis recall antigens suppress HIV-1 replication in anergic donor cells via CD8+ Tcell expansion and increased IL-10 levels. J. Immunol., 172, 1953-1959.
80. Ansari, N.A., Kombe, A.H., Kenyon, T.A., Hone, N.M., Tappero, J.W., Nyirenda, S.T., Binkin, N.J. and Lucas, S.B. (2002) Pathology and causes of death in a group of 128 predominantly HIV-positive patients in Botswana, 1997-998. Int. J. Tuberc. Lung Dis., 6, 55-63.
81. Grant, A.D., Djomand, G. and De Cock, K.M. (1997) Natural history and spectrum of disease in adults with HIV/AIDS in Africa. AIDS, 11 (Suppl. B), S43-S44.
82. Munyati, S.S., Dhoba, T., Makanza, E.D., Mungofa, S., Wellington, M., Mutsvangwa, J., Gwanzura, L., Hakim, J., Nyakabau, M., Mason, P.R., Robertson, V., Rusakaniko, S., Butterworth, A.E. and Corbett, E.L. (2005) Chronic cough in primary health care attendees, Harare, Zimbabwe: diagnosis and impact of HIV infection. Clin. Infect. Dis., 40, 1818-1827.
83. Harries, A.D., Kamenya, A., Subramanyam, V.R., Maher, D., Squire, S.B., Wirima, J.J., Nyangulu, D.S. and Nunn, P. (1997) Screening pulmonary tuberculosis suspects in Malawi: testing different strategies. Trans. R. Soc. Trop. Med. Hyg., 91, 416-419.
84. Odhiambo, J., Kizito, W., Njoroge, A., Wambua, N., Nganga, L., Mburu, M., Mansoer, J., Marum, L., Phillips, E., Chakaya, J. and De Cock, K.M. (2008) Provider-initiated HIV testing and counselling for TB patients and suspects in Nairobi, Kenya. Int. J. Tuberc. Lung Dis., 12, 63-68.
85. van Cleeff, M.R., Kivihya-Ndugga, L., Githui,W., Nganga, L., Odhiambo, J. and Klatser, P.R. (2003) A comprehensive study of the efficiency of the routine pulmonary tuberculosis diagnostic process in Nairobi. Int. J. Tuberc. Lung Dis., 7, 186-189.
86. Le Minor, O., Germani, Y., Chartier, L., Lan, N.H., Lan, N.T., Duc, N.H., Laureillard, D., Fontanet, A., Sar, B., Saman, M., Chan, S., L'Her, P., Mayaud, C. and Vray, M. (2008) Predictors of pneumocystosis or tuberculosis in HIVinfected Asian patients with AFB smearnegative sputum pneumonia. J. Acquir. Immune Defic. Syndr., 48, 620-627.
87. Vray, M., Germani, Y., Chan, S., Duc, N.H., Sar, B., Sarr, F.D., Bercion, R., Rahalison, L., Maynard, M., L'Her, P., Chartier, L. and Mayaud, C. (2008) Clinical features and etiology of pneumonia in acid-fast bacillus sputum smear-negative HIV-infected patients hospitalized in Asia and Africa. AIDS, 22, 1323-1332.
88. De Cock, K.M., Soro, B., Coulibaly, I.M. and Lucas, S.B. (1992) Tuberculosis and HIV infection in sub-Saharan Africa. JAMA, 268, 1581-1587.
89. Murray, J.F. (2005) Pulmonary complications of HIV-1 infection among adults living in sub-Saharan Africa. Int. J. Tuberc. Lung Dis., 9, 826-835.
90. Rosen, M.J. (2006) Chronic cough due to tuberculosis and other infections: ACCP evidence-based clinical practice guidelines. Chest, 129, 197S-201.
91. Munyati, S.S., Redzo, N., Dauya, E., Matambo, R., Makamure, B., Bandason, T., Butterworth, A.E., Gwanzura, L., Rusakaniko, S., Mason, P.R. and Corbett, E.L. (2006) Human immunodeficiency virus, smoking and self-rated health in Harare, Zimbabwe. Int. J. Tuberc. Lung Dis., 10, 1279-1285.
92. Munthali, L., Mwaungulu, J.N.,Munthali, K., Bowie, C. and Crampin, A.C. (2006) Using tuberculosis suspects to identify patients eligible for antiretroviral treatment. Int. J. Tuberc. Lung Dis., 10, 199-202.
93. Srikantiah, P., Lin, R., Walusimbi, M., Okwera, A., Luzze, H., Whalen, C.C., Boom,W.H.,Havlir, D.V. and Charlebois, E.D. (2007) Elevated HIV seroprevalence and risk behavior among Ugandan TB suspects: implications for HIV testing and prevention. Int. J. Tuberc. Lung Dis., 11, 168-174.
94. Scott, J.A., Hall, A.J., Muyodi, C., Lowe, B., Ross, M., Chohan, B., Mandaliya, K., Getambu, E., Gleeson, F., Drobniewski, F. and Marsh, K. (2000) Aetiology, outcome, and risk factors for mortality among adults with acute pneumonia in Kenya. Lancet, 355, 1225-1230.
95. Banda, H.T., Harries, A.D., Welby, S., Boeree, M.J., Wirima, J.J., Subramanyam, V.R., Maher, D. and Nunn, P.A. (1998) Prevalence of tuberculosis in TB suspects with short duration of cough. Trans. R. Soc. Trop. Med. Hyg., 92, 161-163.
96. Mwachari, C., Batchelor, B.I., Paul, J., Waiyaki, P.G. and Gilks, C.F. (1998) Chronic diarrhoea among HIV-infected adult patients in Nairobi, Kenya. J. Infect., 37, 48-53.
97. Gilks, C.F., Otieno, L.S., Brindle, R.J., Newnham, R.S., Lule, G.N., Were, J.B., Simani, P.M., Bhatt, S.M., Okelo, G.B. Waiyaki, P.G. et al. (1992) The presentation and outcome of HIV-related disease in Nairobi. Q. J. Med., 82, 25-32.
98. Grant, A.D. and De Cock, K.M. (1998) The growing challenge of HIV/AIDS in developing countries. Br. Med. Bull., 54, 369-381.
99. Yu, J.K., Bong, C.N., Chen, S.C., Dzimadzi, R., Lu, D.Y., Makombe, S.D., Schouten, E.J., Kamoto, K. and Harries, A.D. (2008) Outcomes in HIV-infected patients who develop tuberculosis after starting antiretroviral treatment in Malawi. Int. J. Tuberc. Lung Dis., 12, 692-694.
100. World Health Organization (2006) Improving the Diagnosis and Treatment of Smear-Negative Pulmonary and Extrapulmonary Tuberculosis Among Adults and Adolescents: Recommendations for HIV Prevalent and Resource Constrained Settings, World Health Organization, Geneva, Switzerland.
101. Archibald, L.K., den Dulk, M.O., Pallangyo, K.J. and Reller, L.B. (1998) Fatal Mycobacterium tuberculosis bloodstream infections in febrile hospitalized adults in Dar es Salaam, Tanzania. Clin. Infect. Dis., 26, 290-296.
102. Lawn, S.D., Harries, A.D., Anglaret, X., Myer, L. and Wood, R. (2008) Early mortality among adults accessing antiretroviral treatment programmes in sub-Saharan Africa. AIDS, 22, 1897-1908.
103. Abouya, L., Coulibaly, I.M., Coulibaly, D., Kassim, S., Ackah, A., Greenberg, A.E., Wiktor, S.Z. and De Cock, K.M. (1995) Radiologic manifestations of pulmonary tuberculosis in HIV-1 and HIV-2-infected patients in Abidjan, Cote d'Ivoire. Tuber. Lung Dis., 76, 436-440.
104. Greenberg, S.D., Frager, D., Suster, B., Walker, S., Stavropoulos, C. and Rothpearl, A. (1994) Active pulmonary tuberculosis in patients with AIDS: spectrum of radiographic findings (including a normal appearance). Radiology, 193, 115-119.
105. Tshibwabwa, T.E., Mwinga, A., Pobee, J.O. and Zumla, A. (1997) Radiological features of pulmonary tuberculosis in 963 HIV-infected adults at three Central African Hospitals. Clin. Radiol., 52, 837-841.
106. Ackah, A.N., Coulibaly, D., Digbeu, H., Diallo, K., Vetter, K.M., Coulibaly, I.M., Greenberg, A.E. and DeCock, K.M. (1995) Response to treatment, mortality, and CD4 lymphocyte counts in HIV-infected persons with tuberculosis in Abidjan, Cote d'Ivoire. Lancet, 345, 607-610.
107. Steingart, K.R., Henry, M., Ng, V., Hopewell, P.C., Ramsay, A., Cunningham, J., Urbanczik, R., Perkins, M., Aziz, M.A. and Pai, M. (2006) Fluorescence versus conventional sputum smear microscopy for tuberculosis: a systematic review. Lancet Infect. Dis., 6, 570-581.
108. Steingart, K.R., Ng, V., Henry, M., Hopewell, P.C., Ramsay, A., Cunningham, J., Urbanczik, R., Perkins, M.D., Aziz, M.A. and Pai, M. (2006) Sputum processing methods to improve the sensitivity of smear microscopy for tuberculosis: a systematic review. Lancet Infect. Dis., 6, 664-674.
109. World Health Organization (2004) Interim Policy on Collaborative TB/HIV Activities, World Health Organization, Geneva, Switzerland.
110. Corbett, E.L., Zezai, A., Cheung, Y.B., Bandason, T., Dauya, E., Munyati, S.S., Butterworth, A.E., Rusakaniko, S., Churchyard, G.J., Mungofa, S., Hayes, R.J. and Mason, P.R. (2008) Providerinitiated symptom screening for tuberculosis: diagnostic value and the impact of HIV. Bull. World Health Org. (in press).
111. Day, J.H., Charalambous, S., Fielding, K.L., Hayes, R.J., Churchyard, G.J. and Grant, A.D. (2006) Screening for tuberculosis prior to isoniazid preventive therapy among HIV-infected gold miners in South Africa. Int. J. Tuberc. Lung Dis., 10, 523-529.
112. Mtei, L., Matee, M., Herfort, O., Bakari, M., Horsburgh, C.R., Waddell, R., Cole, B.F., Vuola, J.M., Tvaroha, S., Kreiswirth, B., Pallangyo, K. and von Reyn, C.F. (2005) High rates of clinical and subclinical tuberculosis among HIVinfected ambulatory subjects in Tanzania. Clin. Infect. Dis., 40, 1500-1507.
113. Karam, F., Mbow, F., Fletcher, H., Senghor, C.S., Coulibaly, K.D., LeFevre, A.M., Ngom Gueye, N.F., Dieye, T., Sow, P.S., Mboup, S. and Lienhardt, C. (2008) Sensitivity of IFN-© release assay to detect latent tuberculosis infection is retained in HIV-infected patients but dependent on HIV/AIDS progression. PLoS ONE, 3, e1441.
114. Lawn, S.D., Bangani, N., Vogt, M., Bekker, L.G., Badri, M., Ntobongwana, M., Dockrell, H.M., Wilkinson, R.J. and Wood, R. (2007) Utility of interferon-© ELISPOT assay responses in highly tuberculosis-exposed patients with advanced HIV infection in South Africa. BMC Infect. Dis., 7, 99.
115. Rangaka, M.X., Wilkinson, K.A., Seldon, R., Van Cutsem, G., Meintjes, G.A., Morroni, C., Mouton, P., Diwakar, L., Connell, T.G., Maartens, G. and Wilkinson, R.J. (2007) Effect of HIV-1 infection on T-cell-based and skin test detection of tuberculosis infection. Am. J. Respir. Crit. Care Med., 175, 514-520.
116. Rangaka, M.X., Diwakar, L., Seldon, R., van Cutsem, G.,Meintjes, G.A., Morroni, C., Mouton, P., Shey, M.S., Maartens, G., Wilkinson, K.A. and Wilkinson, R.J. (2007) Clinical, immunological, and epidemiological importance of antituberculosis T cell responses in HIVinfected Africans. Clin. Infect. Dis., 44, 1639-1646.
117. Chapman, A.L., Munkanta, M., Wilkinson, K.A., Pathan, A.A., Ewer, K., Ayles, H., Reece, W.H., Mwinga, A., Godfrey-Faussett, P. and Lalvani, A. (2002) Rapid detection of active and latent tuberculosis infection in HIV-positive individuals by enumeration of Mycobacterium tuberculosis-specific Tcells. AIDS, 16, 2285-2293.
118. Churchyard, G.J., Scano, F., Grant, A.D. and Chaisson, R.E. (2007) Tuberculosis preventive therapy in the era of HIV infection: overview and research priorities. J. Infect. Dis., 196 (Suppl. 1), S52-S62.
119. Balcells, M.E., Thomas, S.L., Godfrey-Faussett, P. and Grant, A.D. (2006) Isoniazid preventive therapy and risk for resistant tuberculosis. Emerg. Infect. Dis., 12, 744-751.
120. Delgado, J.C., Quinones-Berrocal, J., Thim, S., Miranda, L.F. and Goldfeld, A.E. (2004) Diagnostic and clinical implications of response to tuberculin in two ethnically distinct populations from Peru and Cambodia. Int. J. Tuberc. Lung Dis., 8, 982-987.
121. Caramalho, I., Lopes-Carvalho, T., Ostler, D., Zelenay, S., Haury, M. and Demengeot, J. (2003) Regulatory T cells selectively express toll-like receptors and are activated by lipopolysaccharide. J. Exp. Med., 197, 403-411.
122. Hammer, S.M., Eron, J.J. Jr, Reiss, P., Schooley, R.T., Thompson, M.A., Walmsley, S., Cahn, P., Fischl, M.A., Gatell, J.M.,Hirsch, M.S., Jacobsen, D.M., Montaner, J.S., Richman, D.D., Yeni, P.G. and Volberding, P.A. (2008) Antiretroviral treatment of adult HIV infection: 2008 recommendations of the International AIDS Society-USA panel. JAMA, 300, 555-570.
123. CDC (2008) Trends in tuberculosis-United States, 2007. MMWR Morb. Mortal. Wkly Rep., 57, 281-285.
124. Havlir, D.V., Getahun, H., Sanne, I. and Nunn, P. (2008) Opportunities and challenges for HIV care in overlapping HIV and TB epidemics. JAMA, 300, 423-430.
125. Sok, T., Laureillard, D., Mao, T.E., Thor, C., Mearday, K., Team, B.K., Sokonth, K., Khann, S., Bulifon, S., Isaakidis, P., Chea, S., Chan, S., Kaing, S., Im, S., Marcy, O., Borand, L., Sarthou, J.-L., Yim, S., Sun, S., Oum, S., Sam, L., Lao, P., Sar, B. and Goldfeld, A. (2008) Providing universal access to MDR care. In Cambodia 39th Union World Conference on Lung Health. International Union Against Tuberculosis and Lung Disease.
126. Harries, A.D., Zachariah, R. and Lawn, S.D. (2009) Providing HIV care for coinfected tuberculosis patients: a perspective from sub-Saharan Africa. Int. J. Tuberc. Lung Dis., 13, 6-16.
127. Espinal, M.A., Kim, S.J., Suarez, P.G., Kam, K.M., Khomenko, A.G., Migliori, G.B., Baez, J., Kochi, A., Dye, C. and Raviglione, M.C. (2000) Standard shortcourse chemotherapy for drug-resistant tuberculosis: treatment outcomes in 6 countries. JAMA, 283, 2537-2545.
128. Manosuthi, W., Mankatitham, W., Lueangniyomkul,A., Chimsuntorn, S. and Sungkanuparph, S. (2008) Standard-dose efavirenz vs. standard-dose nevirapine in antiretroviral regimens among HIV-1 and tuberculosis co-infected patients who received rifampicin.HIVMed., 9, 294-299.
129. Boyle, B., Cohen, C., DeJesus, E., Elion, R., Frank, I., Moyle, G. and Sax, P. (2008) Antiretroviral treatment update from the 17th International AIDS Conference. AIDS Read., 18, 570-579.
130. World Health Organization (2004) Scaling up antiretroviral therapy in resourcelimited settings: treatment guidelines for a public health approach (2003 revision), WHO, Geneva, Switzerland.
131. Zachariah, R., FitzGerald, M.,Massaquoi, M., Acabu, A., Chilomo, D., Salaniponi, F.M. and Harries, A.D. (2007) Does antiretroviral treatment reduce case fatality among HIV-positive patients with tuberculosis in Malawi? Int. J. Tuberc. Lung Dis., 11, 848-853.
132. Lawn, S.D., Myer, L., Orrell, C., Bekker, L.G. and Wood, R. (2005) Early mortality among adults accessing a communitybased antiretroviral service in South Africa: implications for programme design. AIDS, 19, 2141-2148.
133. Dheda, K., Lampe, F.C., Johnson, M.A. and Lipman, M.C. (2004) Outcome of HIV-associated tuberculosis in the era of highly active antiretroviral therapy. J. Infect. Dis., 190, 1670-1676.
134. Lawn, S.D., Myer, L., Bekker, L.G. and Wood, R. (2007) Tuberculosis-associated immune reconstitution disease: incidence, risk factors and impact in an antiretroviral treatment service in South Africa. AIDS, 21, 335-341.
135. Lawn, S.D., Bekker, L.G. and Miller, R.F. (2005) Immune reconstitution disease associated with mycobacterial infections in HIV-infected individuals receiving antiretrovirals. Lancet Infect. Dis., 5, 361-373.
136. Lipman, M. and Breen, R. (2006) Immune reconstitution inflammatory syndrome in HIV. Curr. Opin. Infect. Dis., 19, 20-25.
137. Shelburne, S.A., Visnegarwala, F., Darcourt, J.,Graviss, E.A.,Giordano, T.P., White, A.C. Jr, and Hamill, R.J. (2005) Incidence and risk factors for immune reconstitution inflammatory syndrome during highly active antiretroviral therapy. AIDS, 19, 399-406.
138. Meintjes, G., Lawn, S.D., Scano, F., Maartens, G., French, M.A.,Worodria,W., Elliott, J.H.,Murdoch, D., Wilkinson, R.J., Seyler, C., John, L., van der Loeff, M.S., Reiss, P., Lynen, L., Janoff, E.N., Gilks, C. and Colebunders, R. (2008) Tuberculosis-associated immune reconstitution inflammatory syndrome: case definitions for use in resource-limited settings. Lancet Infect. Dis., 8, 516-523.
139. Narita, M., Ashkin, D., Hollender, E.S. and Pitchenik, A.E. (1998) Paradoxical worsening of tuberculosis following antiretroviral therapy in patients with AIDS. Am. J. Respir. Crit. Care Med., 158, 157-161.
140. American Thoracic Society, CDC and Infectious Diseases Society of America (2003) Treatment of tuberculosis.MMWR Recomm. Rep., 52, 1-77.
141. Blackmore, T.K.,Manning, L., Taylor,W.J. andWallis, R.S. (2008) Therapeutic use of infliximab in tuberculosis to control severe paradoxical reaction of the brain and lymph nodes. Clin. Infect. Dis., 47, e83-e85.
142. Bourgarit, A., Carcelain, G., Martinez, V., Lascoux, C., Delcey, V., Gicquel, B., Vicaut, E., Lagrange, P.H., Sereni, D. and Autran, B. (2006) Explosion of tuberculinspecific Th1-responses induces immune restoration syndrome in tuberculosis and HIV co-infected patients. AIDS, 20, F1-F7.
143. Zachariah, R., Teck, R., Ascurra, O., Gomani, P., Manzi, M., Humblet, P., Nunn, P., Salaniponi, F.M. and Harries, A.D. (2005) Can we get more HIV-positive tuberculosis patients on antiretroviral treatment in a rural district ofMalawi? Int. J. Tuberc. Lung Dis., 9, 238-247.
144. Coetzee, D., Hilderbrand, K., Goemaere, E., Matthys, F. and Boelaert, M. (2004) Integrating tuberculosis and HIV care in the primary care setting in South Africa. Trop. Med. Int. Health, 9, A11-A15.
145. Bwire, R., Nagelkerke, N.J. and Borgdorff, M.W. (2006) Finding patients eligible for antiretroviral therapy using TB services as entry point for HIV treatment. Trop. Med. Int. Health, 11, 1567-1575.
146. Libamba, E., Makombe, S.D., Harries, A.D., Schouten, E.J., Yu, J.K., Pasulani, O., Mhango, E., Aberle-Grasse, J., Hochgesang, M., Limbambala, E. and Lungu, D. (2007)Malawi's contribution to "3 by 5": achievements and challenges. Bull. World Health Org., 85, 156-160.
147. Sok, T., Laureillard, D., Lak, K.K., Sun, S., Ung, P., Meas, S., Shapiro, A. and Goldfeld, A. (2005) Leveraging successful TB strategies to introduce HAART in provincial Cambodia. 3rd International AIDS Society Conference on HIV Pathogenesis and Treatment.
148. Thim, S., Sath, S., Sina, M., Tsai, E.Y., Delgado, J.C.,Shapiro,A.E.,Barry,C.E.3rd, Glaziou, P. and Goldfeld, A.E. (2004) A community-based tuberculosis programin Cambodia. JAMA, 292, 566-568.
149. Ferradini, L., Laureillard, D., Prak, N., Ngeth, C., Fernandez, M., Pinoges, L., Puertas, G., Taburet, A.M., Ly, N., Rouzioux, C., Balkan, S., Quillet, C. and Delfraissy, J.F. (2007) Positive outcomes of HAART at 24 months in HIV-infected patients in Cambodia. AIDS, 21, 2293-2301.
150. Granich, R.M., Gilks, C.F., Dye, C., De Cock, K.M. and Williams, B.G. (2009) Universal voluntary HIV testing with immediate antiretroviral therapy as a strategy for elimination of HIV transmission: a mathematical model. Lancet, 373, 48-57.
151. Hutchcroft, J.E. and Bierer, B.E. (1994) Activation-dependent phosphorylation of the T-lymphocyte surface receptor CD28 and associated proteins. Proc. Natl Acad. Sci. USA, 91, 3260-3264.