The TRIM5 gene modulates penile mucosal acquisition of simian immunodeficiency virus in rhesus monkeys

Journal of Virology

Volumn 85, Issue 19, 2011, Pages 10389-10398

  Yeh, Wendy W ^a   Rao, Srinivas S ^b   Lim, So Yon ^a   Zhang, Jinrong ^a   Hraber, Peter T ^c   Brassard, Laura M ^a   Luedemann, Corinne ^a   Todd, John Paul ^b   Dodson, Alan ^d   Shen, Ling ^a   Buzby, Adam P ^a   Whitney, James B ^a   Korber, Bette T ^c   Nabel, Gary J ^b   Mascola, John R ^b   Letvin, Norman L ^a  

^a BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^b NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^c LOS ALAMOS NATIONAL LABORATORY   (United States)

^d BIOQUAL INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALLELE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COHORT ANALYSIS; CONTROLLED STUDY; GENE; GENOTYPE; HEREDITY; HETEROZYGOTE; HETEROZYGOUS PERMISSIVE; HOMOZYGOTE; HOMOZYGOUS PERMISSIVE; HOMOZYGOUS RESTRICTIVE; INFECTION SENSITIVITY; MALE; MUCOSA; NONHUMAN; PENILE MUCOSA; PRIORITY JOURNAL; RHESUS MONKEY; SIMIAN IMMUNODEFICIENCY VIRUS; TRIM5 GENE; VIRUS CELL INTERACTION; VIRUS STRAIN; VIRUS TRANSMISSION;

ANIMALS; CARRIER PROTEINS; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; MACACA MULATTA; MALE; MUCOUS MEMBRANE; PENIS; SIMIAN IMMUNODEFICIENCY VIRUS;

HUMAN IMMUNODEFICIENCY VIRUS 1; MACACA MULATTA; PRIMATE LENTIVIRUS GROUP; PRIMATES; SIMIAN IMMUNODEFICIENCY VIRUS;

EID: 80053976629     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.00854-11     Document Type: Article

References (41)

1. Abrahams, M. R., et al. 2009. Quantitating the multiplicity of infection with human immunodeficiency virus type 1 subtype C reveals a non-Poisson distribution of transmitted variants. J. Virol. 83:3556-3567.
2. Auvert, B., et al. 2005. Randomized, controlled intervention trial of male circumcision for reduction of HIV infection risk: the ANRS 1265 Trial. PLoS Med. 2:e298.
3. Bailey, R. C., et al. 2007. Male circumcision for HIV prevention in young men in Kisumu, Kenya: a randomised controlled trial. Lancet 369:643-656.
4. Dean, M., et al. 1996. Genetic restriction of HIV-1 infection and progression to AIDS by a deletion allele of the CKR5 structural gene. Science 273:1856-1862.
5. Dinh, M. H., M. D. McRaven, Z. Kelley, S. Penugonda, and T. J. Hope. 2010. Keratinization of the adult male foreskin and implications for male circumcision. AIDS 24:899-906.
6. Fellay, J., et al. 2007. A whole-genome association study of major determinants for host control of HIV-1. Science 317:944-947.
7. Fischetti, L., S. M. Barry, T. J. Hope, and R. J. Shattock. 2009. HIV-1 infection of human penile explant tissue and protection by candidate microbicides. AIDS 23:319-328.
8. Giorgi, E. E., et al. 2010. Estimating time since infection in early homogeneous HIV-1 samples using a Poisson model. BMC Bioinformatics 11:532.
9. Goldschmidt, V., et al. 2006. Role of common human TRIM5alpha variants in HIV-1 disease progression. Retrovirology 3:54.
10. Goldstein, S., C. R. Brown, H. Dehghani, J. D. Lifson, and V. M. Hirsch. 2000. Intrinsic susceptibility of rhesus macaque peripheral CD4(+) T cells to simian immunodeficiency virus in vitro is predictive of in vivo viral replication. J. Virol. 74:9388-9395.
11. Gray, R. H., et al. 2007. Male circumcision for HIV prevention in men in Rakai, Uganda: a randomised trial. Lancet 369:657-666.
12. Hatziioannou, T., S. Cowan, U. K. Von Schwedler, W. I. Sundquist, and P. D. Bieniasz. 2004. Species-specific tropism determinants in the human immunodeficiency virus type 1 capsid. J. Virol. 78:6005-6012.
13. Hatziioannou, T., D. Perez-Caballero, A. Yang, S. Cowan, and P. D. Bieniasz. 2004. Retrovirus resistance factors Ref1 and Lv1 are species-specific variants of TRIM5alpha. Proc. Natl. Acad. Sci. U. S. A. 101:10774-10779.
14. Johnston, R. E., et al. 2005. Vaccination of macaques with SIV immunogens delivered by Venezuelan equine encephalitis virus replicon particle vectors followed by a mucosal challenge with SIVsmE660. Vaccine 23:4969-4979.
15. Keckesova, Z., L. M. Ylinen, and G. J. Towers. 2004. The human and African green monkey TRIM5alpha genes encode Ref1 and Lv1 retroviral restriction factor activities. Proc. Natl. Acad. Sci. U. S. A. 101:10780-10785.
16. Keele, B. F., et al. 2008. Identification and characterization of transmitted and early founder virus envelopes in primary HIV-1 infection. Proc. Natl. Acad. Sci. U. S. A. 105:7552-7557.
17. Keele, B. F., et al. 2009. Low-dose rectal inoculation of rhesus macaques by SIVsmE660 or SIVmac251 recapitulates human mucosal infection by HIV-1. J. Exp. Med. 206:1117-1134.
18. Kirmaier, A., et al. 2010. TRIM5 suppresses cross-species transmission of a primate immunodeficiency virus and selects for emergence of resistant variants in the new species. PLoS Biol. 8:e1000462.
19. Letvin, N. L., et al. 2011. Immune and genetic correlates of vaccine protection against mucosal infection by SIV in monkeys. Sci. Transl. Med. 3:81ra36.
20. Lifson, J. D., et al. 2004. Evaluation of the safety, immunogenicity, and protective efficacy of whole inactivated simian immunodeficiency virus (SIV) vaccines with conformationally and functionally intact envelope glycoproteins. AIDS Res. Hum. Retroviruses 20:772-787.
21. Lim, S. Y., et al. 2010. Contributions of Mamu-A*01 status and TRIM5 allele expression, but not CCL3L copy number variation, to the control of SIVmac251 replication in Indian-origin rhesus monkeys. PLoS Genet. 6:e1000997.
22. Lim, S. Y., et al. 2010. TRIM5alpha modulates immunodeficiency virus control in rhesus monkeys. PLoS Pathog. 6:e1000738.
23. Liu, R., et al. 1996. Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection. Cell 86:367-377.
24. Martin, M. P., et al. 2002. Epistatic interaction between KIR3DS1 and HLA-B delays the progression to AIDS. Nat. Genet. 31:429-434.
25. McCoombe, S. G., and R. V. Short. 2006. Potential HIV-1 target cells in the human penis. AIDS 20:1491-1495.
26. Miller, C. J. 1998. Localization of simian immunodeficiency virus-infected cells in the genital tract of male and female rhesus macaques. J. Reprod. Immunol. 41:331-339.
27. Miller, C. J., et al. 1990. Effect of virus dose and nonoxynol-9 on the genital transmission of SIV in rhesus macaques. J. Med. Primatol. 19:401-409.
28. National Research Council. 1996. Guide for the care and use of laboratory animals. National Academy Press, Washington, DC.
29. + T-cell loss and higher titers of neutralizing antibody. J. Virol. 83:5388-5400.
30. Patterson, B. K., et al. 2002. Susceptibility to human immunodeficiency virus-1 infection of human foreskin and cervical tissue grown in explant culture. Am. J. Pathol. 161:867-873.
31. Pereyra, F., et al. 2010. The major genetic determinants of HIV-1 control affect HLA class I peptide presentation. Science 330:1551-1557.
32. Perron, M. J., et al. 2004. TRIM5alpha mediates the postentry block to N-tropic murine leukemia viruses in human cells. Proc. Natl. Acad. Sci. U. S. A. 101:11827-11832.
33. Reynolds, M. R., et al. 2008. Macaques vaccinated with live-attenuated SIV control replication of heterologous virus. J. Exp. Med. 205:2537-2550.
34. Rogers, T. F., et al. 2010. Variability in a dominant block to SIV early reverse transcription in rhesus monkey cells predicts in vivo viral replication and time to death. Virol. J. 7:79.
35. Sakuma, R., A. A. Mael, and Y. Ikeda. 2007. Alpha interferon enhances TRIM5alpha-mediated antiviral activities in human and rhesus monkey cells. J. Virol. 81:10201-10206.
36. Speelmon, E. C., et al. 2006. Genetic association of the antiviral restriction factor TRIM5alpha with human immunodeficiency virus type 1 infection. J. Virol. 80:2463-2471.
37. Staprans, S. I., et al. 2004. Enhanced SIV replication and accelerated progression to AIDS in macaques primed to mount a CD4 T cell response to the SIV envelope protein. Proc. Natl. Acad. Sci. U. S. A. 101:13026-13031.
38. Stremlau, M., et al. 2004. The cytoplasmic body component TRIM5alpha restricts HIV-1 infection in Old World monkeys. Nature 427:848-853.
39. van Manen, D., et al. 2008. The effect of Trim5 polymorphisms on the clinical course of HIV-1 infection. PLoS Pathog. 4:e18.
40. Whitney, J. B., et al. 2009. Monitoring HIV vaccine trial participants for primary infection: studies in the SIV/macaque model. AIDS 23:1453-1460.
41. Yap, M. W., S. Nisole, C. Lynch, and J. P. Stoye. 2004. Trim5alpha protein restricts both HIV-1 and murine leukemia virus. Proc. Natl. Acad. Sci. U. S. A. 101:10786-10791.