Effects of vitamin treatment or supplements with purported antioxidant properties on skin cancer prevention: A meta-analysis of randomized controlled trials

Dermatology

Volumn 223, Issue 1, 2011, Pages 36-44

  Chang, Yoon Jung ^a,b   Myung, Seung Kwon ^a,c   Chung, Sung Tae ^e   Kim, Yeol ^a   Lee, Eun Hyun ^f   Jeon, Young Jee ^g   Park, Chang Hae ^a,d   Seo, Hong Gwan ^a   Huh, Bong Yul ^a  

^a National Cancer Center   (South Korea)

^b National Cancer Center   (South Korea)

^c National Cancer Center   (South Korea)

^d Eulji University   (South Korea)

^e Leaders Dermatology Clinic and   (South Korea)

^f Sungkyunkwan University School of Medicine   (South Korea)

^g Inje University College of Medicine   (South Korea)

Author keywords

Randomized controlled trials, meta analysis; Skin cancer; Vitamin supplements

Indexed keywords

ACETYLSALICYLIC ACID; ALPHA TOCOPHEROL; ASCORBIC ACID; BETA CAROTENE; ETRETIN; ISOTRETINOIN; PLACEBO; RETINOL; VITAMIN;

ANTIOXIDANT ACTIVITY; ARTICLE; BASAL CELL CARCINOMA; CANCER INCIDENCE; CANCER PREVENTION; CANCER RISK; CANCER SURVIVOR; COCHRANE LIBRARY; DRUG EFFICACY; EMBASE; HUMAN; MEDLINE; META ANALYSIS; NONMELANOMA SKIN CANCER; OUTCOME ASSESSMENT; PRIMARY PREVENTION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); SECONDARY PREVENTION; SKIN CANCER; SQUAMOUS CELL CARCINOMA; VITAMIN SUPPLEMENTATION;

ANTIOXIDANTS; DIETARY SUPPLEMENTS; HUMANS; PRIMARY PREVENTION; RANDOMIZED CONTROLLED TRIALS AS TOPIC; SECONDARY PREVENTION; SKIN NEOPLASMS; TREATMENT OUTCOME; VITAMINS;

EID: 80053985339     PISSN: 10188665     EISSN: 14219832     Source Type: Journal    
DOI: 10.1159/000329439     Document Type: Article

References (48)

1. De Hertog SA, Wensveen CA, Bastiaens MT, et al: Relation between smoking and skin cancer. J Clin Oncol 2001; 19: 231-238. (Pubitemid 32063501)
2. Bath-Hextall F, Leonardi-Bee J, Somchand N, et al: Interventions for preventing nonmelanoma skin cancers in high-risk groups. Cochrane Database Syst Rev 2007; 4: CD005414.
3. Curado MP, Edwards B, Shin HR, et al: Cancer Incidence in Five Continents. Lyon, IARC, 2007, vol IX.
4. Euvrard S, Kanitakis J, Claudy A: Skin cancers after organ transplantation. N Engl J Med 2003; 348: 1681-1691. (Pubitemid 36459475)
5. Masini C, Fuchs PG, Gabrielli F, et al: Evidence for the association of human papillomavirus infection and cutaneous squamous cell carcinoma in immunocompetent individuals. Arch Dermatol 2003; 139: 890-894. (Pubitemid 36898924)
6. Sander CS, Chang H, Hamm F, et al: Role of oxidative stress and the antioxidant network in cutaneous carcinogenesis. Int J Dermatol 2004; 43: 326-335. (Pubitemid 38714593)
7. Byers T, Perry G: Dietary carotenes, vitamin C, and vitamin E as protective antioxidants in human cancers. Annu Rev Nutr 1992; 12: 139-159.
8. Deeb KK, Trump DL, Johnson CS: Vitamin D signalling pathways in cancer: potential for anticancer therapeutics. Nat Rev Cancer 2007; 7: 684-700. (Pubitemid 47327412)
9. Asgari MM, Maruti SS, Kushi LH, White E: Antioxidant supplementation and risk of incident melanomas: results of a large prospective cohort study. Arch Dermatol 2009; 145: 879-882.
10. Schaumberg DA, Frieling UM, Rifai N, Cook N: No effect of beta-carotene supplementation on risk of nonmelanoma skin cancer among men with low baseline plasma betacarotene. Cancer Epidemiol Biomarkers Prev 2004; 13: 1079-1080. (Pubitemid 38756721)
11. Greenberg ER, Baron JA, Stukel TA, et al: A clinical trial of beta carotene to prevent basal-cell and squamous-cell cancers of the skin. The Skin Cancer Prevention Study Group. N Engl J Med 1990; 323: 789-795. (Pubitemid 20303876)
12. Bavinck JNB, Tieben LM, Van der Woude FJ, et al: Prevention of skin cancer and reduction of keratotic skin lesions during acitretin therapy in renal transplant recipients: a double-blind, placebo-controlled study. J Clin Oncol 1995; 13: 1933-1938.
13. Levine N, Moon TE, Cartmel B, et al: Trial of retinol and isotretinoin in skin cancer prevention: a randomized, double-blind, controlled trial. Cancer Epidemiol Biomarkers Prev 1997; 6: 957-961. (Pubitemid 27481645)
14. Moon TE, Levine N, Cartmel B, et al: Effect of retinol in preventing squamous cell skin cancer in moderate-risk subjects: a randomized, double-blind, controlled trial. Southwest Skin Cancer Prevention Study Group. Cancer Epidemiol Biomarkers Prev 1997; 6: 949-956. (Pubitemid 27481644)
15. Green A, Williams G, Neale R, et al: Daily sunscreen application and betacarotene supplementation in prevention of basal-cell and squamous-cell carcinomas of the skin: a randomised controlled trial. Lancet 1999; 354: 723-729. (Pubitemid 29405786)
16. Lee IM, Cook NR, Manson JE, et al: Betacarotene supplementation and incidence of cancer and cardiovascular disease: the Women's Health Study. J Natl Cancer Inst 1999; 91: 2102-2106. (Pubitemid 30019571)
17. Cook NR, Le IM, Manson JE, et al: Effects of beta-carotene supplementation on cancer incidence by baseline characteristics in the Physicians' Health Study (United States). Cancer Causes Control 2000; 11: 617-626. (Pubitemid 30636361)
18. Frieling UM, Schaumberg DA, Kupper TS, et al: A randomized, 12-year primary-prevention trial of beta carotene supplementation for nonmelanoma skin cancer in the Physicians' Health Study. Arch Dermatol 2000; 136: 179-184. (Pubitemid 30090756)
19. The Heart Protection Study Group: MRC/BHF Heart Protection Study of antioxidant vitamin supplementation in 20,536 high-risk individuals: a randomised placebo-controlled trial. Lancet 2002; 360: 23-33.
20. Bairati I, Meyer F, Gelinas M, et al: A randomized trial of antioxidant vitamins to prevent second primary cancers in head and neck cancer patients. J Natl Cancer Inst 2005; 97: 481-488. (Pubitemid 40590429)
21. Lonn E, Bosch J, Yusuf S, et al: Effects of long-term vitamin E supplementation on cardiovascular events and cancer: a randomized controlled trial. JAMA 2005; 293: 1338-1347. (Pubitemid 40381486)
22. Myung SK, Kim Y, Ju W, et al: Effects of antioxidant supplements on cancer prevention: meta-analysis of randomized controlled trials. Ann Oncol 2010; 21: 166-179.
23. World Cancer Research Fund/American Institute for Cancer Research: Food, Nutrition, Physical Activity, and the Prevention of Cancer: A Global Perspective. Washington, AIRC, 2007.
24. Bardia A, Tleyjeh IM, Cerhan JR, et al: Efficacy of antioxidant supplementation in reducing primary cancer incidence and mortality: systematic review and meta-analysis. Mayo Clin Proc 2008; 83: 23-34.
25. Moon TE, Levine N, Cartmel B, et al: Design and recruitment for retinoid skin cancer prevention (SKICAP) trials. Cancer Epidemiol Biomarkers Prev 1995; 4: 661-669.
26. Lotan R: Retinoids in cancer chemoprevention. FASEB J 1996; 10: 1031-1039. (Pubitemid 26285979)
27. Taylor PR, Greenwald P: Nutritional interventions in cancer prevention. J Clin Oncol 2005; 23: 333-345. (Pubitemid 46209964)
28. Uliasz A, Spencer JM: Chemoprevention of skin cancer and photoaging. Clin Dermatol 2004; 22: 178-182. (Pubitemid 38950743)
29. Goodman GE, Omenn GS, Thornquist MD, et al: The Carotene and Retinol Efficacy Trial (CARET) to prevent lung cancer in highrisk populations: pilot study with cigarette smokers. Cancer Epidemiol Biomarkers Prev 1993; 2: 389-396.
30. Hennekens CH, Buring JE, Manson JE, et al: Lack of effect of long-term supplementation with beta carotene on the incidence of malignant neoplasms and cardiovascular disease. N Engl J Med 1996; 334: 1145-1149. (Pubitemid 26137972)
31. Cook NR, Stampfer MJ, Ma J, et al: Beta-carotene supplementation for patients with low baseline levels and decreased risks of total and prostate carcinoma. Cancer 1999; 86: 1783-1792. (Pubitemid 29513048)
32. Costa A, De Palo G, Decensi A, et al: Retinoids in cancer chemoprevention. Ann NY Acad Sci 1995; 768: 148-162. (Pubitemid 26078728)
33. Darlington S, Williams G, Neale R, et al: A randomized controlled trial to assess sunscreen application and beta carotene supplementation in the prevention of solar keratoses. Arch Dermatol 2003; 139: 451-455. (Pubitemid 36427609)
34. De Sevaux RG, Smit JV, de Jong EM, et al: Acitretin treatment of premalignant and malignant skin disorders in renal transplant recipients: clinical effects of a randomized trial comparing two doses of acitretin. J Am Acad Dermatol 2003; 49: 407-412. (Pubitemid 37051901)
35. Lee IM, Cook NR, Gaziano JM, et al: Vitamin E in the primary prevention of cardiovascular disease and cancer: the Women's Health Study: a randomized controlled trial. JAMA 2005; 294: 56-65. (Pubitemid 41002839)
36. Mahabir S, Coit D, Liebes L, et al: Randomized, placebo-controlled trial of dietary supplementation of alpha-tocopherol on mutagen sensitivity levels in melanoma patients: a pilot trial. Melanoma Res 2002; 12: 83-90. (Pubitemid 34183693)
37. Omenn GS, Goodman GE, Thornquist MD, et al: Effects of a combination of beta carotene and vitamin A on lung cancer and cardiovascular disease. N Engl J Med 1996; 334: 1150-1155. (Pubitemid 26137973)
38. Tangrea JA, Adrianza E, Helsel WE, et al: Clinical and laboratory adverse effects associated with long-term, low-dose isotretinoin: incidence and risk factors. The Isotretinoin-Basal Cell Carcinomas Study Group. Cancer Epidemiol Biomarkers Prev 1993; 2: 375-380.
39. The Alpha-Tocopheraol BCCPSG: The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers. The Alpha-Tocopherol, Beta Carotene Cancer Prevention Study Group. N Engl J Med 1994; 330: 1029-1035.
40. Weinstock MA, Bingham SF, Lew RA, et al: Topical tretinoin therapy and all-cause mortality. Arch Dermatol 2009; 145: 18-24.
41. Hercberg S, Galan P, Preziosi P, et al: The SU.VI.MAX Study: a randomized, placebocontrolled trial of the health effects of antioxidant vitamins and minerals. Arch Intern Med 2004; 164: 2335-2342. (Pubitemid 39532244)
42. Hercberg S, Ezzedine K, Guinot C, et al: Antioxidant supplementation increases the risk of skin cancers in women but not in men. J Nutr 2007; 137: 2098-2105. (Pubitemid 47367272)
43. Jadad AR, Moore RA, Carroll D, et al: Assessing the quality of reports of randomized clinical trials: is blinding necessary? Control Clin Trials 1996; 17: 1-12. (Pubitemid 26120810)
44. Goldman L, Ausiello DA: Cecil Medicine. Philadelphia, Saunders, 2007.
45. Key TJ, Allen NE, Spencer EA, Travis RC: The effect of diet on risk of cancer. Lancet 2002; 360: 861-868. (Pubitemid 35257961)
46. Hercberg S, Galan P, Preziosi P, et al: The potential role of antioxidant vitamins in preventing cardiovascular diseases and cancers. Nutrition 1998; 14: 513-520. (Pubitemid 28285285)
47. McArdle F, Rhodes LE, Parslew R, et al: UVR-induced oxidative stress in human skin in vivo: effects of oral vitamin C supplementation. Free Radic Biol Med 2002; 33: 1355-1362. (Pubitemid 35284920)
48. Yarosh D, Klein J, O'Connor A, et al: Effect of topically applied T 4 endonuclease V in liposomes on skin cancer in xeroderma pigmentosum: a randomised study. Xeroderma Pigmentosum Study Group. Lancet 2001; 357: 926-929. (Pubitemid 32247282)