Infection of lymphoblastoid cell lines by kaposi's sarcoma-associated herpesvirus: Critical role of cell-associated virus

Journal of Virology

Volumn 85, Issue 19, 2011, Pages 9767-9777

  Myoung, Jinjong ^a,b   Ganem, Don ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DOXYCYCLINE; PUROMYCIN;

ARTICLE; COCULTURE; CONTROLLED STUDY; HERPES VIRUS INFECTION; HUMAN HERPESVIRUS 8; LATENT PERIOD; LYMPHOBLASTOID CELL LINE; LYMPHOMA CELL; NONHUMAN; PRIORITY JOURNAL; VIRION; VIRUS ENTRY; VIRUS GENOME; VIRUS RECOMBINANT; VIRUS TRANSMISSION;

B-LYMPHOCYTES; CELL LINE; HERPESVIRUS 8, HUMAN; HUMANS; VIRUS ACTIVATION; VIRUS INTERNALIZATION; VIRUS LATENCY; VIRUS REPLICATION;

HUMAN HERPESVIRUS 8;

EID: 80053944982     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.05136-11     Document Type: Article

References (48)

1. Akula, S. M., F. Z. Wang, J. Vieira, and B. Chandran. 2001. Human herpesvirus 8 interaction with target cells involves heparan sulfate. Virology 282:245-255.
2. Ambroziak, J. A., et al. 1995. Herpes-like sequences in HIV-infected and uninfected Kaposi's sarcoma patients. Science 268:582-583.
3. Aroeti, B., and Y. I. Henis. 1991. Accumulation of Sendai virus glycoproteins in cell-cell contact regions and its role in cell fusion. J. Biol. Chem. 266: 15845-15849.
4. Barnard, A. L., T. Igakura, Y. Tanaka, G. P. Taylor, and C. R. Bangham. 2005. Engagement of specific T-cell surface molecules regulates cytoskeletal polarization in HTLV-1-infected lymphocytes. Blood 106:988-995.
5. Bechtel, J. T., Y. Liang, J. Hvidding, and D. Ganem. 2003. Host range of Kaposi's sarcoma-associated herpesvirus in cultured cells. J. Virol. 77:6474-6481.
6. Birkmann, A., et al. 2001. Cell surface heparan sulfate is a receptor for human herpesvirus 8 and interacts with envelope glycoprotein K8.1. J. Virol. 75:11583-11593.
7. Blackbourn, D. J., et al. 2000. The restricted cellular host range of human herpesvirus 8. AIDS 14:1123-1133.
8. Brueckner, B., et al. 2005. Epigenetic reactivation of tumor suppressor genes by a novel small-molecule inhibitor of human DNA methyltransferases. Cancer Res. 65:6305-6311.
9. Cesarman, E., Y. Chang, P. S. Moore, J. W. Said, and D. M. Knowles. 1995. Kaposi's sarcoma-associated herpesvirus-like DNA sequences in AIDS-related body-cavity-based lymphomas. N. Engl. J. Med. 332:1186-1191.
10. Cesarman, E., et al. 1995. In vitro establishment and characterization of two AIDS-related lymphoma cell lines (BC-1 and BC-2) containing Kaposi's sarcoma-associated herpesvirus-like (KSHV) DNA sequences. Blood 86: 2708-2714.
11. Chandriani, S., Y. Xu, and D. Ganem. 2010. The lytic transcriptome of Kaposi's sarcoma-associated herpesvirus reveals extensive transcription of noncoding regions, including regions antisense to important genes. J. Virol. 84:7934-7942.
12. Chen, E. H., and E. N. Olson. 2005. Unveiling the mechanisms of cell-cell fusion. Science 308:369-373.
13. Chen, J., et al. 2001. Activation of latent Kaposi's sarcoma-associated herpesvirus by demethylation of the promoter of the lytic transactivator. Proc. Natl. Acad. Sci. U. S. A. 98:4119-4124.
14. Chen, L., and M. Lagunoff. 2005. Establishment and maintenance of Kaposi's sarcoma-associated herpesvirus latency in B cells. J. Virol. 79:14383-14391.
15. Chen, L., and M. Lagunoff. 2007. The KSHV viral interleukin-6 is not essential for latency or lytic replication in BJAB cells. Virology 359:425-435.
16. Deng, H., Y. Liang, and R. Sun. 2007. Regulation of KSHV lytic gene expression. Curr. Top. Microbiol. Immunol. 312:157-183.
17. Ganem, D. 2006. KSHV infection and the pathogenesis of Kaposi's sarcoma. Annu. Rev. Pathol. 1:273-296.
18. Gardella, T., P. Medveczky, T. Sairenji, and C. Mulder. 1984. Detection of circular and linear herpesvirus DNA molecules in mammalian cells by gel electrophoresis. J. Virol. 50:248-254.
19. Grundhoff, A., and D. Ganem. 2004. Inefficient establishment of KSHV latency suggests an additional role for continued lytic replication in Kaposi sarcoma pathogenesis. J. Clin. Invest. 113:124-136.
20. Gummuluru, S., V. N. KewalRamani, and M. Emerman. 2002. Dendritic cell-mediated viral transfer to T cells is required for human immunodeficiency virus type 1 persistence in the face of rapid cell turnover. J. Virol. 76:10692-10701.
21. Hassman, L. M., T. J. Ellison, and D. H. Kedes. 2011. KSHV infects a subset of human tonsillar B cells, driving proliferation and plasmablast differentiation. J. Clin. Invest. 121:752-768.
22. Igakura, T., et al. 2003. Spread of HTLV-I between lymphocytes by virusinduced polarization of the cytoskeleton. Science 299:1713-1716.
23. Jarousse, N., B. Chandran, and L. Coscoy. 2008. Lack of heparan sulfate expression in B-cell lines: implications for Kaposi's sarcoma-associated herpesvirus and murine gammaherpesvirus 68 infections. J. Virol. 82:12591-12597.
24. Kirshner, J. R., D. M. Lukac, J. Chang, and D. Ganem. 2000. Kaposi's sarcoma-associated herpesvirus open reading frame 57 encodes a posttranscriptional regulator with multiple distinct activities. J. Virol. 74:3586-3597.
25. Komanduri, K. V., J. A. Luce, M. S. McGrath, B. G. Herndier, and V. L. Ng. 1996. The natural history and molecular heterogeneity of HIV-associated primary malignant lymphomatous effusions. J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. 13:215-226.
26. Llewellyn, G. N., I. B. Hogue, J. R. Grover, and A. Ono. 2010. Nucleocapsid promotes localization of HIV-1 gag to uropods that participate in virological synapses between T cells. PLoS Pathog. 6:e1001167.
27. Lukac, D. M., J. R. Kirshner, and D. Ganem. 1999. Transcriptional activation by the product of open reading frame 50 of Kaposi's sarcoma-associated herpesvirus is required for lytic viral reactivation in B cells. J. Virol. 73:9348-9361.
28. Lukac, D. M., R. Renne, J. R. Kirshner, and D. Ganem. 1998. Reactivation of Kaposi's sarcoma-associated herpesvirus infection from latency by expression of the ORF 50 transactivator, a homolog of the EBV R protein. Virology 252:304-312.
29. McDonald, D., et al. 2003. Recruitment of HIV and its receptors to dendritic cell-T cell junctions. Science 300:1295-1297.
30. Mesri, E. A., et al. 1996. Human herpesvirus-8/Kaposi's sarcoma-associated herpesvirus is a new transmissible virus that infects B cells. J. Exp. Med. 183:2385-2390.
31. Miller, G., et al. 1997. Selective switch between latency and lytic replication of Kaposi's sarcoma herpesvirus and Epstein-Barr virus in dually infected body cavity lymphoma cells. J. Virol. 71:314-324.
32. Myoung, J., and D. Ganem. 2011. Active lytic infection of human primary tonsillar B cells by KSHV and its noncytolytic control by activated CD4+ T cells. J. Clin. Invest. 121:1130-1140.
33. Myoung, J., and D. Ganem. 2011. Generation of a doxycycline-inducible KSHV producer cell line of endothelial origin: maintenance of tight latency with efficient reactivation upon induction. J. Virol. Methods 174:12-21.
34. Myoung, J., and D. Ganem. 2011. Infection of primary human tonsillar lymphoid cells by KSHV reveals frequent but abortive infection of T cells. Virology 413:1-11.
35. Rappocciolo, G., et al. 2008. Human herpesvirus 8 infects and replicates in primary cultures of activated B lymphocytes through DC-SIGN. J. Virol. 82:4793-4806.
36. Rawling, J., B. Garcia-Barreno, and J. A. Melero. 2008. Insertion of the two cleavage sites of the respiratory syncytial virus fusion protein in Sendai virus fusion protein leads to enhanced cell-cell fusion and a decreased dependency on the HN attachment protein for activity. J. Virol. 82:5986-5998.
37. Renne, R., D. Blackbourn, D. Whitby, J. Levy, and D. Ganem. 1998. Limited transmission of Kaposi's sarcoma-associated herpesvirus in cultured cells. J. Virol. 72:5182-5188.
38. Renne, R., et al. 1996. Lytic growth of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) in culture. Nat. Med. 2:342-346.
39. Rivas, C., A. E. Thlick, C. Parravicini, P. S. Moore, and Y. Chang. 2001. Kaposi's sarcoma-associated herpesvirus LANA2 is a B-cell-specific latent viral protein that inhibits p53. J. Virol. 75:429-438.
40. Russo, J. J., et al. 1996. Nucleotide sequence of the Kaposi sarcoma-associated herpesvirus (HHV8). Proc. Natl. Acad. Sci. U. S. A. 93:14862-14867.
41. Sakurada, S., et al. 2001. Effective human herpesvirus 8 infection of human umbilical vein endothelial cells by cell-mediated transmission. J. Virol. 75: 7717-7722.
42. Shaw, R. N., J. L. Arbiser, and M. K. Offermann. 2000. Valproic acid induces human herpesvirus 8 lytic gene expression in BCBL-1 cells. AIDS 14:899-902.
43. Soulier, J., et al. 1995. Kaposi's sarcoma-associated herpesvirus-like DNA sequences in multicentric Castleman's disease. Blood 86:1276-1280.
44. Sun, R., et al. 1998. A viral gene that activates lytic cycle expression of Kaposi's sarcoma-associated herpesvirus. Proc. Natl. Acad. Sci. U. S. A. 95:10866-10871.
45. Vieira, J., and P. M. O'Hearn. 2004. Use of the red fluorescent protein as a marker of Kaposi's sarcoma-associated herpesvirus lytic gene expression. Virology 325:225-240.
46. Wang, J. H., C. Kwas, and L. Wu. 2009. Intercellular adhesion molecule 1 (ICAM-1), but not ICAM-2 and -3, is important for dendritic cellmediated human immunodeficiency virus type 1 transmission. J. Virol. 83:4195-4204.
47. Xu, Y., et al. 2005. A Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8 ORF50 deletion mutant is defective for reactivation of latent virus and DNA replication. J. Virol. 79:3479-3487.
48. Zhou, F. C., et al. 2002. Efficient infection by a recombinant Kaposi's sarcoma-associated herpesvirus cloned in a bacterial artificial chromosome: application for genetic analysis. J. Virol. 76:6185-6196.