Development of a novel method for triterpenoidal saponins in rat plasma by solid-phase extraction and high-performance liquid chromatography tandem mass spectrometry

Analytical Biochemistry

Volumn 419, Issue 2, 2011, Pages 323-332

  Xu, Huijun ^a   Ji, Xiang ^a   Shi, Xiaowei ^a   Du, Yingfeng ^a   Zhu, Hong ^a   Zhang, Lantong ^a  

^a HEBEI MEDICAL UNIVERSITY   (China)

Author keywords

Liquid chromatography mass spectrometry; Multiswitching monitoring mode; Pharmacokinetics; Pulsatilla chinensis; Solid phase extraction; Triterpenoidal saponins

Indexed keywords

ELECTROSPRAY IONIZATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIGH PRESSURE LIQUID CHROMATOGRAPHY; LIQUIDS; MASS SPECTROMETRY; PHARMACOKINETICS; PHASE SEPARATION; RATS; SAPPHIRE;

LIQUID CHROMATOGRAPHY - MASS SPECTROMETRIES; MONITORING MODE; PULSATILLA CHINENSIS; SOLID-PHASE EXTRACTION; TRITERPENOIDAL SAPONINS;

EXTRACTION;

23 HYDROXYBETULINIC ACID; ANEMOSIDE A3; ANEMOSIDE B4; PLANT EXTRACT; PULSATILLA CHINENSIS EXTRACT; PULSATILLOSIDE B; SAPONIN; SCUTELLARIN; UNCLASSIFIED DRUG;

ACCURACY; ANIMAL EXPERIMENT; ARTICLE; BLOOD SAMPLING; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG STRUCTURE; ELECTROSPRAY MASS SPECTROMETRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MALE; MAXIMUM PLASMA CONCENTRATION; MEDICINAL PLANT; MONITORING; MULTIPLE REACTION MONITORING; NONHUMAN; PRIORITY JOURNAL; PULSATILLA CHINENSIS; QUANTITATIVE ANALYSIS; RAT; SOLID PHASE EXTRACTION; STRUCTURE ANALYSIS; TANDEM MASS SPECTROMETRY; TIME TO MAXIMUM PLASMA CONCENTRATION; VALIDATION STUDY;

PULSATILLA CHINENSIS; RATTUS;

EID: 80054059068     PISSN: 00032697     EISSN: 10960309     Source Type: Journal    
DOI: 10.1016/j.ab.2011.08.045     Document Type: Article

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