Colonization and infection by colistin-resistant Gram-negative bacteria in a cohort of critically ill patients

Clinical Microbiology and Infection

Volumn 17, Issue 11, 2011, Pages

  Kontopidou, F ^a   Plachouras, D ^a   Papadomichelakis, E ^a   Koukos, G ^a   Galani, I ^a   Poulakou, G ^a   Dimopoulos, G ^a   Antoniadou, A ^a   Armaganidis, A ^a   Giamarellou, H ^a,b  

^a UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

^b HYGEIA HOSPITAL   (Greece)

Author keywords

Colistin resistance; Colonization; Intensive care; Klebsiella pneumoniae; Multiresistant gram negative bacteria

Indexed keywords

CARBAPENEM; CEFTAZIDIME; COLISTIN; IMIPENEM; PIPERACILLIN PLUS TAZOBACTAM;

ACINETOBACTER BAUMANNII; ADULT; AGED; ANTIBIOTIC RESISTANCE; ANTIBIOTIC THERAPY; APACHE; ARTICLE; BACTERIAL COLONIZATION; BACTERIAL GROWTH; BACTERIAL STRAIN; BACTERIAL VIRULENCE; BACTERIUM CULTURE; BACTERIUM ISOLATE; BLOODSTREAM INFECTION; COHORT ANALYSIS; COLISTIN RESISTANT GRAM NEGATIVE BACTERIUM; CRITICALLY ILL PATIENT; DISEASE ASSOCIATION; ENTEROBACTER AEROGENES; ENTEROBACTERIACEAE; EPSILOMETER TEST; ESCHERICHIA COLI; FECES; FEMALE; GRAM NEGATIVE BACTERIUM; GRAM NEGATIVE INFECTION; HUMAN; INFECTION RISK; INTENSIVE CARE UNIT; KLEBSIELLA PNEUMONIAE; LENGTH OF STAY; LUNG FLUID; MAJOR CLINICAL STUDY; MALE; MICROFLORA; MINIMUM INHIBITORY CONCENTRATION; MORGANELLA MORGANII; MULTIDRUG RESISTANCE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEUS MIRABILIS; PROVIDENCIA STUARTII; PSEUDOMONAS AERUGINOSA; RECTUM; REPETITIVE CHROMOSOMAL ELEMENTS POLYMERASE CHAIN REACTION; RESPIRATORY SYSTEM; RETROSPECTIVE STUDY; RISK ASSESSMENT; SERRATIA MARCESCENS; SKIN INFECTION; SOFT TISSUE INFECTION; TREATMENT DURATION; URINE; VENTILATOR ASSOCIATED PNEUMONIA;

ENTEROBACTERIACEAE; KLEBSIELLA PNEUMONIAE; NEGIBACTERIA;

EID: 80054056416     PISSN: 1198743X     EISSN: 14690691     Source Type: Journal    
DOI: 10.1111/j.1469-0691.2011.03649.x     Document Type: Article

References (13)

1. Li J, Nation RL, Turnidge JD et al. Colistin: the re-emerging antibiotic for multidrug-resistant Gram-negaive bacterial infections. Lancet Infect Dis 2006; 6: 589-601.
2. Horan TC, Andrus M, Dudeck MA. CDC/NHSN Surveillance definition of health-care associated infection and criteria for specific types of infection in the acute care setting. Am J Infect Control 2008; 36: 309-332.
3. Papadomichelakis E, Kontopidou F, Antoniadou A et al. Screening for resistant gram-negative microorganisms to guide empiric therapy of subsequent infection. Intensive Care Med 2008; 34: 2169-2175.
4. Galani I, Kontopidou F, Souli M et al. Colistin susceptibility testing by Etest and disk diffusion methods. Int J Antimicrob Agents 2008; 31: 434-439.
5. European Committee on Antimicrobial Susceptibility Testing, Clinical breakpoints v1.0. Available at: (accessed 21st December 2009).
6. Antoniadou A, Kontopidou F, Poulakou G et al. Colistin-resistant isolates of Klebsiella pneumoniae emerging in intensive care unit patients: first report of a multiclonal cluster. J Antimicrob Chemother 2007; 59: 786-790.
7. Littlewood JM, Koch C, Lambert PA et al. A ten year review of colomycin. Respir Med 2000; 94: 632-640.
8. Matthaiou DK, Michalopoulos A, Rafailidis PI et al. Risk factors associated with the isolation of colistin-resistant gram-negative bacteria: a matched case-control study. Crit Care Med 2008; 36: 807-811.
9. Zarkotou O, Pournaras S, Voulgari E et al. Risk factors and outcomes associated with acquisition of colistin-resistant KPC-producing Klebsiella pneumoniae: a matched case-control study. J Clin Microbiol 2010; 48: 2271-2274.
10. Kontopoulou K, Protonotariou E, Vasilakos K et al. Hospital outbreak caused by Klebsiella pneumoniae producing KPC-2 beta-lactamase resistant to colistin. J Hosp Infect 2010; 76: 70-73.
11. Marchaim D, Chopra T, Pogue JM et al. Outbreak of colistin-resistant, carbapenem-resistant Klebsiella pneumoniae in metropolitan Detroit, Michigan. Antimicrob Agents Chemother 2011; 55: 593-599.
12. Son JS, Chung DR, Peck KR, Ko KS, Song JH. Nonclonal emergence of colistin-resistant Klebsiella pneumoniae isolates from blood samples in South Korea. Antimicrob Agents Chemother 2010; 54: 560-562.
13. Mentzelopoulos SD, Pratikaki M, Platsouka E et al. Prolonged use of carbapenems and colistin predisposes to ventilator-associated pneumonia by pandrug-resistant Pseudomonas aeruginosa. Intensive Care Med 2007; 33: 1524-1532.