메뉴 건너뛰기




Volumn 9, Issue 6, 2011, Pages 723-732

New anti-thrombotic drugs for stroke prevention

Author keywords

Compliance; New antithrombotic drugs; Recommendations; Stroke prevention

Indexed keywords

ACETYLSALICYLIC ACID; ACETYLSALICYLIC ACID PLUS CLOPIDOGREL; ANTICOAGULANT AGENT; APIXABAN; CILOSTAZOL; CLOPIDOGREL; DABIGATRAN ETEXILATE; PLACEBO; PRASUGREL; RIVAROXABAN; SARPOGRELATE; TERUTROBAN; THIENOPYRIDINE DERIVATIVE; TICAGRELOR; TICLOPIDINE; WARFARIN;

EID: 80054077520     PISSN: 15701611     EISSN: 18756212     Source Type: Journal    
DOI: 10.2174/157016111797484189     Document Type: Review
Times cited : (9)

References (87)
  • 1
  • 2
    • 4644261801 scopus 로고    scopus 로고
    • Antithrombotic and thrombolytic therapy for ischemic stroke: The Seventh ACCP Conference on Antithrombotic and Thrombolytic therapy
    • Albers GW, Amarenco P, Easton JD, Sacco RL, Teal P. Antithrombotic and thrombolytic therapy for ischemic stroke: The Seventh ACCP Conference on Antithrombotic and Thrombolytic therapy. CHEST 2004; 126: 483S-512S.
    • (2004) CHEST , vol.126
    • Albers, G.W.1    Amarenco, P.2    Easton, J.D.3    Sacco, R.L.4    Teal, P.5
  • 3
    • 0037262139 scopus 로고    scopus 로고
    • Long-term outcome after ischaemic stroke/transient ischaemic attack
    • Hankey GJ. Long-term outcome after ischaemic stroke/transient ischaemic attack. Cerebrovasc Dis 2003; 16 (suppl 1): 14-9.
    • (2003) Cerebrovasc Dis , vol.16 , Issue.SUPPL. 1 , pp. 14-19
    • Hankey, G.J.1
  • 4
    • 0006282249 scopus 로고    scopus 로고
    • Italian guidelines for prevention and treatment, January 2010, VI ed. Italy: Publications Catel - Hyperphar Group SpA. Available from
    • Gensini GF, Zaninelli A, Bignamini AA, et al. SPREAD-Stroke, Prevention and Educational Awareness Diffusion. Italian guidelines for prevention and treatment, January 2010, VI ed. Italy: Publications Catel - Hyperphar Group SpA. Available from http://www.spread.it/node/60
    • SPREAD-Stroke, Prevention and Educational Awareness Diffusion
    • Gensini, G.F.1    Zaninelli, A.2    Bignamini, A.A.3
  • 5
    • 77953133723 scopus 로고    scopus 로고
    • Antithrombotic drug use, cerebral microbleeds, and intracerebral hemorrhage: A systematic review of published and unpublished studies
    • Lovelock CE, Cordonnier C, Naka H, et al. Antithrombotic drug use, cerebral microbleeds, and intracerebral hemorrhage: a systematic review of published and unpublished studies. Stroke 2010; 41: 1222-8.
    • (2010) Stroke , vol.41 , pp. 1222-1228
    • Lovelock, C.E.1    Cordonnier, C.2    Naka, H.3
  • 6
    • 0037065502 scopus 로고    scopus 로고
    • Collaborative metaanalysis of randomized trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients
    • Antithrombotic Trialists' Collaboration
    • Antithrombotic Trialists' Collaboration. Collaborative metaanalysis of randomized trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients. BMJ 2002; 324: 71-86.
    • (2002) BMJ , vol.324 , pp. 71-86
  • 7
    • 37649002657 scopus 로고    scopus 로고
    • Low-dose aspirin in patients with stable cardiovascular disease: A meta-analysis
    • Berger JS, Brown DL, Becker RC. Low-dose aspirin in patients with stable cardiovascular disease: a meta-analysis. Am J Med 2008; 121: 43-9.
    • (2008) Am J Med , vol.121 , pp. 43-49
    • Berger, J.S.1    Brown, D.L.2    Becker, R.C.3
  • 8
    • 2042458325 scopus 로고
    • The Canadian American Ticlopidine Study (CATS) in thromboembolic stroke
    • Gent M, Easton JD, Ellis DJ, et al. The Canadian American Ticlopidine Study (CATS) in thromboembolic stroke. Lancet 1989; 19: 442-3.
    • (1989) Lancet , vol.19 , pp. 442-443
    • Gent, M.1    Easton, J.D.2    Ellis, D.J.3
  • 9
    • 0024396437 scopus 로고
    • A randomized trial comparing ticlopidine hydrochloride with aspirin for the prevention of stroke in high-risk patients: Ticlopidine Aspirin Stroke Study Group
    • Hass WK, Easton DJ, Adams HP, et al. A randomized trial comparing ticlopidine hydrochloride with aspirin for the prevention of stroke in high-risk patients: Ticlopidine Aspirin Stroke Study Group. N Engl J Med 1989; 321: 501-7.
    • (1989) N Engl J Med , vol.321 , pp. 501-507
    • Hass, W.K.1    Easton, D.J.2    Adams, H.P.3
  • 10
    • 0141919739 scopus 로고    scopus 로고
    • Effects of aspirin dose when used alone or in combination with clopidogrel in patients with acute coronary syndromes: Observations from the Clopidogrel in Unstable angina to prevent Recurrent Events (CURE) study
    • Peters RJ, Mehta SR, Fox KA, et al. Effects of aspirin dose when used alone or in combination with clopidogrel in patients with acute coronary syndromes: observations from the Clopidogrel in Unstable angina to prevent Recurrent Events (CURE) study. Circulation 2003; 108: 1682-7.
    • (2003) Circulation , vol.108 , pp. 1682-1687
    • Peters, R.J.1    Mehta, S.R.2    Fox, K.A.3
  • 11
    • 58749093909 scopus 로고    scopus 로고
    • Bleeding risk associated with 1 year of dual antiplatelet therapy after percutaneous coronary intervention: Insights from the Clopidogrel for the Reduction of Events During Observation (CREDO) trial
    • Aronow HD, Steinhubl SR, Brennan DM, et al. Bleeding risk associated with 1 year of dual antiplatelet therapy after percutaneous coronary intervention: insights from the Clopidogrel for the Reduction of Events During Observation (CREDO) trial. Am Heart J 2009; 157: 369-74.
    • (2009) Am Heart J , vol.157 , pp. 369-374
    • Aronow, H.D.1    Steinhubl, S.R.2    Brennan, D.M.3
  • 12
    • 0030590746 scopus 로고    scopus 로고
    • A randomized, blinded trial of clopidogrel vs. aspirin in patients at risk of ischaemic events (CAPRIE)
    • CAPRIE Steering Committee
    • CAPRIE Steering Committee. A randomized, blinded trial of clopidogrel vs. aspirin in patients at risk of ischaemic events (CAPRIE). Lancet 1996; 348: 1329-39.
    • (1996) Lancet , vol.348 , pp. 1329-1339
  • 13
    • 76449091888 scopus 로고    scopus 로고
    • Thienopyridine derivatives vs. aspirin for preventing stroke and other serious vascular events in high vascular risk patients
    • Sudlow CL, Mason G, Maurice JB, Wedderburn CJ, Hankey GJ. Thienopyridine derivatives vs. aspirin for preventing stroke and other serious vascular events in high vascular risk patients. Cochrane Database Syst Rev 2009; CD001246.
    • (2009) Cochrane Database Syst Rev
    • Sudlow, C.L.1    Mason, G.2    Maurice, J.B.3    Wedderburn, C.J.4    Hankey, G.J.5
  • 14
    • 58249142825 scopus 로고    scopus 로고
    • Variability in responsiveness to oral antiplatelet therapy
    • Angiolillo DJ. Variability in responsiveness to oral antiplatelet therapy. Am J Cardiol 2009; 103 (3 suppl): 27A-34A.
    • (2009) Am J Cardiol , vol.103 , Issue.SUPPL 3
    • Angiolillo, D.J.1
  • 15
    • 77951723113 scopus 로고    scopus 로고
    • Antiplatelet drugs--do we need new options? With a reappraisal of direct thromboxane inhibitors
    • Coccheri S. Antiplatelet drugs--do we need new options? With a reappraisal of direct thromboxane inhibitors. Drugs 2010; 70: 887-908.
    • (2010) Drugs , vol.70 , pp. 887-908
    • Coccheri, S.1
  • 16
    • 38949119325 scopus 로고    scopus 로고
    • Aspirin "resistance" and risk of cardiovascular morbidity: A systematic review and meta-analysis
    • Krasopoulos G, Brister SJ, Beattie WS, et al. Aspirin "resistance" and risk of cardiovascular morbidity: a systematic review and meta-analysis. BMJ 2008; 336: 195-8.
    • (2008) BMJ , vol.336 , pp. 195-198
    • Krasopoulos, G.1    Brister, S.J.2    Beattie, W.S.3
  • 17
    • 77952075376 scopus 로고    scopus 로고
    • Clopidogrel nonresponsiveness and risk of cardiovascular morbidity. An updated metanalysis
    • Sofi F, Marcucci AR, Gori AM, et al. Clopidogrel nonresponsiveness and risk of cardiovascular morbidity. An updated metanalysis. Thromb Haemost 2010; 103: 841-8.
    • (2010) Thromb Haemost , vol.103 , pp. 841-848
    • Sofi, F.1    Marcucci, A.R.2    Gori, A.M.3
  • 18
    • 28444484957 scopus 로고    scopus 로고
    • Cycloxygenase-1 haplotype modulates platelet response to aspirin
    • Maree AO, Curtin RJ, Chubb A, et al. Cycloxygenase-1 haplotype modulates platelet response to aspirin. J Thromb Haemost 2005; 3: 2340-5.
    • (2005) J Thromb Haemost , vol.3 , pp. 2340-2345
    • Maree, A.O.1    Curtin, R.J.2    Chubb, A.3
  • 19
    • 58749094444 scopus 로고    scopus 로고
    • Cytochrome p-450 polymorphisms and response to clopidogrel
    • Mega JL, Close SL, Wiviott SD, et al. Cytochrome p-450 polymorphisms and response to clopidogrel. N Engl J Med 2009; 360: 354-62.
    • (2009) N Engl J Med , vol.360 , pp. 354-362
    • Mega, J.L.1    Close, S.L.2    Wiviott, S.D.3
  • 20
    • 58749090547 scopus 로고    scopus 로고
    • Genetic determinants of response to clopidogrel and cardiovascular events
    • Tabassome S, Verstuyft C, Mary-Krause M, et al. Genetic determinants of response to clopidogrel and cardiovascular events. N Engl J Med 2009; 360: 363-75.
    • (2009) N Engl J Med , vol.360 , pp. 363-375
    • Tabassome, S.1    Verstuyft, C.2    Mary-Krause, M.3
  • 21
    • 67649522036 scopus 로고    scopus 로고
    • High loading dose of clopidogrel is unable to satisfactorily inhibit platelet reactivity in patients with glycoprotein IIIA gene polymorphism: A genetic substudy of PRAGUE-8 trial
    • Motovska Z, Widimsky P, Kvasnicka J, et al. High loading dose of clopidogrel is unable to satisfactorily inhibit platelet reactivity in patients with glycoprotein IIIA gene polymorphism: a genetic substudy of PRAGUE-8 trial. Blood Coagul Fibrinolysis 2009; 20: 257-62.
    • (2009) Blood Coagul Fibrinolysis , vol.20 , pp. 257-262
    • Motovska, Z.1    Widimsky, P.2    Kvasnicka, J.3
  • 22
    • 56949093392 scopus 로고    scopus 로고
    • Design and rationale of CURRENT-OASIS 7: A randomized, 2 x 2 factorial trial evaluating optimal dosing strategies for clopidogrel and aspirin in patients with ST and non-ST-elevation acute coronary syndromes managed with an early invasive strategy
    • Mehta SR, Bassand JP, Chrolavicius S, et al. Design and rationale of CURRENT-OASIS 7: a randomized, 2 x 2 factorial trial evaluating optimal dosing strategies for clopidogrel and aspirin in patients with ST and non-ST-elevation acute coronary syndromes managed with an early invasive strategy. Am Heart J 2008; 156: 1080-8.
    • (2008) Am Heart J , vol.156 , pp. 1080-1088
    • Mehta, S.R.1    Bassand, J.P.2    Chrolavicius, S.3
  • 23
    • 0022970057 scopus 로고
    • Trial of repeated low-dose aspirin in diabetic angiopathy
    • Di Minno G, Silver MJ, Cerbone AM, Murphy S. Trial of repeated low-dose aspirin in diabetic angiopathy. Blood 1986; 68: 886-91.
    • (1986) Blood , vol.68 , pp. 886-891
    • Di Minno, G.1    Silver, M.J.2    Cerbone, A.M.3    Murphy, S.4
  • 24
    • 57349163413 scopus 로고    scopus 로고
    • Aspirin and clopidogrel resistance -myth or reality: An update
    • Gupta S, Gupta MM. Aspirin and clopidogrel resistance -myth or reality: an update. Indian Heart J 2008; 60: 245-53.
    • (2008) Indian Heart J , vol.60 , pp. 245-253
    • Gupta, S.1    Gupta, M.M.2
  • 25
    • 56849091335 scopus 로고    scopus 로고
    • Antiplatelet therapy: Anti-ischemic benefits vs. bleeding risk
    • Gibson CM. Antiplatelet therapy: anti-ischemic benefits vs. bleeding risk. J Interv Cardiol 2008; 21 (suppl 1):S3-9.
    • (2008) J Interv Cardiol , vol.21 , Issue.SUPPL. 1 , pp. 3-9
    • Gibson, C.M.1
  • 26
    • 30444453441 scopus 로고    scopus 로고
    • International prevalence, recognition, and treatment of cardiovascular risk factors in outpatients with atherothrombosis
    • Bhatt DL, Steg PG, Ohman EM, et al. International prevalence, recognition, and treatment of cardiovascular risk factors in outpatients with atherothrombosis. JAMA 2006; 295: 180-9.
    • (2006) JAMA , vol.295 , pp. 180-189
    • Bhatt, D.L.1    Steg, P.G.2    Ohman, E.M.3
  • 27
    • 70349680747 scopus 로고    scopus 로고
    • Three-Year follow-up and event rates in the international Reduction of Atherothrombosis for Continued Health Registry
    • Alberts MJ, Bhatt DL, Mas JL, et al. Three-Year follow-up and event rates in the international REduction of Atherothrombosis for Continued Health Registry. Eur Heart J 2009; 30: 2318-26.
    • (2009) Eur Heart J , vol.30 , pp. 2318-2336
    • Alberts, M.J.1    Bhatt, D.L.2    Mas, J.L.3
  • 28
    • 33744783988 scopus 로고    scopus 로고
    • The stroke in Italy and related impact on outcome (SIRIO) study: Design and baseline data
    • Toso V, Carolei A, Gensini GF, et al. The stroke in Italy and related impact on outcome (SIRIO) study: design and baseline data. Neurol Sci 2006; 27: S263-S267.
    • (2006) Neurol Sci , vol.27 , pp. 263-267
    • Toso, V.1    Carolei, A.2    Gensini, G.F.3
  • 29
    • 41349117377 scopus 로고    scopus 로고
    • Risk factors and treatment at recurrent stroke onset: Results from the Recurrent Stroke Quality and Epidemiology (RESQUE) Study
    • Leoo T, Lindgren A, Petersson J, von Arbin M. Risk factors and treatment at recurrent stroke onset: Results from the Recurrent Stroke Quality and Epidemiology (RESQUE) Study. Cerebrovasc Dis 2008; 25: 254-60.
    • (2008) Cerebrovasc Dis , vol.25 , pp. 254-260
    • Leoo, T.1    Lindgren, A.2    Petersson, J.3    von Arbin, M.4
  • 30
    • 58249143713 scopus 로고    scopus 로고
    • Advances in antiplatelet therapy: Agents in clinical development
    • Angiolillo DJ, Bhatt DL, Gurbel PA, et al. Advances in antiplatelet therapy: agents in clinical development. Am J Cardiol 2009; 103 (Suppl): 40A-51A.
    • (2009) Am J Cardiol , vol.103 , Issue.SUPPL
    • Angiolillo, D.J.1    Bhatt, D.L.2    Gurbel, P.A.3
  • 31
    • 84884782925 scopus 로고    scopus 로고
    • ADP receptors antagonists
    • In: Michelson AD, Ed., San Diego, CA: Academic Press
    • Cattaneo M. ADP receptors antagonists. In: Michelson AD, Ed. Platelet. San Diego, CA: Academic Press 2006; pp. 1127-44.
    • (2006) Platelet , pp. 1127-1144
    • Cattaneo, M.1
  • 32
    • 33845451677 scopus 로고    scopus 로고
    • A comparison of prasugrel and clopidogrel loading doses on platelet function: Magnitude of platelet inhibition is related to active metabolite formation
    • Brandt JT, Payne CD, Wiviott SD, et al. A comparison of prasugrel and clopidogrel loading doses on platelet function: magnitude of platelet inhibition is related to active metabolite formation. Am Heart J 2007; 153: 66.e9-16.
    • (2007) Am Heart J , vol.153 , Issue.66
    • Brandt, J.T.1    Payne, C.D.2    Wiviott, S.D.3
  • 33
    • 34250714831 scopus 로고    scopus 로고
    • The greater antiplatelet effects of prasugrel as compared to clopidogrel reflect more efficient generation of its active metabolite with similar antiplatelet activity to that of clopidogrel's active metabolite
    • Sugidachi A, Ogawa T, Kurihara A, et al. The greater antiplatelet effects of prasugrel as compared to clopidogrel reflect more efficient generation of its active metabolite with similar antiplatelet activity to that of clopidogrel's active metabolite. J Thromb Haemost 2007; 5: 1545-51.
    • (2007) J Thromb Haemost , vol.5 , pp. 1545-1551
    • Sugidachi, A.1    Ogawa, T.2    Kurihara, A.3
  • 34
    • 33748680917 scopus 로고    scopus 로고
    • Evaluation of prasugrel compared with clopidogrel in patients with acute coronary syndromes: Design and rationale for the TRial to assess Improvement in Therapeutic Outcomes by optimizing platelet InhibitioN with prasugrel Thrombolysis In Myocardial Infarction 38 (TRITON-TIMI 38)
    • Wiviott SD, Antman EM, Gibson CM, et al. Evaluation of prasugrel compared with clopidogrel in patients with acute coronary syndromes: design and rationale for the TRial to assess Improvement in Therapeutic Outcomes by optimizing platelet InhibitioN with prasugrel Thrombolysis In Myocardial Infarction 38 (TRITON-TIMI 38). Am Heart J 2006; 152: 627-35.
    • (2006) Am Heart J , vol.152 , pp. 627-635
    • Wiviott, S.D.1    Antman, E.M.2    Gibson, C.M.3
  • 35
    • 36148983750 scopus 로고    scopus 로고
    • Prasugrel vs. clopidogrel in patients with acute coronary syndromes
    • Wiviott SD, Braunwald E, McCabe CH, et al. Prasugrel vs. clopidogrel in patients with acute coronary syndromes. N Engl J Med 2007; 357: 2001-15.
    • (2007) N Engl J Med , vol.357 , pp. 2001-2015
    • Wiviott, S.D.1    Braunwald, E.2    McCabe, C.H.3
  • 36
    • 69249213604 scopus 로고    scopus 로고
    • Ticagrelor binds to the human P2Y (12) receptor independently from ADP but antagonizes ADP induced receptor signaling and platelet aggregation
    • Van Giezen JJ, Nilsson L, Berntsson P, et al. Ticagrelor binds to the human P2Y (12) receptor independently from ADP but antagonizes ADP induced receptor signaling and platelet aggregation. J Thromb Haemost 2009; 7: 1556-65.
    • (2009) J Thromb Haemost , vol.7 , pp. 1556-1565
    • van Giezen, J.J.1    Nilsson, L.2    Berntsson, P.3
  • 37
    • 0032800250 scopus 로고    scopus 로고
    • Specific impairment of human platelet P2Y (AC) ADP receptor mediated signaling by the antiplatelet drug clopidogrel
    • Geiger J, Brich J, Honig-Liedl P, et al. Specific impairment of human platelet P2Y (AC) ADP receptor mediated signaling by the antiplatelet drug clopidogrel. Arterioscler Thromb Vasc Biol 1999; 19: 2007-11.
    • (1999) Arterioscler Thromb Vasc Biol , vol.19 , pp. 2007-2011
    • Geiger, J.1    Brich, J.2    Honig-Liedl, P.3
  • 38
    • 13044263119 scopus 로고    scopus 로고
    • A key role of adenosine diphosphate in the irreversible platelet aggregation induced by the PAR1-activating peptide through the late activation of phosphoinositide 3-kinase
    • Trumel C, Payrastre B, Plantavid M, et al. A key role of adenosine diphosphate in the irreversible platelet aggregation induced by the PAR1-activating peptide through the late activation of phosphoinositide 3-kinase. Blood 1999; 94: 4156-65.
    • (1999) Blood , vol.94 , pp. 4156-4165
    • Trumel, C.1    Payrastre, B.2    Plantavid, M.3
  • 39
    • 5344257562 scopus 로고    scopus 로고
    • ADP receptor P2Y12 is expressed in vascular smooth muscle cells and stimulates contrac tion in human blood vessels
    • Wihlborg AK, Wang L, Braun OO, et al. ADP receptor P2Y12 is expressed in vascular smooth muscle cells and stimulates contrac tion in human blood vessels. Arterioscler Thromb Vasc Biol 2004; 24: 1810-5.
    • (2004) Arterioscler Thromb Vasc Biol , vol.24 , pp. 1810-1815
    • Wihlborg, A.K.1    Wang, L.2    Braun, O.O.3
  • 40
    • 77749345735 scopus 로고    scopus 로고
    • Efficacy and safety of ticagrelor: A reversible P2Y12 receptor antagonist
    • Anderson SD, Shah NK, Yim J, Epstein BJ. Efficacy and safety of ticagrelor: a reversible P2Y12 receptor antagonist. Ann Pharmacother 2010; 44: 524-37.
    • (2010) Ann Pharmacother , vol.44 , pp. 524-537
    • Anderson, S.D.1    Shah, N.K.2    Yim, J.3    Epstein, B.J.4
  • 41
    • 33646261670 scopus 로고    scopus 로고
    • Pharmacodynamics, pharmacokinetics, and safety of the oral reversible P2Y12 antagonist AZD6140 with aspirin in patients with atherosclerosis: A double-blind comparison to clopidogrel with aspirin
    • Husted S, Emanuelsson H, Heptinstall S, Sandset PM, Wickens M, Peters G. Pharmacodynamics, pharmacokinetics, and safety of the oral reversible P2Y12 antagonist AZD6140 with aspirin in patients with atherosclerosis: a double-blind comparison to clopidogrel with aspirin. Eur Heart J 2006; 27: 1038-47.
    • (2006) Eur Heart J , vol.27 , pp. 1038-1047
    • Husted, S.1    Emanuelsson, H.2    Heptinstall, S.3    Sandset, P.M.4    Wickens, M.5    Peters, G.6
  • 42
    • 62949141274 scopus 로고    scopus 로고
    • Comparison of ticagrelor, the first reversible oral P2Y (12) receptor antagonist, with clopidogrel in patients with acute coronary syndromes: Rationale, design, and baseline characteristics of the PLATelet inhibition and patient Outcomes (PLATO) trial
    • James S, Akerblom A, Cannon CP, et al. Comparison of ticagrelor, the first reversible oral P2Y (12) receptor antagonist, with clopidogrel in patients with acute coronary syndromes: rationale, design, and baseline characteristics of the PLATelet inhibition and patient Outcomes (PLATO) trial. Am Heart J 2009; 157: 599-605.
    • (2009) Am Heart J , vol.157 , pp. 599-605
    • James, S.1    Akerblom, A.2    Cannon, C.P.3
  • 43
    • 70149101223 scopus 로고    scopus 로고
    • Ticagrelor vs. clopidogrel in patients with acute coronary syndromes
    • Wallentin L, Becker RC, Budaj A, et al. Ticagrelor vs. clopidogrel in patients with acute coronary syndromes. N Engl J Med 2009; 361: 1045-57.
    • (2009) N Engl J Med , vol.361 , pp. 1045-1057
    • Wallentin, L.1    Becker, R.C.2    Budaj, A.3
  • 44
    • 36148940945 scopus 로고    scopus 로고
    • Intensifying platelet inhibition-navigating between Scylla and Charybdis
    • Bhatt DL. Intensifying platelet inhibition-navigating between Scylla and Charybdis. N Engl J Med 2007; 357: 2078-81.
    • (2007) N Engl J Med , vol.357 , pp. 2078-2081
    • Bhatt, D.L.1
  • 45
    • 33846012500 scopus 로고    scopus 로고
    • Terutroban sodium. Prostanoid tp receptor antagonist, antithrombotic agent, antiatherosclerotic agent
    • Sorbera LA, Serradell N, Bolos J, Bayes M. Terutroban sodium. Prostanoid tp receptor antagonist, antithrombotic agent, antiatherosclerotic agent. Drugs Future 2006; 31: 867-73.
    • (2006) Drugs Future , vol.31 , pp. 867-873
    • Sorbera, L.A.1    Serradell, N.2    Bolos, J.3    Bayes, M.4
  • 46
    • 25444465119 scopus 로고    scopus 로고
    • Atherosclerosis regression and TP receptor inhibition: Effect of S 18886 on plaque size and composition - a magnetic resonance imaging study
    • Viles-Gonzales JF, Fuster V, Corti R, et al. Atherosclerosis regression and TP receptor inhibition: effect of S 18886 on plaque size and composition - a magnetic resonance imaging study. Eur Heart J 2005; 26: 1557-61.
    • (2005) Eur Heart J , vol.26 , pp. 1557-1561
    • Viles-Gonzales, J.F.1    Fuster, V.2    Corti, R.3
  • 47
    • 21744443164 scopus 로고    scopus 로고
    • S18886, a new specific TP receptor antagonist is safe and as effective as aspirin in inhibiting platelet aggregation in patients with peripheral arterial disease
    • TAIPAD Study Group
    • Fiessinger JN, TAIPAD Study Group. S18886, a new specific TP receptor antagonist is safe and as effective as aspirin in inhibiting platelet aggregation in patients with peripheral arterial disease. Eur Heart J 2004; 25: 89-90.
    • (2004) Eur Heart J , vol.25 , pp. 89-90
    • Fiessinger, J.N.1
  • 48
    • 64549164466 scopus 로고    scopus 로고
    • Rationale and design of a randomized, double-blind, parallel-group study of terutroban 30mg/day vs. aspirin 100 mg/day in stroke patients: The prevention of cerebrovascular and cardiovascular events of ischemic origin with terutroban in patients with a history of ischemic stroke or transient ischemic attack (PERFORM) study
    • Bousser MG, Amarenco P, Chamorro A, et al. Rationale and design of a randomized, double-blind, parallel-group study of terutroban 30mg/day vs. aspirin 100 mg/day in stroke patients: the prevention of cerebrovascular and cardiovascular events of ischemic origin with terutroban in patients with a history of ischemic stroke or transient ischemic attack (PERFORM) study. Cerebrovasc Dis 2009; 27: 509-18.
    • (2009) Cerebrovasc Dis , vol.27 , pp. 509-518
    • Bousser, M.G.1    Amarenco, P.2    Chamorro, A.3
  • 49
    • 46249118961 scopus 로고    scopus 로고
    • Sarpogrelate-SarpoAspirin comparative clinical study for efficacy and safety in secondary prevention of cerebral infarction (S-ACCESS): A randomized, double-blind, aspirin controlled trial
    • for S-ACCESS Study Group
    • Shinohara Y, Nishimaru K, Sawada T, for S-ACCESS Study Group. Sarpogrelate-SarpoAspirin comparative clinical study for efficacy and safety in secondary prevention of cerebral infarction (S-ACCESS): a randomized, double-blind, aspirin controlled trial. Stroke 2008; 39: 1827-33.
    • (2008) Stroke , vol.39 , pp. 1827-1833
    • Shinohara, Y.1    Nishimaru, K.2    Sawada, T.3
  • 50
    • 52449085759 scopus 로고    scopus 로고
    • A randomized study assessing the impact of cilostazol on platelet function profiles in patients with diabetes mellitus and coronary artery disease on dual antiplatelet therapy: Results of the OPTIMUS-2 study
    • Angiolillo DJ, Capranzano P, Goto S, et al. A randomized study assessing the impact of cilostazol on platelet function profiles in patients with diabetes mellitus and coronary artery disease on dual antiplatelet therapy: results of the OPTIMUS-2 study. Eur Heart J 2008; 29: 2202-11.
    • (2008) Eur Heart J , vol.29 , pp. 2202-2211
    • Angiolillo, D.J.1    Capranzano, P.2    Goto, S.3
  • 51
    • 79952268676 scopus 로고    scopus 로고
    • Cilostazol vs. aspirin for secondary prevention of vascular events after stroke of arterial origin
    • Kamal AK, Naqvi I, Husain MR, Khealani BA. Cilostazol vs. aspirin for secondary prevention of vascular events after stroke of arterial origin. Cochrane Database Syst Rev 2011; CD008076.
    • (2011) Cochrane Database Syst Rev
    • Kamal, A.K.1    Naqvi, I.2    Husain, M.R.3    Khealani, B.A.4
  • 52
    • 34347394385 scopus 로고    scopus 로고
    • Meta-analysis: Antithrombotic therapy to prevent stroke in patients who have non-valvular atrial fibrillation
    • Hart G, Pearce LA, Aguilar MI. Meta-analysis: antithrombotic therapy to prevent stroke in patients who have non-valvular atrial fibrillation. Ann Intern Med 2007; 146: 857-67.
    • (2007) Ann Intern Med , vol.146 , pp. 857-867
    • Hart, G.1    Pearce, L.A.2    Aguilar, M.I.3
  • 53
    • 0346496571 scopus 로고    scopus 로고
    • National trends in antiarrhythmic and antithrombotic medication use in atrial fibrillation
    • Fang MC, Stafford RS, Ruskin JN, Singer DE. National trends in antiarrhythmic and antithrombotic medication use in atrial fibrillation Arch Intern Med 2004; 164: 55-60.
    • (2004) Arch Intern Med , vol.164 , pp. 55-60
    • Fang, M.C.1    Stafford, R.S.2    Ruskin, J.N.3    Singer, D.E.4
  • 54
    • 78649508381 scopus 로고    scopus 로고
    • Factors affecting adherence to guidelines for antithrombotic therapy in elderly patients with atrial fibrillation admitted to internal medicine wards
    • Marcucci M, Iorio A, Nobili A, et al. Factors affecting adherence to guidelines for antithrombotic therapy in elderly patients with atrial fibrillation admitted to internal medicine wards. Eur J Int Med 2010; 21: 516-23.
    • (2010) Eur J Int Med , vol.21 , pp. 516-523
    • Marcucci, M.1    Iorio, A.2    Nobili, A.3
  • 55
    • 0032569650 scopus 로고    scopus 로고
    • Warfarin use following ischemic stroke among medicare patients with atrial fibrillation
    • Brass L, Krumholz L, Scinto J, et al. Warfarin use following ischemic stroke among medicare patients with atrial fibrillation. Arch Intern Med 1998; 158: 2093-100.
    • (1998) Arch Intern Med , vol.158 , pp. 2093-2100
    • Brass, L.1    Krumholz, L.2    Scinto, J.3
  • 56
    • 65649145705 scopus 로고    scopus 로고
    • Effect of clopidogrel added to aspirin in patients with atrial fibrillation
    • ACTIVE Investigators
    • Connolly SJ, Pogue J, Hart RG, et al.; ACTIVE Investigators. Effect of clopidogrel added to aspirin in patients with atrial fibrillation. N Engl J Med 2009; 360: 2066-78.
    • (2009) N Engl J Med , vol.360 , pp. 2066-2078
    • Connolly, S.J.1    Pogue, J.2    Hart, R.G.3
  • 57
    • 33744945247 scopus 로고    scopus 로고
    • Clopidogrel plus aspirin vs. oral anticoagulation for atrial fibrillation in the Atrial fibrillation Clopidogrel Trial with Irbesartan for prevention of Vascular Events (ACTIVE W): A randomised controlled trial
    • The ACTIVE Writing Group on behalf of the ACTIVE Investigators
    • The ACTIVE Writing Group on behalf of the ACTIVE Investigators. Clopidogrel plus aspirin vs. oral anticoagulation for atrial fibrillation in the Atrial fibrillation Clopidogrel Trial with Irbesartan for prevention of Vascular Events (ACTIVE W): a randomised controlled trial. Lancet 2006; 367: 1903-12.
    • (2006) Lancet , vol.367 , pp. 1903-1912
  • 58
    • 84879264620 scopus 로고    scopus 로고
    • Management of atrial fibrillation
    • Lafuente C, Mahe I, Extramiana F. Management of atrial fibrillation. BMJ 2009; 339: b5216.
    • (2009) BMJ , vol.339
    • Lafuente, C.1    Mahe, I.2    Extramiana, F.3
  • 59
    • 5644295138 scopus 로고    scopus 로고
    • NASPEAF Investigators. Comparative effects of antiplatelet, anticoagulant, or combined therapy in patients with valvular and non-valvular atrial fibrillation: A randomized multicenter study
    • Perez-Gomez F, Alegria E, Berjon J, et al.; NASPEAF Investigators. Comparative effects of antiplatelet, anticoagulant, or combined therapy in patients with valvular and non-valvular atrial fibrillation: a randomized multicenter study. J Am Coll Cardiol 2004; 44: 1557-66.
    • (2004) J Am Coll Cardiol , vol.44 , pp. 1557-1566
    • Perez-Gomez, F.1    Alegria, E.2    Berjon, J.3
  • 60
    • 77955050385 scopus 로고    scopus 로고
    • Combined oral anticoagulants and antiplatelets: Benefits and risks
    • Vedovati MC, Becattini C, Agnelli G. Combined oral anticoagulants and antiplatelets: benefits and risks. Intern Emerg Med 2010; 5: 281-90.
    • (2010) Intern Emerg Med , vol.5 , pp. 281-290
    • Vedovati, M.C.1    Becattini, C.2    Agnelli, G.3
  • 61
    • 45949095568 scopus 로고    scopus 로고
    • American College of Chest Physicians: Antithrombotic therapy in atrial fibrillation: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition)
    • Singer DE, Albers GW, Dalen JE, et al. American College of Chest Physicians: Antithrombotic therapy in atrial fibrillation: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition). Chest 2008; 133: 546S-92S.
    • (2008) Chest , vol.133
    • Singer, D.E.1    Albers, G.W.2    Dalen, J.E.3
  • 62
    • 0031729679 scopus 로고    scopus 로고
    • Oral anticoagulation. Mechanism of action, clinical effectiveness, and optimal therapeutic range
    • Hirsh J, Dalen JE, Anderson DR, et al. Oral anticoagulation. Mechanism of action, clinical effectiveness, and optimal therapeutic range. Chest 1998; 114: 445S-69S.
    • (1998) Chest , vol.114
    • Hirsh, J.1    Dalen, J.E.2    Anderson, D.R.3
  • 63
    • 0041694480 scopus 로고    scopus 로고
    • Ximelagatran compared with warfarin for prevention of thromboembolism in patients with non-valvular atrial fibrillation: Rationale, objectives, and design of a pair of clinical studies and baseline patient characteristics (SPORTIF III and V)
    • Halperin JL. Ximelagatran compared with warfarin for prevention of thromboembolism in patients with non-valvular atrial fibrillation: Rationale, objectives, and design of a pair of clinical studies and baseline patient characteristics (SPORTIF III and V). Am Heart J 2003; 146: 431-8.
    • (2003) Am Heart J , vol.146 , pp. 431-438
    • Halperin, J.L.1
  • 65
    • 35348879239 scopus 로고    scopus 로고
    • Dabigatran with or without concomitant aspirin compared with warfarin alone in patients with non-valvular atrial fibrillation (PETRO Study)
    • Ezekowitz MD, Reilly PA, Nehmiz G, et al. Dabigatran with or without concomitant aspirin compared with warfarin alone in patients with non-valvular atrial fibrillation (PETRO Study). Am J Cardiol 2007; 100: 1419-26.
    • (2007) Am J Cardiol , vol.100 , pp. 1419-1426
    • Ezekowitz, M.D.1    Reilly, P.A.2    Nehmiz, G.3
  • 66
    • 70349306707 scopus 로고    scopus 로고
    • Dabigatran vs. warfarin in patients with atrial fibrillation
    • Connolly SJ, Ezekowitz MD, Yusuf S, et al. Dabigatran vs. warfarin in patients with atrial fibrillation. N Engl J Med 2009; 361: 1139-51.
    • (2009) N Engl J Med , vol.361 , pp. 1139-1151
    • Connolly, S.J.1    Ezekowitz, M.D.2    Yusuf, S.3
  • 67
    • 25844525489 scopus 로고    scopus 로고
    • Safety pharmacodynamics and pharmacokinetics of BAY39-7959, an oral direct factor Xa inhibitor
    • Kubitza D, Becka M, Voith B, et al. Safety pharmacodynamics and pharmacokinetics of BAY39-7959, an oral direct factor Xa inhibitor. Clin Pharmacol Ther 2005; 78:412-21.
    • (2005) Clin Pharmacol Ther , vol.78 , pp. 412-421
    • Kubitza, D.1    Becka, M.2    Voith, B.3
  • 68
    • 57449094606 scopus 로고    scopus 로고
    • Comparative pharmacodynamics and pharmacokinetics of oral direct thrombin and factor Xa inhibitors development
    • Eriksson BI, Quinlan DJ, Weitz JI. Comparative pharmacodynamics and pharmacokinetics of oral direct thrombin and factor Xa inhibitors development. Clin Pharmacokinet 2009; 48: 1-22.
    • (2009) Clin Pharmacokinet , vol.48 , pp. 1-22
    • Eriksson, B.I.1    Quinlan, D.J.2    Weitz, J.I.3
  • 69
    • 29144518504 scopus 로고    scopus 로고
    • Safety pharmacodynamics and pharmacokinetics of BAY39-7959, an oral direct factor Xa inhibitor-after multiple dosing in healthy male subjects
    • Kubitza D, Becka M, Wensing G, et al. Safety pharmacodynamics and pharmacokinetics of BAY39-7959, an oral direct factor Xa inhibitor-after multiple dosing in healthy male subjects. Eur J Clin Pharmacol 2005; 61: 873-80.
    • (2005) Eur J Clin Pharmacol , vol.61 , pp. 873-880
    • Kubitza, D.1    Becka, M.2    Wensing, G.3
  • 71
    • 33746805812 scopus 로고    scopus 로고
    • Novel factor Xa inhibitors for the prevention and treatment of thromboembolic diseases
    • Kubitza D, Haas S. Novel factor Xa inhibitors for the prevention and treatment of thromboembolic diseases. Expert Opin Investig Drugs 2006; 15: 843-55.
    • (2006) Expert Opin Investig Drugs , vol.15 , pp. 843-855
    • Kubitza, D.1    Haas, S.2
  • 72
    • 77749289263 scopus 로고    scopus 로고
    • Comparative efficacy and safety of the novel oral anticoagulants dabigatran, rivaroxaban and apixaban in preclinical and clinical development
    • Ufer M. Comparative efficacy and safety of the novel oral anticoagulants dabigatran, rivaroxaban and apixaban in preclinical and clinical development. Thromb Haemost 2010; 103: 572-85.
    • (2010) Thromb Haemost , vol.103 , pp. 572-585
    • Ufer, M.1
  • 73
    • 67649562905 scopus 로고    scopus 로고
    • Rivaroxaban vs. placebo in patients with acute coronary syndromes (Atlas ACS-TIMI 46): A randomized double blind, phase II trial
    • Mega JL, Braunwald E, Mohanavelu S, et al. Rivaroxaban vs. placebo in patients with acute coronary syndromes (Atlas ACS-TIMI 46): a randomized double blind, phase II trial. Lancet 2009; 374: 29-38.
    • (2009) Lancet , vol.374 , pp. 29-38
    • Mega, J.L.1    Braunwald, E.2    Mohanavelu, S.3
  • 74
    • 85058721877 scopus 로고    scopus 로고
    • Rivaroxaban-Once daily, oral, direct factor Xa inhibition Compared with vitamin K antagonism for prevention of stroke and Embolism Trial in Atrial Fibrillation: Rationale and Design of the ROCKET AF study
    • The Executive Steering Committee, on behalf of the ROCKET AF Study Investigators
    • The Executive Steering Committee, on behalf of the ROCKET AF Study Investigators. Rivaroxaban-Once daily, oral, direct factor Xa inhibition Compared with vitamin K antagonism for prevention of stroke and Embolism Trial in Atrial Fibrillation: Rationale and Design of the ROCKET AF study. Am Heart J 2010; 159: 340-7.
    • (2010) Am Heart J , vol.159 , pp. 340-347
  • 76
    • 34249310268 scopus 로고    scopus 로고
    • Oral direct Factor Xa inhibitors in development for the prevention and treatment of thromboembolic diseases
    • Turpie AGG. Oral direct Factor Xa inhibitors in development for the prevention and treatment of thromboembolic diseases. Arterioscler Thromb Vasc Biol 2007; 27: 1238-47.
    • (2007) Arterioscler Thromb Vasc Biol , vol.27 , pp. 1238-1247
    • Turpie, A.G.G.1
  • 77
    • 42149172523 scopus 로고    scopus 로고
    • Apixaban, an oral, direct and selective factor Xa inhibitor:, antithrombotic and antihemostatic studies
    • Wong PC, Crain EJ, Xin B, et al. Apixaban, an oral, direct and selective factor Xa inhibitor:, antithrombotic and antihemostatic studies. J Thromb Haemost 2007; 6: 820-9.
    • (2007) J Thromb Haemost , vol.6 , pp. 820-829
    • Wong, P.C.1    Crain, E.J.2    Xin, B.3
  • 78
    • 76749166335 scopus 로고    scopus 로고
    • Assessment of metabolic drug-drug interaction potential of apixaban through cytochrome P450 phenotyping, inhibition, and induction studies
    • Wang L, Zhang D, Raghavan N, et al. assessment of metabolic drug-drug interaction potential of apixaban through cytochrome P450 phenotyping, inhibition, and induction studies. Drug Metab Dispos 2010; 38: 448-58.
    • (2010) Drug Metab Dispos , vol.38 , pp. 448-458
    • Wang, L.1    Zhang, D.2    Raghavan, N.3
  • 79
    • 77649249878 scopus 로고    scopus 로고
    • Apixaban for Reduction In Stroke and Other ThromboemboLic Events in Atrial Fibrillation (ARISTOTLE) trial: Design and rationale
    • Lopes RD, Alexander JH, Al-Khatib SM, et al. Apixaban for Reduction In Stroke and Other ThromboemboLic Events in Atrial Fibrillation (ARISTOTLE) trial: design and rationale. Am Heart J 2010; 159: 331-9.
    • (2010) Am Heart J , vol.159 , pp. 331-339
    • Lopes, R.D.1    Alexander, J.H.2    Al-Khatib, S.M.3
  • 80
    • 77649254746 scopus 로고    scopus 로고
    • Rationale and design of AVERROES: Apixaban vs. acetylsalicylic acid to prevent stroke in atrial fibrillation patients who have failed or are unsuitable forvitamin K antagonist treatment
    • Eikelboom J W, O'Donnell M, Yusuf S, et al. Rationale and design of AVERROES: Apixaban vs. acetylsalicylic acid to prevent stroke in atrial fibrillation patients who have failed or are unsuitable forvitamin K antagonist treatment. Am Heart J 2010; 159: 348-53.
    • (2010) Am Heart J , vol.159 , pp. 348-353
    • Eikelboom, J.W.1    O'Donnell, M.2    Yusuf, S.3
  • 81
    • 79953901937 scopus 로고    scopus 로고
    • What do the RE-LY, AVERROES and ROCKET-AF trials tell us for stroke prevention in atrial fibrillation
    • Ahrens I, Lip GYH, Peter K. What do the RE-LY, AVERROES and ROCKET-AF trials tell us for stroke prevention in atrial fibrillation? Thromb Haemost 2011; 105: 574-8.
    • (2011) Thromb Haemost , vol.105 , pp. 574-578
    • Ahrens, I.1    Lip, G.Y.H.2    Peter, K.3
  • 82
    • 33646158921 scopus 로고    scopus 로고
    • Association between hospital process performance and outcomes among patients with acute coronary syndromes
    • Peterson ED, Roe MT, Mulgund J, et al. Association between hospital process performance and outcomes among patients with acute coronary syndromes. JAMA 2006; 295: 1912-20.
    • (2006) JAMA , vol.295 , pp. 1912-1920
    • Peterson, E.D.1    Roe, M.T.2    Mulgund, J.3
  • 83
    • 45849092207 scopus 로고    scopus 로고
    • Potentiation and priming of platelet activation: A potential target for antiplatelet therapy
    • Gresele P, Falcinelli E, Momi S. Potentiation and priming of platelet activation: a potential target for antiplatelet therapy. Trends Pharmacol Sci 2008; 29: 352-60.
    • (2008) Trends Pharmacol Sci , vol.29 , pp. 352-360
    • Gresele, P.1    Falcinelli, E.2    Momi, S.3
  • 84
    • 0027182792 scopus 로고
    • The protein encoded by a growth arrest specific gene (gas6) is a new member of the vitamin K-dependent proteins related to protein S, a negative co-regulator in the blood coagulation cascade
    • Manfioletti G, Brancolini C, Avanzi G, Schneider C. The protein encoded by a growth arrest specific gene (gas6) is a new member of the vitamin K-dependent proteins related to protein S, a negative co-regulator in the blood coagulation cascade. Mol Cell Biol 1993; 13: 4976-85.
    • (1993) Mol Cell Biol , vol.13 , pp. 4976-4985
    • Manfioletti, G.1    Brancolini, C.2    Avanzi, G.3    Schneider, C.4
  • 85
    • 0035800880 scopus 로고    scopus 로고
    • Matrix metalloproteinase inhibition after myocardial infarction: A new approach to prevent heart failure?
    • Creemers EE, Cleutjens JP, Smits JF, Daemen MJ. Matrix metalloproteinase inhibition after myocardial infarction: a new approach to prevent heart failure? Circ Res 2001; 89: 201-10.
    • (2001) Circ Res , vol.89 , pp. 201-210
    • Creemers, E.E.1    Cleutjens, J.P.2    Smits, J.F.3    Daemen, M.J.4
  • 86
    • 4444283150 scopus 로고    scopus 로고
    • Release of soluble CD40 ligand after platelet activation. Studies on the solubilization phase
    • Otterdal K, Pedersen TM, Solum NO. Release of soluble CD40 ligand after platelet activation. Studies on the solubilization phase. Thromb Res 2004; 114: 167-77.
    • (2004) Thromb Res , vol.114 , pp. 167-177
    • Otterdal, K.1    Pedersen, T.M.2    Solum, N.O.3
  • 87
    • 0035806894 scopus 로고    scopus 로고
    • Increased bleeding tendency and decreased susceptibility to thromboembolism in mice lacking the prostaglandin E2 receptor subtype EP3
    • Ma H, Hara A, Xiao CY, et al. Increased bleeding tendency and decreased susceptibility to thromboembolism in mice lacking the prostaglandin E2 receptor subtype EP3. Circulation 2001; 104: 1176-80.
    • (2001) Circulation , vol.104 , pp. 1176-1180
    • Ma, H.1    Hara, A.2    Xiao, C.Y.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.