Characterization of CD3+CD4-CD8- (double negative) T cells reconstitution in patients following hematopoietic stem-cell transplantation

Transplant Immunology

Volumn 25, Issue 4, 2011, Pages 180-186

  Ye, Haige ^a   Chang, Yingjun ^a   Zhao, Xiangyu ^a   Huang, Xiaojun ^a  

^a PEKING UNIVERSITY PEOPLE S HOSPITAL   (China)

Author keywords

AGVHD; CD3+CD4 CD8 double negative T cells; HSCT; Reconstitution

Indexed keywords

CD19 ANTIGEN; CD28 ANTIGEN; CD3 ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; INTERLEUKIN 2 RECEPTOR ALPHA;

ACUTE GRAFT VERSUS HOST DISEASE; ADULT; ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION; ARTICLE; CD19+ T LYMPHOCYTE; CD3+ CD4- CD8- T LYMPHOCYTE; CD3+ CD8+ CD28- T LYMPHOCYTE; CD4+ CD25+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CHILD; CONTROLLED STUDY; ENGRAFTMENT; FEMALE; HEMATOLOGIC DISEASE; HUMAN; HUMAN CELL; IMMUNITY; LYMPHOCYTE COUNT; LYMPHOCYTE FUNCTION; MAJOR CLINICAL STUDY; MALE; NEUTROPHIL ENGRAFTMENT; PLATELET ENGRAFTMENT; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; RELAPSE; SCHOOL CHILD; SURVIVAL; T LYMPHOCYTE RECONSTITUTION; T LYMPHOCYTE SUBPOPULATION; TRANSPLANTATION TOLERANCE;

ADOLESCENT; ADULT; ANTIGENS, CD3; ANTIGENS, CD4; ANTIGENS, CD8; FEMALE; FOLLOW-UP STUDIES; GRAFT VS HOST DISEASE; HEMATOLOGIC NEOPLASMS; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMANS; MALE; MIDDLE AGED; RECOVERY OF FUNCTION; T-LYMPHOCYTES, REGULATORY; TIME FACTORS; TRANSPLANTATION, HOMOLOGOUS;

EID: 80054056848     PISSN: 09663274     EISSN: 18785492     Source Type: Journal    
DOI: 10.1016/j.trim.2011.08.004     Document Type: Article

References (30)

1. Martin-Antonio B., Granell M., Urbano-Ispizua A. Genomic polymorphisms of the innate immune system and allogeneic stem cell transplantation. Expert Rev Hematol 2010, 3:411-427.
2. Thomson C.W., Lee B.P., Zhang L. Double-negative regulatory T cells: non-conventional regulators. Immunol Res 2006, 35:163-178.
3. Zhang D., Yang W., Degauque N., Tian Y., Mikita A., Zheng X.X. New differentiation pathway for double-negative regulatory T cells that regulates the magnitude of immune responses. Blood 2007, 109:4071-4079.
4. Zhang Z.X., Yang L., Young K.J., DuTemple B., Zhang L. Identification of a previously unknown antigen-specific regulatory T cell and its mechanism of suppression. Nat Med 2000, 6:782-789.
5. Torrealba J.R., Zhou D., Chen W., Zhang L. Double negative T-regulatory cells promote allograft tolerance in a murine semiallogeneic cardiac transplant model. Transplantation 2006, 82:612-613.
6. Chen W., Ford M.S., Young K.J., Zhang L. The role and mechanisms of double negative regulatory T cells in the suppression of immune responses. Cell Mol Immunol 2004, 1:328-335.
7. Ford M.S., Young K.J., Zhang Z., Ohashi P.S., Zhang L. The immune regulatory function of lymphoproliferative double negative T cells in vitro and in vivo. J Exp Med 2002, 196:261-267.
8. McIver Z., Serio B., Dunbar A., O'Keefe C.L., Powers J., Wlodarski M., et al. Double-negative regulatory T cells induce allotolerance when expanded after allogeneic haematopoietic stem cell transplantation. Br J Haematol 2008, 141:170-178.
9. Zhang X.H., Huang X.J., Liu K.Y., Xu L.P., Liu D.H., Chen H., et al. Modified conditioning regimen busulfan-cyclophosphamide followed by allogeneic stem cell transplantation in patients with multiple myeloma. Chin Med J (Engl). 2007, 120:463-468.
10. Huang X.J., Liu D.H., Liu K.Y., Xu L.P., Chen H., Han W., et al. Haploidentical hematopoietic stem cell transplantation without in vitro T-cell depletion for the treatment of hematological malignancies. Bone Marrow Transplant 2006, 38:291-297.
11. Keith MS. Graft-vs-Host Disease. Thomas'Hematopoietic Cell Transplantation.3rd edn. Section 4, 50:635-64.
12. Jiang S.P., Lechler R.I., He X.S., Huang J.F. Regulatory T cells and transplantation tolerance. Hum Immunol 2006, 67:765-776.
13. Waldmann H., Cobbold S. Exploiting tolerance processes in transplantation. Science 2004, 305:209-212.
14. Adeegbe D., Bayer A.L., Levy R.B., Malek T.R. Cutting edge: allogeneic CD4+CD25+Foxp3+ T regulatory cells suppress autoimmunity while establishing transplantation tolerance. J Immunol 2006, 176:7149-7153.
15. Jiang S., Lechler R.I. Regulatory T cells in the control of transplantation tolerance and autoimmunity. Am J Transplant 2003, 3:516-524.
16. Fischer K., Voelkl S., Heymann J., Przybylski G.K., Mondal K., Laumer M., et al. Isolation and characterization of human antigen-specific TCR alpha beta+CD4(-)CD8- double-negative regulatory T cells. Blood 2005, 105:2828-2835.
17. Priatel J.J., Utting O., Teh H.S. TCR/self-antigen interactions drive double-negative T cell peripheral expansion and differentiation into suppressor cells. J Immunol 2001, 167:6188-6194.
18. D'Acquisto F., Crompton T. CD3(+)CD4(-)CD8(-) (double negative) T cells: saviours or villains of the immune response?. Biochem Pharmacol 2011, 82:333-340.
19. Jun H.X., Jun C.Y., Yu Z.X. In vivo induction of T-cell hyporesponsiveness and alteration of immunological cells of bone marrow grafts using granulocyte colony-stimulating factor. Haematologica 2004, 89:1517-1524.
20. Lu D.P., Dong L., Wu T., Huang X.J., Zhang M.J., Han W., et al. Conditioning including antithymocyte globulin followed by unmanipulated HLA-mismatched/haploidentical blood and marrow transplantation can achieve comparable outcomes with HLA-identical sibling transplantation. Blood 2006, 107:3065-3073.
21. Novitzky N., Davison G.M. Immune reconstitution following hematopoietic stem-cell transplantation. Cytotherapy 2001, 3:211-220.
22. Ford M.S., Zhang Z.X., Chen W., Zhang L. Double-negative T regulatory cells can develop outside the thymus and do not mature from CD8+ T cell precursors. J Immunol 2006, 177:2803-2809.
23. Young K.J., DuTemple B., Phillips M.J., Zhang L. Inhibition of graft-versus-host disease by double-negative regulatory T cells. J Immunol 2003, 171:134-141.
24. Zhang Z.X., Stanford W.L., Zhang L. Ly-6A is critical for the function of double negative regulatory T cells. Eur J Immunol 2002, 32:1584-1592.
25. Zhang Z.X., Young K., Zhang L. CD3+CD4-CD8- alphabeta-TCR+T cell as immune regulatory cell. J Mol Med 2001, 79:419-427.
26. Keever-Taylor C.A., Klein J.P., Eastwood D., Bredeson C., Margolis D.A., Burns W.H., et al. Factors affecting neutrophil and platelet reconstitution following T cell-depleted bone marrow transplantation: differential effects of growth factor type and role of CD34(+) cell dose. Bone Marrow Transplant 2001, 27:791-800.
27. Chang Y.J., Xu L.P., Liu D.H., Liu K.Y., Han W., Chen Y.H., et al. The impact of CD34+ cell dose on platelet engraftment in pediatric patients following unmanipulated haploidentical blood and marrow transplantation. Pediatr Blood Cancer 2009, 53:1100-1106.
28. Chang Y.J., Xu L.P., Liu D.H., Liu K.Y., Han W., Chen Y.H., et al. Platelet engraftment in patients with hematologic malignancies following unmanipulated haploidentical blood and marrow transplantation: effects of CD34+ cell dose and disease status. Biol Blood Marrow Transplant 2009, 15:632-638.
29. Yang K., Fan Z.P., Liu Q.F., Zhang Y. Effect of donor CD4+CD25+ regulatory T cells on hematopoietic and immune reconstitution, GVHD and disease-free survival after allogeneic hematopoietic stem cell transplantation. Nan Fang Yi Ke Da Xue Xue Bao 2008, 28:537-541.
30. Ma Y., He K.M., Garcia B., Min W., Jevnikar A., Zhang Z.X. Adoptive transfer of double negative T regulatory cells induces B-cell death in vivo and alters rejection pattern of rat-to-mouse heart transplantation. Xenotransplantation 2008, 15:56-63.