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Volumn 36, Issue 12, 2011, Pages 2460-2468

Antidepressant and proneurogenic influence of environmental enrichment in mice: Protective effects VS recovery

Author keywords

adult hippocampal neurogenesis; cell survival; doublecortin; environmental enrichment; learned helplessness; Porsolt test

Indexed keywords

AGE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL POPULATION; DEPRESSION; ENVIRONMENTAL ENRICHMENT; ENVIRONMENTAL PROTECTION; EXPOSURE; FEMALE; HIPPOCAMPUS; MOOD DISORDER; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; RAT; STRESS;

EID: 80054717995     PISSN: 0893133X     EISSN: 1740634X     Source Type: Journal    
DOI: 10.1038/npp.2011.134     Document Type: Article
Times cited : (23)

References (50)
  • 1
    • 0024217602 scopus 로고
    • Forced swimming test in rats: Effects of desipramine administration and the period of exposure to the test on struggling behavior, swimming, immobility and defecation rate
    • DOI 10.1016/0014-2999(88)90068-4
    • Armario A, Gavalda A, Marti O (1988). Forced swimming test in rats: Effect of desipramine administration and the period of exposure to the test on struggling behavior, swimming, immobility and defecation rate. Eur J Pharmacol 158: 207-212. (Pubitemid 19012752)
    • (1988) European Journal of Pharmacology , vol.158 , Issue.3 , pp. 207-212
    • Armario, A.1    Gavalda, A.2    Marti, O.3
  • 2
    • 0024494422 scopus 로고
    • Discovery of antidepressant activity by forced swimming test may depend on pre-exposure of rats to a stressful situation
    • DOI 10.1007/BF00442247
    • Borsini F, Lecci A, Sessarego A, Frassine R, Meli A (1989). Discovery of antidepressant activity by forced swimming test may depend on pre-exposure of rats to a stressful situation. Psychopharmacology (Berl) 97: 183-188. (Pubitemid 19040159)
    • (1989) Psychopharmacology , vol.97 , Issue.2 , pp. 183-188
    • Borsini, F.1    Lecci, A.2    Sessarego, A.3    Frassine, R.4    Meli, A.5
  • 3
    • 0021135816 scopus 로고
    • Changes in neurotransmitter amino acids and protein in CNS areas of mice subjected to differential housing conditions
    • Cordoba F, Yusta B, Munoz-Blanco J (1984). Changes in neurotransmitter amino acids and protein in CNS areas of mice subjected to differential housing conditions. Pharmacol Biochem Behav 21: 349-352. (Pubitemid 14015646)
    • (1984) Pharmacology Biochemistry and Behavior , vol.21 , Issue.3 , pp. 349-352
    • Cordoba, F.1    Yusta, B.2    Munoz-Blanco, J.3
  • 4
    • 46249100907 scopus 로고    scopus 로고
    • Nature vs. nurture: Can enrichment rescue the behavioural phenotype of BDNF heterozygous mice?
    • Chourbaji S, Brandwein C, Vogt MA, Dormann C, Hellweg R, Gass P (2008). Nature vs. nurture: Can enrichment rescue the behavioural phenotype of BDNF heterozygous mice? Behav Brain Res 192: 254-258.
    • (2008) Behav Brain Res , vol.192 , pp. 254-258
    • Chourbaji, S.1    Brandwein, C.2    Vogt, M.A.3    Dormann, C.4    Hellweg, R.5    Gass, P.6
  • 6
    • 0029081299 scopus 로고
    • Active behaviors in the rat forced swimming test differentially produced by serotonergic and noradrenergic antidepressants
    • Detke MJ, Rickels M, Lucki I (1995). Active behaviors in the rat forced swimming test differentially produced by serotonergic and noradrenergic antidepressants. Psychopharmacology (Berl) 121: 66-72.
    • (1995) Psychopharmacology (Berl , vol.121 , pp. 66-72
    • Detke, M.J.1    Rickels, M.2    Lucki, I.3
  • 8
    • 33750618527 scopus 로고    scopus 로고
    • Therapeutic and protective effect of environmental enrichment against psychogenic and neurogenic stress
    • DOI 10.1016/j.bbr.2006.08.016, PII S0166432806004621
    • Fox C, Merali Z, Harrison C (2006). Therapeutic and protective effect of environmental enrichment against psychogenic and neurogenic stress. Behav Brain Res 175: 1-8. (Pubitemid 44691931)
    • (2006) Behavioural Brain Research , vol.175 , Issue.1 , pp. 1-8
    • Fox, C.1    Merali, Z.2    Harrison, C.3
  • 10
    • 72849153134 scopus 로고    scopus 로고
    • Exercise in the treatment of depression
    • Greer TL, Trivedi MH (2009). Exercise in the treatment of depression. Curr Psychiatry Rep 11: 466-472.
    • (2009) Curr Psychiatry Rep , vol.11 , pp. 466-472
    • Greer, T.L.1    Trivedi, M.H.2
  • 11
    • 0024842515 scopus 로고
    • Effects of ethanol on fight- or swim-stressed mice in Porsolt's swim test
    • DOI 10.1016/0893-133X(89)90034-1
    • Hilakivi LA, Durcan MJ, Lister RG (1989). Effects of ethanol on fight- or swim-stressed mice in Porsolt's swim test. Neuropsychopharmacology 2: 293-298. (Pubitemid 20025257)
    • (1989) Neuropsychopharmacology , vol.2 , Issue.4 , pp. 293-298
    • Hilakivi, L.A.1    Durcan, M.J.2    Lister, R.G.3
  • 12
    • 17144425358 scopus 로고    scopus 로고
    • Environmental enrichment for laboratory rodents
    • Hutchinson E, Avery A, Vandewoude S (2005). Environmental enrichment for laboratory rodents. ILAR J 46: 148-161. (Pubitemid 40514523)
    • (2005) ILAR Journal , vol.46 , Issue.2 , pp. 148-161
    • Hutchinson, E.1    Avery, A.2    VandeWoude, S.3
  • 13
    • 41249099823 scopus 로고    scopus 로고
    • The neurogenic reserve hypo thesis: What is adult hippocampal neurogenesis good for?
    • Kempermann G (2008). The neurogenic reserve hypothesis: What is adult hippocampal neurogenesis good for? Trends Neurosci 31: 163-169.
    • (2008) Trends Neurosci , vol.31 , pp. 163-169
    • Kempermann, G.1
  • 15
    • 0030937293 scopus 로고    scopus 로고
    • More hippocampal neurons in adult mice living in an enriched environment
    • DOI 10.1038/386493a0
    • Kempermann G, Kuhn HG, Gage FH (1997b). More hippocampal neurons in adult mice living in an enriched environment. Nature 386: 493-495. (Pubitemid 27164074)
    • (1997) Nature , vol.386 , Issue.6624 , pp. 493-495
    • Kempermann, G.1    Kuhn, H.G.2    Gage, F.H.3
  • 16
    • 0032080116 scopus 로고    scopus 로고
    • Experience-induced neurogenesis in the senescent dentate gyrus
    • Kempermann G, Kuhn HG, Gage FH (1998). Experience-induced neurogenesis in the senescent dentate gyrus. J Neurosci 18: 3206-3212. (Pubitemid 28186013)
    • (1998) Journal of Neuroscience , vol.18 , Issue.9 , pp. 3206-3212
    • Kempermann, G.1    Kuhn, H.G.2    Gage, F.H.3
  • 17
    • 20444416669 scopus 로고    scopus 로고
    • Enriched environment increases neural stem/progenitor cell proliferation and neurogenesis in the subventricular zone of stroke-lesioned adult rats
    • DOI 10.1161/01.STR.0000166197.94147.59
    • Komitova M, Mattsson B, Johansson BB, Eriksson PS (2005). Enriched environment increases neural stem/progenitor cell proliferation and neurogenesis in the subventricular zone of stroke-lesioned adult rats. Stroke 36: 1278-1282. (Pubitemid 40798751)
    • (2005) Stroke , vol.36 , Issue.6 , pp. 1278-1282
    • Komitova, M.1    Mattsson, B.2    Johansson, B.B.3    Eriksson, P.S.4
  • 18
    • 47149083991 scopus 로고    scopus 로고
    • Effects of enriched environment on animal models of neurodegenerative diseases and psychiatric disorders
    • Laviola G, Hannan AJ, Macri S, Solinas M, Jaber M (2008). Effects of enriched environment on animal models of neurodegenerative diseases and psychiatric disorders. Neurobiol Dis 31: 159-168.
    • (2008) Neurobiol Dis , vol.31 , pp. 159-168
    • Laviola, G.1    Hannan, A.J.2    Macri, S.3    Solinas, M.4    Jaber, M.5
  • 19
    • 34249708528 scopus 로고    scopus 로고
    • Exposure to environmental enrichment elicits differential hippocampal cell proliferation: Role of individual responsiveness to anxiety
    • DOI 10.1002/dneu.20322
    • Leal-Galicia P, Saldivar-Gonzalez A, Morimoto S, Arias C (2007). Exposure to environmental enrichment elicits differential hippocampal cell proliferation: Role of individual responsiveness to anxiety. Dev Neurobiol 67: 395-405. (Pubitemid 47066949)
    • (2007) Developmental Neurobiology , vol.67 , Issue.4 , pp. 395-405
    • Leal-Galicia, P.1    Saldivar-Gonzalez, A.2    Morimoto, S.3    Arias, C.4
  • 20
    • 70349820060 scopus 로고    scopus 로고
    • Thymidine analog methods for studies of adult neurogenesis are not equally sensitive
    • Leuner B, Glasper ER, Gould E (2009). Thymidine analog methods for studies of adult neurogenesis are not equally sensitive. J Comp Neurol 517: 123-133.
    • (2009) J Comp Neurol , vol.517 , pp. 123-133
    • Leuner, B.1    Glasper, E.R.2    Gould, E.3
  • 21
    • 33745173141 scopus 로고    scopus 로고
    • Pronounced individual variation in the response to the stimulatory action of exercise on immature hippocampal neurons
    • DOI 10.1002/hipo.20175
    • Llorens-Martin M, Torres-Aleman I, Trejo JL (2006). Pronounced individual variation in the response to the stimulatory action of exercise on immature hippocampal neurons. Hippocampus 16: 480-490. (Pubitemid 44712072)
    • (2006) Hippocampus , vol.16 , Issue.5 , pp. 480-490
    • Llorens-Martin, M.1    Torres-Aleman, I.2    Trejo, J.L.3
  • 22
    • 63349097497 scopus 로고    scopus 로고
    • Mechanisms mediating brain plasticity: IGF1 and adult hippocampal neurogenesis
    • Llorens-Martin M, Torres-Aleman I, Trejo JL (2009). Mechanisms mediating brain plasticity: IGF1 and adult hippocampal neurogenesis. Neuroscientist 15: 134-148.
    • (2009) Neuroscientist , vol.15 , pp. 134-148
    • Llorens-Martin, M.1    Torres-Aleman, I.2    Trejo, J.L.3
  • 23
    • 34250813616 scopus 로고    scopus 로고
    • Both increases in immature dentate neuron number and decreases of immobility time in the forced swim test occurred in parallel after environmental enrichment of mice
    • DOI 10.1016/j.neuroscience.2007.04.054, PII S0306452207005404
    • Llorens-Martin MV, Rueda N, Martinez-Cue C, Torres-Aleman I, Florez J, Trejo JL (2007). Both increases in immature dentate neuron number and decreases of immobility time in the forced swim test occurred in parallel after environmental enrichment of mice. Neuroscience 147: 631-638. (Pubitemid 46990652)
    • (2007) Neuroscience , vol.147 , Issue.3 , pp. 631-638
    • Llorens-Martin, M.V.1    Rueda, N.2    Martinez-Cue, C.3    Torres-Aleman, I.4    Florez, J.5    Trejo, J.L.6
  • 24
    • 77957872719 scopus 로고    scopus 로고
    • Differential regulation of the variations induced by environmental richness in adult neurogenesis as a function of time
    • Llorens-Martin M, Tejeda GS, Trejo JL (2010). Differential regulation of the variations induced by environmental richness in adult neurogenesis as a function of time. A dual birthdating analysis. PLoS One 5: E12188.
    • (2010) A dual birthdating analysis. PLoS One , vol.5
    • Llorens-Martin, M.1    Tejeda, G.S.2    Trejo, J.L.3
  • 25
    • 52449089202 scopus 로고    scopus 로고
    • Environmental enrichment provides a cognitive reserve to be spent in the case of brain lesion
    • Mandolesi L, De Bartolo P, Foti F, Gelfo F, Federico F, Leggio MG et al (2008). Environmental enrichment provides a cognitive reserve to be spent in the case of brain lesion. J Alzheimers Dis 15: 11-28.
    • (2008) J Alzheimers Dis , vol.15 , pp. 11-28
    • Mandolesi, L.1    De Bartolo, P.2    Foti, F.3    Gelfo, F.4    Federico, F.5    Leggio, M.G.6
  • 26
    • 0037151272 scopus 로고    scopus 로고
    • Differential effects of environmental enrichment on behavior and learning of male and female Ts65Dn mice, a model for Down syndrome
    • DOI 10.1016/S0166-4328(02)00026-8, PII S0166432802000268
    • Martinez-Cue C, Baamonde C, Lumbreras M, Paz J, Davisson MT, Schmidt C et al (2002). Differential effects of environmental enrichment on behavior and learning of male and female Ts65Dn mice, a model for Down syndrome. Behav Brain Res 134: 185-200. (Pubitemid 34912698)
    • (2002) Behavioural Brain Research , vol.134 , Issue.1-2 , pp. 185-200
    • Martinez-Cue, C.1    Baamonde, C.2    Lumbreras, M.3    Paz, J.4    Davisson, M.T.5    Schmidt, C.6    Dierssen, M.7    Florez, J.8
  • 27
    • 33745684603 scopus 로고    scopus 로고
    • Hippocampal neurogenesis is not required for behavioral effects of environmental enrichment
    • Meshi D, Drew MR, Saxe M, Ansorge MS, David D, Santarelli L et al (2006). Hippocampal neurogenesis is not required for behavioral effects of environmental enrichment. Nat Neurosci 9: 729-731.
    • (2006) Nat Neurosci , vol.9 , pp. 729-731
    • Meshi, D.1    Drew, M.R.2    Saxe, M.3    Ansorge, M.S.4    David, D.5    Santarelli, L.6
  • 28
    • 33748571875 scopus 로고    scopus 로고
    • Neuroprotective effects of cognitive enrichment
    • DOI 10.1016/j.arr.2006.04.004, PII S1568163706000535, Adaptive Cellular Plasticity in Aging
    • Milgram NW, Siwak-Tapp CT, Araujo J, Head E (2006). Neuroprotective effects of cognitive enrichment. Ageing Res Rev 5: 354-369. (Pubitemid 44374431)
    • (2006) Ageing Research Reviews , vol.5 , Issue.3 , pp. 354-369
    • Milgram, N.W.1    Siwak-Tapp, C.T.2    Araujo, J.3    Head, E.4
  • 29
    • 34548801253 scopus 로고    scopus 로고
    • Aging, plasticity and environmental enrichment: Structural changes and neurotransmitter dynamics in several areas of the brain
    • DOI 10.1016/j.brainresrev.2007.03.011, PII S0165017307000604
    • Mora F, Segovia G, del Arco A (2007). Aging, plasticity and environmental enrichment: Structural changes and neurotransmitter dynamics in several areas of the brain. Brain Res Rev 55: 78-88. (Pubitemid 47422232)
    • (2007) Brain Research Reviews , vol.55 , Issue.1 , pp. 78-88
    • Mora, F.1    Segovia, G.2    Del Arco, A.3
  • 30
    • 0022633469 scopus 로고
    • Serial stressors: Prior exposure to a stressor modulates its later effectiveness on gastric ulceration and corticosterone release
    • DOI 10.1016/S0163-1047(86)90761-2
    • Murison R, Overmier JB, Skoglund EJ (1986). Serial stressors: Prior exposure to a stressor modulates its later effectiveness on gastric ulceration and corticosterone release. Behav Neural Biol 45: 185-195. (Pubitemid 16164034)
    • (1986) Behavioral and Neural Biology , vol.45 , Issue.2 , pp. 185-195
    • Murison, R.1    Overmier, J.B.2    Skoglund, E.J.3
  • 31
    • 48249085840 scopus 로고    scopus 로고
    • Antidepressant drug-induced stimulation of mouse hippocampal neurogenesis is age-dependent and altered by early life stress
    • Navailles S, Hof PR, Schmauss C (2008). Antidepressant drug-induced stimulation of mouse hippocampal neurogenesis is age-dependent and altered by early life stress. J Comp Neurol 509: 372-381.
    • (2008) J Comp Neurol , vol.509 , pp. 372-381
    • Navailles, S.1    Hof, P.R.2    Schmauss, C.3
  • 32
    • 70450223117 scopus 로고    scopus 로고
    • The neurobiology of brain and cognitive reserve: Mental and physical activity as modulators of brain disorders
    • Nithianantharajah J, Hannan AJ (2009). The neurobiology of brain and cognitive reserve: Mental and physical activity as modulators of brain disorders. Prog Neurobiol 89: 369-382.
    • (2009) Prog Neurobiol , vol.89 , pp. 369-382
    • Nithianantharajah, J.1    Hannan, A.J.2
  • 33
    • 33645103788 scopus 로고    scopus 로고
    • Environmental enrichment and voluntary exercise massively increase neurogenesis in the adult hippocampus via dissociable pathways
    • Olson AK, Eadie BD, Ernst C, Christie BR (2006). Environmental enrichment and voluntary exercise massively increase neurogenesis in the adult hippocampus via dissociable pathways. Hippocampus 16: 250-260.
    • (2006) Hippocampus , vol.16 , pp. 250-260
    • Olson, A.K.1    Eadie, B.D.2    Ernst, C.3    Christie, B.R.4
  • 34
  • 35
    • 0018268297 scopus 로고
    • Behavioural despair in rats: A new model sensitive to antidepressant treatments
    • Porsolt RD, Anton G, Blavet N, Jalfre M (1978). Behavioural despair in rats: A new model sensitive to antidepressant treatments. Eur J Pharmacol 47: 379-391.
    • (1978) Eur J Pharmacol , vol.47 , pp. 379-391
    • Porsolt, R.D.1    Anton, G.2    Blavet, N.3    Jalfre, M.4
  • 37
    • 0017618768 scopus 로고
    • Depression: A new animal model sensitive to antidepressant treatments
    • Porsolt RD, Le Pichon M, Jalfre M (1977b). Depression: A new animal model sensitive to antidepressant treatments. Nature 266: 730-732. (Pubitemid 8073804)
    • (1977) Nature , vol.266 , Issue.5604 , pp. 730-732
    • Porsolt, R.D.1    Le Pichon, M.2    Jalfre, M.3
  • 38
    • 26844435328 scopus 로고    scopus 로고
    • Stress-induced enhancement of fear learning: An animal model of posttraumatic stress disorder
    • DOI 10.1016/j.neubiorev.2005.04.010, PII S0149763405000606
    • Rau V, DeCola JP, Fanselow MS (2005). Stress-induced enhancement of fear learning: An animal model of posttraumatic stress disorder. Neurosci Biobehav Rev 29: 1207-1223. (Pubitemid 41446896)
    • (2005) Neuroscience and Biobehavioral Reviews , vol.29 , Issue.8 , pp. 1207-1223
    • Rau, V.1    DeCola, J.P.2    Fanselow, M.S.3
  • 39
    • 61349157339 scopus 로고    scopus 로고
    • Exposure to a stressor produces a long lasting enhancement of fear learning in rats
    • Rau V, Fanselow MS (2009). Exposure to a stressor produces a long lasting enhancement of fear learning in rats. Stress 12: 125-133.
    • (2009) Stress , vol.12 , pp. 125-133
    • Rau, V.1    Fanselow, M.S.2
  • 40
    • 34249017269 scopus 로고    scopus 로고
    • Influence of prior experience with homotypic or heterotypic stressor on stress reactivity in catecholaminergic systems
    • DOI 10.1080/10253890701404078, PII 778862123
    • Sabban EL, Serova LI (2007). Influence of prior experience with homotypic or heterotypic stressor on stress reactivity in catecholaminergic systems. Stress 10: 137-143. (Pubitemid 46789480)
    • (2007) Stress , vol.10 , Issue.2 , pp. 137-143
    • Sabban, E.L.1    Serova, L.I.2
  • 41
    • 63349100105 scopus 로고    scopus 로고
    • Enrich the environment to empower the brain
    • Sale A, Berardi N, Maffei L (2009). Enrich the environment to empower the brain. Trends Neurosci 32: 233-239.
    • (2009) Trends Neurosci , vol.32 , pp. 233-239
    • Sale, A.1    Berardi, N.2    Maffei, L.3
  • 43
    • 78650254503 scopus 로고    scopus 로고
    • Environmental enrichment requires adult neurogenesis to facilitate the recovery from psychosocial stress
    • Schloesser RJ, Lehmann M, Martinowich K, Manji HK, Herkenham M (2010). Environmental enrichment requires adult neurogenesis to facilitate the recovery from psychosocial stress. Mol Psychiatry 15: 1152-1163.
    • (2010) Mol Psychiatry , vol.15 , pp. 1152-1163
    • Schloesser, R.J.1    Lehmann, M.2    Martinowich, K.3    Manji, H.K.4    Herkenham, M.5
  • 44
    • 33744503719 scopus 로고    scopus 로고
    • Environmental enrichment promotes neurogenesis and changes the extracellular concentrations of glutamate and GABA in the hippocampus of aged rats
    • DOI 10.1016/j.brainresbull.2005.11.005, PII S0361923005004612
    • Segovia G, Yague AG, Garcia-Verdugo JM, Mora F (2006). Environmental enrichment promotes neurogenesis and changes the extracellular concentrations of glutamate and GABA in the hippocampus of aged rats. Brain Res Bull 70: 8-14. (Pubitemid 43796308)
    • (2006) Brain Research Bulletin , vol.70 , Issue.1 , pp. 8-14
    • Segovia, G.1    Yague, A.G.2    Garcia-Verdugo, J.M.3    Mora, F.4
  • 45
    • 0031451187 scopus 로고    scopus 로고
    • Antisense inhibition of 5-hydroxytryptamine(2a) receptor induces an antidepressant-like effect in mice
    • Sibille E, Sarnyai Z, Benjamin D, Gal J, Baker H, Toth M (1997). Antisense inhibition of 5-hydroxytryptamine2a receptor induces an antidepressant-like effect in mice. Mol Pharmacol 52: 1056-1063. (Pubitemid 28013724)
    • (1997) Molecular Pharmacology , vol.52 , Issue.6 , pp. 1056-1063
    • Sibille, E.1    Sarnyai, Z.2    Benjamin, D.3    Gal, J.4    Baker, H.5    Toth, M.6
  • 46
    • 33746869655 scopus 로고    scopus 로고
    • Selective breeding for divergence in novelty-seeking traits: Heritability and enrichment in spontaneous anxiety-related behaviors
    • DOI 10.1007/s10519-006-9058-7
    • Stead JD, Clinton S, Neal C, Schneider J, Jama A, Miller S et al (2006). Selective breeding for divergence in novelty-seeking traits: Heritability and enrichment in spontaneous anxietyrelated behaviors. Behav Genet 36: 697-712. (Pubitemid 44188085)
    • (2006) Behavior Genetics , vol.36 , Issue.5 , pp. 697-712
    • Stead, J.D.H.1    Clinton, S.2    Neal, C.3    Schneider, J.4    Jama, A.5    Miller, S.6    Vazquez, D.M.7    Watson, S.J.8    Akil, H.9
  • 47
    • 77956440516 scopus 로고    scopus 로고
    • The anxiolytic effect of environmental enrichment is mediated via amygdalar CRF receptor type 1
    • Sztainberg Y, Kuperman Y, Tsoory M, Lebow M, Chen A (2010). The anxiolytic effect of environmental enrichment is mediated via amygdalar CRF receptor type 1. Mol Psychiatry 15: 905-917.
    • (2010) Mol Psychiatry , vol.15 , pp. 905-917
    • Sztainberg, Y.1    Kuperman, Y.2    Tsoory, M.3    Lebow, M.4    Chen, A.5
  • 48
    • 38649115676 scopus 로고    scopus 로고
    • The effects of exercise on spatial learning and anxiety-like behavior are mediated by an IGF-I-dependent mechanism related to hippocampal neurogenesis
    • Trejo JL, Llorens-Martin MV, Torres-Aleman I (2008). The effects of exercise on spatial learning and anxiety-like behavior are mediated by an IGF-I-dependent mechanism related to hippocampal neurogenesis. Mol Cell Neurosci 37: 402-411.
    • (2008) Mol Cell Neurosci , vol.37 , pp. 402-411
    • Trejo, J.L.1    Llorens-Martin, M.V.2    Torres-Aleman, I.3
  • 50
    • 0033360314 scopus 로고    scopus 로고
    • Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus
    • DOI 10.1038/6368
    • van Praag H, Kempermann G, Gage FH (1999). Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus. Nat Neurosci 2: 266-270. (Pubitemid 30491298)
    • (1999) Nature Neuroscience , vol.2 , Issue.3 , pp. 266-270
    • Van Praag, H.1    Kempermann, G.2    Gage, F.H.3


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