P16 Immunoreactivity in unusual types of cervical adenocarcinoma does not reflect human papillomavirus infection

Histopathology

Volumn 57, Issue 3, 2010, Pages 342-350

  Houghton, Oisin ^a   Jamison, Jackie ^b   Wilson, Robbie ^b   Carson, James ^b   McCluggage, W Glenn ^a  

^a ROYAL GROUP OF HOSPITALS TRUST   (United Kingdom)

^b ANTRIM AREA HOSPITAL   (United Kingdom)

Author keywords

adenocarcinoma; cervix; human papillomavirus; linear array genotyping; p16

Indexed keywords

PROTEIN P16; VIRUS DNA;

ARTICLE; DNA EXTRACTION; FEMALE; GENOTYPE; HUMAN; HUMAN PAPILLOMAVIRUS TYPE 16; HUMAN PAPILLOMAVIRUS TYPE 18; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MAJOR CLINICAL STUDY; POLYMERASE CHAIN REACTION; PREVALENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; UTERINE CERVIX CARCINOMA; WART VIRUS;

ADENOCARCINOMA; CERVIX UTERI; DNA, VIRAL; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; NEOPLASM PROTEINS; PAPILLOMAVIRUS INFECTIONS; TUMOR MARKERS, BIOLOGICAL; UTERINE CERVICAL NEOPLASMS;

HUMAN PAPILLOMAVIRUS;

EID: 77951849943     PISSN: 03090167     EISSN: 13652559     Source Type: Journal    
DOI: 10.1111/j.1365-2559.2010.03632.x     Document Type: Article

References (38)

1. Walboomers J.M., Jacobs M.V., Manos M.M. et al. Human papillomavirus is a necessary cause of invasive cervical cancer worldwide. J. Pathol. 1999 189 12 19.
2. Pirog E.C., Kleter B., Olgac S. et al. Prevalence of human papillomavirus DNA in different histological subtypes of cervical adenocarcinoma. Am. J. Pathol. 2000 157 1055 1062.
3. Hee J.A., Kim K.R., Kim I.S. Prevalence of human papillomavirus DNA in various histological subtypes of cervical adenocarcinoma: a population-based study. Mod. Pathol. 2005 18 528 534.
4. O'Neill C.J., McCluggage W.G. p16 expression in the female genital tract and its value in diagnosis. Adv. Anat. Pathol. 2006 13 8 15.
5. Kojima A., Mikami Y., Sudo T. et al. Gastric morphology and immunophenotype predict poor outcome in mucinous adenocarcinoma of the uterine cervix. Am. J. Surg. Pathol. 2007 31 664 672.
6. McCluggage W.G., Shah R., Connolly L.E., McBride H.A. Intestinal-type cervical adenocarcinoma in situ and adenocarcinoma exhibit a partial enteric immunophenotype with consistent expression of CDX2. Int. J. Gynecol. Pathol. 2007 27 92 100.
7. Zheng T., Holford T.R., Ma Z. et al. The continuing increase in adenocarcinoma of the uterine cervix: a birth cohort phenomenon. Int. J. Epidemiol. 1996 25 252 258.
8. Davis J.R., Moon L.B. Increased incidence of adenocarcinoma of the uterine cervix. Obstet. Gynecol. 1975 45 79 83.
9. Bosch F.X., Manos M.M., Munoz N. et al. Prevalence of human papillomavirus in cervical cancer: a worldwide perspective. International Biological Study on Cervical Cancer (IBSCC) Study Group. J. Natl Cancer Inst. 1995 87 796 802.
10. Duggan M.A., McGregor S.E., Benoit J.L. et al. The human papillomavirus status of invasive cervical adenocarcinoma: a clinicopathological and outcome analysis. Hum. Pathol. 1995 26 319 325.
11. Tenti P., Romagnoli S., Silini E. et al. Human papillomavirus types 16 and 18 infection in infiltrating adenocarcinoma of the cervix: PCR analysis of 138 cases and correlation with histologic type and grade. Am. J. Clin. Pathol. 1996 106 52 56.
12. Skylderg B.M., Murray E., Lambkin H. et al. Adenocarcinoma of the uterine cervix in Ireland and Sweden: human papillomavirus infection and biologic alterations. Mod. Pathol. 1999 12 675 682.
13. Stoler M.H., Rhodes C.R., Whitbeck A. et al. Human papillomavirus type 16 and 18 gene expression in cervical neoplasias. Hum. Pathol. 1992 23 117 128.
14. Park J.S., Hwang E.S., Park S.N. et al. Physical status and expression of HPV genes in cervical cancers. Gynecol. Oncol. 1997 65 121 129.
15. McCluggage W.G. Endocervical glandular lesions: controversial aspects and ancillary techniques. J. Clin. Pathol. 2003 56 164 173.
16. Young R.H., Clement P.B. Endocervical adenocarcinoma and its variants: their morphology and differential diagnosis. Histopathology 2002 41 1080 1088.
17. Hirschowitz L., Sen C., Murdoch J. Primary endometrioid adenocarcinoma of the cervix with widespread squamous metaplasia-a potential diagnostic pitfall. Diagn. Pathol. 2007 2 40.
18. Tavassoli F.A., Devilee P. eds. World Health Organization Classification of Tumours. Pathology and genetics. Tumours of the breast and female genital organs. Lyon: IARC Press, 2003.
19. Kato K., Suzuka K., Ozaki T. et al. Primary hepatoid adenocarcinoma of the uterine cervix. Int. J. Gynecol. Cancer 2007 17 1150 1154.
20. Ishikura H., Scully R.E. Hepatoid carcinoma of the ovary. A newly described tumor. Cancer 1987 60 2775 2784.
21. Hoshida Y., Nagakawa T., Mano S. et al. Hepatoid adenocarcinoma of the endometrium associated with alpha-fetoprotein production. Int. J. Gynecol. Pathol. 1996 15 266 269.
22. Xu J.Y., Hashi A., Kondo T. et al. Absence of human papillomavirus infection in minimal deviation adenocarcinoma and lobular endocervical glandular hyperplasia. Int. J. Gynecol. Pathol. 2005 24 296 302.
23. Toki T., Zhai Y.L., Park J.S., Fujii S. Infrequent occurrence of high-risk human papillomavirus and of p53 mutation in minimal deviation adenocarcinoma of the cervix. Int. J. Gynecol. Pathol. 1999 18 215 219.
24. Fukushima M., Shimano S., Yamakawa Y. et al. The detection of human papillomavirus (HPV) in a case of minimal deviation adenocarcinoma of the uterine cervix (adenoma malignum) using in situ hybridization. Jpn. J. Clin. Oncol. 1990 20 407 412.
25. Waggoner S.E., Anderson S.M., Van Eyck S., Fuller J., Luce M.C., Herbst A.L. Human papillomavirus detection and p53 expression in clear cell adenocarcinoma of the cervix and vagina. Obstet. Gynecol. 1994 84 404 408.
26. Milde-Langosch K., Schreiber C., Becker G. et al. Human papillomavirus detection in cervical adenocarcinoma by polymerase chain reaction. Hum. Pathol. 1993 24 590 594.
27. Nofech-Mozes S., Khalifa M.M., Ismiil N. et al. Detection of HPV-DNA by a PCR-based method in formalin-fixed, paraffin-embedded tissue from rare endocervical carcinoma types. Appl. Immunohistochem. Mol. Morphol. 2010 18 80 85.
28. Sano T., Oyama T., Kashiwabara K. et al. Expression status of p16 protein is associated with human papillomavirus oncogenic potential in cervical and genital lesions. Am. J. Pathol. 1998 153 1741 1748.
29. Klaes R., Friedrich T., Spitkovsky D. et al. Overexpression of p16INK4a as a specific marker for dysplastic and neoplastic epithelial cells of the cervix uteri. Int. J. Cancer 2001 92 276 284.
30. Phillips V., Kelly P., McCluggage W.G. Increased p16 expression in high-grade serous and undifferentiated carcinoma compared with other morphologic types of ovarian carcinoma. Int. J. Gynecol. Pathol. 2009 28 179 186.
31. O'Neill C.J., McBride H.A., Connolly L.E., McCluggage W.G. Uterine leiomyosarcomas are characterized by high p16, p53 and MIB1 expression in comparison with usual leiomyomas, leiomyoma variants and smooth muscle tumours of uncertain malignant potential. Histopathology 2007 50 851 858.
32. O'Neill C.J., McBride H.A., Connolly L.E. et al. High-grade ovarian serous carcinoma exhibits significantly higher p16 expression than low-grade serous carcinoma and serous borderline tumour. Histopathology 2007 50 773 779.
33. Chiesa-Vottero A.G., Malpica A., Deavers M.T. et al. Immunohistochemical overexpression of p16 and p53 in uterine serous carcinoma and ovarian high-grade serous carcinoma. Int. J. Gynecol. Pathol. 2007 26 328 333. (Pubitemid 46986071)
34. Yemelyanova A., Hongxiu J., Shih I.M. et al. Utility of p16 expression for distinction of uterine serous carcinomas from endometrial endometrioid and endocervical adenocarcinomas: immunohistochemical analysis of 201 cases. Am. J. Surg. Pathol. 2009 33 1504 1514.
35. Hashi A., Xu J.Y., Kondo T. et al. p16INK4a overexpression independent of human papillomavirus infection in lobular endocervical glandular hyperplasia. Int. J. Gynecol. Pathol. 2006 25 187 194.
36. Truskinovsky A.M., Stelow E.B., Jessurum J., Pambuccian S.E. Staining for p16 of cervical mesonephric remnants and hyperplasia: a potential diagnostic pitfall. Mod. Pathol. 2006 19 (Suppl. 1 199A.
37. Milde-Langosch K., Reithdorf S., Kraws-Poppinghaus A. Expression of cyclin-dependent kinase inhibitors p16, p21 and p27 in HPV-positive and HPV-negative cervical adenocarcinomas. Virchows Arch. 2001 439 55 61.
38. Mikami Y., Kikoyawa T., Hata S. et al. Gastrointestinal immunophenotype in adenocarcinomas of the uterine cervix and related glandular lesions: a possible link between lobular endocervical glandular hyperplasia/pyloric gland metaplasia and 'adenoma malignum'. Mod. Pathol. 2004 17 962 972.