Tryptophan-mPEGs: Novel excipients that stabilize salmon calcitonin against aggregation by non-covalent PEGylation

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 79, Issue 3, 2011, Pages 646-657

  Mueller, Claudia ^a,b   Capelle, Martinus A H ^c   Arvinte, Tudor ^a,c   Seyrek, Emek ^a   Borchard, Gerrit ^a,b  

^a UNIVERSITY OF GENEVA   (Switzerland)

^b Centre Interuniversitaire de Recherche et d'Enseignement   (France)

^c Therapeomic Inc   (Switzerland)

Author keywords

Non covalent PEGylation; Protein aggregation; Protein formulation; Salmon calcitonin; Stability

Indexed keywords

CITRATE SODIUM; EXCIPIENT; MACROGOL; SALCATONIN; TRYPTOPHAN;

ARTICLE; BLOOD COMPATIBILITY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOTOXICITY; FLUORESCENCE MICROSCOPY; HEMOLYSIS; HUMAN; HUMAN CELL; LIGHT SCATTERING; MOLECULAR WEIGHT; PH; PHYSICAL CHEMISTRY; PROTEIN AGGREGATION; SYNTHESIS; TURBIDITY;

CALCITONIN; CELL LINE; CELL PROLIFERATION; CELL SURVIVAL; DRUG COMPOUNDING; DRUG STABILITY; ERYTHROCYTES; EXCIPIENTS; HEMOLYSIS; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; KERATINOCYTES; MICROSCOPY, FLUORESCENCE; POLYETHYLENE GLYCOLS; PROTEIN STABILITY; SPECTROMETRY, FLUORESCENCE; TRYPTOPHAN;

EID: 80053943573     PISSN: 09396411     EISSN: 18733441     Source Type: Journal    
DOI: 10.1016/j.ejpb.2011.06.003     Document Type: Article

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