Deletion of the secretory vesicle proteins IA-2 and IA-2β disrupts circadian rhythms of cardiovascular and physical activity

FASEB Journal

Volumn 23, Issue 9, 2009, Pages 3226-3232

  Kim, Soo Mi ^a   Power, Andrea ^d   Brown, Timothy M ^d   Constance, Cara M ^e,g   Coon, Steven L ^b   Nishimura, Takuya ^c   Hirai, Hiroki ^c   Cai, Tao ^c   Eisner, Christoph ^a   Weaver, David R ^f   Piggins, Hugh D ^d   Klein, David C ^b   Schnermann, Jürgen ^a   Notkins, Abner L ^c  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^b EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

^c NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH   (United States)

^d UNIVERSITY OF MANCHESTER   (United Kingdom)

^e Department of Biology   (United States)

^f UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^g HIRAM COLLEGE   (United States)

Author keywords

Behavior; Blood pressure; Diabetes; Heart rate; Temperature

Indexed keywords

SECRETORY PROTEIN; SECRETORY PROTEIN IA 2; SECRETORY PROTEIN IA 2BETA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BODY TEMPERATURE; BRAIN; CARDIOVASCULAR FUNCTION; CIRCADIAN RHYTHM; CONTROLLED STUDY; GENE DELETION; GENE EXPRESSION; GENETIC TRANSCRIPTION; HEART ELECTROPHYSIOLOGY; HEART RATE; IN SITU HYBRIDIZATION; MALE; MOUSE; NERVE CELL; NEUROENDOCRINE SYSTEM; NONHUMAN; NUCLEOTIDE SEQUENCE; OSCILLATOR; PHYSICAL ACTIVITY; PRIORITY JOURNAL; PROTEIN SECRETION; PROTEIN STRUCTURE; SECRETORY VESICLE; SUPRACHIASMATIC NUCLEUS;

ANIMALS; CIRCADIAN RHYTHM; ELECTROPHYSIOLOGY; HEMODYNAMICS; MICE; RECEPTOR-LIKE PROTEIN TYROSINE PHOSPHATASES, CLASS 8; RNA, MESSENGER; SECRETORY VESICLES; SUPRACHIASMATIC NUCLEUS;

EID: 70349313588     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.09-132019     Document Type: Article

References (30)

1. Dunlap, J. C., Loros, J. J., and DeCoursey, P. J. (2004) Chronobiology: Biological Timekeeping, Sinauer Associates, Sunderland, MA, USA
2. Reppert, S. M., Moore, R. Y., and Klein, D. C. (1991) Suprachiasmatic Nucleus: The Mind's Clock, Oxford University Press, New York
3. Brown, T. M., and Piggins, H. D. (2007) Electrophysiology of the suprachiasmatic circadian clock. Prog. Neurobiol. 82, 229-255
4. Reppert, S. M., and Weaver, D. R. (2002) Coordination of circadian timing in mammals. Nature 418, 935-941
5. Aton, S. J., Colwell, C. S., Harmar, A. J., Waschek, J., and Herzog, E. D. (2005) Vasoactive intestinal polypeptide mediates circadian rhythmicity and synchrony in mammalian clock neurons. Nat. Neurosci. 8, 476-483 (Pubitemid 41007565)
6. Brown, T. M., Hughes, A. T., and Piggins, H. D. (2005) Gastrin-releasing peptide promotes suprachiasmatic nuclei cellular rhythmicity in the absence of vasoactive intestinal polypeptide-VPAC2 receptor signaling. J. Neurosci. 25, 11155-11164
7. Lan, M. S., Wasserfall, C., Maclaren, N. K., and Notkins, A. L. (1996) IA-2, a transmembrane protein of the protein tyrosine phosphatase family, is a major autoantigen in insulin-dependent diabetes mellitus. Proc. Natl. Acad. Sci. U. S. A. 93, 6367-6370 (Pubitemid 26230311)
8. Lu, J., Li, Q., Xie, H., Chen, Z. J., Borovitskaya, A. E., Maclaren, N. K., Notkins, A. L., and Lan, M. S. (1996) Identification of a second transmembrane protein tyrosine phosphatase, IA-2β, as an autoantigen in insulin-dependent diabetes mellitus: precursor of the 37-kDa tryptic fragment. Proc. Natl. Acad. Sci. U. S. A. 93, 2307-2311 (Pubitemid 26104346)
9. Notkins, A. L., and Lernmark, A. (2001) Autoimmune type 1 diabetes: resolved and unresolved issues. J. Clin. Invest. 108, 1247-1252 (Pubitemid 33107747)
10. Saeki, K., Zhu, M., Kubosaki, A., Xie, J., Lan, M. S., and Notkins, A. L. (2002) Targeted disruption of the protein tyrosine phosphatase- like molecule IA-2 results in alterations in glucose tolerance tests and insulin secretion. Diabetes 51, 1842-1850 (Pubitemid 34564297)
11. Kubosaki, A., Gross, S., Miura, J., Saeki, K., Zhu, M., Nakamura, S., Hendriks, W., and Notkins, A. L. (2004) Targeted disruption of the IA-2β gene causes glucose intolerance and impairs insulin secretion but does not prevent the development of diabetes in NOD mice. Diabetes 53, 1684-1691 (Pubitemid 38857025)
12. Kubosaki, A., Nakamura, S., and Notkins, A. L. (2005) Dense core vesicle proteins IA-2 and IA-2β: metabolic alterations in double knockout mice. Diabetes 54(Suppl. 2), S46-S51 (Pubitemid 43343330)
13. Kubosaki, A., Nakamura, S., Clark, A., Morris, J. F., and Notkins, A. L. (2006) Disruption of the transmembrane dense core vesicle proteins IA-2 and IA-2β causes female infertility. Endocrinology 147, 811-815 (Pubitemid 43112998)
14. Nishimura, T., Kubosaki, A., Ito, Y., and Notkins, A. L. (2009) Disturbances in the secretion of neurotransmitters in IA-2/IA-2β null mice: changes in behavior, learning and lifespan. Neuroscience 159, 427-437
15. Kim, S. M., Mizel, D., Huang, Y. G., Briggs, J. P., and Schnermann, J. (2006) Adenosine as a mediator of macula densadependent inhibition of renin secretion. Am. J. Physiol. Renal Physiol. 290, F1016-F1023 (Pubitemid 43724900)
16. Shearman, L. P., Zylka, M. J., Weaver, D. R., Kolakowski, L. F., Jr., and Reppert, S. M. (1997) Two period homologs: circadian expression and photic regulation in the suprachiasmatic nuclei. Neuron 19, 1261-1269
17. Brown, T. M., Banks, J. R., and Piggins, H. D. (2006) A novel suction electrode recording technique for monitoring circadian rhythms in single and multiunit discharge from brain slices. J. Neurosci. Methods 156, 173-181
18. Brown, T. M., Colwell, C. S., Waschek, J. A., and Piggins, H. D. (2007) Disrupted neuronal activity rhythms in the suprachiasmatic nuclei of vasoactive intestinal polypeptide-deficient mice. J. Neurophysiol. 97, 2553-2558
19. Harashima, S., Clark, A., Christie, M. R., and Notkins, A. L. (2005) The dense core transmembrane vesicle protein IA-2 is a regulator of vesicle number and insulin secretion. Proc. Natl. Acad. Sci. U. S. A. 102, 8704-8709 (Pubitemid 40862799)
20. Albus, H., Bonnefont, X., Chaves, I., Yasui, A., Doczy, J., van der Horst, G. T., and Meijer, J. H. (2002) Cryptochrome-deficient mice lack circadian electrical activity in the suprachiasmatic nuclei. Curr. Biol. 12, 1130-1133 (Pubitemid 34766936)
21. Maywood, E. S., Reddy, A. B., Wong, G. K., O'Neill, J. S., O'Brien, J. A., McMahon, D. G., Harmar, A. J., Okamura, H., and Hastings, M. H. (2006) Synchronization and maintenance of timekeeping in suprachiasmatic circadian clock cells by neuropeptidergic signaling. Curr. Biol. 16, 599-605
22. Hughes, A. T., Fahey, B., Cutler, D. J., Coogan, A. N., and Piggins, H. D. (2004) Aberrant gating of photic input to the suprachiasmatic circadian pacemaker of mice lacking the VPAC2 receptor. J. Neurosci. 24, 3522-3526 (Pubitemid 38481108)
23. van der Horst, G. T., Muijtjens, M., Kobayashi, K., Takano, R., Kanno, S., Takao, M., de Wit, J., Verkerk, A., Eker, A. P., van Leenen, D., Buijs, R., Bootsma, D., Hoeijmakers, J. H., and Yasui, A. (1999) Mammalian Cry1 and Cry2 are essential for maintenance of circadian rhythms. Nature 398, 627-630 (Pubitemid 29183691)
24. Vitaterna, M. H., Selby, C. P., Todo, T., Niwa, H., Thompson, C., Fruechte, E. M., Hitomi, K., Thresher, R. J., Ishikawa, T., Miyazaki, J., Takahashi, J. S., and Sancar, A. (1999) Differential regulation of mammalian period genes and circadian rhythmicity by cryptochromes 1 and 2. Proc. Natl. Acad. Sci. U. S. A. 96, 12114-12119 (Pubitemid 29502867)
25. Bunger, M. K., Wilsbacher, L. D., Moran, S. M., Clendenin, C., Radcliffe, L. A., Hogenesch, J. B., Simon, M. C., Takahashi, J. S., and Bradfield, C. A. (2000) Mop3 is an essential component of the master circadian pacemaker in mammals. Cell 103, 1009-1017 (Pubitemid 32037390)
26. Zheng, B., Albrecht, U., Kaasik, K., Sage, M., Lu, W., Vaishnav, S., Li, Q., Sun, Z. S., Eichele, G., Bradley, A., and Lee, C. C. (2001) Nonredundant roles of the mPer1 and mPer2 genes in the mammalian circadian clock. Cell 105, 683-694 (Pubitemid 32524120)
27. Bae, K., Jin, X., Maywood, E. S., Hastings, M. H., Reppert, S. M., and Weaver, D. R. (2001) Differential functions of mPer1, mPer2, and mPer3 in the SCN circadian clock. Neuron 30, 525-536 (Pubitemid 32530594)
28. Bae, K., and Weaver, D. R. (2007) Transient, light-induced rhythmicity in mPer-deficient mice. J. Biol. Rhythms 22, 85-88 (Pubitemid 46041616)
29. DeBruyne, J. P., Weaver, D. R., and Reppert, S. M. (2007) CLOCK and NPAS2 have overlapping roles in the suprachiasmatic circadian clock. Nat. Neurosci. 10, 543-545
30. Mahapatra, N. R., O'Connor, D. T., Vaingankar, S. M., Hikim, A. P., Mahata, M., Ray, S., Staite, E., Wu, H., Gu, Y., Dalton, N., Kennedy, B. P., Ziegler, M. G., Ross, J., and Mahata, S. K. (2005) Hypertension from targeted ablation of chromogranin A can be rescued by the human ortholog. J. Clin. Invest. 115, 1942-1952 (Pubitemid 40979734)