Diagnostic value of quantitative PCR for adenovirus detection in stool samples as compared with antigen detection and cell culture in haematopoietic stem cell transplant recipients

Clinical Microbiology and Infection

Volumn 17, Issue 11, 2011, Pages 1674-1680

  Jeulin, H ^a,b   Salmon, A ^a   Bordigoni, P ^a,b   Venard, V ^a,b  

^a CHU NANCY BRABOIS   (France)

^b EA RHEM 4369   (France)

Author keywords

Adenovirus; Haematopoietic stem cell transplant recipients; PCR; Stool samples

Indexed keywords

CIDOFOVIR; RIBAVIRIN; VIRUS DNA;

ADENOVIREMIA; ADENOVIRUS; ADENOVIRUS INFECTION; ADOLESCENT; ADOPTIVE IMMUNOTHERAPY; ADULT; ANTIGEN DETECTION; ANTIVIRAL THERAPY; ARTICLE; BONE MARROW TRANSPLANTATION; CELL CULTURE; CELLULAR IMMUNITY; CHILD; CLINICAL ARTICLE; CORD BLOOD STEM CELL TRANSPLANTATION; DIAGNOSTIC VALUE; DNA EXTRACTION; FECES; FEMALE; GRAFT RECIPIENT; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HIGH RISK PATIENT; HUMAN; INFANT; LEUKOCYTE; MALE; NONHUMAN; PERIPHERAL BLOOD STEM CELL TRANSPLANTATION; POLYMERASE CHAIN REACTION; PRESCHOOL CHILD; PRIORITY JOURNAL; QUANTITATIVE DIAGNOSIS; QUANTITATIVE POLYMERASE CHAIN REACTION; RETROSPECTIVE STUDY; SCHOOL CHILD; TREATMENT DURATION; VIREMIA; VIRUS DETECTION; VIRUS LOAD;

ADENOVIRIDAE;

EID: 80054070909     PISSN: 1198743X     EISSN: 14690691     Source Type: Journal    
DOI: 10.1111/j.1469-0691.2011.03488.x     Document Type: Article

References (26)

1. Feuchtinger T, Lang P, Handgretinger R. Adenovirus infection after allogeneic stem cell transplantation. Leuk Lymphoma 2007; 48: 244-255.
2. Leen AM, Bollard CM, Myers GD, Rooney CM. Adenoviral infections in hematopoietic stem cell transplantation. Biol Blood Marrow Transplant 2006; 12: 243-251.
3. Myers GD, Bollard CM, Wu MF et al. Reconstitution of adenovirus-specific cell-mediated immunity in pediatric patients after hematopoietic stem cell transplantation. Bone Marrow Transplant 2007; 39: 677-686.
4. Bruno B, Gooley T, Hackman RC, Davis C, Corey L, Boeckh M. Adenovirus infection in hematopoietic stem cell transplantation: effect of ganciclovir and impact on survival. Biol Blood Marrow Transplant 2003; 9: 341-352.
5. Chakrabarti S, Collingham KE, Stevens RH, Pillay D, Fegan CD, Milligan DW. Isolation of viruses from stools in stem cell transplant recipients: a prospective surveillance study. Bone Marrow Transplant 2000; 25: 277-282.
6. Hale GA, Heslop HE, Krance RA et al. Adenovirus infection after pediatric bone marrow transplantation. Bone Marrow Transplant 1999; 23: 277-282.
7. van Tol MJ, Kroes AC, Schinkel J et al. Adenovirus infection in paediatric stem cell transplant recipients: increased risk in young children with a delayed immune recovery. Bone Marrow Transplant 2005; 36: 39-50.
8. Bordigoni P, Carret AS, Venard V, Witz F, Le Faou A. Treatment of adenovirus infections in patients undergoing allogeneic hematopoietic stem cell transplantation. Clin Infect Dis 2001; 32: 1290-1297.
9. Leen AM, Rooney CM. Adenovirus as an emerging pathogen in immunocompromised patients. Br J Haematol 2005; 128: 135-144.
10. Gustafson I, Lindblom A, Yun Z et al. Quantification of adenovirus DNA in unrelated donor hematopoietic stem cell transplant recipients. J Clin Virol 2008; 43: 79-85.
11. Zaia J, Baden L, Boeckh MJ et al. Viral disease prevention after hematopoietic cell transplantation. Bone Marrow Transplant 2009; 44: 471-482.
12. Lenaerts L, De Clercq E, Naesens L. Clinical features and treatment of adenovirus infections. Rev Med Virol 2008; 18: 357-374.
13. Leen AM, Myers GD, Bollard CM et al. T-cell immunotherapy for adenoviral infections of stem-cell transplant recipients. Ann N Y Acad Sci 2005; 1062: 104-115.
14. Aissi-Rothe L, Decot V, Venard V et al. Rapid generation of full clinical-grade human antiadenovirus cytotoxic T cells for adoptive immunotherapy. J Immunother 2010; 33: 414-424.
15. Lion T, Kosulin K, Landlinger C et al. Monitoring of adenovirus load in stool by real-time PCR permits early detection of impending invasive infection in patients after allogeneic stem cell transplantation. Leukemia 2010; 24: 706-714.
16. Heim A, Ebnet C, Harste G, Pring-Akerblom P. Rapid and quantitative detection of human adenovirus DNA by real-time PCR. J Med Virol 2003; 70: 228-239.
17. Robin M, Marque-Juillet S, Scieux C et al. Disseminated adenovirus infections after allogeneic hematopoietic stem cell transplantation: incidence, risk factors and outcome. Haematologica 2007; 92: 1254-1257.
18. Symeonidis N, Jakubowski A, Pierre-Louis S et al. Invasive adenoviral infections in T-cell-depleted allogeneic hematopoietic stem cell transplantation: high mortality in the era of cidofovir. Transpl Infect Dis 2007; 9: 108-113.
19. Yusuf U, Hale GA, Carr J et al. Cidofovir for the treatment of adenoviral infection in pediatric hematopoietic stem cell transplant patients. Transplantation 2006; 81: 1398-1404.
20. Paczesny S, Salmon A, Clement L, Venard V, Bordigoni P. Prompt versus preemptive intervention with cidofovir for adenovirus diseases after allogeneic stem cell transplantation: impact on survival in a single center experience of 25 patients. J Pediatr Hematol Oncol 2005; 27: 463.
21. de Pagter AP, Haveman LM, Schuurman R, Schutten M, Bierings M, Boelens JJ. Adenovirus DNA positivity in nasopharyngeal aspirate preceding hematopoietic stem cell transplantation: a very strong risk factor for adenovirus DNAemia in pediatric patients. Clin Infect Dis 2009; 49: 1536-1539.
22. Stock R, Harste G, Madisch I, Heim A. A rapid quantitative PCR-based assay for testing antiviral agents against human adenoviruses demonstrates type specific differences in ribavirin activity. Antiviral Res 2006; 72: 34-41.
23. Chakrabarti S, Collingham KE, Fegan CD, Pillay D, Milligan DW. Adenovirus infections following haematopoietic cell transplantation: is there a role for adoptive immunotherapy? Bone Marrow Transplant 2000; 26: 305-307.
24. Teramura T, Naya M, Yoshihara T, Kanoh G, Morimoto A, Imashuku S. Adenoviral infection in hematopoietic stem cell transplantation: early diagnosis with quantitative detection of the viral genome in serum and urine. Bone Marrow Transplant 2004; 33: 87-92.
25. Heemskerk B, Lankester AC, van Vreeswijk T et al. Immune reconstitution and clearance of human adenovirus viremia in pediatric stem-cell recipients. J Infect Dis 2005; 191: 520-530.
26. Feuchtinger T, Lucke J, Hamprecht K et al. Detection of adenovirus-specific T cells in children with adenovirus infection after allogeneic stem cell transplantation. Br J Haematol 2005; 128: 503-509.