Deletion of Ia-2 and/or Ia-2β in mice decreases insulin secretion by reducing the number of dense core vesicles

Diabetologia

Volumn 54, Issue 9, 2011, Pages 2347-2357

  Cai, T ^a   Hirai, H ^a   Zhang, G ^b   Zhang, M ^c   Takahashi, N ^d   Kasai, H ^d   Satin, L S ^c,e   Leapman, R D ^b   Notkins, A L ^a  

^a NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH   (United States)

^b NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING   (United States)

^c VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^d UNIVERSITY OF TOKYO   (Japan)

^e UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

Autophagy; Capacitance; Dense core vesicle; Diabetes; Electron microscopy; Gene knockout; Insulin; Pancreatic islet; Protein tyrosine phosphates; Two photon microscopy

Indexed keywords

AUTOANTIGEN; CALCIUM CHANNEL L TYPE; CATHEPSIN D; GLUCOSE; ISLET ANTIGEN 2; ISLET ANTIGEN 2 BETA; MEMBRANE PROTEIN; PROINSULIN; PROTEIN TYROSINE PHOSPHATASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; AUTOPHAGY; CALCIUM CELL LEVEL; CALCIUM CURRENT; CALCIUM TRANSPORT; CELL COUNT; CELL SIZE; CELL STRUCTURE; CELL VACUOLE; CONTROLLED STUDY; DENSE CORE VESICLE; ELECTRON MICROSCOPY; ENZYME ACTIVITY; EXOCYTOSIS; FEMALE; FLUORESCENCE MICROSCOPY; GENE DELETION; INSULIN RELEASE; INSULIN SYNTHESIS; LYSOSOME; MALE; MOUSE; NONHUMAN; OSCILLATION; PANCREAS ISLET CELL; PATCH CLAMP; PRIORITY JOURNAL; VOLTAGE CLAMP;

ANIMALS; AUTOPHAGY; CALCIUM; CATHEPSIN D; EXOCYTOSIS; FEMALE; GENE DELETION; INSULIN; ISLETS OF LANGERHANS; MALE; MICE; MICE, KNOCKOUT; MICROSCOPY, ELECTRON; MICROTUBULE-ASSOCIATED PROTEINS; MODELS, ANIMAL; RECEPTOR-LIKE PROTEIN TYROSINE PHOSPHATASES, CLASS 8; SECRETORY VESICLES;

EID: 80054715948     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-011-2221-6     Document Type: Article

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