Corneal alternations induced by topical application of benzalkonium chloride in rabbit

PLoS ONE

Volumn 6, Issue 10, 2011, Pages

  Chen, Wensheng ^a   Li, Zhiyuan ^a   Hu, Jiaoyue ^a   Zhang, Zhenhao ^a   Chen, Lelei ^a   Chen, Yongxiong ^a   Liu, Zuguo ^a  

^a XIAMEN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BENZALKONIUM CHLORIDE; MUCIN 5AC; MYOSIN ADENOSINE TRIPHOSPHATASE; PROTEIN ZO1; 6 CARBOXYFLUORESCEIN; 6-CARBOXYFLUORESCEIN; BENZALKONIUM; FLUORESCEIN DERIVATIVE; MEMBRANE PROTEIN; PHOSPHOPROTEIN; ZONULA OCCLUDENS-1 PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AQUEOUS HUMOR FLOW; ARTICLE; CONFOCAL MICROSCOPY; CONJUNCTIVA; CONTROLLED STUDY; CORNEA DISEASE; CORNEA ENDOTHELIUM; CORNEA PERMEABILITY; DRY EYE; EPITHELIUM CELL; EXPERIMENTAL RABBIT; FLUORESCENCE ANGIOGRAPHY; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; MALE; NONHUMAN; PERMEABILITY BARRIER; PROTEIN EXPRESSION; SLIT LAMP; STROMA CELL; TEAR FLOW; TIGHT JUNCTION; ANIMAL; CORNEA; CORNEA EPITHELIUM; CORNEA STROMA; DRUG EFFECT; FLUORESCENCE MICROSCOPY; FLUORESCENT ANTIBODY TECHNIQUE; LACRIMAL FLUID; METABOLISM; PATHOLOGY; PERMEABILITY; RABBIT; STAINING; TOPICAL DRUG ADMINISTRATION;

ORYCTOLAGUS CUNICULUS;

ACTOMYOSIN; ADMINISTRATION, TOPICAL; ANIMALS; BENZALKONIUM COMPOUNDS; CONJUNCTIVA; CORNEA; CORNEAL STROMA; ENDOTHELIUM, CORNEAL; EPITHELIUM, CORNEAL; FLUORESCEINS; FLUORESCENT ANTIBODY TECHNIQUE; MALE; MEMBRANE PROTEINS; MICROSCOPY, CONFOCAL; MICROSCOPY, FLUORESCENCE; PERMEABILITY; PHOSPHOPROTEINS; RABBITS; STAINING AND LABELING; TEARS;

EID: 80053974962     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0026103     Document Type: Article

References (34)

1. Baudouin C, LabbéA, Liang H, Pauly A, Brignole-Baudouin, (2010) Preservatives in eyedrops: The good, the bad and the ugly. Prog Retin Eye Res 29: 312-314.
2. Rathore MS, Majumdar DK, (2006) Effect of formulation factor on in vitro trans-corneal permeation of gatifloxacin from aqueous drops. AAPS Pharm Sci 7: 57.
3. Romanowski EG, Mah FS, Kowalski RP, Yates KA, Gordon YJ, (2008) Benzalkonium chloride enhances the antibacterial efficacy of gatifloxacin an experimental rabbit model of intrastrmal keratitis. J Ocul Pharmacol Ther 24: 380-384.
4. Pisella PJ, Fillacier K, Elena PP, Elena PP, Debbasch C, Baudouin C, (2000) Comparison of the effects of preserved and unpreserved formulations of timolol on the ocular surface of albino rabbits. Ophthalmic Res 32: 3-8.
5. Labbe A, Pauly A, Liang H, Brignole-Baudouin F, Martin C, et al. (2006) Comparison of toxicological profiles of benzalkonium chloride and polyquaternium-1: an experimental study. J Ocul Pharmacol Ther 22: 267-278.
6. Swan KC, (1944) Reactivity of the ocular tissue to wetting agents. Am J Ophthalmol 27: 1118-1122.
7. Liang H, Baudouin C, Pauly A, Brignole-Baudouin, (2008) Conjunctival and corneal reactions in rabbits following short- and repeated exposure to preservative-free tafluprost, commercially available latanoprost and 0.02% benzalkonium chloride. Br J Ophthalmol 92: 1275-1282.
8. Pauly A, Brignole-Baudouim, Labbe A, Liang H, Warnet JM, et al. (2007) New tools for the evaluation of toxic ocular surface changes in the rat. Invest Ophthalmol Vis Sci 48: 5473-5483.
9. Bourne WM, (2003) Biology of the corneal endothelium in health and disease. Eye 17: 912-918.
10. Edelhauser HF, (2006) The balance between corneal transparency and edema: the Protor Lecture. Invest Ophthalmol Vis Sci 47: 1755-1767.
11. Srinivas SP, (2010) Dynamic regulation of barrier integrity of the corneal endothelium. Optom Vis Sci 84: E239-254.
12. Riley MV, Winkler BS, Starnes CA, Peters MI, Dang L, (1998) Regulation of corneal endotheliual barrier function by adenosine, cylic AMP, and protein kinases. Invest Ophthalmol Vis Sci 39: 2076-2084.
13. Mandell KJ, Holley GP, Parkos CA, Edelhauser HF, (2006) Antibody blockade of junctional adhesion molecule-A in rabbit corneal endothelial tight junctions produces corneal swelling. Invest Ophthalmol Vis Sci 47: 2408-2416.
14. Ramachandran C, Srinivas SP, (2010) Formation and disassembly of adherens and tight junctions in the corneal endothelium: regulation by actomyosin contraction. Invest Ophthalmol Vis Sci 51: 2139-2148.
15. Shivanna M, Rajashehar G, Srinvias SP, (2010) Barrier dysfunction of the corneal endothelium in response to TNF-α: Role of p38 MAP kinase. Invest Ophthalmol Vis Sci 51: 1575-1582.
16. Lemp MA, (1995) Report of the National Eye Institute/Industry Workshop on Clinical Trials in Dry Eye. CLAO J 21: 221-232.
17. Lin H, Li W, Dong N, Chen W, Liu J, et al. (2010) Changes in corneal epithelial layer inflammatory cells in aqueous tear-deficient dry eye. Invest Ophthalmol Vis Sci 51: 122-128.
18. Chen W, Zhao K, Li X, Yoshitomi T, (2007) Keratoconjunctivitis sicca modifies epithelial stem cell proliferation kinetics in conjunctiva. Cornea 26: 1101-1106.
19. Chen W, Hara K, Tian Q, Zhao K, Yoshitomi T, (2007) Existence of small slow-cycling Langerhans cells in the limbal basal epithelium that express ABCG2. Exp Eye Res 84: 626-634.
20. Chen W, Lin H, Dong N, Sanae T, Liu Z, et al. (2010) Cauterization of central cornea induced recruitment of major histocompatibility complex class II+ Langerhans cells from limbal basal epithelium. Cornea 29: 73-79.
21. Xiong C, Chen D, Liu J, Liu B, Li N, et al. (2008) A rabbit dry eye model induced by topical medication of a preservative benzalkonium chloride. Invest Ophthalmol Vis Sci 49: 1850-1856.
22. Yi X, Wang Y, Yu FS, (2000) Corneal epithelial tight junctions and their response to lipopolysaccharide challenge. Invest Ophthalmol Vis Sci 41: 4093-4100.
23. Ban Y, Dota A, Cooper LJ, Fullwood NJ, Nakamura T, et al. (2003) Tight junction-related protein expression and distribution in human corneal epithelium. Exp Eye Res 76: 663-669.
24. Hutcheon AE, Sippel KC, Zieske JD, (2007) Examination of restoration of epithelial barrier function following superficial keratectomy. Exp Eye Res 84: 32-38.
25. Kimura K, Teranishi S, Fukata K, Kawamato K, Nishita T, (2008) Delayed disruption of barrier function in cultured human corneal epithelial cells induced by tumor necrosis factor-α in a manner dependent on NF-kB. Invest Ophthalmol Vis Sci 49: 565-571.
26. Kusano M, Uematus M, Kumagami T, Sasaki H, Kitaoka T, (2010) Evaluation of acute corneal barrier change induced by topically applied preservatives using corneal transepithelial electric resistance in vivo. Cornea 29: 80-85.
27. Nakamura T, Teshima M, Kitahara T, Sasaki H, Uematus M, et al. (2010) Sensitive and real-time method for evaluating corneal barrier considering tear flow. Bio Pharm Bull 33: 107-110.
28. Pauly A, Meloni M, Brignole-Baudouin F, Warnet J-M, Baudouin C, (2009) Multiple endpoint analysis of the 3D-reconstituted corneal epithelium after treatment with benzalkonium chloride: early detection of toxic damage. Invest Ophthalmol Vis Sci 50: 1644-1652.
29. Rustom A, Saffrich R, Markovic I, Walther P, Gerades HH, (2004) Nanotubular highways highways for intercellular organelle transport. Science 303: 1007-1010.
30. Önfelt B, Nedvetzki S, Yanagi K, Davis DM, (2004) Cutting edge: Membrane nanotubes connect immune cells. J Immunol 173: 1511-1513.
31. Chinnery HR, Pearlman E, McMenamin PG, (2008) Cutting edge: Membrane nanotubes in vivo: a feature of MHC class II+ cells in the mouse cornea. J Immunol 180: 5779-5783.
32. Crone C, Olesen SP, (1982) Electrical resistance of brain microvascular endothelium. Brain Res 241: 49-55.
33. Vandenbrouchke E, Metha D, Minshall R, Malik AB, (2008) Regulation of endothelial junctional permeability. Ann N Y Acad Sci 1123: 134-145.
34. Srinivas SP, (2010) Dynamic regulation of barrier integrity of the corneal endothelium. Optom Vis Sci; 87: E239-54.