Coenzyme Q10 deficiency in septic shock patients

Critical Care

Volumn 15, Issue 5, 2011, Pages

  Dupic, Laurent ^a   Huet, Olivier ^b,c   Duranteau, Jacques ^c  

^a HÔPITAL NECKER ENFANTS MALADES   (France)

^b BAKER IDI HEART AND DIABETES INSTITUTE   (Australia)

^c Laboratoire d'Etude de la Microcirculation   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA TOCOPHEROL; ANTIOXIDANT; CYTOCHROME C; HIGH DENSITY LIPOPROTEIN; LIPOPOLYSACCHARIDE; LOW DENSITY LIPOPROTEIN; MITO Q; PLACEBO; SIMVASTATIN; THIOL; UBIDECARENONE; UBIQUINOL CYTOCHROME C REDUCTASE; UNCLASSIFIED DRUG; UNCOUPLING PROTEIN; DRUG DERIVATIVE; UBIQUINONE; VITAMIN;

ANTIOXIDANT ACTIVITY; APOPTOSIS; COENZYME Q10 DEFICIENCY; DEGENERATIVE DISEASE; DISEASE SEVERITY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DRUG EFFICACY; ENDOTHELIUM CELL; EXPERIMENTAL INFECTION; EXPERIMENTAL RAT; FRIEDREICH ATAXIA; HEART FAILURE; HUMAN; HUNTINGTON CHOREA; HYPOTENSION; MEMBRANE POTENTIAL; METABOLIC DISORDER; MITOCHONDRIAL MEMBRANE; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL RESPIRATION; NONHUMAN; NOTE; OXIDATIVE STRESS; PARKINSON DISEASE; PATHOPHYSIOLOGY; PRIORITY JOURNAL; SEPSIS; SEPTIC SHOCK; SUPPLEMENTATION; BLOOD; FEMALE; INFLAMMATION; MALE;

FEMALE; HUMANS; INFLAMMATION; MALE; SHOCK, SEPTIC; UBIQUINONE; VITAMINS;

EID: 80054102659     PISSN: 13648535     EISSN: 1466609X     Source Type: Journal    
DOI: 10.1186/cc10429     Document Type: Note

References (10)

1. Donnino MW, Cocchi MN, Salciccioli JD, Kim D, Naini A, Buettner C, Akuthota P. Coenzyme Q10 levels are low and are associated with the inflammatory cascade in septic shock. Crit Care 2011, 15:R189. 10.1186/cc10343, 21827677.
2. Singer M. Mitochondrial function in sepsis: acute phase versus multiple organ failure. Crit Care Med 2007, 35(9 Suppl):S441-448.
3. Huet O, Obata R, Aubron C, Spraul-Davit A, Charpentier J, Laplace C, Nguyen-Khoa T, Conti M, Vicaut E, Mira JP, Duranteau J. Plasma-induced endothelial oxidative stress is related to the severity of septic shock. Crit Care Med 2007, 35:821-826. 10.1097/01.CCM.0000257464.79067.AF, 17255877, 17255877.
4. Harrois A, Huet O, Duranteau J. Alterations of mitochondrial function in sepsis and critical illness. Curr Opin Anaesthesiol 2009, 22:143-149. 10.1097/ACO.0b013e328328d1cc, 19390243.
5. Quinzii CM, Hirano M, DiMauro S. CoQ10 deficiency diseases in adults. Mitochondrion 2007, Suppl:S122-S126.
6. McMurray JJ, Dunselman P, Wedel H, Cleland JG, Lindberg M, Hjalmarson A, Kjekshus J, Waagstein F, Apetrei E, Barrios V, Böhm M, Kamenský G, Komajda M, Mareev V, Wikstrand J, . CORONA Study Group Coenzyme Q10, rosuvastatin, and clinical outcomes in heart failure: a pre-specified substudy of CORONA (Controlled Rosuvastatin Multinational Study in Heart Failure). J Am Coll Cardiol 2010, 56:1196-1204. 10.1016/j.jacc.2010.02.075, 20883926, CORONA Study Group.
7. Chuang YC, Chan JY, Chang AY, Sikorska M, Borowy-Borowski H, Liou CW, Chan SH. Neuroprotective effects of coenzyme Q10 at rostral ventrolateral medulla against fatality during experimental endotoxemia in the rat. Shock 2003, 19:427-432. 10.1097/01.shk.0000048900.46342.37, 12744485.
8. Lowes DA, Thottakam BM, Webster NR, Murphy MP, Galley HF. The mitochondria-targeted antioxidant MitoQ protects against organ damage in a lipopolysaccharide-peptidoglycan model of sepsis. Free Radic Biol Med 2008, 45:1559-1565. 10.1016/j.freeradbiomed.2008.09.003, 18845241.
9. Supinski GS, Murphy MP, Callahan LA. MitoQ administration prevents endotoxin-induced cardiac dysfunction. Am J Physiol Regul Integr Comp Physiol 2009, 297:R1095-1102. 10.1152/ajpregu.90902.2008, 2763820, 19657095.
10. Brealey DA, Singer M, Terblanche M. Potential metabolic consequences of statins in sepsis. Crit Care Med 2011, 39:1514-1520. 10.1097/CCM.0b013e31820eb74f, 21317651.