Levamisole binding sites in Haemonchus contortus

International Journal for Parasitology

Volumn 28, Issue 3, 1998, Pages 413-418

  Moreno Guzman M J ^a   Coles, G C ^b   Jimenez Gonzalez A ^a   Criado Fornelio, A ^a   Ros Moreno, R M ^a   Rodriguez Caabeiro F ^a  

^a UNIVERSITY OF ALCALÁ   (Spain)

^b Langford House ^*  (United Kingdom)

Author keywords

Anthelmintic resistance; Cholinergic receptor; Haemonchus contortus; Levamisole

Indexed keywords

ALPHA BUNGAROTOXIN; CHOLINERGIC RECEPTOR; LEVAMISOLE; PROTEIN;

ANIMAL TISSUE; ARTICLE; BINDING SITE; DISSOCIATION CONSTANT; DRUG BINDING; DRUG RESISTANCE; HAEMONCHUS CONTORTUS; NONHUMAN; RECEPTOR DENSITY;

ANIMALS; ANTINEMATODAL AGENTS; BINDING SITES; BINDING, COMPETITIVE; BUNGAROTOXINS; CHOLINERGIC ANTAGONISTS; DRUG RESISTANCE; FECES; HAEMONCHUS; LEVAMISOLE; PARASITE EGG COUNT; RECEPTORS, CHOLINERGIC; SHEEP;

ANIMALIA; HAEMONCHUS CONTORTUS; NEMATODA;

EID: 0032033841     PISSN: 00207519     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0020-7519(97)00198-7     Document Type: Article

References (15)

1. [1] Waller PJ, Dash KM, Barger IA, Le Jambre LF, Plant J. Anthelmintic resistance in nematode parasites of sheep: learning from Australian experience. Vet Rec 1995;136: 411-413.
2. [2] Hong C, Hunt KR, Coles GC. Ocurrence of anthelmintic resistant nematodes on sheep farms in England and goat farms in England and Wales. Vet Rec 1996;139:83-86.
3. [3] Kwa MSG, Veenstra JG, Roos MH. Molecular characterisation of β-tubulin genes present in benzimidazole resistant populations of Haemonchus contortus. Mol Biochem Parasitol 1993;60:133-144.
4. [4] Harrow ID, Gration KAF. Mode of action of the anthelmintics morantel, pyrantel and levamisole on the muscle cell membrane of the nematode Ascaris suum. Pest Sci 1985;16:662-672.
5. [5] Martin RJ, Pennington AJ, Duittoz AH, Robertson S, Kusel JR. The physiology and pharmacology of neuromuscular transmission in the nematode parasite Ascaris suum. Parasitology 1991;102:541-558.
6. [6] Lewis JA, Wu C-H, Berg H, Levine JH. The genetics of levamisole resistance in the nematode Caenorhabditis elegans. Genetics 1980;95:905-928.
7. [7] Lewis JA, Wu C-H. Levine JH, Berg H. Levamisole-resistant mutants of the nematode Caenorhabditis elegans appear to lack pharmacological acetylcholine receptors. Neuroscience 1980;5:967-989.
8. [8] Lewis JA, Fleming JT, McLafferty S, Murphy H, Wu C-H. The levamisole receptor, a cholinergic receptor of the nematode Caenorhabditis elegans. Mol Pharmacol 1987;31:185-193.
9. [9] Sangster NC, Riley FL, Collins GH. Investigation of the mechanism of levamisole resistance in trichostrongylid nematodes of sheep. Int J Parasitol 1988;8:813-818.
10. [10] Sangster NC, Davis CW, Collins G.H.. Effects of cholinergic drugs on longitudinal contraction in levamisole-susceptible and -resistant Haemonchux contortus. Int J Parasitol 1991;21:689-695.
11. [11] Sangster NC, Bjorn H. Levamisole resistance in Haemonchus contortus selected at different stages of infection. Int J Parasitol 1995;25:343-348.
12. [12] Hembry FG, Miller JE, Sims SD, Rodriguez S, Stagg LC. Efficacy of repeated doses of levamisole, morantel, fenbendazole and ivermectin against gastrointestinal nematodes in ewes. Am J Vet Res 1986;47:1677-1679.
13. [13] MAFF. Manual of veterinary parasitological techniques. Reference book 418. London: HMSO, 1986.
14. [14] Lowry OH, Rosebrough N, Farr A, Randall R. Protein measurement with the Folin phenol reagent. J Biol Chem 1951;193:265-275.
15. [15] Schaeffer JM, Haines HW. Avermectin binding in Caenorhabditis elegans. A two-state model for the avermectin binding site. Biochem Pharmacol 1989;14:2329-2338.