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Volumn 705, Issue , 2011, Pages 669-678

Human KDN (deaminated neuraminic acid) and its elevated expression in cancer cells: Mechanism and significance

Author keywords

Cancer; Deaminated neuraminic acid; KDN

Indexed keywords

2 KETO 3 DEOXY DEXTRO GLYCERO DEXTRO GALACTO NONONIC ACID; MANNOSE; NEURAMINIC ACID; SIALIC ACID SYNTHASE; SYNTHETASE; UNCLASSIFIED DRUG; 2 KETO 3 DEOXY GLYCERO GALACTO NONONIC ACID 9 PHOSPHATE SYNTHETASE; 2-KETO-3-DEOXY-GLYCERO-GALACTO-NONONIC ACID 9-PHOSPHATE SYNTHETASE; BIOLOGICAL MARKER; GLYCOCONJUGATE; LYASE; N ACETYLNEURAMINATE SYNTHASE; N-ACETYLNEURAMINATE SYNTHASE; NEURAMINIC ACID DERIVATIVE;

EID: 80054023440     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4419-7877-6_35     Document Type: Conference Paper
Times cited : (5)

References (34)
  • 1
    • 0022978138 scopus 로고
    • A naturally occurring deaminated neuraminic acid, 3-deoxy-D-glycero-D- galacto-nonulosonic acid (KDN). Its unique occurrence at the nonreducing ends of oligosialyl chains in polysialoglycoprotein of rainbow trout eggs
    • Nadano D, Iwasaki M, Endo S, Kitajima K, Inoue S, Inoue Y (1986) A naturally occurring deaminated neuraminic acid, 3-deoxy-D-glycero-D-galacto- nonulosonic acid (KDN). Its unique occurrence at the nonreducing ends of oligosialyl chains in polysialoglycoprotein of rainbow trout eggs. J Biol Chem 261:11550-11557
    • (1986) J Biol Chem , vol.261 , pp. 11550-11557
    • Nadano, D.1    Iwasaki, M.2    Endo, S.3    Kitajima, K.4    Inoue, S.5    Inoue, Y.6
  • 2
    • 84863676218 scopus 로고    scopus 로고
    • KDN (deaminated neuraminic acid): Dreamful past and exciting future of the newest member of the sialic acid family
    • Inoue S, Kitajima K (2006) KDN (deaminated neuraminic acid): dreamful past and exciting future of the newest member of the sialic acid family. Glycoconj J 23:277-290
    • (2006) Glycoconj J , vol.23 , pp. 277-290
    • Inoue, S.1    Kitajima, K.2
  • 3
    • 0017665490 scopus 로고
    • Antigen of "serum sickness" type of het-erophile antibodies in human sera: Identification as gangliosides with N-glycolylneuraminic acid
    • Higashi H, Naiki M, Matsuo S, Okouchi K (1977) Antigen of "serum sickness" type of het-erophile antibodies in human sera: identification as gangliosides with N-glycolylneuraminic acid. Biochem Biophys Res Comm 79:388-305
    • (1977) Biochem Biophys Res Comm , vol.79 , pp. 388-305
    • Higashi, H.1    Naiki, M.2    Matsuo, S.3    Okouchi, K.4
  • 4
    • 0029780695 scopus 로고    scopus 로고
    • Identification of 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN, deamino-neuraminic acid) residues in mammalian tissues and human lung carcinoma cells. Chemical evidence of the occurrence of KDN glycoconjugates in mammals
    • Inoue S, Kitajima K, Inoue Y (1996) Identification of 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN, deamino-neuraminic acid) residues in mammalian tissues and human lung carcinoma cells. Chemical evidence of the occurrence of KDN glycoconjugates in mammals. J Biol Chem 271:24341-24344
    • (1996) J Biol Chem , vol.271 , pp. 24341-24344
    • Inoue, S.1    Kitajima, K.2    Inoue, Y.3
  • 5
    • 0004152761 scopus 로고    scopus 로고
    • New findings in KDN glycobiology: From lower vertebrates to human
    • Lee YC, Inoue Y, Troy FA (eds Gakushin, Osaka
    • Inoue S, Inoue Y (1999) New findings in KDN glycobiology: from lower vertebrates to human. In: Lee YC, Inoue Y, Troy FA (eds) Sialobiology and other novel forms of glycosyla-tion. Gakushin, Osaka, pp 57-67
    • (1999) Sialobiology and Other Novel Forms of Glycosyla-tion , pp. 57-67
    • Inoue, S.1    Inoue, Y.2
  • 6
    • 0032538423 scopus 로고    scopus 로고
    • Identification of free deaminated sialic acid (2-keto-3-deoxy-D-glycero- D-galacto-nononic acid) in human red blood cells and its elevated expression in fetal cord red blood cells and ovarian cancer cells
    • Inoue S, Lin SL, Chang T, Wu SH, Yao CW, Chu TY, Troy FA, Inoue Y (1998) Identification of free deaminated sialic acid (2-keto-3-deoxy-D-glycero-D- galacto-nononic acid) in human red blood cells and its elevated expression in fetal cord red blood cells and ovarian cancer cells. J Biol Chem 273:27199-27204
    • (1998) J Biol Chem , vol.273 , pp. 27199-27204
    • Inoue, S.1    Lin, S.L.2    Chang, T.3    Wu, S.H.4    Yao, C.W.5    Chu, T.Y.6    Troy, F.A.7    Inoue, Y.8
  • 8
    • 0024391058 scopus 로고
    • Biosynthesis of W-glycolylneuraminic acid. The primary site of hydroxylation of N-acetylneuraminic acid is the cytosolic sugar nucleotide pool
    • Muchmore EA, Milewski M, Varki A, Diaz S (1989) Biosynthesis of W-glycolylneuraminic acid. The primary site of hydroxylation of N-acetylneuraminic acid is the cytosolic sugar nucleotide pool. J Biol Chem 264:20216-20223
    • (1989) J Biol Chem , vol.264 , pp. 20216-20223
    • Muchmore, E.A.1    Milewski, M.2    Varki, A.3    Diaz, S.4
  • 9
    • 0023824137 scopus 로고
    • The biosynthesis of W-glycolylneurminic acid occurs by hydroxyla-tion of the CMP-glycoside of W-acetylneuraminic acid
    • Shaw L, Schauer R (1988) The biosynthesis of W-glycolylneurminic acid occurs by hydroxyla-tion of the CMP-glycoside of W-acetylneuraminic acid. Biol Chem Hoppe-Seyler 369:477-486
    • (1988) Biol Chem Hoppe-Seyler , vol.369 , pp. 477-486
    • Shaw, L.1    Schauer, R.2
  • 10
    • 0033551826 scopus 로고    scopus 로고
    • Biosynthesis of KDN (2-keto-3-deoxy-D-glycero-D-galacto-nononic acid). Identification and characterization of a KDN-9-phosphate synthetase activity from trout testis
    • Angata T, Nakata D, Matsuda T, Kitajima K, Troy FA II (1999) Biosynthesis of KDN (2-keto-3-deoxy-D-glycero-D-galacto-nononic acid). Identification and characterization of a KDN-9-phosphate synthetase activity from trout testis. J Biol Chem 274:22949-22956
    • (1999) J Biol Chem , vol.274 , pp. 22949-22956
    • Angata, T.1    Nakata, D.2    Matsuda, T.3    Kitajima, K.4    Troy, F.A.I.I.5
  • 11
    • 0033873907 scopus 로고    scopus 로고
    • Molecular cloning and expression of the mouse W-acetylneuraminic acid 9-phosphate synthase which does not have deaminon-euraminic acid (KDN) 9-phosphate synthase activity
    • Nakata D, Close BE, Colley KJ, Matsuda T, Kitajima K (2000) Molecular cloning and expression of the mouse W-acetylneuraminic acid 9-phosphate synthase which does not have deaminon-euraminic acid (KDN) 9-phosphate synthase activity. Biochem Biophys Res Comm 273:642-648
    • (2000) Biochem Biophys Res Comm , vol.273 , pp. 642-648
    • Nakata, D.1    Close, B.E.2    Colley, K.J.3    Matsuda, T.4    Kitajima, K.5
  • 12
    • 0014011699 scopus 로고
    • The sialic acids VII. N-acylmannosamine kinase from rat liver
    • Kundig W, Ghosh S, Roseman S (1966) The sialic acids VII. N-acylmannosamine kinase from rat liver. J Biol Chem 241:5619-5626
    • (1966) J Biol Chem , vol.241 , pp. 5619-5626
    • Kundig, W.1    Ghosh, S.2    Roseman, S.3
  • 13
    • 0034625409 scopus 로고    scopus 로고
    • Cloning and expression of the human W-acetylneuraminic acid phosphate synthase gene with 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid biosynthetic ability
    • Lawrence SM, Huddleston KA, Pitts LR, Nguyen N, Lee YC, Vann WF, Coleman TA, Betenbaugh MJ (2000) Cloning and expression of the human W-acetylneuraminic acid phosphate synthase gene with 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid biosynthetic ability. J Biol Chem 275:17869-17877
    • (2000) J Biol Chem , vol.275 , pp. 17869-17877
    • Lawrence, S.M.1    Huddleston, K.A.2    Pitts, L.R.3    Nguyen, N.4    Lee, Y.C.5    Vann, W.F.6    Coleman, T.A.7    Betenbaugh, M.J.8
  • 14
    • 0033517095 scopus 로고    scopus 로고
    • Elevated expression of free deaminon-euraminic acid in mammalian cells cultured in mannose-rich media
    • Angata T, Nakata D, Matsuda T, Kitajima K (1999) Elevated expression of free deaminon-euraminic acid in mammalian cells cultured in mannose-rich media. Biochem Biophys Res Comm 261:326-331
    • (1999) Biochem Biophys Res Comm , vol.261 , pp. 326-331
    • Angata, T.1    Nakata, D.2    Matsuda, T.3    Kitajima, K.4
  • 15
    • 84863704420 scopus 로고    scopus 로고
    • Oral ingestion of mannose alters the expression level of deaminoneuraminic acid (KDN) in mouse organs
    • Go S, Sato C, Furuhata K, Kitajima K (2006) Oral ingestion of mannose alters the expression level of deaminoneuraminic acid (KDN) in mouse organs. Glycoconj J 23:411-421
    • (2006) Glycoconj J , vol.23 , pp. 411-421
    • Go, S.1    Sato, C.2    Furuhata, K.3    Kitajima, K.4
  • 16
    • 33746868364 scopus 로고    scopus 로고
    • Identification and partial characterization of soluble and membrane-bound KDN (deaminoneuraminic acid)-glycoproteins in human ovarian teratocarcinoma PA-1, and enhanced expression of free and bound KDN in cells cultured in mannose-rich media
    • Inoue S, Poongodi GL, Suresh N, Chang T, Inoue Y (2006) Identification and partial characterization of soluble and membrane-bound KDN (deaminoneuraminic acid)-glycoproteins in human ovarian teratocarcinoma PA-1, and enhanced expression of free and bound KDN in cells cultured in mannose-rich media. Glycoconj J 23:401-410
    • (2006) Glycoconj J , vol.23 , pp. 401-410
    • Inoue, S.1    Poongodi, G.L.2    Suresh, N.3    Chang, T.4    Inoue, Y.5
  • 19
    • 34247104697 scopus 로고    scopus 로고
    • Hypoxia-enhanced expression of free deaminoneuraminic acid in human cancer cells
    • Go S, Sato C, Yin J, Kannagi R, Kitajima K (2007) Hypoxia-enhanced expression of free deaminoneuraminic acid in human cancer cells. Biochem Biophys Res Comm 357:537-542
    • (2007) Biochem Biophys Res Comm , vol.357 , pp. 537-542
    • Go, S.1    Sato, C.2    Yin, J.3    Kannagi, R.4    Kitajima, K.5
  • 20
    • 0025886960 scopus 로고
    • Expression of human glucose transporters in Xenopus oocytes: Kinetic characterization and substrate specificities of the erythrocyte, liver, and brain isoforms
    • Gould GW, Thomas HM, Jess TJ, Bell GI (1991) Expression of human glucose transporters in Xenopus oocytes: kinetic characterization and substrate specificities of the erythrocyte, liver, and brain isoforms. Biochemistry 30:5139-5145
    • (1991) Biochemistry , vol.30 , pp. 5139-5145
    • Gould, G.W.1    Thomas, H.M.2    Jess, T.J.3    Bell, G.I.4
  • 21
    • 0030760044 scopus 로고    scopus 로고
    • Human fibroblasts prefer mannose over glucose as a source of mannose for W-glycosylation. Evidence for the functional importance of transported mannose
    • Panneerselvam K, Etchison JR, Freeze HH (1997) Human fibroblasts prefer mannose over glucose as a source of mannose for W-glycosylation. Evidence for the functional importance of transported mannose. J Biol Chem 272:23123-23129
    • (1997) J Biol Chem , vol.272 , pp. 23123-23129
    • Panneerselvam, K.1    Etchison, J.R.2    Freeze, H.H.3
  • 23
    • 0027407881 scopus 로고
    • Synthesis of CMP-deaminoneuraminic acid (CMP-KDN) using the CTP: CMP-3-deoxynonulosonate cytidylyl-transferase from rainbow trout testis. Identification and characterization of a CMP-KDN synthetase
    • Terada T, Kitajima K, Inoue S, Ito F, Troy FA, Inoue Y (1993) Synthesis of CMP-deaminoneuraminic acid (CMP-KDN) using the CTP: CMP-3-deoxynonulosonate cytidylyl-transferase from rainbow trout testis. Identification and characterization of a CMP-KDN synthetase. J Biol Chem 268:2640-2648
    • (1993) J Biol Chem , vol.268 , pp. 2640-2648
    • Terada, T.1    Kitajima, K.2    Inoue, S.3    Ito, F.4    Troy, F.A.5    Inoue, Y.6
  • 24
    • 0034868247 scopus 로고    scopus 로고
    • Molecular cloning of a unique CMP-sialic acid synthetase that effectively utilizes both deaminon-euraminic acid (KDN) and W-acetylneuraminic acid (Neu5Ac) as substrates
    • Nakata D, Munster A, Gerardy-Schahn R, Aoki N, Matsuda T, Kitajima K (2001) Molecular cloning of a unique CMP-sialic acid synthetase that effectively utilizes both deaminon-euraminic acid (KDN) and W-acetylneuraminic acid (Neu5Ac) as substrates. Glycobiology 11:685-692
    • (2001) Glycobiology , vol.11 , pp. 685-692
    • Nakata, D.1    Munster, A.2    Gerardy-Schahn, R.3    Aoki, N.4    Matsuda, T.5    Kitajima, K.6
  • 25
    • 0030827128 scopus 로고    scopus 로고
    • A bifunctional enzyme catalyzes the first two steps in N-acetylneuraminic acid biosynthesis of rat liver: Purification and characterization of UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase
    • Hinderlich S, Stasche R, Zeitler R, Reutter W (1997) A bifunctional enzyme catalyzes the first two steps in N-acetylneuraminic acid biosynthesis of rat liver: purification and characterization of UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase. J Biol Chem 272:24313-24318
    • (1997) J Biol Chem , vol.272 , pp. 24313-24318
    • Hinderlich, S.1    Stasche, R.2    Zeitler, R.3    Reutter, W.4
  • 27
    • 0023893097 scopus 로고
    • A novel ganglioside, de-N-acetyl-GM3(II3Neu NH2LacCer), acting as a strong promoter for epidermal growth factor receptor kinase and as a stimulator for cell growth
    • Hanai N, Dohi T, Nores GA, Hakomori S (1988) A novel ganglioside, de-N-acetyl-GM3(II3Neu NH2LacCer), acting as a strong promoter for epidermal growth factor receptor kinase and as a stimulator for cell growth. J Biol Chem 263:6296-6301
    • (1988) J Biol Chem , vol.263 , pp. 6296-6301
    • Hanai, N.1    Dohi, T.2    Nores, G.A.3    Hakomori, S.4
  • 28
    • 0025276458 scopus 로고
    • Biosynthesis and turnover of O-acetyl groups in the gangliosides of human melanoma cells
    • Manji AE, Sjoberg ER, Diaz S, Varki A (1990) Biosynthesis and turnover of O-acetyl groups in the gangliosides of human melanoma cells. J Biol Chem 265:13091-13103
    • (1990) J Biol Chem , vol.265 , pp. 13091-13103
    • Manji, A.E.1    Sjoberg, E.R.2    Diaz, S.3    Varki, A.4
  • 30
    • 0028177140 scopus 로고
    • Monoclonal antibody specific for a28-linked oligo deaminated neuraminic acid (KDN) sequences in glycoproteins, preparation and characterization of a monoclonal antibody and its application in immunohistochemistry
    • Kanamori A, Inoue S, Xulei Z, Zuber C, Roth J, Kitajima K, Ye J, Troy FA Jr, Inoue Y (1994) Monoclonal antibody specific for a28-linked oligo deaminated neuraminic acid (KDN) sequences in glycoproteins, preparation and characterization of a monoclonal antibody and its application in immunohistochemistry. Histochemistry 101:333-340
    • (1994) Histochemistry , vol.101 , pp. 333-340
    • Kanamori, A.1    Inoue, S.2    Xulei, Z.3    Zuber, C.4    Roth, J.5    Kitajima, K.6    Ye, J.7    Troy Jr., F.A.8    Inoue, Y.9
  • 31
    • 0027538667 scopus 로고
    • Monoclonal antibody specific to a23-linked deaminated neuraminyl b-galactosyl sequence
    • Yu S, Kitajima K, Inoue Y (1993) Monoclonal antibody specific to a23-linked deaminated neuraminyl b-galactosyl sequence. Glycobiology 3:31-36
    • (1993) Glycobiology , vol.3 , pp. 31-36
    • Yu, S.1    Kitajima, K.2    Inoue, Y.3
  • 32
    • 0027936417 scopus 로고
    • Discovery of a new type of sialidase, "kDNase" which specifically hydrolyzes deaminoneuraminyl (3-deoxy-D-glycero -D-galacto-2-nonurosonic acid) but not W-acetylneuraminyl linkages
    • Kitajima K, Kuroyanagi H, Terada T, Inoue S, Ye J, Troy FA Jr, Inoue Y (1994) Discovery of a new type of sialidase, "KDNase" which specifically hydrolyzes deaminoneuraminyl (3-deoxy-D-glycero -D-galacto-2-nonurosonic acid) but not W-acetylneuraminyl linkages. J Biol Chem 269:21415-21419
    • (1994) J Biol Chem , vol.269 , pp. 21415-21419
    • Kitajima, K.1    Kuroyanagi, H.2    Terada, T.3    Inoue, S.4    Ye, J.5    Troy Jr., F.A.6    Inoue, Y.7
  • 34
    • 0042027767 scopus 로고    scopus 로고
    • Ultrasensitive analysis of sialic aids and oligo/polysialic acids by fluorometric high-performance liquid chromatography
    • Inoue S, Inoue Y (2003) Ultrasensitive analysis of sialic aids and oligo/polysialic acids by fluorometric high-performance liquid chromatography. Methods Enzymol 362:543-560
    • (2003) Methods Enzymol , vol.362 , pp. 543-560
    • Inoue, S.1    Inoue, Y.2


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