Spinocerebellar ataxia type 2 (SCA2) is associated with TDP-43 pathology

Acta Neuropathologica

Volumn 122, Issue 3, 2011, Pages 375-378

  Toyoshima, Yasuko ^a   Tanaka, Hajime ^b   Shimohata, Mitsuteru ^b   Kimura, Kakuhei ^b   Morita, Takashi ^b   Kakita, Akiyoshi ^a   Takahashi, Hitoshi ^a  

^a NIIGATA UNIVERSITY   (Japan)

^b Shinrakuen Hospital   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

TAR DNA BINDING PROTEIN;

ADULT; ARM DISEASE; BRAIN ATROPHY; BRAIN WEIGHT; CAG REPEAT; CASE REPORT; CELL INCLUSION; CELL LOSS; CYTOPLASM; DISEASE SEVERITY; DNA DETERMINATION; FAMILY HISTORY; GAIT DISORDER; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LEG DISEASE; LETTER; MALE; MOTONEURON; ONSET AGE; PRIORITY JOURNAL; PROTEIN DEFECT; PROTEIN PHOSPHORYLATION; SPINOCEREBELLAR ATAXIA TYPE 2; SPINOCEREBELLAR DEGENERATION; SUBSTANTIA NIGRA; SYMPTOM;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; BRAIN; DNA-BINDING PROTEINS; FAMILY HEALTH; FEMALE; HUMANS; INCLUSION BODIES; MALE; MIDDLE AGED; NEURONS; PEPTIDES; SPINOCEREBELLAR ATAXIAS;

EID: 80054715358     PISSN: 00016322     EISSN: 14320533     Source Type: Journal    
DOI: 10.1007/s00401-011-0862-7     Document Type: Letter

References (6)

1. AC Elden HJ Kim MP Hart, et al. 2010 Ataxin-2 intermediate-length polyglutamine expansions are associated with increased risk for ALS Nature 466 1069 1075 20740007 10.1038/nature09320 1:CAS:528:DC%2BC3cXhtVOnurvF
2. T Lee YR Li C Ingre, et al. 2011 Ataxin-2 intermediate-length polyglutamine expansions in European ALS patients Hum Mol Genet 20 1697 1700 21292779 10.1093/hmg/ddr045 1:CAS:528:DC%2BC3MXksFSkurk%3D
3. Y Nishihira CF Tan O Onodere, et al. 2008 Sporadic amyotrophic lateral sclerosis: two pathological patterns shown by analysis of distribution of TDP-43-immunoreactive neuronal and glial cytoplasmic and glial cytoplasmic inclusions Acta Neuropathol 116 169 182 18481073 10.1007/s00401-008-0385-z 1:CAS:528:DC%2BD1cXosVyisLc%3D
4. C Schwab T Arai M Hasegawa, et al. 2008 Colocalization of transactivation-responsive DNA-binding protein 43 and Huntington in inclusions of Huntington disease J Neuropathol Exp Neurol 67 1159 1165 19018245 10.1097/NEN.0b013e31818e8951
5. K Seidel WFA den Dunnen C Schulz, et al. 2010 Axonal inclusions in spinocerebellar ataxia type 3 Acta Neuropathol 120 449 460 20635090 10.1007/s00401-010-0717-7 1:CAS:528:DC%2BC3cXhtVaqsbfN
6. C-F Tan M Yamada Y Toyoshima, et al. 2009 Selective occurrence of TDP-43-immunoreactive inclusions in the lower motor neurons in Machado-Joseph disease Acta Neuropathol 118 553 560 19526244 10.1007/s00401-009-0552-x