Efficacy and safety of intraoperative radiotherapy in breast cancer: A systematic review

Cancer Letters

Volumn 313, Issue 1, 2011, Pages 15-25

  Ruano Ravina, A ^a,b,c   Cantero Munoz P ^a   Eraso Urien A ^d  

^a Galician Agency for Health Technology Assessment   (Spain)

^b UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

^c CIBER de Epidemiología y Salud Pública   (Spain)

^d Catalan Institute of Oncology ICO   (Spain)

Author keywords

Breast neoplasms; Intraoperative radiotherapy; Systematic review

Indexed keywords

BREAST CANCER; BREAST FIBROSIS; CANCER CONTROL; CLINICAL EFFECTIVENESS; EARLY CANCER; EDEMA; EXTERNAL BEAM RADIOTHERAPY; FOLLOW UP; HEMATOMA; HUMAN; HYPERPIGMENTATION; INCIDENCE; INFECTION; INTRAOPERATIVE RADIOTHERAPY; LYMPHEDEMA; MASTECTOMY; MASTITIS; META ANALYSIS; OVERALL SURVIVAL; PAIN; PATIENT SAFETY; PRIORITY JOURNAL; RADIATION DERMATITIS; RADIATION NECROSIS; SEROMA; SHORT SURVEY; SYSTEMATIC REVIEW;

EID: 80054107268     PISSN: 03043835     EISSN: 18727980     Source Type: Journal    
DOI: 10.1016/j.canlet.2011.08.020     Document Type: Review

References (42)

1. P. Boyle, B. Levin (Eds.), World Cancer Report 2008 (Internet Monography), 2008, (accessed 22.07.11). http://www.iarc.fr/en/publications/pdfs-online/wcr/2008/wcr_2008.pdf.
2. M. Lippman, Cáncer de mama, in: A.S. Fauci, E. Braunwald, D.L. Kasper, S.L. Hauser, D.L. Longo, J.L. Jameson, et al. (Eds.), Harrison Principios de Medicina Interna (Internet Monography), 17th ed. McGraw Hill Medical, Columbus, OH, 2009, (accessed 22.07.11). http://www.harrisonmedicina.com/content.aspx?aID=3716764&searchStr=c%C3%A1ncer+colorrectal.
3. Ferlay J., Autier P., Boniol M., Heanue M., Colombet M., Boyle P. Estimates of the cancer incidence and mortality in Europe in 2006. Ann. Oncol. 2007, 18:581-592.
4. American Cancer Society, Cancer Facts and Figures 2009 (Internet Monography), 2009, (accessed 22.07.11). http://www.cancer.org/acs/groups/content/@nho/documents/document/f861009final90809pdf.pdf.
5. Área de Epidemiología Ambiental y Cáncer, Centro Nacional de Epidemiología, La situación del cáncer en España, Ministerio de Sanidad y Consumo, Madrid, 2005.
6. The American Joint Committee on Cancer (AJCC), What is Cancer Staging? 2008, (accessed 22.07.11). http://www.cancerstaging.org/staging/index.html.
7. C. Viana Zulaica, Cáncer de mama (Internet), Fisterrae, Casitérides, 2009, (accessed 22.07.11). http://www.fisterra.com/fisterrae/.
8. Cuncins-Hearn A., Saunders C., Walsh D., Borg M., Buckingham J., Frizelle F., et al. A Systematic Review of Intraoperative Radiotherapy in Early Stage Breast Cancer 2002, Australian Safety and Efficacy Register of New Interventional Procedures-Surgical (ASERNIP-S), Stepney, SA.
9. National Cancer Institute, Breast Cancer Treatment (PDQ®) (Internet), National Cancer Institute, Bethesda, (accessed 19.07.11). http://www.cancer.gov/cancertopics/pdq/treatment/breast/healthprofessional.
10. ESMO, Minimum clinical recommendations for diagnosis, adjuvant treatment and follow-up of primary breast cancer, Ann. Oncol. 16 (2005) i7-i9.
11. Bartelink H., Horiot J.C., Poortmans P.M., Struikmans H., Van den Bogaert W., Fourquet A., et al. Impact of a higher radiation dose on local control and survival in breast-conserving therapy of early breast cancer: 10-year results of the randomized boost versus no boost EORTC 22881-10882 trial. J. Clin. Oncol. 2007, 25(22):3259-3265.
12. Willett C.G., Czito B.G., Tyler D.S. Intraoperative radiation therapy. J. Clin. Oncol. 2007, 25(8):971-977.
13. Veronesi U., Gatti G., Luini A., Intra M., Orecchia R., Borgen P., et al. Intraoperative radiation therapy for breast cancer: technical notes. Breast J. 2003, 9(2):106-112.
14. Clarke M., Collins R., Darby S., Davies C., Elphinstone P., Evans E., et al. Early breast cancer trialists' collaborative group (EBCTCG). Effects of radiotherapy and of differences in the extent of surgery for early breast cancer on local recurrence and 15-year survival: an overview of the randomised trials. Lancet 2005, 366(9503):2087-2106.
15. Vaidya J.S., Joseph D.J., Tobias J.S., Bulsara M., Wenz F., Saunders C., et al. Targeted intraoperative radiotherapy versus whole breast radiotherapy for breast cancer (TARGIT-A trial): an international, prospective, randomised, non-inferiority phase 3 trial. Lancet 2010, 376(9735):91-102.
16. R. Almazán Ortega, A. Ruano Raviña, Radioterapia intraoperatoria en el cáncer de páncreas, Santiago de Compostela: Consellería de Sanidade, Axencia de Avaliación de Tecnoloxías Sanitarias de Galicia, avalia-t, 2007, Serie Avaliación de Tecnoloxías, Consulta Técnica. Informe N°.: CT2007/01.
17. Ruano-Ravina A., Almazán Ortega R., Guedea F. Intraoperative radiotherapy in pancreatic cancer. A systematic review. Radiother. Oncol. 2008, 87(3):318-325.
18. Cuncins-Hearn A., Saunders C., Walsh D., Borg M., Buckingham J., Frizelle F., et al. A systematic review of intraoperative radiotherapy in early breast cancer. Breast Cancer Res. Treat. 2004, 85(3):271-280.
19. Sauer G., Strnad V., Kurzeder C., Kreienberg R., Sauer R. Partial breast irradiation after breast-conserving surgery. Strahlenther. Onkol. 2005, 181(1):1-8.
20. Skandarajah A.R., Lynch A.C., Mackay J.R., Ngan S., Heriot A.G. The role of intraoperative radiotherapy in solid tumors. Ann. Surg. Oncol. 2009, 16(3):735-744.
21. Petit J.Y., Veronesi U., Rey P., Rotmensz N., Botteri E., Rietjens M., et al. Nipple-sparing mastectomy: risk of nipple-areolar recurrences in a series of 579 cases. Breast Can. Res. Treat. 2009, 114(1):97-101.
22. Sedlmayer F., Fastner G., Merz F., Deutschmann H., Reitsamer R., Menzel C., et al. IORT with electrons as boost strategy during breast conserving therapy in limited stage breast cancer: results of an ISIORT pooled analysis. Strahlenther. Onkol. 2007, 183(Spec No. 2):32-34.
23. Vaidya J.S., Baum M., Tobias J.S., Massarut S., Wenz F., Murphy O., et al. Targeted intraoperative radiotherapy (TARGIT) yields very low recurrence rates when given as a boost. Int. J. Radiat. Oncol. Biol. Phys. 2006, 66(5):1335-1338.
24. Intra M., Leonardi C., Luini A., Veronesi P., Gennari R., Gatti G., et al. Full-dose intraoperative radiotherapy with electrons in breast surgery: broadening the indications. Arch. Surg. 2005, 140(10):936-939.
25. Kraus-Tiefenbacher U., Scheda A., Steil V., Hermann B., Kehrer T., Bauer L., et al. Intraoperative radiotherapy (IORT) for breast cancer using the intrabeam system. Tumori 2005, 91(4):339-345.
26. Veronesi U., Orecchia R., Luini A., Galimberti V., Gatti G., Intra M., et al. Full-dose intraoperative radiotherapy with electrons during breast-conserving surgery: experience with 590 cases. Ann. Surg. 2005, 242(1):101-106.
27. Ivaldi G.B., Leonardi M.C., Orecchia R., Zerini D., Morra A., Galimberti V., et al. Preliminary results of electron intraoperative therapy boost and hypofractionated external beam radiotherapy after breast-conserving surgery in premenopausal women. Int. J. Radiat. Oncol. Biol. Phys. 2008, 72(2):485-493.
28. Wenz F., Welzel G., Keller A., Blank E., Vorodi F., Herskind C., et al. Early initiation of external beam radiotherapy (EBRT) may increase the risk of long-term toxicity in patients undergoing intraoperative radiotherapy (IORT) as a boost for breast cancer. Breast 2008, 17(6):617-622.
29. Kraus-Tiefenbacher U., Bauer L., Scheda A., Fleckenstein K., Keller A., Herskind C., et al. Long-term toxicity of an intraoperative radiotherapy boost using low energy X-rays during breast-conserving surgery. Int. J. Radiat. Oncol. Biol. Phys. 2006, 66(2):377-381.
30. Mussari S., Sabino Della Sala W., Busana L., Vanoni V., Eccher C., Zani B., et al. Full-dose intraoperative radiotherapy with electrons in breast cancer. First report on late toxicity and cosmetic results from a single-institution experience. Strahlenther. Onkol. 2006, 182(10):589-595.
31. Joseph D.J., Bydder S., Jackson L.R., Corica T., Hastrich D.J., Oliver D.J., et al. Prospective trial of intraoperative radiation treatment for breast cancer. ANZ J. Surg. 2004, 74(12):1043-1048.
32. Surveillance Epidemiology and End Results (SEER) (Website), SEER Cancer Statistics Review 1975-2006, Table 4.1, Cancer of the Female Breast (Invasive), National Cancer Institute, Bethesda, 2009, (accessed 25.07.11). http://seer.cancer.gov/csr/1975_2006/browse_csr.php?section=4&page=sect_04_table.01.html.
33. Sant M., Allemani C., Santaquilani M., Knijn A., Marchesi F., Capocaccia R., et al. EUROCARE-4. Survival of cancer patients diagnosed in 1995-1999. Results and commentary. Eur. J. Cancer 2009, 45:931-991.
34. Tobias J.S., Vaidya J.S., Keshtgar M., Douek M., Metaxas M., Stacey C., et al. Breast-conserving surgery with intra-operative radiotherapy: the right approach for the 21st century?. Clin. Oncol. (R. Coll. Radiol.) 2006, 18(3):220-228.
35. Calvo F.A., Meirino R.M., Orecchia R. Intraoperative radiation therapy part 2. Clinical results. Crit. Rev. Oncol. Hematol. 2006, 59(2):116-127.
36. Holmes D.R., Baum M., Joseph D. The TARGIT trial: targeted intraoperative radiation therapy versus conventional postoperative whole-breast radiotherapy after breast-conserving surgery for the management of early-stage invasive breast cancer (a trial update). Am. J. Surg. 2007, 194(4):507-510.
37. Gomez-Izurriaga A., Moreno Jiménez M., Martínez-Monge R. Tratmiento radioterápico del cáncer de mama: estándares y nuevas tendencias. Irradiación parcial acelerada de la mama. Rev. Med. Univ. Navarra. 2008, 52(1):25-36.
38. Merrick H.W., Hager E., Dobelbower R.R. Intraoperative radiation therapy for breast cancer. Surg. Oncol. Clin. N. Am. 2003, 12(4):1065-1078.
39. Luini A., Orecchia R., Gatti G., Intra M., Ciocca M., Galimberti V., et al. The pilot trial on intraoperative radiotherapy with electrons (ELIOT): update on the results. Breast Can. Res. Treat. 2005, 93(1):55-59.
40. Della Sala S.W., Pellegrini M., Bernardi D., Franzoso F., Valentini M., Di Michele S., et al. Mammographic and ultrasonographic comparison between intraoperative radiotherapy (IORT) and conventional external radiotherapy (RT) in limited-stage breast cancer, conservatively treated. Eur. J. Radiol. 2006, 59(2):222-230.
41. National Cancer Institute, Common Terminology Criteria for Adverse Events (CTCAE) Version 4.0. (Internet), 2009, (accessed 25.07.11). http://evs.nci.nih.gov/ftp1/CTCAE/About.html.
42. Sapmer P.M., Pérez-Escutia M.A., Cabezas M.A. Toxicidad en tratamientos de abdomen y pelvis: tipo de toxicidad y escalas de valoración. Oncología 2005, 28(2):71-77.