Ovarian low-grade serous carcinoma involving the cervix mimicking a cervical primary

International Journal of Gynecological Pathology

Volumn 30, Issue 6, 2011, Pages 613-619

  Malpica, Anais ^a   Deavers, Michael T ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

Cervix; Immunohistochemistry; Low grade serous carcinoma; Metastasis; Metastatic adenocarcinoma; Metastatic serous carcinoma; Ovarian carcinoma; Serous carcinoma; WT 1

Indexed keywords

CISPLATIN; ESTROGEN RECEPTOR; PACLITAXEL; PEROXIDASE; PROTEIN P16; WT1 PROTEIN;

ADENOCARCINOMA; ADULT; ARTICLE; CANCER DIAGNOSIS; CANCER EPIDEMIOLOGY; CANCER RADIOTHERAPY; CANCER RECURRENCE; CASE REPORT; CLINICAL FEATURE; FEMALE; HUMAN; IMMUNOPEROXIDASE STAINING; IN SITU HYBRIDIZATION; METASTASIS; MICROSCOPY; OMENTECTOMY; OMENTUM; OVARY CARCINOMA; PAPANICOLAOU TEST; PELVIS LYMPH NODE; PERITONEAL BIOPSY; PREOPERATIVE PERIOD; PRIORITY JOURNAL; SALPINGOOOPHORECTOMY; UTERINE CERVIX BIOPSY; UTERINE CERVIX CARCINOMA; UTERINE CERVIX CONIZATION; UTERINE ENDOCERVIX; WART VIRUS;

ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; COMBINED MODALITY THERAPY; CYSTADENOCARCINOMA, SEROUS; DIAGNOSIS, DIFFERENTIAL; DIAGNOSTIC ERRORS; FEMALE; GYNECOLOGIC SURGICAL PROCEDURES; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; MIDDLE AGED; NEOPLASM GRADING; NEOPLASM RECURRENCE, LOCAL; OVARIAN NEOPLASMS; UTERINE CERVICAL NEOPLASMS;

EID: 80053958429     PISSN: 02771691     EISSN: 15387151     Source Type: Journal    
DOI: 10.1097/PGP.0b013e318217137e     Document Type: Article

References (22)

1. Lemoine NR, Hall PA. Epithelial tumors metastatic to the uterine cervix. A study of 33 cases and review of the literature. Cancer 1986;57:2002-5. (Pubitemid 16113777)
2. Mazur MT, Hsueh S, Gersell DJ. Metastases to the female genital tract. Cancer 1984;53:1978-84.
3. Mulvany NJ, Nirenberg A, Oster AG. Non-primary cervical adenocarcinomas. Pathology 1996;28:293-7. (Pubitemid 27170913)
4. Danielian PJ. Ovarian metastatic carcinoma presenting as a primary cervical carcinoma. Acta Obstet Gynecol Scand 1990;69:265-6. (Pubitemid 20350189)
5. McComas BC, Farnum JB, Donaldson RC. Ovarian carcinoma presenting as a cervical metastasis. Obstet Gynecol 1984;63:593-6 (Pubitemid 14175033)
6. Way S. Carcinoma metastatic in the cervix. Gynecol Oncol 1980;9:298-302. (Pubitemid 10080221)
7. McCluggage WG, Hurrell DP, Kennedy K. Metastatic carcinomas in the cervix mimicking primary cervical adenocarcinoma and adenocarcinoma in situ. Report of a series of cases. Am J Surg Pathol 2010;34:735-41.
8. Dvoretsky P, Richards K, Angel C, et al. Distribution of disease at autopsy in 100 women with ovarian cancer. Hum Pathol 1988;19:57-63 (Pubitemid 18065871)
9. Guidozzi F, Sonnendecker EW, Wright C. Ovarian cancer with metastatic deposits in the cervix, vagina, or vulva preceding primary cytoreductive surgery. Gynecol Oncol 1993;49:225-8. (Pubitemid 23169995)
10. Tarraza HM, Muntz HG, De Cain M, et al. Cervical metastases in advanced ovarian malignancies. Eur J Gynaecol Oncol 1993;14:274-8. (Pubitemid 23214412)
11. Korhonen M, Stenback F. Adenocarcinoma metastatic to the uterine cervix. Gynecol Obstet Invest 1984;17:57-65. (Pubitemid 14220962)
12. Young RH, Clement PB. Endocervical adenocarcinoma and its variants: their morphology and differential diagnosis. Histopathology 2002;41:185-207. (Pubitemid 35013941)
13. Seltzer V, Spitzer M. Psammoma bodies in papillary adeno-carcinoma of the endocervix. Int J Gynecol Pathol 1983;2: 216-21. (Pubitemid 14235229)
14. Zhou C, Gilks CB, Hayes M, et al. Papillary serous carcinoma of the uterine cervix. A clinicopathologic study of 17 cases. Am J Surg Pathol 1998;22:113-20. (Pubitemid 28016760)
15. Nofech-Mozes S, Khalifa MA, Ismiil N, et al. Immunophenotyping of serous carcinoma of the female genital tract. Mod Pathol 2008;21:1147-55.
16. Wong KK, Lu KH, Malpica A, et al. Significantly greater expression of ER, PR, and ECAD in advanced-staged low-grade ovarian serous carcinoma as revealed by immunohistochemical analysis. Int J Gynecol Pathol 2007;26:404-9. (Pubitemid 47476325)
17. Castrillon DH, Lee KR, Nucci MR. Distinction between endometrial and endocervical adenocarcinoma: an immunohistochemical study. Int J Gynecol Pathol 2010;21:4-10.
18. McCluggage WG, Sumathi VP, McBride HA, et al. A panel of immunohistochemical stains including carcinoembryonic antigen, vimentin and estrogen receptor aids the distinction between primary endometrial and endocervical adenocarcinomas. Int J Gynecol Pathol 2002;21:11-5. (Pubitemid 34008347)
19. Nofech-Mozes S, Rasty G, Ismiil N, et al. Immunohistochemical characterization of endocervical papillary serous carcinoma. Int J Gynecol Cancer 2006;16:286-92.
20. O'Neill CJ, McBride HA, Connolly LE, et al. High-grade ovarian serous carcinoma exhibits significantly higher p16 expression than low-grade serous carcinoma and serous borderline tumour. Histopathology 2007;50:773-9. (Pubitemid 46683935)
21. Houghton O, Jamison J, Wilson R, et al. p16 immunoreactivity in unusual types of cervical adenocarcinoma does not reflect human papillomavirus infection. Histopathology 2010; 57:342-50.
22. Nofech-Mozes S, Khalifa MA, Ismiil N, et al. Detection of HPV-DNA by PCR-based method in formalin-fixed, paraffin embedded tissue from rare endocervical carcinoma types. Appl Immunohistochem Mol Morphol 2010;18:80-5.