Chronic obstructive pulmonary disease and lung cancer: A lethal association

American Journal of Respiratory and Critical Care Medicine

Volumn 184, Issue 8, 2011, Pages 866-867

  Barnes, Peter J ^a   Adcock, Ian M ^a  

^a NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADAM PROTEIN; CARCINOGEN; DOUBLE STRANDED DNA; GLUCOCORTICOID; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MATRIX METALLOPROTEINASE; NICOTINIC RECEPTOR; SONIC HEDGEHOG PROTEIN; STAT3 PROTEIN; TOBACCO SMOKE; TRANSCRIPTION FACTOR NRF2; TRANSFORMING GROWTH FACTOR BETA;

CANCER INCIDENCE; CANCER RISK; CANCER SUSCEPTIBILITY; CELL PROLIFERATION; CHRONIC OBSTRUCTIVE LUNG DISEASE; DETOXIFICATION; DISEASE ASSOCIATION; DNA POLYMORPHISM; EDITORIAL; EMPHYSEMA; EPIGENETICS; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; IN VITRO STUDY; LETHALITY; LUNG ADENOCARCINOMA; LUNG ALVEOLUS EPITHELIUM; LUNG CANCER; LUNG CARCINOGENESIS; LUNG METASTASIS; LUNG SMALL CELL CANCER; LUNG SQUAMOUS CELL CARCINOMA; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RISK REDUCTION; SEX RATIO; SMOKING; SPIROMETRY; TUMOR GROWTH;

FEMALE; HUMANS; LUNG NEOPLASMS; MALE; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE;

EID: 80054696628     PISSN: 1073449X     EISSN: 15354970     Source Type: Journal    
DOI: 10.1164/rccm.201108-1436ED     Document Type: Editorial

References (18)

1. Anthonisen NR, Skeans MA, Wise RA, Manfreda J, Kanner RE, Connett JE. The effects of a smoking cessation intervention on 14.5-year mortality: a randomized clinical trial. Ann Intern Med 2005;142:233-239. (Pubitemid 40216240)
2. Wasswa-Kintu S, GanWQ, Man SF, Pare PD, Sin DD. Relationship between reduced forced expiratory volume in one second and the risk of lung cancer: a systematic review and meta-analysis. Thorax 2005;60:570-575. (Pubitemid 40966211)
3. Brenner DR, McLaughlin JR, Hung RJ. Previous lung diseases and lung cancer risk: a systematic review and meta-analysis. PLoS ONE 2011;6:e17479.
4. Young RP, Hopkins RJ, Christmas T, Black PN, Metcalf P, Gamble GD. COPD prevalence is increased in lung cancer, independent of age, sex and smoking history. Eur Respir J 2009;34:380-386.
5. Papi A, Casoni G, Caramori G, Guzzinati I, Boschetto P, Ravenna F, Calia N, Petruzzelli S, Corbetta L, Cavallesco G, et al. COPD increases the risk of squamous histological subtype in smokers who develop non-small cell lung carcinoma. Thorax 2004;59:679-681. (Pubitemid 39061531)
6. de Torres JP, Marin JM, Casanova C, Cote C, Carrizo S, Cordoba-Lanus E, Baz-Dávila R, Zulueta JJ, Aguirre-Jaime A, Saetta M, et al. Lung cancer in patients with COPD: incidence and predicting factors. Am J Respir Crit Care Med 2011;184:913-919.
7. Gullon JA, Suarez I, Medina A, Rubinos G, Fernandez R, Gonzalez I. Role of emphysema and airway obstruction in prognosis of lung cancer. Lung Cancer 2011;71:182-185.
8. Young RP, Hopkins RJ. COPD and lung cancer linked at a molecular genetic level. Chest 2011;140:266-267.
9. Adcock IM, Caramori G, Barnes PJ. Chronic obstructive pulmonary disease and lung cancer: new molecular insights. Respiration 2011;81:265-284.
10. Qu P, Roberts J, Li Y, Albrecht M, Cummings OW, Eble JN, Du H, Yan C. Stat3 downstream genes serve as biomarkers in human lung carcinomas and chronic obstructive pulmonary disease. Lung Cancer 2009;63:341-347.
11. Caramori G, Adcock IM, Casolari P, Ito K, Jazrawi E, Tsaprouni L, Villetti G, Civelli M, Carnini C, Chung KF, Barnes PJ, Papi A. Unbalanced oxidant-induced DNA damage and repair in COPD: a link towards lung cancer. Thorax 2011;66:521-527.
12. Turner MC, Chen Y, Krewski D, Calle EE, Thun MJ. Chronic obstructive pulmonary disease is associated with lung cancer mortality in a prospective study of never smokers. Am J Respir Crit Care Med 2007;176:285-290. (Pubitemid 47195879)
13. Malhotra D, Thimmulappa R, Navas-Acien A, Sandford A, Elliott M, Singh A, Chen L, Zhuang X, Hogg J, Pare P, et al. Decline in NRF2 regulated antioxidants in COPD lungs due to loss of its positive regulator DJ-1. Am J Respir Crit Care Med 2008;178:592-604.
14. Mercado N, Thimmulappa R, Thomas CM, Fenwick PS, Chana KK, Donnelly LE, Biswal S, Ito K, Barnes PJ. Decreased histone deacetylase 2 impairs Nrf2 activation by oxidative stress. Biochem Biophys Res Commun 2011;406:292-298.
15. Cho HY, Kleeberger SR. Nrf2 protects against airway disorders. Toxicol Appl Pharmacol 2010;244:43-56.
16. Foschino Barbaro MP, Carpagnano GE, Spanevello A, Cagnazzo MG, Barnes PJ. Inflammation, oxidative stress and systemic effects in mild chronic obstructive pulmonary disease. Int J Immunopathol Pharmacol 2007;20:753-763.
17. Maksimova E, Yie TA, Rom WN. In vitro mechanisms of lovastatin on lung cancer cell lines as a potential chemopreventive agent. Lung 2008;186:45-54.
18. Khurana V, Bejjanki HR, Caldito G, Owens MW. Statins reduce the risk of lung cancer in humans: a large case-control study of US veterans. Chest 2007;131:1282-1288. (Pubitemid 46762329)