Role of GSK-3β in the osteogenic differentiation of palatal mesenchyme

PLoS ONE

Volumn 6, Issue 10, 2011, Pages

  Nelson, Emily R ^a   Levi, Benjamin ^a   Sorkin, Michael ^a   James, Aaron W ^a   Liu, Karen J ^b   Quarto, Natalina ^a,c   Longaker, Michael T ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b KING'S COLLEGE LONDON   (United Kingdom)

^c UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

DICKKOPF 1 PROTEIN; GLYCOGEN SYNTHASE KINASE 3BETA; SONIC HEDGEHOG PROTEIN; WNT PROTEIN; GLYCOGEN SYNTHASE KINASE 3; GLYCOGEN SYNTHASE KINASE 3 BETA;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BONE DEVELOPMENT; CONTROLLED STUDY; CRANIOFACIAL DEVELOPMENT; EMBRYO; GENE EXPRESSION; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; IN VIVO STUDY; MESENCHYME; MOUSE; MOUSE EMBRYO; NONHUMAN; OSSIFICATION; PALATE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; UPREGULATION; ANIMAL; ANIMAL EMBRYO; C57BL MOUSE; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; MESODERM; METABOLISM; MUTATION; ORGANOGENESIS; PHENOTYPE; PRENATAL DEVELOPMENT; WNT SIGNALING PATHWAY;

ERINACEIDAE;

ANIMALS; EMBRYO, MAMMALIAN; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GLYCOGEN SYNTHASE KINASE 3; HEDGEHOG PROTEINS; MESODERM; MICE; MICE, INBRED C57BL; MUTATION; ORGANOGENESIS; OSTEOGENESIS; PALATE; PHENOTYPE; UP-REGULATION; WNT SIGNALING PATHWAY;

EID: 80054703601     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0025847     Document Type: Article

References (29)

1. Liu KJ, Arron JR, Stankunas K, Crabtree GR, Longaker MT, (2007) Chemical rescue of cleft palate and midline defects in conditional GSK-3beta mice. Nature 446: 79-82.
2. Doble BW, Patel S, Wood GA, Kockeritz LK, Woodgett JR, (2007) Functional redundancy of GSK-3alpha and GSK-3beta in Wnt/beta-catenin signaling shown by using an allelic series of embryonic stem cell lines. Dev Cell 12: 957-971.
3. Lan Y, Ryan RC, Zhang Z, Bullard SA, Bush JO, et al. (2006) Expression of Wnt9b and activation of canonical Wnt signaling during midfacial morphogenesis in mice. Dev Dyn 235: 1448-1454.
4. Juriloff DM, Harris MJ, McMahon AP, Carroll TJ, Lidral AC, (2006) Wnt9b is the mutated gene involved in multifactorial nonsyndromic cleft lip with or without cleft palate in A/WySn mice, as confirmed by a genetic complementation test. Birth Defects Res A Clin Mol Teratol 76: 574-579.
5. Cordero D, Marcucio R, Hu D, Gaffield W, Tapadia M, et al. (2004) Temporal perturbations in sonic hedgehog signaling elicit the spectrum of holoprosencephaly phenotypes. J Clin Invest 114: 485-494.
6. Enomoto H, Nelson CM, Somerville RP, Mielke K, Dixon LJ, et al. (2010) Cooperation of two ADAMTS metalloproteases in closure of the mouse palate identifies a requirement for versican proteolysis in regulating palatal mesenchyme proliferation. Development 137: 4029-4038.
7. Day TF, Guo X, Garrett-Beal L, Yang Y, (2005) Wnt/beta-catenin signaling in mesenchymal progenitors controls osteoblast and chondrocyte differentiation during vertebrate skeletogenesis. Dev Cell 8: 739-750.
8. Hill TP, Spater D, Taketo MM, Birchmeier W, Hartmann C, (2005) Canonical Wnt/beta-catenin signaling prevents osteoblasts from differentiating into chondrocytes. Dev Cell 8: 727-738.
9. Reinhold MI, Kapadia RM, Liao Z, Naski MC, (2006) The Wnt-inducible transcription factor Twist1 inhibits chondrogenesis. J Biol Chem 281: 1381-1388.
10. ten Berge D, Brugmann SA, Helms JA, Nusse R, (2008) Wnt and FGF signals interact to coordinate growth with cell fate specification during limb development. Development 135: 3247-3257.
11. St-Jacques B, Hammerschmidt M, McMahon AP, (1999) Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation. Genes Dev 13: 2072-2086.
12. Behr B, Longaker MT, Quarto N, (2010) Differential activation of canonical Wnt signaling determines cranial sutures fate: a novel mechanism for sagittal suture craniosynostosis. Dev Biol 344: 922-940.
13. Levi B, James AW, Nelson ER, Brugmann SA, Sorkin M, et al. (2011) Role of Indian hedgehog signaling in palatal osteogenesis. Plast Reconstr Surg 127: 1182-1190.
14. Quarto N, Behr B, Longaker MT, (2010) Opposite spectrum of activity of canonical Wnt signaling in the osteogenic context of undifferentiated and differentiated mesenchymal cells: implications for tissue engineering. Tissue Eng Part A 16: 3185-3197.
15. Mosimann C, Hausmann G, Basler K, (2009) Beta-catenin hits chromatin: regulation of Wnt target gene activation. Nat Rev Mol Cell Biol 10: 276-286.
16. Nusse R, Fuerer C, Ching W, Harnish K, Logan C, et al. (2008) Wnt signaling and stem cell control. Cold Spring Harb Symp Quant Biol 73: 59-66.
17. Reya T, Clevers H, (2005) Wnt signalling in stem cells and cancer. Nature 434: 843-850.
18. Jin YR, Turcotte TJ, Crocker AL, Han XH, Yoon JK, (2011) The canonical Wnt signaling activator, R-spondin2, regulates craniofacial patterning and morphogenesis within the branchial arch through ectodermal-mesenchymal interaction. Dev Biol 352: 1-13.
19. Kawano Y, Kypta R, (2003) Secreted antagonists of the Wnt signalling pathway. J Cell Sci 116: 2627-2634.
20. Baron R, Rawadi G, (2007) Targeting the Wnt/beta-catenin pathway to regulate bone formation in the adult skeleton. Endocrinology 148: 2635-2643.
21. Canalis E, Giustina A, Bilezikian JP, (2007) Mechanisms of anabolic therapies for osteoporosis. N Engl J Med 357: 905-916.
22. Yavropoulou MP, Yovos JG, (2007) The role of the Wnt signaling pathway in osteoblast commitment and differentiation. Hormones (Athens) 6: 279-294.
23. Doble BW, Woodgett JR, (2007) Role of glycogen synthase kinase-3 in cell fate and epithelial-mesenchymal transitions. Cells Tissues Organs 185: 73-84.
24. Nalesso G, Sherwood J, Bertrand J, Pap T, Ramachandran M, et al. (2011) WNT-3A modulates articular chondrocyte phenotype by activating both canonical and noncanonical pathways. J Cell Biol 193: 551-564.
25. Grumolato L, Liu G, Mong P, Mudbhary R, Biswas R, et al. (2010) Canonical and noncanonical Wnts use a common mechanism to activate completely unrelated coreceptors. Genes Dev 24: 2517-2530.
26. Pongracz JE, Stockley RA, (2006) Wnt signalling in lung development and diseases. Respir Res 7: 15.
27. Hoeflich KP, Luo J, Rubie EA, Tsao MS, Jin O, et al. (2000) Requirement for glycogen synthase kinase-3beta in cell survival and NF-kappaB activation. Nature 406: 86-90.
28. Taya Y, O'Kane S, Ferguson MW, (1999) Pathogenesis of cleft palate in TGF-beta3 knockout mice. Development 126: 3869-3879.
29. James AW, Theologis AA, Brugmann SA, Xu Y, Carre AL, et al. (2009) Estrogen/estrogen receptor alpha signaling in mouse posterofrontal cranial suture fusion. PLoS ONE 4: e7120.