Ureaplasmas: From commensal flora to serious infections

Reviews and Research in Medical Microbiology

Volumn 22, Issue 4, 2011, Pages 73-83

  Juhász, Emese ^a,b   Ostorházi, Eszter ^b   Pónyai, Katinka ^b   Silló, Pálma ^b   Párducz, László ^c   Rozgonyi, Ferenc ^b  

^a UNIVERSITY OF SZEGED   (Hungary)

^b SEMMELWEIS UNIVERSITY   (Hungary)

^c Pandy Kalman Bekes County Hospital   (Hungary)

Author keywords

antibiotic resistance; characterization; clinical features; diagnostic methods; treatment; Ureaplasma parvum; Ureaplasma urealyticum

Indexed keywords

AZITHROMYCIN; BACTERIAL ANTIGEN; CLARITHROMYCIN; DOXYCYCLINE; ERYTHROMYCIN; JOSAMYCIN; MACROLIDE; PRISTINAMYCIN; QUINOLINE DERIVED ANTIINFECTIVE AGENT; ROXITHROMYCIN; TETRACYCLINE; VIRULENCE FACTOR;

ANTIBIOTIC RESISTANCE; ANTIBIOTIC THERAPY; ARTICLE; BACTERIAL CELL WALL; BACTERIUM IDENTIFICATION; CLINICAL FEATURE; COMMENSAL; FLORA; HUMAN; IMMUNE DEFICIENCY; IMMUNOLOGY; INFECTION PREVENTION; LABORATORY DIAGNOSIS; MENINGITIS; NONHUMAN; PERICARDITIS; PREMATURITY; PRIORITY JOURNAL; SEROTYPE; SEXUALLY TRANSMITTED DISEASE; UREAPLASMA; UREAPLASMA INFECTION; VERY LOW BIRTH WEIGHT;

EID: 80053954459     PISSN: 0954139X     EISSN: 14735601     Source Type: Journal    
DOI: 10.1097/MRM.0b013e328349477d     Document Type: Article

References (46)

1. Schelonka RL, Waites KB. Ureaplasma infection and neonatal lung disease. Semin Perinatol 2007; 31:2-9. (Pubitemid 46273657)
2. Viscardi RM, Hasday JD. Role of Ureaplasma species in neonatal chronic lung disease: epidemiologic and experimental evidence. Pediatr Res 2009; 65:84R-90R.
3. Waites KB, Schelonka RL, Xiao L, Grigsby PL, Novy MJ. Congenital and opportunistic infections: Ureaplasma species and Mycoplasma hominis. Semin Fetal Neonatal Med 2009; 14:190-199.
4. Momynaliev K, Klubin A, Chelysheva V, Selezneva O, Akopian T, Govorun V. Comparative genome analysis of Ureaplasma parvum clinical isolates. Res Microbiol 2007; 158:371-378. (Pubitemid 46810198)
5. Glass JI, Lefkowitz EJ, Glass JS, Heiner CR, Chen EY, Cassell GH. The complete sequence of the mucosal pathogen Ureaplasma urealyticum. Nature 2000; 407:757-762.
6. Mallard K, Schopfer K, Bodmer T. Development of real-time PCR for the differential detection and quantification of Ureaplasma urealyticum and Ureaplasma parvum. J Microbiol Methods 2005; 60:13-19. (Pubitemid 39573332)
7. Tarrant WP, Gonzalez-Berjon JM, Cernoch PL, Olsen RJ, Musser JM. Spontaneous bacterial pericarditis with tamponade due to Ureaplasma spp. J Clin Microbiol 2009; 47:1965-1968.
8. Waites KB, Katz B, Schelonka RL. Mycoplasmas and ureaplasmas as neonatal pathogens. Clin Microbiol Rev 2005; 18:757-789. (Pubitemid 41504514)
9. Geissdörfer W, Sandner G, John S, Gessner A, Schoerner C, Schröppel K. Ureaplasma urealyticum meningitis in an adult patient. J Clin Microbiol 2008; 46:1141-1143. (Pubitemid 351380019)
10. De Francesco MA, Negrini R, Pinsi G, Peroni L, Manca N. Detection of Ureaplasma biovars and polymerase chain reaction- based subtyping of Ureaplasma parvum in women with or without symptoms of genital infections. Eur J Clin Microbiol Infect Dis 2009; 28:641-646.
11. García-Castillo M, Morosini MI, Gálvez M, Baquero F, del Campo R, Meseguer MA. Differences in biofilm development and antibiotic susceptibility among clinical Ureaplasma urealyticum and Ureaplasma parvum isolates. J Antimicrob Chemother 2008; 62:1027-1030.
12. Volgmann T, Ohlinger R, Panzig B. Ureaplasma urealyticum: harmless commensal or underestimated enemy of human reproduction? A review. Arch Gynecol Obstet 2005; 273:133-139. (Pubitemid 41666958)
13. Colaizy TT, Kuforiji T, Sklar RS, Pillers DA. PCR methods in clinical investigations of human ureaplasmas: a minireview. Mol Genet Metab 2003; 80:389-397. (Pubitemid 37491199)
14. Bayraktar MR, Ozerol IH, Gucluer N, Celik O. Prevalence and antibiotic susceptibility of Mycoplasma hominis and Ureaplasma urealyticum in pregnant women. Int J Infect Dis 2010; 14:90-95.
15. Cao X, Wang Y, Hu X, Qing H, Wang H. Real-time TaqMan polymerase chain reaction assays for quantitative detection and differentiation of Ureaplasma urealyticum and Ureaplasma parvum. Diagn Microbiol Infect Dis 2007; 57:373-378. (Pubitemid 46498648)
16. Christopoulos P, Deligeoroglou E, Papadias K. Genital mycoplasmas in nonsexually active young females with vaginal discharge. Int J Gynaecol Obstet 2007; 97:49-50. (Pubitemid 46357539)
17. Soni S, Alexander S, Verlander N, Saunders P, Richardson D, Fisher M, et al. The prevalence of urethral and rectal Mycoplasma genitalium and its associations in men who have sex with men attending a genitourinary medicine clinic. Sex Transm Infect 2010; 86:21-24.
18. Lee YS, Kim JY, Kim JC, Park WH, Choo MS, Lee KS. Prevalence and treatment efficacy of genitourinary mycoplasmas in women with overactive bladder symptoms. Korean J Urol 2010; 51:625-630.
19. Hartmann M. Genital mycoplasmas. J Dtsch Dermatol Ges 2009; 7:371-377.
20. Deguchi T, Yoshida T, Miyazawa T, Yasuda M, Tamaki M, Ishiko H, et al. Association of Ureaplasma urealyticum (biovar 2) with nongonococcal urethritis. Sex Transm Dis 2004; 31:192-195. (Pubitemid 38252905)
21. MacKenzie CR, Nischik N, Kram R, Krauspe R, Jäger M, Henrich B. Fatal outcome of a disseminated dual infection with drugresistant Mycoplasma hominis and Ureaplasma parvum originating from a septic arthritis in an immunocompromised patient. Int J Infect Dis 2010; 14 (Suppl 3):307-309.
22. Sköldenberg OG, Rysinska AD, Neander G, Muren OH, Ahl TE. Ureaplasma urealyticum infection in total hip arthroplasty leading to revision. J Arthroplasty 2010; 25:1170.e11- 1170.e13.
23. Arber C, Buser A, Heim D, Weisser M, Tyndall A, Tichelli A, et al. Septic polyarthritis with Ureaplasma urealyticum in a patient with prolonged agammaglobulinemia and B-cell aplasia after allogeneic HSCT and rituximab pretreatment. Bone Marrow Transplant 2007; 40:597-598. (Pubitemid 47382132)
24. Morioka I, Fujibayashi H, Enoki E, Yokoyama N, Yokozaki H, Matsuo M. Congenital pneumonia with sepsis caused by intrauterine infection of Ureaplasma parvum in a term newborn: a first case report. J Perinatol 2010; 30:359-362.
25. Pinna GS, Skevaki CL, Kafetzis DA. The siginifancance of Ureaplasma urealyticum as a pathogenic agent in the paediatric population. Curr Opin Infect Dis 2006; 19:283-289. (Pubitemid 43740368)
26. Hashimoto O, Yoshida T, Ishiko H, Ido M, Deguchi T. Quantitative detection and phylogeny-based identification of mycoplasmas and ureaplasmas from human immunodeficiency virus type 1-positive patients. J Infect Chemother 2006; 12:25-30.
27. Murray PR. Mycoplasma and ureaplasma: manual of clinical microbiology. 9th ed. vol 1. ASM Press; 2007. pp. 1004-1020.
28. Lee AH, Ramanujam T, Ware P, Edelstein PH, Brooks JJ, Freundlich B, et al. Molecular diagnosis of ureaplasma urealyticum septic arthritis in a patient with hypogammaglobulinemia. Arthritis Rheum 1992; 35:443-448.
29. Petrikkos GL, Hadjisoteriou M, Daikos GL. PCR versus culture in the detection of vaginal Ureaplasma urealyticum and Mycoplasma hominis. Int J Gynaecol Obstet 2007; 97:202-203. (Pubitemid 46733983)
30. Yoshida T, Maeda S, Deguchi T, Ishiko H. Phylogeny-based rapid identification of mycoplasmas and ureaplasmas from urethritis patients. J Clin Microbiol 2002; 40:105-110. (Pubitemid 34027609)
31. Cao X, Jiang Z, Wang Y, Gong R, Zhang C. Two multiplex realtime TaqMan polymerase chain reaction systems for simultaneous detecting and serotyping of Ureaplasma parvum. Diagn Microbiol Infect Dis 2007; 59:109-111. (Pubitemid 47391179)
32. Yi J, Yoon BH, Kim EC. Detection and biovar discrimination of Ureaplasma urealyticum by real-time PCR. Mol Cell Probes 2005; 19:255-260. (Pubitemid 40982568)
33. Moser SA, Mayfield CA, Duffy LB, Waites KB. Genotypic characterization of Ureaplasma species by pulsed field gel electrophoresis. J Microbiol Methods 2006; 67:606-610. (Pubitemid 44740204)
34. Diaz N, Dessì D, Dessole S, Fiori PL, Rappelli P. Rapid detection of coinfections by Trichomonas vaginalis, Mycoplasma hominis, and Ureaplasma urealyticum by a new multiplex polymerase chain reaction. Diagn Microbiol Infect Dis 2010; 67:30-36.
35. Shi G, Wen SY, Chen SH, Wang SQ. Fabrication and optimization of the multiplex PCR-based oligonucleotide microarray for detection of Neisseria gonorrhoeae, Chlamydia trachomatis and Ureaplasma urealyticum. J Microbiol Methods 2005; 62:245-256. (Pubitemid 40991443)
36. Bao T, Chen R, Zhang J, Li D, Guo Y, Liang P, et al. Simultaneous detection of Ureaplasma parvum, Ureaplasma urealyticum, Mycoplasma genitalium and Mycoplasma hominis by fluorescence polarization. J Biotechnol 2010; 150:41-43.
37. Takahashi S, Takeyama K, Miyamoto S, Ichihara K, Maeda T, Kunishima Y, et al. Detection of Mycoplasma genitalium, Mycoplasma hominis, Ureaplasma urealyticum, and Ureaplasma parvum DNAs in urine from asymptomatic healthy young Japanese men. J Infect Chemother 2006; 12:269-271. (Pubitemid 44760506)
38. Beeton ML, Chalker VJ, Maxwell NC, Kotecha S, Spiller OB. Concurrent titration and determination of antibiotic resistance in Ureaplasma species with identification of novel point mutations in genes associated with resistance. Antimicrob Agents Chemother 2009; 53:2020-2027.
39. Beeton ML, Chalker VJ, Kotecha S, Spiller OB. Comparison of ull gyrA, gyrB, parC and parE gene sequences between all Ureaplasma parvum and Ureaplasma urealyticum serovars to separate true fluoroquinolone antibiotic resistance mutations from nonresistance polymorphism. J Antimicrob Chemother 2009; 64:529-538.
40. Lu C, Ye T, Zhu G, Feng P, Ma H, Lu R, et al. Phenotypic and genetic characteristics of macrolide and lincosamide resistant Ureaplasma urealyticum isolated in Guangzhou, China. Curr Microbiol 2010; 61:44-49.
41. Kilic D, Basar MM, Kaygusuz S, Yilmaz E, Basar H, Batislam E. Prevalence and treatment of Chlamydia trachomatis, Ureaplasma urealyticum, and Mycoplasma hominis in patients with nongonococcal urethritis. Jpn J Infect Dis 2004; 57:17-20. (Pubitemid 38404736)
42. Duffy L, Glass J, Hall G, Avery R, Rackley R, Peterson S, et al. Fluoroquinolone resistance in Ureaplasma parvum in the United States. J Clin Microbiol 2006; 44:1590-1591.
43. Shimada Y, Deguchi T, Nakane K, Masue T, Yasuda M, Yokoi S, et al. Emergence of clinical strains of Mycoplasma genitalium harbouring alterations in ParC associated with fluoroquinolone resistance. Int J Antimicrob Agents 2010; 36:255-258.
44. Dongya M, Wencheng X, Xiaobo M, Lu W. Transition mutations in 23S rRNA account for acquired resistance to macrolides in Ureaplasma urealyticum. Microb Drug Resist 2008; 14:183-186.
45. Pereyre S, Métifiot M, Cazanave C, Renaudin H, Charron A, Bébéar C, et al. Characterisation of in vitro-selected mutants of Ureaplasma parvum resistant to macrolides and related antibiotics. Int J Antimicrob Agents 2007; 29:207-211. (Pubitemid 46073671)
46. Roberts MC, Kenny GE. TetM tetracycline-resistant determinants in Ureaplasma urealyticum. Pediatr Infect Dis 1986; 5 (6 Suppl):S338-S340. (Pubitemid 17200768)