Enzymological analysis of the tumor suppressor A-C1 reveals a novel group of phospholipid-metabolizing enzymes

Journal of Lipid Research

Volumn 52, Issue 11, 2011, Pages 1927-1935

  Shinohara, Naoki ^a,b   Uyama, Toru ^a   Jin, Xing Hua ^a,c   Tsuboi, Kazuhito ^a   Tonai, Takeharu ^d   Houchi, Hitoshi ^b   Ueda, Natsuo ^a  

^a KAGAWA UNIVERSITY   (Japan)

^b KAGAWA UNIVERSITY HOSPITAL   (Japan)

^c QIQIHAR MEDICAL UNIVERSITY   (China)

^d National Hospital Organization   (Japan)

Author keywords

Glycerophospholipid; HRAS like suppressor; Lecithin retinol acyltransferase; Phospholipase A acyltransferase

Indexed keywords

A C1 PROTEIN; ACYLTRANSFERASE; LYSOPHOSPHATIDYLCHOLINE; MESSENGER RNA; PHOSPHATIDYLCHOLINE; PHOSPHATIDYLETHANOLAMINE; PHOSPHOLIPASE A1; PHOSPHOLIPASE A2; RECOMBINANT A C1 PROTEIN; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN; CELL STRAIN COS7; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME PURIFICATION; ENZYME SUBSTRATE; HEART; HOMOGENATE; HUMAN; HUMAN TISSUE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PHOSPHOLIPID METABOLISM; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SKELETAL MUSCLE; TESTIS; TISSUE DISTRIBUTION;

AMINO ACID SEQUENCE; ANIMALS; BIOCATALYSIS; COS CELLS; ENZYME ASSAYS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; MICE; MOLECULAR SEQUENCE DATA; PHOSPHOLIPIDS; PROTEINS; RATS;

EID: 80054100966     PISSN: 00222275     EISSN: 15397262     Source Type: Journal    
DOI: 10.1194/jlr.M015081     Document Type: Article

References (35)

1. Kudo, I., and M. Murakami. 2002. Phospholipase A 2 enzymes. Prostaglandins Other Lipid Mediat. 68-69: 3-58.
2. Schaloske, R. H., and E. A. Dennis. 2006. The phospholipase A 2 superfamily and its group numbering system. Biochim. Biophys. Acta. 1761: 1246-1259. (Pubitemid 44755364)
3. Shindou, H., and T. Shimizu. 2009. Acyl-CoA: lysophospholipid acyltransferases. J. Biol. Chem. 284: 1-5.
4. Aoki, J., A. Inoue, K. Makide, N. Saiki, and H. Arai. 2007. Structure and function of extracellular phospholipase A 1 belonging to the pancreatic lipase gene family. Biochimie. 89: 197-204. (Pubitemid 46161954)
5. Shindou, H., D. Hishikawa, T. Harayama, K. Yuki, and T. Shimizu. 2009. Recent progress on acyl CoA: lysophospholipid acyltransferase research. J. Lipid Res. 50 (Suppl.): 46-51.
6. Shimizu, T. 2009. Lipid mediators in health and disease: enzymes and receptors as therapeutic targets for the regulation of immunity and inflammation. Annu. Rev. Pharmacol. Toxicol. 49: 123-150.
7. Choi, J. W., D. R. Herr, K. Noguchi, Y. C. Yung, C. W. Lee, T. Mutoh, M. E. Lin, S. T. Teo, K. E. Park, A. N. Mosley, et al. 2010. LPA receptors: subtypes and biological actions. Annu. Rev. Pharmacol. Toxicol. 50: 157-186.
8. Rando, R. R. 2002. Membrane-bound lecithin-retinol acyltransferase. Biochem. Biophys. Res. Commun. 292: 1243-1250. (Pubitemid 34681093)
9. Blaner, W. S., S. M. O'Byme, N. Wongsiriroj, J. Kluwe, D. M. D'Ambrosio, H. Jiang, R. F. Schwabe, E. M. Hillman, R. Piantedosi, and J. Libien. 2009. Hepatic stellate cell lipid droplets: a specialized lipid droplet for retinoid storage. Biochim. Biophys. Acta. 1791: 467-473.
10. Anantharaman, V., and L. Aravind. 2003. Evolutionary history, structural features and biochemical diversity of the NlpC/P60 superfamily of enzymes. Genome Biol. 4: R11.
11. Shyu, R-Y., Y-C. Hsieh, F-M. Tsai, C-C. Wu, and S-Y. Jiang. 2008. Cloning and functional characterization of the HRASLS2 gene. Amino Acids. 35: 129-137.
12. Hajnal, A., R. Klemenz, and R. Schäfer. 1994. Subtraction cloning of H-rev107, a gene specifically expressed in H-ras resistant fibroblasts. Oncogene. 9: 479-490. (Pubitemid 24041527)
13. Sers, C., U. Emmenegger, K. Husmann, K. Bucher, A. C. Andres, and R. Schäfer. 1997. Growth-inhibitory activity and downregulation of the class II tumor-suppressor gene H-rev107 in tumor cell lines and experimental tumors. J. Cell Biol. 136: 935-944. (Pubitemid 27098748)
14. DiSepio, D., C. Ghosn, R. L. Eckert, A. Deucher, N. Robinson, M. Duvic, R. A. Chandraratna, and S. Nagpal. 1998. Identification and characterization of a retinoid-induced class II tumor suppressor/ growth regulatory gene. Proc. Natl. Acad. Sci. USA. 95: 14811-14815. (Pubitemid 29003712)
15. Huang, S-L., R-Y. Shyu, M-Y. Yeh, and S-Y. Jiang. 2000. Cloning and characterization of a novel retinoid-inducible gene 1 (RIG1) deriving from human gastric cancer cells. Mol. Cell. Endocrinol. 159: 15-24. (Pubitemid 30067636)
16. Akiyama, H., Y. Hiraki, M. Noda, C. Shigeno, H. Ito, and T. Nakamura. 1999. Molecular cloning and biological activity of a novel Ha-Ras suppressor gene predominantly expressed in skeletal muscle, heart, brain, and bone marrow by differential display using clonal mouse EC cells, ATDC5. J. Biol. Chem. 274: 32192-32197.
17. 2+-independent phosphatidylethanolamine N-acyltransferase generating the anadamide precursor and its congeners. J. Biol. Chem. 282: 3614-3623.
18. 1/2 of the thiol hydrolase type. J. Lipid Res. 50: 685-693.
19. Uyama, T., X-H. Jin, K. Tsuboi, T. Tonai, and N. Ueda. 2009. Characterization of the human tumor suppressors TIG3 and HRASLS2 as phospholipid-metabolizing enzymes. Biochim. Biophys. Acta. 1791: 1114-1124.
20. 2+-independent phosphatidylethanolamine N-acyltransferases. Biochim. Biophys. Acta. 1791: 32-38.
21. Ueda, N., K. Tsuboi, and T. Uyama. 2010. N-acylethanolamine metabolism with special reference to N-acylethanolamine-hydrolyzing acid amidase (NAAA). Prog. Lipid Res. 49: 299-315.
22. Ueda, N., K. Tsuboi, and T. Uyama. 2010. Enzymological studies on the biosynthesis of N-acylethanolamines. Biochim. Biophys. Acta. 1801: 1274-1285.
23. 2 (AdPLA). J. Biol. Chem. 283: 25428-25436.
24. Ito, H., H. Akiyama, C. Shigeno, and T. Nakamura. 2001. Isolation, characterization, and chromosome mapping of a human A-C1 Ha- Ras suppressor gene (HRASLS). Cytogenet. Cell Genet. 93: 36-39. (Pubitemid 32727541)
25. Kaneda, A., M. Kaminishi, K. Yanagihara, T. Sugimura, and T. Ushijima. 2002. Identification of silencing of nine genes in human gastric cancers. Cancer Res. 62: 6645-6650. (Pubitemid 35364133)
26. Jahng, W. J., L. Xue, and R. R. Rando. 2003. Lecithin retinol acyltransferase is a founder member of a novel family of enzymes. Biochemistry. 42: 12805-12812. (Pubitemid 37385811)
27. Schmid, P. C., P. V. Reddy, V. Natarajan, and H. H. O. Schmid. 1983. Metabolism of N-acylethanolamine phospholipids by a mammalian phosphodiesterase of the phospholipase D type. J. Biol. Chem. 258: 9302-9306.
28. Arai, H., K. Inoue, Y. Natori, Y. Banno, Y. Nozawa, and S. Nojima. 1985. Intracellular phospholipase activities of Tetrahymena pyriformis. J. Biochem. 97: 1525-1532. (Pubitemid 15008050)
29. Bradford, M. M. 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72: 248-254.
30. Yamano, Y., A. Asano, K. Ohyama, M. Ohta, R. Nishio, and I. Morishima. 2008. Expression of the Ha-Ras suppressor family member 5 gene in the maturing rat testis. Biosci. Biotechnol. Biochem. 72: 1360-1363. (Pubitemid 351872489)
31. Kobayashi, T., T. Masaki, M. Sugiyama, Y. Atomi, Y. Furukawa, and Y. Nakamura. 2006. A gene encoding a family with sequence similarity 84, member A (FAM84A) enhanced migration of human colon cancer cells. Int. J. Oncol. 29: 341-347.
32. Huang, X-P., T-H. Rong, J-Y. Wang, Y-Q. Tang, B-J. Li, D-R. Xu, M-Q. Zhao, L-J. Zhang, Y. Fang, X-D. Su, et al. 2006. Negative implication of C-MYC as an amplification target in esophageal cancer. Cancer Genet. Cytogenet. 165: 20-24. (Pubitemid 43254648)
33. Tsai, F-M., R-Y. Shyu, and S-Y. Jiang. 2006. RIG1 inhibits the Ras/ mitogen-activated protein kinase pathway by suppressing the activation of Ras. Cell. Signal. 18: 349-358. (Pubitemid 41661350)
34. Tsai, F-M., R-Y. Shyu, S-C. Lin, C-C. Wu, and S-Y. Jiang. 2009. Induction of apoptosis by the retinoid inducible growth regulator RIG1 depends on the NC motif in HtTA cervical cancer cells. BMC Cell Biol. 10: 15.
35. Henis, Y. I., J. F. Hancock, and I. A. Prior. 2009. Ras acylation, compartmentalization and signaling nanoclusters. Mol. Membr. Biol. 26: 80-92.