NKp46 + cells express granulysin in multiple cutaneous adverse drug reactions

Allergy: European Journal of Allergy and Clinical Immunology

Volumn 66, Issue 11, 2011, Pages 1469-1476

  Schlapbach, C ^a   Zawodniak, A ^a   Irla, N ^a   Adam, J ^a   Hunger, R E ^a   Yerly, D ^a   Pichler, W J ^a   Yawalkar, N ^a  

^a UNIVERSITY OF BERN   (Switzerland)

Author keywords

acute generalized exanthematous pustulosis; cutaneous adverse drug reaction; drug allergy; drug hypersensitivity; fixed drug eruption; granulysin; granzyme B; maculopapular exanthema; natural killer cells; NKp46 (NCR1 CD335); toxic epidermal necrolysis

Indexed keywords

CD3 ANTIGEN; CD8 ANTIGEN; GRANULYSIN; PROTEIN P46;

ADULT; ARTICLE; CD8+ T LYMPHOCYTE; CELL ACTIVATION; CELL INFILTRATION; CLINICAL ARTICLE; CONTROLLED STUDY; DERMIS; DISEASE SEVERITY; EPIDERMIS; HUMAN; HUMAN TISSUE; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; NATURAL KILLER CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUALITATIVE ANALYSIS; QUANTITATIVE ANALYSIS; SKIN TOXICITY; TISSUE SECTION; TOXIC EPIDERMAL NECROLYSIS;

ADULT; AGED; AGED, 80 AND OVER; ANTIGENS, DIFFERENTIATION, T-LYMPHOCYTE; CD8-POSITIVE T-LYMPHOCYTES; DRUG ERUPTIONS; EPIDERMAL NECROLYSIS, TOXIC; FEMALE; HUMANS; KILLER CELLS, NATURAL; LYMPHOCYTE ACTIVATION; MALE; MIDDLE AGED; NATURAL CYTOTOXICITY TRIGGERING RECEPTOR 1; SKIN; UP-REGULATION; YOUNG ADULT;

EID: 80053933341     PISSN: 01054538     EISSN: 13989995     Source Type: Journal    
DOI: 10.1111/j.1398-9995.2011.02677.x     Document Type: Article

References (26)

1. Pichler WJ,. Delayed drug hypersensitivity reactions. Ann Intern Med 2003; 139: 683-693.
2. Bigby M, Jick S, Jick H, Arndt K,. Drug-induced cutaneous reactions. A report from the Boston Collaborative Drug Surveillance Program on 15,438 consecutive inpatients, 1975 to 1982. JAMA 1986; 256: 3358-3363. (Pubitemid 17201796)
3. Lee HY, Tay LK, Thirumoorthy T, Pang SM,. Cutaneous adverse drug reactions in hospitalised patients. Singapore Med J 2010; 51: 767-774.
4. Bronnimann M, Yawalkar N,. Histopathology of drug-induced exanthems: is there a role in diagnosis of drug allergy? Curr Opin Allergy Clin Immunol 2005; 5: 317-321. (Pubitemid 41017645)
5. Chung WH, Hung SI, Yang JY, Su SC, Huang SP, Wei CY, et al., Granulysin is a key mediator for disseminated keratinocyte death in Stevens-Johnson syndrome and toxic epidermal necrolysis. Nat Med 2008; 14: 1343-1350.
6. Zawodniak A, Lochmatter P, Yerly D, Kawabata T, Lerch M, Yawalkar N, et al., In vitro detection of cytotoxic T and NK cells in peripheral blood of patients with various drug-induced skin diseases. Allergy 2010; 65: 376-384.
7. Morel E, Escamochero S, Cabanas R, Diaz R, Fiandor A, Bellon T,. CD94/NKG2C is a killer effector molecule in patients with Stevens-Johnson syndrome and toxic epidermal necrolysis. J Allergy Clin Immunol 2010; 125: 703-710, 710 e1-710 e8.
8. Posadas SJ, Padial A, Torres MJ, Mayorga C, Leyva L, Sanchez E, et al., Delayed reactions to drugs show levels of perforin, granzyme B, and Fas-L to be related to disease severity. J Allergy Clin Immunol 2002; 109: 155-161. (Pubitemid 34112146)
9. Tewary P, Yang D, de la Rosa G, Li Y, Finn MW, Krensky AM, et al., Granulysin activates antigen-presenting cells through TLR4 and acts as an immune alarmin. Blood 2010; 116: 3465-3474.
10. Gregoire C, Chasson L, Luci C, Tomasello E, Geissmann F, Vivier E, et al., The trafficking of natural killer cells. Immunol Rev 2007; 220: 169-182. (Pubitemid 350045566)
11. Walzer T, Jaeger S, Chaix J, Vivier E,. Natural killer cells: from CD3(-)NKp46(+) to post-genomics meta-analyses. Curr Opin Immunol 2007; 19: 365-372. (Pubitemid 46687010)
12. Luci C, Reynders A, Ivanov II, Cognet C, Chiche L, Chasson L, et al., Influence of the transcription factor RORgammat on the development of NKp46+ cell populations in gut and skin. Nat Immunol 2009; 10: 75-82.
13. Ozkaya E,. Fixed drug eruption: state of the art. J Dtsch Dermatol Ges 2008; 6: 181-188. (Pubitemid 351361060)
14. Yawalkar N,. Maculopapular drug eruptions. In:, Pichler W, editor. Drug hypersensitivity. Karger: Basel, 2007: 242-250.
15. Bastuji-Garin S, Rzany B, Stern RS, Shear NH, Naldi L, Roujeau JC,. Clinical classification of cases of toxic epidermal necrolysis, Stevens-Johnson syndrome, and erythema multiforme. Arch Dermatol 1993; 129: 92-96. (Pubitemid 23029676)
16. Sidoroff A, Halevy S, Bavinck JN, Vaillant L, Roujeau JC,. Acute generalized exanthematous pustulosis (AGEP)-a clinical reaction pattern. J Cutan Pathol 2001; 28: 113-119. (Pubitemid 32112994)
17. Schlapbach C, Ochsenbein A, Kaelin U, Hassan AS, Hunger RE, Yawalkar N,. High numbers of DC-SIGN+ dendritic cells in lesional skin of cutaneous T-cell lymphoma. J Am Acad Dermatol 2010; 62: 995-1004.
18. Pichler WJ, Tilch J,. The lymphocyte transformation test in the diagnosis of drug hypersensitivity. Allergy 2004; 59: 809-820. (Pubitemid 39005820)
19. Nassif A, Bensussan A, Boumsell L, Deniaud A, Moslehi H, Wolkenstein P, et al., Toxic epidermal necrolysis: effector cells are drug-specific cytotoxic T cells. J Allergy Clin Immunol 2004; 114: 1209-1215. (Pubitemid 39469167)
20. Stur K, Karlhofer FM, Stingl G,. Soluble FAS ligand: a discriminating feature between drug-induced skin eruptions and viral exanthemas. J Invest Dermatol 2007; 127: 802-807. (Pubitemid 46434660)
21. Viard I, Wehrli P, Bullani R, Schneider P, Holler N, Salomon D, et al., Inhibition of toxic epidermal necrolysis by blockade of CD95 with human intravenous immunoglobulin. Science 1998; 282: 490-493. (Pubitemid 28483679)
22. Shiohara T,. Fixed drug eruption: pathogenesis and diagnostic tests. Curr Opin Allergy Clin Immunol 2009; 9: 316-321.
23. Teraki Y, Shiohara T,. IFN-gamma-producing effector CD8+ T cells and IL-10-producing regulatory CD4+ T cells in fixed drug eruption. J Allergy Clin Immunol 2003; 112: 609-615. (Pubitemid 37108568)
24. Demoly P, Pichler W, Pirmohamed M, Romano A,. Important questions in Allergy: 1-drug allergy/hypersensitivity. Allergy 2008; 63: 616-619. (Pubitemid 351490413)
25. O'Leary JG, Goodarzi M, Drayton DL, von Andrian UH,. T cell- and B cell-independent adaptive immunity mediated by natural killer cells. Nat Immunol 2006; 7: 507-516.
26. Paust S, Senman B, von Andrian UH,. Adaptive immune responses mediated by natural killer cells. Immunol Rev 2010; 235: 286-296.