Dynamic in-situ eutectic formation for topical drug delivery

Journal of Pharmacy and Pharmacology

Volumn 63, Issue 11, 2011, Pages 1428-1436

  Fiala, Sarah ^a   Brown, Marc B ^b,c   Jones, Stuart A ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF HERTFORDSHIRE   (United Kingdom)

^c MEDPHARM LTD   (United Kingdom)

Author keywords

eutectic; lidocaine; o w cream; prilocaine; spray

Indexed keywords

FLUORINATED HYDROCARBON; LIDOCAINE; PRILOCAINE; PROPELLANT; SILICONE;

ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CREAM; DIFFUSION; DRUG ADMINISTRATION ROUTE; DRUG DELIVERY SYSTEM; DRUG MIXTURE; DRUG TRANSPORT; HUMAN; HUMAN TISSUE; MELTING POINT; MEMBRANE TRANSPORT; MOLECULAR DYNAMICS; PHYSICAL CHEMISTRY; SKIN PENETRATION; TEMPERATURE SENSITIVITY; THERMODYNAMICS;

ADMINISTRATION, CUTANEOUS; ANESTHETICS, COMBINED; ANESTHETICS, LOCAL; BIOLOGICAL TRANSPORT; DRUG DELIVERY SYSTEMS; HUMANS; LIDOCAINE; PRILOCAINE; SKIN;

EID: 80054093391     PISSN: 00223573     EISSN: 20427158     Source Type: Journal    
DOI: 10.1111/j.2042-7158.2011.01346.x     Document Type: Article

References (30)

1. Benson HA,. Transdermal drug delivery: penetration enhancement techniques. Curr Drug Deliv 2005; 2: 23-33. (Pubitemid 40590918)
2. Juhlin L, et al,. A lidocaine-prilocaine cream for superficial skin surgery and painful lesions. Acta Derm Venereol 1980; 60: 544-546. (Pubitemid 11197218)
3. Fiala S, et al,. An investigation into the influence of binary drug solutions upon diffusion and partition processes in model membranes. J Pharm Pharmacol 2008; 60: 1615-1623.
4. Fiala S,. Topical drug delivery enhancement using eutectic systems. University of London PhD thesis. 2010.
5. Fiala S, et al,. A fundamental investigation into the effects of eutectic formation on transmembrane transport. Int J Pharm 2010; 393: 68-73.
6. Henry R, et al,. TEMPE: Topical eutectic-like mixture for premature ejaculation. Expert Opin Drug Deliv 2008; 5: 251-261. (Pubitemid 351308315)
7. Henry R, Morales A,. Topical lidocaine-prilocaine spray for the treatment of premature ejaculation: a proof of concept study. Int J Impot Res 2003; 15: 277-281. (Pubitemid 37101662)
8. Henry R,. Prilocaine and hydrofluorocarbon aerosol preparations. 1999; US patent no. 5858331.
9. Jones SA, et al,. Determining degree of saturation after application of transiently supersaturated metered dose aerosols for topical delivery of corticosteroids. J Pharm Sci 2009; 98: 543-554.
10. Reid ML, et al,. Manipulation of corticosteroid release from a transiently supersaturated topical metered dose aerosol using a residual miscible co-solvent. Pharm Res 2008; 25: 2573-2580.
11. Reid ML, et al,. Transient drug supersaturation kinetics of beclomethasone dipropionate in rapidly drying films. Int J Pharm 2009; 371: 114-119.
12. Woolfson AD, et al,. Development and characterisation of a moisture-activated bioadhesive drug delivery system for percutaneous local anaesthesia. Int J Pharm 1998; 169: 83-94. (Pubitemid 28352601)
13. Woolfson AD, et al,. Concentration response analysis of percutaneous local-anesthetic formulations. Br J Anaesth 1988; 61: 589-592.
14. Garrett ER, Chemburk PB,. Evaluation control and prediction of drug diffusion through polymeric membranes. I. Methods reproducibility of steady-state diffusion studies. J Pharm Sci 1968; 57: 944-948.
15. Twist JN, Zatz JL,. Membrane solvent solute interaction in a model permeation system. J Pharm Sci 1988; 77: 536-540. (Pubitemid 19036946)
16. Higuchi T,. Physical chemical analysis of percutaneous absorption process from creams and ointments. J Soc Cosmet Chem 1960; 11: 85-97.
17. Brodin A, et al,. Phase diagram and aqueous solubility of the lidocaine-prilocaine binary system. J Pharm Sci 1984; 73: 481-484. (Pubitemid 14134322)
18. Williams A,. Transdermal and Topical Drug Delivery. London: Pharmaceutical Press, 2003: 83-103.
19. Ganem-Quintanar A, et al,. Ex vivo oral mucosal permeation of lidocaine hydrochloride with sucrose fatty acid esters as absorption enhancers. Int. J. Pharm. Sci. 1998; 173: 203-210. (Pubitemid 29027774)
20. Nyqvist-Mayer AA, et al,. Drug release studies on an oil-water emulsion based on a eutectic mixture of lidocaine and prilocaine as the dispersed phase. J Pharm Sci 1986; 75: 365-373. (Pubitemid 16137104)
21. Amidon GE, et al,. Theoretical and experimental studies of transport of micelle-solubilized solutes. J Pharm Sci 1982; 71: 77-84. (Pubitemid 12110408)
22. Perez-Buendia MD, et al,. Permeation mechanisms through artificial lipoidal membranes and effects of synthetic surfactants on xenobiotic permeability. Arzneimittelforschung 1993; 43: 789-794. (Pubitemid 23210999)
23. Leveque N, et al,. Use of a molecular form technique for the penetration of supersaturated solutions of salicylic acid across silicone membranes and human skin in vitro. Int J Pharm 2006; 318: 49-54. (Pubitemid 43963299)
24. Valenta C, et al,. The dermal delivery of lignocaine: influence of ion pairing. Int J Pharm 2000; 197: 77-85. (Pubitemid 30125779)
25. Smith JC, Irwin WJ,. Ionisation and the effect of absorption enhancers on transport of salicylic acid through silastic rubber and human skin. Int J Pharm 2000; 210: 69-82. (Pubitemid 32332643)
26. Moser K, et al,. Passive skin penetration enhancement and its quantification in vitro. Eur J Pharm Biopharm 2001; 52: 103-112. (Pubitemid 32755887)
27. Kang L, et al,. Physicochemical studies of lidocaine-menthol binary systems for enhanced membrane transport. Int J Pharm 2000; 206: 35-42.
28. Yuan XD, Capomacchia AC,. The binary eutectic of NSAIDS and two-phase liquid system for enhanced membrane permeation. Pharm Dev Tech 2005; 10: 1-10. (Pubitemid 40315524)
29. Stott PW, et al,. Mechanistic study into the enhanced transdermal permeation of a model beta-blocker, propranolol, by fatty acids: a melting point depression effect. Int J Pharm 2001; 219: 161-176. (Pubitemid 32391375)
30. Kaplun-Frischoff Y, Touitou E,. Testosterone skin permeation enhancement by menthol through formation of eutectic with drug and interaction with skin lipids. J Pharm Sci 1997; 86: 1394-1399. (Pubitemid 28018321)