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Volumn 6, Issue 10, 2011, Pages

Elucidation of the glucose transport pathway in glucose transporter 4 via steered molecular dynamics simulations

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; GLUCOSE; GLUCOSE TRANSPORTER 4; HYDROXYL GROUP; SUGAR; AMINO ACID;

EID: 80053957237     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0025747     Document Type: Article
Times cited : (18)

References (49)
  • 2
    • 0027507306 scopus 로고
    • A major superfamily of transmembrane facilitators that catalyse uniport, symport and antiport
    • Marger MD, Saier MH Jr, (1993) A major superfamily of transmembrane facilitators that catalyse uniport, symport and antiport. Trends Biochem Sci 18: 13-20.
    • (1993) Trends Biochem Sci , vol.18 , pp. 13-20
    • Marger, M.D.1    Saier Jr., M.H.2
  • 3
    • 0036270751 scopus 로고    scopus 로고
    • Regulated transport of the glucose transporter GLUT4
    • Bryant NJ, Govers R, James DE, (2002) Regulated transport of the glucose transporter GLUT4. Nat Rev Mol Cell Biol 3: 267-277.
    • (2002) Nat Rev Mol Cell Biol , vol.3 , pp. 267-277
    • Bryant, N.J.1    Govers, R.2    James, D.E.3
  • 4
    • 0024512585 scopus 로고
    • Identification of a novel gene encoding an insulin-responsive glucose transporter protein
    • Birnbaum MJ, (1989) Identification of a novel gene encoding an insulin-responsive glucose transporter protein. Cell 57: 305-315.
    • (1989) Cell , vol.57 , pp. 305-315
    • Birnbaum, M.J.1
  • 7
    • 0942279700 scopus 로고    scopus 로고
    • Cysteine-scanning mutagenesis of transmembrane segment 1 of glucose transporter GLUT1: extracellular accessibility of helix positions
    • Heinze M, Monden I, Keller K, (2004) Cysteine-scanning mutagenesis of transmembrane segment 1 of glucose transporter GLUT1: extracellular accessibility of helix positions. Biochemistry 43: 931-936.
    • (2004) Biochemistry , vol.43 , pp. 931-936
    • Heinze, M.1    Monden, I.2    Keller, K.3
  • 8
    • 0034646292 scopus 로고    scopus 로고
    • Cysteine scanning mutagenesis of helices 2 and 7 in GLUT1 identifies an exofacial cleft in both transmembrane segments
    • Olsowski A, Monden I, Krause G, Keller K, (2000) Cysteine scanning mutagenesis of helices 2 and 7 in GLUT1 identifies an exofacial cleft in both transmembrane segments. Biochemistry 39: 2469-2474.
    • (2000) Biochemistry , vol.39 , pp. 2469-2474
    • Olsowski, A.1    Monden, I.2    Krause, G.3    Keller, K.4
  • 9
    • 28244474472 scopus 로고    scopus 로고
    • Cysteine-scanning mutagenesis and substituted cysteine accessibility analysis of transmembrane segment 4 of the Glut1 glucose transporter
    • Mueckler M, Makepeace C, (2005) Cysteine-scanning mutagenesis and substituted cysteine accessibility analysis of transmembrane segment 4 of the Glut1 glucose transporter. J Biol Chem 280: 39562-39568.
    • (2005) J Biol Chem , vol.280 , pp. 39562-39568
    • Mueckler, M.1    Makepeace, C.2
  • 10
    • 0033574571 scopus 로고    scopus 로고
    • Transmembrane segment 5 of the Glut1 glucose transporter is an amphipathic helix that forms part of the sugar permeation pathway
    • Mueckler M, Makepeace C, (1999) Transmembrane segment 5 of the Glut1 glucose transporter is an amphipathic helix that forms part of the sugar permeation pathway. J Biol Chem 274: 10923-10926.
    • (1999) J Biol Chem , vol.274 , pp. 10923-10926
    • Mueckler, M.1    Makepeace, C.2
  • 11
    • 2942726276 scopus 로고    scopus 로고
    • Relative proximity and orientation of helices 4 and 8 of the GLUT1 glucose transporter
    • Alisio A, Mueckler M, (2004) Relative proximity and orientation of helices 4 and 8 of the GLUT1 glucose transporter. J Biol Chem 279: 26540-26545.
    • (2004) J Biol Chem , vol.279 , pp. 26540-26545
    • Alisio, A.1    Mueckler, M.2
  • 12
    • 0036479247 scopus 로고    scopus 로고
    • Analysis of transmembrane segment 10 of the Glut1 glucose transporter by cysteine-scanning mutagenesis and substituted cysteine accessibility
    • Mueckler M, Makepeace C, (2002) Analysis of transmembrane segment 10 of the Glut1 glucose transporter by cysteine-scanning mutagenesis and substituted cysteine accessibility. J Biol Chem 277: 3498-3503.
    • (2002) J Biol Chem , vol.277 , pp. 3498-3503
    • Mueckler, M.1    Makepeace, C.2
  • 13
    • 0034622585 scopus 로고    scopus 로고
    • Cysteine-scanning mutagenesis of transmembrane segment 11 of the GLUT1 facilitative glucose transporter
    • Hruz PW, Mueckler MM, (2000) Cysteine-scanning mutagenesis of transmembrane segment 11 of the GLUT1 facilitative glucose transporter. Biochemistry 39: 9367-9372.
    • (2000) Biochemistry , vol.39 , pp. 9367-9372
    • Hruz, P.W.1    Mueckler, M.M.2
  • 14
    • 1642375338 scopus 로고    scopus 로고
    • Analysis of transmembrane segment 8 of the GLUT1 glucose transporter by cysteine-scanning mutagenesis and substituted cysteine accessibility
    • Mueckler M, Makepeace C, (2004) Analysis of transmembrane segment 8 of the GLUT1 glucose transporter by cysteine-scanning mutagenesis and substituted cysteine accessibility. J Biol Chem 279: 10494-10499.
    • (2004) J Biol Chem , vol.279 , pp. 10494-10499
    • Mueckler, M.1    Makepeace, C.2
  • 15
    • 0026701389 scopus 로고
    • Site-directed mutagenesis of GLUT1 in helix 7 residue 282 results in perturbation of exofacial ligand binding
    • Hashiramoto M, Kadowaki T, Clark AE, Muraoka A, Momomura K, et al. (1992) Site-directed mutagenesis of GLUT1 in helix 7 residue 282 results in perturbation of exofacial ligand binding. J Biol Chem 267: 17502-17507.
    • (1992) J Biol Chem , vol.267 , pp. 17502-17507
    • Hashiramoto, M.1    Kadowaki, T.2    Clark, A.E.3    Muraoka, A.4    Momomura, K.5
  • 16
    • 0027997421 scopus 로고
    • Glutamine 161 of Glut1 glucose transporter is critical for transport activity and exofacial ligand binding
    • Mueckler M, Weng W, Kruse M, (1994) Glutamine 161 of Glut1 glucose transporter is critical for transport activity and exofacial ligand binding. J Biol Chem 269: 20533-20538.
    • (1994) J Biol Chem , vol.269 , pp. 20533-20538
    • Mueckler, M.1    Weng, W.2    Kruse, M.3
  • 17
    • 0026738934 scopus 로고
    • Amino acid substitutions at tryptophan 388 and tryptophan 412 of the HepG2 (Glut1) glucose transporter inhibit transport activity and targeting to the plasma membrane in Xenopus oocytes
    • Garcia JC, Strube M, Leingang K, Keller K, Mueckler MM, (1992) Amino acid substitutions at tryptophan 388 and tryptophan 412 of the HepG2 (Glut1) glucose transporter inhibit transport activity and targeting to the plasma membrane in Xenopus oocytes. J Biol Chem 267: 7770-7776.
    • (1992) J Biol Chem , vol.267 , pp. 7770-7776
    • Garcia, J.C.1    Strube, M.2    Leingang, K.3    Keller, K.4    Mueckler, M.M.5
  • 18
    • 0028043145 scopus 로고
    • Replacement of both tryptophan residues at 388 and 412 completely abolished cytochalasin B photolabelling of the GLUT1 glucose transporter
    • Inukai K, Asano T, Katagiri H, Anai M, Funaki M, et al. (1994) Replacement of both tryptophan residues at 388 and 412 completely abolished cytochalasin B photolabelling of the GLUT1 glucose transporter. Biochem J302 (Pt 2): 355-361.
    • (1994) Biochem J , vol.302 , Issue.Pt 2 , pp. 355-361
    • Inukai, K.1    Asano, T.2    Katagiri, H.3    Anai, M.4    Funaki, M.5
  • 19
    • 0032518852 scopus 로고    scopus 로고
    • Serine-294 and threonine-295 in the exofacial loop domain between helices 7 and 8 of glucose transporters (GLUT) are involved in the conformational alterations during the transport process
    • Doege H, Schurmann A, Ohnimus H, Monser V, Holman GD, et al. (1998) Serine-294 and threonine-295 in the exofacial loop domain between helices 7 and 8 of glucose transporters (GLUT) are involved in the conformational alterations during the transport process. Biochem J329 (Pt 2): 289-293.
    • (1998) Biochem J , vol.329 , Issue.Pt 2 , pp. 289-293
    • Doege, H.1    Schurmann, A.2    Ohnimus, H.3    Monser, V.4    Holman, G.D.5
  • 20
    • 0028246067 scopus 로고
    • Substitution of tyrosine 293 of GLUT1 locks the transporter into an outward facing conformation
    • Mori H, Hashiramoto M, Clark AE, Yang J, Muraoka A, et al. (1994) Substitution of tyrosine 293 of GLUT1 locks the transporter into an outward facing conformation. J Biol Chem 269: 11578-11583.
    • (1994) J Biol Chem , vol.269 , pp. 11578-11583
    • Mori, H.1    Hashiramoto, M.2    Clark, A.E.3    Yang, J.4    Muraoka, A.5
  • 21
    • 59649109384 scopus 로고    scopus 로고
    • Homology modeling of GLUT4, an insulin regulated facilitated glucose transporter and docking studies with ATP and its inhibitors
    • Mohan SS, Perry JJ, Poulose N, Nair BG, Anilkumar G, (2009) Homology modeling of GLUT4, an insulin regulated facilitated glucose transporter and docking studies with ATP and its inhibitors. J Biomol Struct Dyn 26: 455-464.
    • (2009) J Biomol Struct Dyn , vol.26 , pp. 455-464
    • Mohan, S.S.1    Perry, J.J.2    Poulose, N.3    Nair, B.G.4    Anilkumar, G.5
  • 23
    • 0029976301 scopus 로고    scopus 로고
    • Subcellular trafficking kinetics of GLU4 mutated at the N- and C-terminal
    • Araki S, Yang J, Hashiramoto M, Tamori Y, Kasuga M, et al. (1996) Subcellular trafficking kinetics of GLU4 mutated at the N- and C-terminal. The Biochemical journal 315 (Pt 1): 153-159.
    • (1996) The Biochemical Journal , vol.315 , Issue.Pt 1 , pp. 153-159
    • Araki, S.1    Yang, J.2    Hashiramoto, M.3    Tamori, Y.4    Kasuga, M.5
  • 24
    • 0027517451 scopus 로고
    • Identification of the carboxy terminus as important for the isoform-specific subcellular targeting of glucose transporter proteins
    • Verhey KJ, Hausdorff SF, Birnbaum MJ, (1993) Identification of the carboxy terminus as important for the isoform-specific subcellular targeting of glucose transporter proteins. The Journal of cell biology 123: 137-147.
    • (1993) The Journal of Cell Biology , vol.123 , pp. 137-147
    • Verhey, K.J.1    Hausdorff, S.F.2    Birnbaum, M.J.3
  • 26
    • 78649949857 scopus 로고    scopus 로고
    • Molecular Dynamics Simulation Studies of GLUT4: Substrate-Free and Substrate-Induced Dynamics and ATP-Mediated Glucose Transport Inhibition
    • Mohan S, Sheena A, Poulose N, Anilkumar G, (2010) Molecular Dynamics Simulation Studies of GLUT4: Substrate-Free and Substrate-Induced Dynamics and ATP-Mediated Glucose Transport Inhibition. PLoS ONE 5: e14217.
    • (2010) PLoS ONE , vol.5
    • Mohan, S.1    Sheena, A.2    Poulose, N.3    Anilkumar, G.4
  • 27
    • 0037159240 scopus 로고    scopus 로고
    • Molecular determinants of sugar transport regulation by ATP
    • Levine KB, Cloherty EK, Hamill S, Carruthers A, (2002) Molecular determinants of sugar transport regulation by ATP. Biochemistry 41: 12629-12638.
    • (2002) Biochemistry , vol.41 , pp. 12629-12638
    • Levine, K.B.1    Cloherty, E.K.2    Hamill, S.3    Carruthers, A.4
  • 29
    • 4143116650 scopus 로고    scopus 로고
    • Computational studies of membrane channels
    • Roux B, Schulten K, (2004) Computational studies of membrane channels. Structure 12: 1343-1351.
    • (2004) Structure , vol.12 , pp. 1343-1351
    • Roux, B.1    Schulten, K.2
  • 31
    • 54949153447 scopus 로고    scopus 로고
    • Modeling of glycerol-3-phosphate transporter suggests a potential 'tilt' mechanism involved in its function
    • Tsigelny IF, Greenberg J, Kouznetsova V, Nigam SK, (2008) Modeling of glycerol-3-phosphate transporter suggests a potential 'tilt' mechanism involved in its function. J Bioinform Comput Biol 6: 885-904.
    • (2008) J Bioinform Comput Biol , vol.6 , pp. 885-904
    • Tsigelny, I.F.1    Greenberg, J.2    Kouznetsova, V.3    Nigam, S.K.4
  • 32
    • 34447253999 scopus 로고    scopus 로고
    • Sugar transport across lactose permease probed by steered molecular dynamics
    • Jensen MO, Yin Y, Tajkhorshid E, Schulten K, (2007) Sugar transport across lactose permease probed by steered molecular dynamics. Biophys J 93: 92-102.
    • (2007) Biophys J , vol.93 , pp. 92-102
    • Jensen, M.O.1    Yin, Y.2    Tajkhorshid, E.3    Schulten, K.4
  • 33
    • 62449268980 scopus 로고    scopus 로고
    • Molecular simulations elucidate the substrate translocation pathway in a glutamate transporter
    • Gu Y, Shrivastava IH, Amara SG, Bahar I, (2009) Molecular simulations elucidate the substrate translocation pathway in a glutamate transporter. Proc Natl Acad Sci U S A 106: 2589-2594.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 2589-2594
    • Gu, Y.1    Shrivastava, I.H.2    Amara, S.G.3    Bahar, I.4
  • 35
    • 0141754098 scopus 로고    scopus 로고
    • Gating of MscL studied by steered molecular dynamics
    • Gullingsrud J, Schulten K, (2003) Gating of MscL studied by steered molecular dynamics. Biophys J 85: 2087-2099.
    • (2003) Biophys J , vol.85 , pp. 2087-2099
    • Gullingsrud, J.1    Schulten, K.2
  • 36
    • 55149103351 scopus 로고    scopus 로고
    • Dynamic mechanism of fatty acid transport across cellular membranes through FadL: molecular dynamics simulations
    • Zou H, Zheng M, Luo X, Zhu W, Chen K, et al. (2008) Dynamic mechanism of fatty acid transport across cellular membranes through FadL: molecular dynamics simulations. The journal of physical chemistry B 112: 13070-13078.
    • (2008) The Journal of Physical Chemistry B , vol.112 , pp. 13070-13078
    • Zou, H.1    Zheng, M.2    Luo, X.3    Zhu, W.4    Chen, K.5
  • 38
    • 0015577390 scopus 로고
    • Structural requirements for binding to the sugar-transport system of the human erythrocyte
    • Barnett JE, Holman GD, Munday KA, (1973) Structural requirements for binding to the sugar-transport system of the human erythrocyte. Biochem J131: 211-221.
    • (1973) Biochem J , vol.131 , pp. 211-221
    • Barnett, J.E.1    Holman, G.D.2    Munday, K.A.3
  • 39
    • 0015806825 scopus 로고
    • An explanation of the asymmetric binding of sugars to the human erythrocyte sugar-transport systems
    • Barnett JE, Holman GD, Munday KA, (1973) An explanation of the asymmetric binding of sugars to the human erythrocyte sugar-transport systems. Biochem J135: 539-541.
    • (1973) Biochem J , vol.135 , pp. 539-541
    • Barnett, J.E.1    Holman, G.D.2    Munday, K.A.3
  • 40
    • 0032477798 scopus 로고    scopus 로고
    • QLS motif in transmembrane helix VII of the glucose transporter family interacts with the C-1 position of D-glucose and is involved in substrate selection at the exofacial binding site
    • Seatter MJ, De la Rue SA, Porter LM, Gould GW, (1998) QLS motif in transmembrane helix VII of the glucose transporter family interacts with the C-1 position of D-glucose and is involved in substrate selection at the exofacial binding site. Biochemistry 37: 1322-1326.
    • (1998) Biochemistry , vol.37 , pp. 1322-1326
    • Seatter, M.J.1    de la Rue, S.A.2    Porter, L.M.3    Gould, G.W.4
  • 41
    • 0020360929 scopus 로고
    • Effects of temperature on basal and insulin-stimulated glucose transport activities in fat cells. Further support for the translocation hypothesis of insulin action
    • Ezaki O, Kono T, (1982) Effects of temperature on basal and insulin-stimulated glucose transport activities in fat cells. Further support for the translocation hypothesis of insulin action. J Biol Chem 257: 14306-14310.
    • (1982) J Biol Chem , vol.257 , pp. 14306-14310
    • Ezaki, O.1    Kono, T.2
  • 42
    • 12144289984 scopus 로고    scopus 로고
    • Glide: a new approach for rapid, accurate docking and scoring. 1. Method and assessment of docking accuracy
    • Friesner RA, Banks JL, Murphy RB, Halgren TA, Klicic JJ, et al. (2004) Glide: a new approach for rapid, accurate docking and scoring. 1. Method and assessment of docking accuracy. J Med Chem 47: 1739-1749.
    • (2004) J Med Chem , vol.47 , pp. 1739-1749
    • Friesner, R.A.1    Banks, J.L.2    Murphy, R.B.3    Halgren, T.A.4    Klicic, J.J.5
  • 44
    • 0029878720 scopus 로고    scopus 로고
    • VMD: visual molecular dynamics
    • 27-38
    • Humphrey W, Dalke A, Schulten K, (1996) VMD: visual molecular dynamics. J Mol Graph 14: 33-38, 27-38.
    • (1996) J Mol Graph , vol.14 , pp. 33-38
    • Humphrey, W.1    Dalke, A.2    Schulten, K.3
  • 45
    • 33846823909 scopus 로고
    • Particle mesh Eward: An N.log(N) method for Eward sums in large systems
    • Darden T, York D, Pedersen L, (1993) Particle mesh Eward: An N.log(N) method for Eward sums in large systems. J Chem Phys 98: 10089-10092.
    • (1993) J Chem Phys , vol.98 , pp. 10089-10092
    • Darden, T.1    York, D.2    Pedersen, L.3
  • 47
    • 0000388705 scopus 로고    scopus 로고
    • LINCS: A linear constraint solver for molecular simulations
    • Hess B, Bekker H, Berendsen H, Fraaije J, (1997) LINCS: A linear constraint solver for molecular simulations. J Comput Chem 18: 1463-1472.
    • (1997) J Comput Chem , vol.18 , pp. 1463-1472
    • Hess, B.1    Bekker, H.2    Berendsen, H.3    Fraaije, J.4
  • 48
    • 84986519238 scopus 로고
    • The weighted histogram analysis method for free-energy calculations on biomolecules: 1. the method
    • Kumar S, Bouzida D, Swendsen R, Kollman P, Rosenberg J, (1992) The weighted histogram analysis method for free-energy calculations on biomolecules: 1. the method. J Comput Chem 13: 1011-1021.
    • (1992) J Comput Chem , vol.13 , pp. 1011-1021
    • Kumar, S.1    Bouzida, D.2    Swendsen, R.3    Kollman, P.4    Rosenberg, J.5
  • 49
    • 0029633155 scopus 로고
    • The calculation of the potential of mean force using computersimulations
    • Roux B, (1995) The calculation of the potential of mean force using computersimulations. Comput Phys Commun 91: 275-282.
    • (1995) Comput Phys Commun , vol.91 , pp. 275-282
    • Roux, B.1


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