Perceptual training strongly improves visual motion perception in schizophrenia

Brain and Cognition

Volumn 77, Issue 2, 2011, Pages 248-256

  Norton, Daniel J ^a   McBain, Ryan K ^a,c   Öngür, Dost ^a,b   Chen, Yue ^a,b  

^a MCLEAN HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

Cognitive; Motion processing; Neuroplasticity; Neuroscience; Perception; Perceptual learning; Schizophrenic

Indexed keywords

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DIRECTIONAL VISION; DISCRIMINATION LEARNING; FEMALE; HUMAN; MALE; MENTAL TASK; MOTOR NERVE CONDUCTION; MOVEMENT PERCEPTION; NERVE CELL PLASTICITY; PRIORITY JOURNAL; SCHIZOPHRENIA; TASK PERFORMANCE; VISUAL DISCRIMINATION; VISUAL STIMULATION; VISUAL THRESHOLD; VISUOMOTOR COORDINATION;

ADULT; DISCRIMINATION LEARNING; FEMALE; HUMANS; MALE; MIDDLE AGED; MOTION PERCEPTION; PHOTIC STIMULATION; PRACTICE (PSYCHOLOGY); SCHIZOPHRENIA; VISUAL PERCEPTION;

EID: 80054085410     PISSN: 02782626     EISSN: 10902147     Source Type: Journal    
DOI: 10.1016/j.bandc.2011.08.003     Document Type: Article

References (66)

1. Ball K., Sekuler R. A specific and enduring improvement in visual motion discrimination. Science 1982, 218:697-698.
2. Balu D.T., Coyle J.T. Neuroplasticity signaling pathways linked to the pathophysiology of schizophrenia. Neuroscience and Biobehavioral Reviews 2011, 35:848-870.
3. Balu, D. T., Carlson, G. C., Talbot, K., Kazi, H., Hill-Smith, T. E., & Easton, R. M., et al. (in press). Akt1 deficiency in schizophrenia and impairment of hippocampal plasticity and function. Hippocampus.
4. Brenner C.A., Wilt M.A., Lysaker P.H., Koyfman A., O'Donnell B.F. Psychometrically matched visual-processing tasks in schizophrenia spectrum disorders. Journal of Abnormal Psychology 2003, 112:28-37.
5. Brittain P., Ffytche D.H., McKendrick A., Surguladze S. Visual processing, social cognition and functional outcome in schizophrenia. Psychiatry Research 2010, 178:270-275.
6. Buckley P.F., Pillai A., Howell K.R. Brain-derived neurotrophic factor: Findings in schizophrenia. Current Opinion in Psychiatry 2011, 24:122-127.
7. Butefisch C.M., Davis B.C., Wise S.P., Sawaki L., Kopylev L., Classen J., et al. Mechanisms of use-dependent plasticity in the human motor cortex. Proceedings of the National Academy of Sciences of the United States of America 2000, 97:3661-3665.
8. Butler P.D., Abeles I.Y., Weiskopf N.G., Tambini A., Jalbrzikowski M., Legatt M.E., et al. Sensory contributions to impaired emotion processing in schizophrenia. Schizophrenia Bulletin 2009, 35:1095-1107.
9. Chen Y. Abnormal visual motion processing in schizophrenia: A review of research progress. Schizophrenia Bulletin 2011, 37:709-715.
10. Chen Y., Bidwell L.C., Holzman P.S. Visual motion integration in schizophrenia patients, their first-degree relatives, and patients with bipolar disorder. Schizophrenia Research 2005, 74:271-281.
11. Chen Y., Grossman E.D., Bidwell L.C., Yurgelun-Todd D., Gruber S.A., Levy D.L., et al. Differential activation patterns of occipital and prefrontal cortices during motion processing: Evidence from normal and schizophrenic brains. Cognitive Affective & Behavioral Neuroscience 2008, 8:293-303.
12. Chen Y., Nakayama K., Levy D.L., Matthysse S., Holzman P.S. Psychophysical isolation of a motion-processing deficit in schizophrenics and their relatives and its association with impaired smooth pursuit. Proceedings of the National Academy of Sciences of the United States of America 1999, 96:4724-4729.
13. Chen Y., Nakayama K., Levy D.L., Matthysse S., Holzman P.S. Processing of global, but not local, motion direction is deficient in schizophrenia. Schizophrenia Research 2003, 61:215-227.
14. Chen Y., Norton D., Ongur D. Altered center-surround motion inhibition in schizophrenia. Biological Psychiatry 2008, 64:74-77.
15. Chen Y., Palafox G.P., Nakayama K., Levy D.L., Matthysse S., Holzman P.S. Motion perception in schizophrenia. Archives of General Psychiatry 1999, 56:149-154.
16. Clementz B.A., McDowell J.E., Dobkins K.R. Compromised speed discrimination among schizophrenia patients when viewing smooth pursuit targets. Schizophrenia Research 2007, 95:61-64.
17. Daskalakis Z.J., Christensen B.K., Fitzgerald P.B., Chen R. Dysfunctional neural plasticity in patients with schizophrenia. Archives of General Psychiatry 2008, 65:378-385.
18. Edwards B.G., Barch D.M., Braver T.S. Improving prefrontal cortex function in schizophrenia through focused training of cognitive control. Frontiers in Human Neuroscience 2010, 4:32.
19. Fahle M. Perceptual learning: Specificity versus generalization. Current Opinions in Neurobiology 2005, 15:154-160.
20. Fine I., Jacobs R.A. Comparing perceptual learning tasks: A review. Journal of Vision 2002, 2:190-203.
21. First, M. B., Spitzer, R. L., Gibbon, M., & Williams, J. B. W. (2002). Structured clinical interview for DSM-IV-TR Axis I disorders-Patient edition (SCID-I/P, 11/2002 revision). Biometrics Research Department, New York.
22. First, M. B., Gibbon, M., & William, J. B. (2002). Structure clinical interview for DSM-IV-TR axis I disorders - Non-patient edition (SCID-I/NP, 11/2002b revision) New York, NY Biometric Research Department, New York State Psychiatric Institute.
23. Fisher M., Holland C., Merzenich M.M., Vinogradov S. Using neuroplasticity-based auditory training to improve verbal memory in schizophrenia. American Journal of Psychiatry 2009, 166:805-811.
24. Fisher M., Holland C., Subramaniam K., Vinogradov S. Neuroplasticity-based cognitive training in schizophrenia: An interim report on the effects 6 months later. Schizophrenia Bulletin 2010, 36:869-879.
25. Frankle W., Lerma J., Laruelle M. The synaptic hypothesis of schizophrenia. Neuron 2003, 39:205-216.
26. Gibson E.J. Perceptual learning. Annual Review of Psychology 1963, 14:29-56.
27. Gilbert C.D., Sigman M., Crist R.E. The neural basis of perceptual learning. Neuron 2001, 31:681-697.
28. Goto Y., Grace A.A. Alterations in medial prefrontal cortical activity and plasticity in rats with disruption of cortical development. Biological Psychiatry 2006, 60:1259-1267.
29. Goto Y., Yang C.R., Otani S. Functional and dysfunctional synaptic plasticity in prefrontal cortex: Roles in psychiatric disorders. Biological Psychiatry 2010, 67:199-207.
30. Green C.S., Bavelier D. Action video game modifies visual selective attention. Nature 2003, 423:534-537.
31. Green M.F., Butler P.D., Chen Y., Geyer M.A., Silverstein S., Wynn J.K., et al. Perception Measurement in clinical trials of schizophrenia: Promising paradigms from CNTRICS. Schizophrenia Bulletin 2009, 35:163-181.
32. Haut K.M., Lim K.O., MacDonald A. Prefrontal cortical changes following cognitive training in patients with chronic schizophrenia: Effects of practice, generalization, and specificity. Neuropsychopharmacology 2010, 35:1850-1859.
33. Horan W.P., Green M.F., Knowlton B.J., Wynn J.K., Mintz J., Nuechterlein K.H. Impaired implicit learning in schizophrenia. Neuropsychology 2008, 22:606-617.
34. Hua T., Bao P., Huang C.B., Wang Z., Xu J., Zhou Y., et al. Perceptual learning improves contrast sensitivity of V1 neurons in cats. Current Biology 2010, 20:887-894.
35. Javitt D.C. When doors of perception close: Bottom-up models of disrupted cognition in schizophrenia. Annual Review of Clinical Psychology 2009, 5:249-275.
36. Johansson G. Visual perception of biological motion and a model for its analysis. Perception & Psychophysics 1973, 14:201-211.
37. Kantrowitz J.T., Butler P.D., Schecter I., Silipo G., Javitt D.C. Seeing the world dimly: The impact of early visual deficits on visual experience in schizophrenia. Schizophrenia Bulletin 2009, 35:1085-1094.
38. Kay S., Fiszbein A., Opler L. The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophrenia Bulletin 1987, 13:261-276.
39. Kelemen O., Erdelyi R., Pataki I., Benedek G., Janka Z., Keri S. Theory of mind and motion perception in schizophrenia. Neuropsychology 2005, 19:494-500.
40. Kim J., Doop M.L., Blake R., Park S. Impaired visual recognition of biological motion in schizophrenia. Schizophrenia Research 2005, 77:299-307.
41. Kim D., Wylie G., Pasternak R., Butler P.D., Javitt D.C. Magnocellular contributions to impaired motion processing in schizophrenia. Schizophrenia Research 2006, 82:1-8.
42. Leitman D.I., Sehatpour P., Higgins B.A., Foxe J.J., Silipo G., Javitt D.C. Sensory deficits and distributed hierarchical dysfunction in schizophrenia. American Journal of Psychiatry 2010, 167:818-827.
43. Lencer R., Nagel M., Sprenger A., Heide W., Binkofski F. Reduced neuronal activity in the V5 complex underlies smooth-pursuit deficit in schizophrenia: Evidence from an fMRI study. Neuroimage 2005, 24:1256-1259.
44. Liu Z. Perceptual learning in motion discrimination that generalizes across motion directions. Proceedings of the National Academy of Sciences of the United States of America 1999, 96:14085-14087.
45. Liu Z., Weinshall D. Mechanisms of generalization in perceptual learning. Vision Research 2000, 40:97-109.
46. McBain R., Norton D., Chen Y. Differential roles of low and high spatial frequency content in abnormal facial emotion perception in schizophrenia. Schizophrenia Research 2010, 122:151-155.
47. Newsome W., Pare E.B. A selective impairment of motion perception following lesions of the middle temporal visual area (MT). Journal of Neuroscience 1988, 8:2201-2211.
48. Norton D., McBain R., Holt D.J., Ongur D., Chen Y. Association of impaired facial affect recognition with basic facial and visual processing deficits in schizophrenia. Biological Psychiatry 2009, 65:1094-1098.
49. Norton D., Öngür D., Stromeyer C., Chen Y. Altered temporal interaction in response to two light pulses in schizophrenia. Schizophrenia Research 2008, 103:275-282.
50. Nuechterlein K.H., Green M.F., Kern R.S., Baade L.E., Barch D.M., Cohen J.D., et al. The MATRICS consensus cognitive battery, part 1: Test selection, reliability, and validity. American Journal of Psychiatry 2008, 165:203-213.
51. Paffen C.L., Verstraten F.A., Vidnyánszky Z. Attention-based perceptual learning increases binocular rivalry suppression of irrelevant visual features. Journal of Vision 2008, 8:25.1-25.11.
52. Pajonk F.G., Wobrock T., Gruber O., Scherk H., Berner D., Kaizl I., et al. Hippocampal plasticity in response to exercise in schizophrenia. Archives of General Psychiatry 2010, 67:133-143.
53. Pourtois G., Rauss K.S., Vuilleumier P., Schwartz S. Effects of perceptual learning on primary visual cortex activity in humans. Vision Research 2008, 48:55-62.
54. Saffell T., Matthews N. Task-specific perceptual learning on speed and direction discrimination. Vision Research 2003, 43:1365-1374.
55. Schwartz S., Maquet P., Frith C. Neural correlates of perceptual learning: A functional MRI study of visual texture discrimination. Proceedings of the National Academy of Sciences of the United States of America 2002, 99:17137-17142.
56. Sergi M.J., Green M.F. Social perception and early visual processing in schizophrenia. Schizophrenia Research 2003, 59:233-241.
57. Siegert R.J., Weatherall M., Bell E.M. Is implicit sequence learning impaired in schizophrenia? A meta-analysis. Brain and Cognition 2008, 67:351-359.
58. Slaghuis W.L., Holthouse T., Hawkes A., Bruno R. Eye movement and visual motion perception in schizophrenia II: Global coherent motion as a function of target velocity and stimulus density. Experimental Brain Research 2007, 182:415-426.
59. Stuve T., Friedman L., Jesberger J.A., Gilmore G., Strauss M.E., Meltzer H. The relationship between smooth pursuit performance, motion perception and sustained visual attention in patients with schizophrenia and normal controls. Psychological Medicine 1997, 27:143-152.
60. Tadin D., Kim J., Doop M.L., Gibson C., Lappin J.S., Blake R., et al. Weakened center-surround interactions in visual motion processing in schizophrenia. Journal of Neuroscience 2006, 26:11403-11412.
61. Wang J., Brown R., Dobkins K.R., McDowell J.E., Clementz B.A. Diminished parietal cortex activity associated with poor motion direction discrimination performance in schizophrenia. Cerebral Cortex 2010, 20:1749-1755.
62. Watanabe T., Nanez J.E., Sasaki Y. Perceptual learning without perception. Nature 2001, 413:844-848.
63. Wechsler D. Manual for the adult intelligence scale-revised 1981, Psychological Corporation, New York.
64. Yotsumoto Y., Sasaki Y., Chan P., Vasios C.E., Bonmassar G., Ito N., et al. Location-specific cortical activation changes during sleep after training for perceptual learning. Current Biology 2009, 19:1278-1282.
65. Zohary E., Celebrini S., Britten K.H., Newsome W.T. Neuronal plasticity that underlies improvement in perceptual performance. Science 1994, 263:1289-1292.
66. Zucker R.S., Regehr W.G. Short-term synaptic plasticity. Annual Review of Physiology 2002, 64:355-405.