Remodeling of Endothelial Cell Nucleus Exposed to Three Different Mechanical Stimuli

Journal of Biomechanical Science and Engineering

Volumn 3, Issue 2, 2008, Pages 63-74

  Ohashi, Toshiro ^a   Hanamura, Kazuhiko ^a   Azuma, Daisaku ^a   Sakamoto, Naoya ^a   Sato, Masaaki ^a  

^a TOHOKU UNIVERSITY   (Japan)

Author keywords

Cyclic Stretching; Cytoskeletal Meshworks; Endothelial Cells; Hydrostatic Pressure; Nucleus Remodeling; Shear Stress

Indexed keywords

EID: 80054706443     PISSN: 18809863     EISSN: None     Source Type: Journal    
DOI: 10.1299/jbse.3.63     Document Type: Article

References (27)

1. Levesque, M.J. and Nerem, R.M., The Elongation and Orientation of Cultured Endothelial Cells in Response to Shear Stress, Trans ASME Journal of Biomechanical Engineering, Vol. 107 (1985), pp. 341–347.
2. Nerem, R.M. Levesque, M.J., Cornhill, J.F., Vascular Endothelial Morphology As an Indicator of the Pattern of Blood Flow, Trans ASME Journal of Biomechanical Engineering, Vol. 103 (1981), pp. 172–176.
3. Kataoka, N. Ujita, S., Sato, M., Effect of Flow Direction on the Morphological Responses of Cultured Bovine Aortic Endothelial Cells, Medical & Biological Engineering & Computing, Vol. 36 (1998), pp. 122–128.
4. Ohashi, T., Sugawara, H., Matsumoto, T., Sato, M., Surface Topography Measurement and Intracellular Stress Analysis of Cultured Endothelial Cells Exposed to Fluid Shear Stress, JSME International Journal Series C, Vol. 43 (2000), pp. 780–786.
5. Davies, P.F., Flow-Mediated Endothelial Mechanotransduction. Physiological Review, Vol. 75, (1995), pp. 519–560.
6. Wang, J.H.-C., Goldschmidt-Clermont, P., Wille, J., Yin, F.C.-P., Specificity of Endothelial Cell Orientation in Response to Cyclic Mechanical Stretching, Journal of Biomechanics, Vol. 34 (2001), pp. 1563–1572.
7. Ohashi, T., Masuda, M., Matsumoto, T., Sato, M., Nonuniform Strain of Substrate Induces Local Development of Stress Fibers in Endothelial Cells Under Uniaxial Cyclic Stretching, Clinical Hemorheology and Microcirculation, Vol. 37 (2007a), pp. 37–46.
8. Ohashi, T., Sugaya, Y., Sakamoto, N., Sato, M., Hydrostatic Pressure Influences Morphology and Expression of VE-Cadherin of Vascular Endothelial Cells, Journal of Biomechanics, Vol. 40, No. 11 (2007b), pp. 2399–2405.
9. Sugaya, Y., Sakamoto, N., Ohashi, T., Sato, M., Elongation and Random Orientation of Bovine Endothelial Cells in Response to Hydrostatic Pressure: Comparison with Responses to Shear Stress, JSME International Journal Series C, Vol. 46, No. 4 (2003), pp. 1248–1255.
10. Chen, J., Fabry, B., Schiffrin, E.L., Wang, N., Twisting Integrin Receptors Increases Endothelin-1 Gene Expression in Endothelial Cells, American Journal of Physiology Cell Physiology, Vol. 280 (2001), C1475-C1484.
11. Maniotis, A.J., Chen, C.S., Ingber, D.E., Demonstration of Mechanical Connections Between Integrins, Cytoskeletal Filaments, and Nucleoplasm That Stabilize Nuclear Structure, Proceedings of the National Academy of Sciences of the United States of America, Vol. 94 (1997), pp. 849–854.
12. Deguchi, S., Maeda, K., Ohashi, T., Sato, M., Flow-Induced Hardening of Endothelial Nucleus As an Intracellular Stress-Bearing Organelle, Journal of Biomechanics, Vol. 38 (2005), pp. 1751–1759.
13. Guilak, F., Compression-Induced Changes in the Shape and Volume of the Chondrocyte nucleus, Journal of Biomechanics, Vol. 28 (1995), pp. 1529–1541.
14. Caille, N., Tardy, Y., Meister, J.-J., Assessment of Strain Field in Endothelial Cells Subjected to Uniaxial Deformation of Their Substrate, Annals of Biomedical Engineering, Vol. 26 (1998), pp. 409–416.
15. Ingber, D.E., Fibronectin Controls Capillary Endothelial Cell Growth by Modulating Cell Shape, Proceedings of the National Academy of Sciences of the United States of America, Vol. 87 (1990), pp. 3579–3583.
16. Ohashi, T. Ishii, Y., Ishikawa, Y., Matsumoto, T., Sato, M., Experimental and Numerical Analyses of Local Mechanical Properties Measured by Atomic Force Microscopy for Sheared Endothelial Cells, BioMedical Materials and Engineering, Vol. 12, No. 3 (2002), pp. 319–327.
17. Cornhill, J.F., Levesque, M.J., Herderick, E.E., Nerem, R.M., Kilman, J.W., Vasco, J.S., Quantitative Study of the Rabit Aortic Endothelium Using Vascular Casts, Atherosclerosis, Vol. 35 (1980), pp. 321–337.
18. Flaherty, J.T., Pierce, J.E., Ferrans, V.J., Patel, D.J., Tucker, W.K., Fry, D.L., Endothelial Nuclear Patterns in the Canine Arterial Tree with Particular Reference to Hemodynamic Events, Circulation Research, Vol. 30 (1972), pp. 23–33.
19. Caille, N., Thoumine, O., Tardy, Y., Meister, J.-J., Contribution of the Nucleus to the Mechanical Properties of Endothelial Cells, Journal of Biomechanics, Vol. 35 (2002), pp. 177–187.
20. Hazel, A.L. and Pedley, T.J., Vascular Endothelial Cells Minimize the Total Force on Their Nuclei, Biophysical Journal, Vol. 78 (2000), pp. 47–54.
21. Wang, H.-B., Dembo, M., Hanks, S.K., Wang, Y.l., Focal Adhesion Kinase Is Involved in Mechanosensing During Fibroblast Migration, Proceedings of the National Academy of Sciences of the United States of America, Vol. 98, No. 20 (2001), pp. 11295–11300.
22. Davies, P.F., Zilberberg, J., Helmke, B.P., Spatial Microstimuli in Endothelial Mechanosignaling, Circulation Research, Vol. 92 (2003), pp. 359–370.
23. Jean, R.P., Chen, C.S., Spector, A.A., Finite-Element Analysis of the Adhesion-Cytoskeleton-Nucleus Mechanotransduction Pathway During Endothelial Cell Rounding: Axisymmetric Model, Trans ASME Journal of Biomechanical Engineering, Vol. 127 (2005), pp. 594–600.
24. Dewey, C.F., Jr., Bussolari, S.R., Gimbrone, M.A. Jr., Davies, P.F., The Dynamic Response of Vascular Endothelial Cells to Fluid Shear Stress, Trans ASME Journal of Biomechanical Engineering, Vol. 103, (1981), pp. 177–184.
25. Warabi, E., Wada, Y., Kajiwara, H., Kobayashi, M., Koshiba, N., Hisada, T., Shibata, M., Ando, J., Tsuchiya, M., Kodama, T., Noguchi, N.,, Effect on Endothelial Cell Gene Expression of Shear Stress, Oxygen Concentration, and Low-Density Lipoprotein as Studied by A Novel Flow Cell Culture System, Free Radical Biology & Medicine,, Vol. 37, (2004), pp. 682–694.
26. Galbraith, C.G., Skalak, R., Chien, S., Shear Stress Induces Spatial Reorganization of the Endothelial Cell Cytoskeleton, Cell Motility and the Cytoskeleton, Vol. 40 (1998), pp. 317–330.
27. Ingber, D.E., Tensegrity: The Architectural Basis of Cellular Mechanotransduction, Annual Review of Physiology, Vol. 59, (1997), pp. 575–599.