Refining cage change routines: Comparison of cardiovascular responses to three different ways of cage change in rats

Laboratory Animals

Volumn 45, Issue 3, 2011, Pages 167-173

  Meller, A ^a   Kasanen, I ^b   Ruksenas O ^c   Apanaviciene N ^c   Baturaite, Z ^c   Voipio, H M ^d   Nevalainen, T ^b  

^a UNIVERSITY OF HELSINKI   (Finland)

^b UNIVERSITY OF EASTERN FINLAND   (Finland)

^c VILNIUS UNIVERSITY   (Lithuania)

^d UNIVERSITY OF OULU   (Finland)

Author keywords

Blood pressure; Cage change; Heart rate; Rat; Refinement

Indexed keywords

ANIMAL BEHAVIOR; ANIMAL CARE; ANIMAL EXPERIMENT; ARTICLE; CAGE CHANGE; CARDIOVASCULAR RESPONSE; CONTROLLED STUDY; HEART RATE; INTERMETHOD COMPARISON; MALE; MATERIALS HANDLING; MEAN ARTERIAL PRESSURE; MEDICAL INSTRUMENTATION; NONHUMAN; RAT; TELEMETRY; ANIMAL; ANIMAL HOUSING; ANIMAL HUSBANDRY; BLOOD PRESSURE; EVALUATION; METHODOLOGY; PHYSIOLOGICAL STRESS; SOCIAL ENVIRONMENT; SPECIES DIFFERENCE; SPRAGUE DAWLEY RAT; WISTAR RAT;

ANIMALIA; RATTUS; RATTUS NORVEGICUS; RODENTIA;

ANIMAL HUSBANDRY; ANIMALS; BEHAVIOR, ANIMAL; BLOOD PRESSURE; HEART RATE; HOUSING, ANIMAL; MALE; RATS; RATS, SPRAGUE-DAWLEY; RATS, WISTAR; SOCIAL ENVIRONMENT; SPECIES SPECIFICITY; STRESS, PHYSIOLOGICAL;

EID: 80054696996     PISSN: 00236772     EISSN: None     Source Type: Journal    
DOI: 10.1258/la.2011.010134     Document Type: Article

References (41)

1. Burn CC, Peters A, Mason GJ. Acute effects of cage cleaning at different frequencies on laboratory rat behaviour and welfare. Anim Welfare 2006;15:161-71
2. Duke JL, Zammit TG, Lawson DM. The effects of routine cage-changing on cardiovascular and behavioral parameters in male Sprague-Dawley rats. Contemp Top Lab Anim Sci 2001;40:17-20
3. Sharp J, Azar T, Lawson D. Does cage size affect heart rate and blood pressure of male rats at rest or after procedures that induce stress-like responses? Contemp Top Lab Anim Sci 2003;42:8-12
4. Kemppinen N, Meller A, Mauranen K, Kohila T, Nevalainen T. The effect of dividing walls, a tunnel, and restricted feeding on cardiovascular responses to cage change and gavage in rats (Rattus norvegicus). J Am Assoc Lab Anim Sci 2009;48:157-65
5. Doerning B. Effects of routine animal husbandry and experimental procedures on physiological parameters of rats. Humane Society of the United States, Workshop on Refinement in Toxicological Methods, New Orleans, 14 March 1999. See http://www.hsus.org/web-files/PDF/ARI/ARIS_Doerning_Toxpaper.pdf (last checked 28 September 2010)
6. Balcombe JP, Barnard ND, Sandusky C. Laboratory routines cause animal stress. Contemp Top Lab Anim Sci 2004;43:42-51
7. Voipio HM, Nevalainen T, Halonen P, Hakumaki M, Bjork E. Role of cage material, working style and hearing sensitivity in perception of animal care noise. Lab Anim 2006;40:400-9
8. Schnecko A, Witte K, Lemmer B. Effects of routine procedures on cardiovascular parameters of Sprague-Dawley rats in periods of activity and rest. J Exp Anim Sci 1998;38:181-90
9. Van Loo PLP, Kruitwagen CLJJ, Van Zutphen LFM, Koolhaas JM, Baumans V. Modulation of aggression in male mice: influence of cage cleaning regime and scent marks. Anim Welfare 2000;9:281-95
10. Burn CC. What is it like to be a rat? Rat sensory perception and its implications for experimental design and rat welfare. Appl Anim Behav Sci 2008;112:1-32
11. Beynon RJ, Hurst JL. Urinary proteins and the modulation of chemical scents in mice and rats. Peptides 2004;25:1553-63
12. Hurst JL. Introduction to rodents. In: Poole T, ed. The UFAW Handbook on the Care and Management of Laboratory Animals, Volume I. Terrestrial Vertebrates. 7th edn. Oxford, UK: Blackwell Science, 1999:262-73
13. Feenstra MG, Botterblom MH, van Uum JF. Novelty-induced increase in dopamine release in the rat prefrontal cortex in vivo: inhibition by diazepam. Neurosci Lett 1995;189:81-4
14. Saibaba P, Sales GD, Stodulski G, Hau J. Behaviour of rats in their home cages: daytime variations and effects of routine husbandry procedures analysed by time sampling techniques. Lab Anim 1996;30:13-21
15. Burn CC, Mason GJ. Effects of cage-cleaning frequency on laboratory rat reproduction, cannibalism, and welfare. Appl Anim Behav Sci 2008;114:235-47
16. Nicklas W, Baneux P, Boot R, et al. Recommendations for the health monitoring of rodent and rabbit colonies in breeding and experimental units. Lab Anim 2002;36:20-42
17. Baturaite Z, Voipio HM, Ruksenas O, et al. Comparison of and habituation to four common methods of handling and lifting of rats with cardiovascular telemetry. Scand J Lab Anim Sci 2005;32:137-48
18. Kilkenny C, Browne WJ, Cuthill IC, Emerson M, Altman DG. Improving bioscience research reporting: The ARRIVE guidelines for reporting animal research. PLoS Biol 2010;8:e1000412
19. Hooijmans CR, Leenaars M, Ritskes-Hoitinga M. A gold standard publication checklist to improve the quality of animal studies, to fully integrate the three Rs, and to make systematic reviews more feasible. Altern Lab Anim 2010;38:167-82
20. Mason GJ, Dallaire J, Ware N. Murid stress odours: a review and a 'low tech' method of collection. Anim Welfare 2009;18:301-10
21. Hurst J. Making sense of scents: reducing aggression and uncontrolled variation in laboratory mice. NC3Rs #2 Mouse Scents and Optimal Husbandry 2005:1-8
22. 2007/526/EC. Commission Recommendation on 18 June 2007 on Guidelines for the Accommodation and Care of Animals used for Experimental and Other Scientific Purposes (2007/526/EC). Brussels 2007. See http://eur-Lex.Europa.eu/JOHtml.do?uri=OJ:L:2007:197:SOM:EN:HTML (last checked 28 September 2010)
23. Burn CC, Mason GJ. Rats seem indifferent between their own scent-marked homecages and clean cages. Appl Anim Behav Sci 2008;115:201-10
24. Brockway BP, Mills PA, Azar SH. A new method for continuous chronic measurement and recording of blood pressure, heart rate and activity in the rat via radio-telemetry. Clin Exp Hypertens A 1991;13:885-95
25. Guler NF, Ubeyli ED. Theory and applications of biotelemetry. J Med Syst 2002;26:159-78
26. Kramer K, Kinter LB. Evaluation and applications of radiotelemetry in small laboratory animals. Physiol Genomics 2003;13:197-205
27. Harkin A, Connor TJ, O'Donnell JM, Kelly JP. Physiological and behavioral responses to stress: what does a rat find stressful? Lab Anim 2002;31:42-50
28. Irvine RJ, White J, Chan R. The influence of restraint on blood pressure in the rat. J Pharmacol Toxicol Methods 1997;38:157-62
29. Krohn TC, Hansen AK, Dragsted N. Telemetry as a method for measuring the impact of housing conditions on rats' welfare. Anim Welfare 2003;12:53-62
30. Gregory NG. Physiology and Behaviour of Animal Suffering. 1st edn. Oxford, UK: Blackwell Science Ltd, 2004
31. Kvetnansky R, Pacak K, Fukuhara K, et al. Sympathoadrenal system in stress. Interaction with the hypothalamic-pituitary-adrenocortical system. Ann NY Acad Sci 1995;771:131-58
32. Matteri RL, Carroll JA, Dyer CJ. Neuroendocrine responses to stress. In: Moberg GP, Mench J, eds. The Biology of Animal Stress: Basic Principles and Implications for Animal Welfare. 1st edn. New York: CAB International, 2000:43-76
33. Sapolsky RM. Endocrinolgy of the stress-response. In: Becker JB, Breedlove SM, Crews D, McCarthy MM, eds. Behavioral Endocrinology. 2nd edn. Cambridge, MA: MIT Press, 2002:409-49
34. Arras M, Rettich A, Seifert B, Kasermann HP, Rulicke T. Should laboratory mice be anaesthetized for tail biopsy? Lab Anim 2007;41:30-45
35. Cinelli P, Rettich A, Seifert B, Burki K, Arras M. Comparative analysis and physiological impact of different tissue biopsy methodologies used for the genotyping of laboratory mice. Lab Anim 2007;41:174-84
36. Sei H, Furuno N, Morita Y. Diurnal changes of blood pressure, heart rate and body temperature during sleep in the rat. J Sleep Res 1997;6:113-19
37. Zhang B, Sannajust F. Diurnal rhythms of blood pressure, heart rate, and locomotor activity in adult and old male wistar rats. Physiol Behav 2000;70:375-80
38. Fokkema DS, Koolhaas JM, van der Gugten J. Individual characteristics of behavior, blood pressure, and adrenal hormones in colony rats. Physiol Behav 1995;57:857-62
39. Lawson DM, Churchill M, Churchill PC. The effects of housing enrichment on cardiovascular parameters in spontaneously hypertensive rats. Contemp Top Lab Anim Sci 2000;39:9-13
40. van den Buuse M, Van Acker SA, Fluttert M, De Kloet ER. Blood pressure, heart rate, and behavioral responses to psychological 'novelty' stress in freely moving rats. Psychophysiology 2001;38:490-9
41. Krohn TC, Hansen AK, Dragsted N. The impact of cage ventilation on rats housed in IVC systems. Lab Anim 2003;37:85-93