Dynamic life of a skin keratinocyte: An intimate tryst with the master regulator p63

Indian Journal of Experimental Biology

Volumn 49, Issue 10, 2011, Pages 721-731

  Romano, Rose Anne ^a   Sinha, Satrajit ^a  

^a UNIVERSITY AT BUFFALO   (United States)

Author keywords

Np63; Hair follicles; Keratinocyte; P53; Skin; Transcription; Transgenic animal models

Indexed keywords

KERATIN; PHOSPHOPROTEIN; TP63 PROTEIN, HUMAN; TRANSACTIVATOR PROTEIN; TRANSCRIPTION FACTOR; TRP63 PROTEIN, MOUSE; TUMOR SUPPRESSOR PROTEIN;

ANIMAL; CYTOLOGY; EPIDERMIS; GENETICS; HAIR FOLLICLE; HUMAN; KERATINOCYTE; METABOLISM; MOUSE; PHYSIOLOGY; REVIEW; SKIN;

ANIMALS; EPIDERMIS; HAIR FOLLICLE; HUMANS; KERATINOCYTES; KERATINS; MICE; PHOSPHOPROTEINS; SKIN; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS; TUMOR SUPPRESSOR PROTEINS;

ANIMALIA; MUS;

EID: 80054030583     PISSN: 00195189     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (56)

1. Blanpain C & Fuchs E. Epidermal homeostasis: a balancing act of stem cells in the skin, Nat Rev Mol Cell Biol, 10 (2009) 207.
2. Koster M I & Roop D R, Mechanisms regulating epithelial stratification, Annu Rev Cell Dev Biol, 23 (2007) 93.
3. Fuchs E, Scratching the surface of skin development, Nature, 445 (2007) 834.
4. Candi E, Schmidt R & Melino G, The cornified envelope: a model of cell death in the skin, Nat Rev Mol Cell Biol, 6 (2005) 328.
5. Lechler T & Fuchs E, Asymmetric cell divisions promote stratification and differentiation of mammalian skin, Nature, 437 (2005) 275.
6. Watt F M, Lo Celso C & Silva-Vargas V, Epidermal stem cells: an update, Curr Opin Genet Dev, 16 (2006) 518.
7. Yang A, Kaghad M, Wang Y, Gillett E, Fleming M D, Dotsch V, Andrews N C, Caput D & McKeon F, p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities. Mol Cell, 2 (1998) 305.
8. King K E & Weinberg W C, P63: defining roles in morphogenesis, homeostasis, and neoplasia of the epidermis, Mol Carcinog, 46 (2007) 716.
9. Barbieri C E & Pietenpol J A, p63 and epithelial biology, Exp Cell Res, 312 (2006) 695.
10. Mangiulli M, Valletti A, Caratozzolo M F, Tullo A, Sbisa E, Pesole G & D'Erchia A M, Identification and functional characterization of two new transcriptional variants of the human p63 gene, Nucleic acids research, 37 (2009) 6092.
11. Beyer U & Dobbelstein M, Non-hominid TP63 lacks retroviral LTRs but contains a novel conserved upstream exon, Cell cycle, 10 (2011)
12. Candi E, Cipollone R, Rivetti di Val Cervo P, Gonfloni S, Melino G & Knight R, p63 in epithelial development, Cell Mol Life Sci, 65 (2008) 3126.
13. Crum C P & McKeon F D, p63 in epithelial survival, germ cell surveillance, and neoplasia, Annu Rev Pathol, 5 (2010) 349.
14. Koster M I. p63 in skin development and ectodermal dysplasias, J Invest Dermatol, 130 (2010) 2352.
15. Laurikkala J, Mikkola M L, James M, Tummers M, Mills A A & Thesleff I, p63 regulates multiple signalling pathways required for ectodermal organogenesis and differentiation, Development, 133 (2006) 1553.
16. Romano R A, Ortt K, Birkaya B, Smalley K & Sinha S, An active role of the DeltaN isoform of p63 in regulating basal keratin genes K5 and K14 and directing epidermal cell fate, PLoS One, 4 (2009) e5623.
17. Suh E K, Yang A, Kettenbach A, Bamberger C, Michaelis A H, Zhu Z, Elvin J A, Bronson R T, Crum C P & McKeon F, p63 protects the female germ line during meiotic arrest, Nature, 444 (2006) 624.
18. Mills A A, Zheng B, Wang X J, Vogel H, Roop D R & Bradley A, p63 is a p53 homologue required for limb and epidermal morphogenesis, Nature 398 (1999) 708.
19. Yang A, Schweitzer R, Sun D, Kaghad M, Walker N, Bronson R T, Tabin C, Sharpe A, Caput D, Crum C & McKeon F, p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development, Nature, 398 (1999) 714.
20. Koster M I, Kim S, Mills A A, DeMayo F J & Roop D R, p63 is the molecular switch for initiation of an epithelial stratification program, Genes Dev, 18 (2004) 126.
21. Truong A B, Kretz M, Ridky T W, Kimmel R & Khavari P A, p63 regulates proliferation and differentiation of developmentally mature keratinocytes, Genes Dev 20 (2006) 3185.
22. De Rosa L, Antonini D, Ferone G, Russo M T, Yu P B, Han R & Missero C, p63 Suppresses non-epidermal lineage markers in a bone morphogenetic protein-dependent manner via repression of Smad7, J Biol Chem, 284 (2009) 30574.
23. Shalom-Feuerstein R, Lena A M, Zhou H, De La Forest D.S, Van Bokhoven H, Candi E, Melino G & Aberdam D, DeltaNp63 is an ectodermal gatekeeper of epidermal morphogenesis. Cell Death Differ, 18 (2011) 887.
24. Su X, Paris M, Gi Y J, Tsai K Y, Cho M S, Lin Y L, Biernaskie J A, Sinha S, Prives C, Pevny L H, Miller F D & Flores E R, TAp63 prevents premature aging by promoting adult stem cell maintenance, Cell Stem Cell, 5 (2009) 64.
25. Guo X, Keyes W M, Papazoglu C, Zuber J, Li W, Lowe S W, Vogel H & Mills A A. TAp63 induces senescence and suppresses tumorigenesis in vivo, Nature cell biology, 11 (2009) 1451.
26. Rinne T, Brunner H G & van Bokhoven H. p63-associated disorders, Cell cycle, 6 (2007) 262.
27. Candi E, Rufini A, Terrinoni A, Dinsdale D, Ranalli M, Paradisi A, De Laurenzi V, Spagnoli L G, Catani M V, Ramadan S, Knight R A & Melino G, Differential roles of p63 isoforms in epidermal development: selective genetic complementation in p63 null mice, Cell Death Differ, 13 (2006) 1037.
28. Romano R A, Birkaya B & Sinha S, A functional enhancer of keratin14 is a direct transcriptional target of deltaNp63, J Invest Dermatol, 127 (2007) 1175.
29. Kurita T, Mills A A & Cunha G R, Roles of p63 in the diethylstilbestrol-induced cervicovaginal adenosis, Development, 131 (2004) 1639.
30. Kurita T, Cunha G R, Robboy S J, Mills A A & Medina R T, Differential expression of p63 isoforms in female reproductive organs, Mech Dev, 122 (2005) 1043.
31. Cheng W, Jacobs W B, Zhang J J, Moro A, Park J H, Kushida M, Qiu W, Mills A A & Kim P C, DeltaNp63 plays an anti-apoptotic role in ventral bladder development, Development,133 (2006) 4783.
32. Bakkers J, Hild M, Kramer C, Furutani-Seiki M & Hammerschmidt M, Zebrafish DeltaNp63 is a direct target of Bmp signaling and encodes a transcriptional repressor blocking neural specification in the ventral ectoderm, Dev Cell, 2 (2002) 617.
33. Medawar A, Virolle T, Rostagno P, de la Forest-Divonne S, Gambaro K, Rouleau M & Aberdam D, DeltaNp63 is essential for epidermal commitment of embryonic stem cells. PLoS One 3, (2008) e3441.
34. Schneider M R, Schmidt-Ullrich R & Paus R, The hair follicle as a dynamic miniorgan. Curr Biol, 19 (2009) R132.
35. Romano R A, Smalley K, Liu S & Sinha S, Abnormal hair follicle development and altered cell fate of follicular keratinocytes in transgenic mice expressing DeltaNp63alpha, Development, 137 (2010) 1431.
36. Senoo M, Pinto F, Crum C P & McKeon F, p63 Is essential for the proliferative potential of stem cells in stratified epithelia, Cell, 129 (2007) 523.
37. Romano R A, Birkaya B & Sinha S, Defining the regulatory elements in the proximal promoter of DeltaNp63 in keratinocytes: Potential roles for Sp1/Sp3, NF-Y, and p63, J Invest Dermatol, 126 (2006) 1469.
38. Borrelli S, Testoni B, Callari M, Alotto D, Castagnoli C, Romano R A, Sinha S, Vigano A M & Mantovani R, Reciprocal regulation of p63 by C/EBP delta in human keratinocytes, BMC Mol Biol, 8 (2007) 85.
39. Pozzi S, Boergesen M, Sinha S, Mandrup S & Mantovani R, Peroxisome proliferator-activated receptor-alpha is a functional target of p63 in adult human keratinocytes, J Invest Dermatol, 129 (2009) 2376.
40. Fontemaggi G, Gurtner A, Damalas A, Costanzo A, Higashi Y, Sacchi A, Strano S, Piaggio G & Blandino G. deltaEF1 repressor controls selectively p53 family members during differentiation, Oncogene, 24 (2005) 7273.
41. Nguyen B C, Lefort K, Mandinova A, Antonini D, Devgan V, Della Gatta G, Koster M I, Zhang Z, Wang J, Tommasi di Vignano A, Kitajewski J, Chiorino G, Roop D R, Missero C & Dotto G P, Cross-regulation between Notch and p63 in keratinocyte commitment to differentiation, Genes Dev, 20 (2006) 1028.
42. Fukunishi N, Katoh I, Tomimori Y, Tsukinoki K, Hata R, Nakao A, Ikawa Y & Kurata S. Induction of DeltaNp63 by the newly identified keratinocyte-specific transforming growth factor beta Signaling Pathway with Smad2 and IkappaB Kinase alpha in squamous cell carcinoma, Neoplasia, 12 (2010) 969.
43. Harmes D C, Bresnick E, Lubin E A, Watson J K, Heim K E, Curtin J C, Suskind A M, Lamb J & DiRenzo J. Positive and negative regulation of deltaN-p63 promoter activity by p53 and deltaN-p63-alpha contributes to differential regulation of p53 target genes, Oncogene, 22 (2003) 7607.
44. Waltermann A, Kartasheva N N & Dobbelstein M. Differential regulation of p63 and p73 expression, Oncogene, 22 (2003) 5686.
45. Chu W K, Dai P M, Li H L & Chen J K. Transcriptional activity of the DeltaNp63 promoter is regulated by STAT3, J Biol Chem, 283 (2008) 7328.
46. Wu G, Osada M, Guo Z, Fomenkov A, Begum S, Zhao M, Upadhyay S, Xing M, Wu F, Moon C, Westra W H, Koch W M, Mantovani R, Califano J A, Ratovitski E, Sidransky D & Trink B, DeltaNp63alpha up-regulates the Hsp70 gene in human cancer, Cancer Res, 65 (2005) 758.
47. Antonini D, Rossi B, Han R, Minichiello A, Di Palma T, Corrado M, Banfi S, Zannini M, Brissette J L & Missero C, An autoregulatory loop directs the tissue-specific expression of p63 through a long-range evolutionarily conserved enhancer, Mol Cell Biol, 26 (2006) 3308.
48. Sinha S, Degenstein L, Copenhaver C & Fuchs E, Defining the regulatory factors required for epidermal gene expression, Mol Cell Biol, 20 (2000) 2543.
49. Sinha S & Fuchs E, Identification and dissection of an enhancer controlling epithelial gene expression in skin, Proc Natl Acad Sci U S A, 98 (2001) 2455.
50. Lena A M, Shalom-Feuerstein R, Rivetti di Val Cervo P, Aberdam D, Knight R A, Melino G & Candi E, miR-203 represses 'stemness' by repressing DeltaNp63, Cell Death Differ, 15 (2008) 1187.
51. Yi R, Poy M N, Stoffel M & Fuchs E, A skin microRNA promotes differentiation by repressing 'stemness', Nature, 452 (2008) 225.
52. Rossi M, Aqeilan R I, Neale M, Candi E, Salomoni P, Knight R A, Croce C M & Melino G. The E3 ubiquitin ligase Itch controls the protein stability of p63, Proc Natl Acad Sci U S A, 103 (2006) 12753.
53. Vivo M, Di Costanzo A, Fortugno P, Pollice A, Calabro V & La Mantia G, Downregulation of DeltaNp63alpha in keratinocytes by p14ARF-mediated SUMO-conjugation and degradation, Cell Cycle, 8 (2009) 3537.
54. Di Costanzo A, Festa L, Duverger O, Vivo M, Guerrini L, La Mantia G, Morasso M I & Calabro V, Homeodomain protein Dlx3 induces phosphorylation-dependent p63 degradation, Cell Cycle, 8 (2009) 1185.
55. Li Y, Peart M J & Prives C, Stxbp4 regulates DeltaNp63 stability by suppression of RACK1-dependent degradation, Mol Cell Biol, 29 (2009) 3953.
56. Zhang J, Jun Cho S & Chen X, RNPC1, an RNA-binding protein and a target of the p53 family, regulates p63 expression through mRNA stability, Proc Natl Acad Sci U S A, 107 (2010) 9614.