Neuroprotective effects of coenzyme Q10 at rostral ventrolateral medulla against fatality during experimental endotoxemia in the rat

Shock

Volumn 19, Issue 5, 2003, Pages 427-432

  Chuang, Yao Chung ^a,b,c   Chan, Julie Y H ^d   Chang, Alice Y W ^a,b   Sikorska, Marianna ^e   Borowy Borowski, Henryk ^e   Liou, Chai Wei ^c   Chan, Samuel H H ^a,b  

^a Center for Neuroscience   (Taiwan)

^b NATIONAL SUN YAT SEN UNIVERSITY   (Taiwan)

^c CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

^d KAOHSIUNG VETERANS GENERAL HOSPITAL   (Taiwan)

^e NATIONAL RESEARCH COUNCIL CANADA   (Canada)

Author keywords

Cardiovascular depression; Mitochondrial enzymes; Mortality; Peroxynitrite; Superoxide anion; Survival time

Indexed keywords

LIPOPOLYSACCHARIDE; PROPOFOL; SUPEROXIDE; UBIDECARENONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFECT; DRUG MECHANISM; ELECTROENCEPHALOGRAM; ENDOTOXEMIA; FATALITY; HYPOTENSION; MALE; MEDULLA OBLONGATA; MICROINJECTION; MORTALITY; NEUROPROTECTION; NONHUMAN; RAT; SURVIVAL TIME; SYMPATHETIC TONE; VASOMOTOR REFLEX;

ANIMALS; DISEASE MODELS, ANIMAL; ENDOTOXEMIA; ESCHERICHIA COLI; LIPOPOLYSACCHARIDES; MALE; MEDULLA OBLONGATA; MICROINJECTIONS; RATS; RATS, SPRAGUE-DAWLEY; SUPEROXIDES; SURVIVAL RATE; TIME FACTORS; UBIQUINONE;

EID: 0142236759     PISSN: 10732322     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.shk.0000048900.46342.37     Document Type: Article

References (35)

1. Tjardes T, Neugebauer E: Sepsis research in the next millennium: concentrate on the software rather than the hardware. Shock 17:1-8, 2002.
2. Singer M, Brealey D: Mitochondrial dysfunction in sepsis. Biochem Soc Symp 66:149-166, 1999.
3. Bowton DL: CNS effects of sepsis. Crit Care Clin 5:785-792, 1989.
4. Hung TP, Chen ST: Prognosis of deeply comatose patients on ventilators. J Neurol Neurosurg Psychiatry 58:75-80, 1995.
5. Ernster L, Dallner G: Biochemical, physiological and medical aspects of ubiquinone function. Biochim Biophys Acta 1271:195-204, 1995.
6. Frei B, Kim MC, Ames BN: Ubiquinol-10 is an effective lipid-soluble antioxidant at physiological concentrations. Proc Natl Acad Sci USA 87:4879-4883, 1990.
7. Forsmark-Andrée P, Ernster L: Evidence for a protective effect of endogenous ubiquinol against oxidative damage to mitochondrial protein and DNA during lipid peroxidation. Mol Aspects Med 15(Suppl):S73-S81, 1994.
8. 10 administration increases brain mitochondrial concentrations and exerts neuroprotective effects. Proc Natl Acad Sci USA 95:8892-8897, 1998.
9. Shults CW, Schapira AHV: A cue to queue for CoQ? Neurology 57:375-376, 2001.
10. 10. Am J Health Syst Pharm 56:519-521, 1999.
11. Yien UW, Hseu SS, Lee LC, Kuo TBJ, Lee TY, Chan SHH: Spectral analysis of systemic arterial pressure and heart rate signals as a prognostic tool for the prediction of patient outcome in the intensive care unit. Crit Care Med 25:258-266, 1997.
12. Kuo TBJ, Yien HW, Hseu SS, Yang CCH, Lin YY, Lee LC, Chan SHH: Diminished vasomotor component of systemic arterial pressure signals and baroreflex in brain death. Am J Physiol 273:H1291-H1298, 1997.
13. Yen DHT, Yien HW, Wang LM, Lee CH, Chan SHH: Spectral analysis of systemic arterial pressure and heart rate signals of patients with acute respiratory failure induced by severe organophosphate poisoning. Crit Care Med 28:2805-2811, 2000.
14. Yang MW, Kuo TBJ, Lin SM, Chan KH, Chan SHH: Continuous, on-line, real-time spectral analysis of SAP signals during cardiopulmonary bypass. Am J Physiol 268:H2329-H2335, 1995.
15. Kuo TBJ, Yang CCH, Chan SHH: Selective activation of vasomotor component of SAP spectrum by nucleus reticularis ventrolateralis in rats. Am J Physiol 272:H485-H492, 1997.
16. Chuang YC, Tsai JL, Chang AYW, Chan JYH, Liou CW, Chan SHH: Dysfunction of mitochondrial respiratory chain in rostral ventrolateral medulla during experimental endotoxemia in the rat. J Biomed Sci 9:542-548, 2002.
17. Borowy-Borowski H, Sikorska M, Walker PR: Water-soluble composition of bioactive lipophilic compounds. US Patent No. 6,045,826 (April 4, 2000).
18. Chan JYH, Wang SH, Chan SHH: Differential roles of iNOS and nNOS at rostral ventrolateral medulla during experimental endotoxemia in the rat. Shock 15:65-72, 2001.
19. Yang CH, Shyr MH, Kuo TBJ, Tan PPC, Chan SHH: Effects of propofol on nociceptive response and power spectra of electroencephalographic and systemic arterial pressure signals in the rat: correlation with plasma concentration. J Pharmacol Exp Ther 275:1568-1574, 1995.
20. Chan SHH, Wang LL, Wang SH, Chan JYH: Differential cardiovascular responses to blockade of nNOS or iNOS in rostral ventrolateral medulla of the rat. Br J Pharmacol 133:606-614, 2001.
21. Yen DHT, Yen JC, Len WB, Wang LM, Lee CH, Chan SHH: Spectral changes in systemic arterial pressure signals during acute mevinphos intoxication in the rat. Shock 15:35-41, 2001.
22. Chan JYH, Wang LL, Wu KLH, Chan SHH: Reduced functional expression and molecular synthesis of inducible nitric oxide synthase in rostral ventrolateral medulla of spontaneously hypertensive rats. Circulation 104:1676-1681, 2001.
23. Didion SP, Hathaway CA, Faraci FM: Superoxide levels and function of cerebral blood vessels after inhibition of CuZn-SOD. Am J Physiol 281:H1697-H1703, 2001.
24. Cerutti C, Barrew C, Paultre C: Baroreflex modulation of blood pressure and heart rate variabilities in rats: assessment by spectral analysis. Am J Physiol 266:H1993-H2000, 1994.
25. Julien C, Zhang ZQ, Cerutti C, Barres C: Hemodynamic analysis of arterial pressure oscillations in conscious rats. J Auton Nerv Syst 50:239-252, 1995.
26. Fink MP: Cytopathic hypoxia. Mitochondrial dysfunction as mechanism contributing to organ dysfunction in sepsis. Crit Care Clin 17:219-237, 2001.
27. Radi R, Rodriguez M, Castro L, Telleri R: Inhibition of mitochondrial electron transport by peroxynitrite. Arch Biochem Biophys 308:89-95, 1994.
28. Szabó C: The pathophysiological role of peroxynitrite in shock, inflammation, and ischemia-reperfusion injury. Shock 6:79-88, 1996.
29. Chan SHH, Wang LL, Ou CC, Chan JYH: Contribution of peroxynitrite to fatal cardiovascular depression induced by overproduction of nitric oxide in rostral ventrolateral medulla of the rat. Neuropharmacology 43:889-898, 2002.
30. Sugino K, Dohi K, Yamada K, Kawasaki T: Changes in the levels of endogenous antioxidants in the liver of mice with experimental endotoxemia and the protective effects of the antioxidants. Surgery 105:200-206, 1989.
31. 10, and L-canavanine as protective agents against lipid peroxidation and nitric oxide generation in endotoxin-induced shock in rat brain. Pharmacol Res 43:257-263, 2001.
32. Schöpfer F, Riobó N, Carreras MC, Alvarez B, Radi R, Boveris B, Cadenas E, Poderoso JJ: Oxidation of ubiquinol by peroxynitrite: implications for protection of mitochondria against nitrosative damage. Biochem J 349:35-42, 2000.
33. Maier B, Schwerdtfeger K, Mautes A, Holanda M, Muller M, Steudel WI, Marzi I: Differential release of interleukines 6, 8, and 10 in cerebrospinal fluid and plasma after traumatic brain injury. Shock 15:421-426, 2001.
34. Woodroofe MN: Cytokine production in the central nervous system. Neurology 45(Suppl 6):S6-S10, 1995.
35. 10 on the mediator cascade of sepsis. Circ Shock 39:178-187, 1993.