Development of high-throughput perfusion-based microbioreactor platform capable of providing tunable dynamic tensile loading to cells and its application for the study of bovine articular chondrocytes

Biomedical Microdevices

Volumn 13, Issue 4, 2011, Pages 789-798

  Wu, Min Hsien ^a   Wang, Hsin Yao ^b   Liu, Heng Liang ^a   Wang, Shih Siou ^a   Liu, Yen Ting ^a   Chen, Yan Ming ^a   Tsai, Shiao Wen ^a   Lin, Chun Li ^c  

^a CHANG GUNG UNIVERSITY   (Taiwan)

^b CHANG GUNG UNIVERSITY   (Taiwan)

^c NATIONAL YANG MING UNIVERSITY   (Taiwan)

Author keywords

Articular chondrocytes; High throughput; Mechanical stimulations; Microbioreactors; Perfusion culture; Tensile strain

Indexed keywords

ARTICULAR CHONDROCYTES; HIGH THROUGHPUT; MECHANICAL STIMULATION; MICRO BIOREACTOR; PERFUSION CULTURES;

ANIMAL CELL CULTURE; BIOREACTORS; BODY FLUIDS; CELLS; CYTOLOGY; DYNAMICS; FINITE ELEMENT METHOD; LOADING; MAMMALS; METABOLISM; MICROCHANNELS; PHYSIOLOGICAL MODELS; PHYSIOLOGY; PNEUMATICS; TENSILE STRESS; THROUGHPUT;

TENSILE STRAIN;

COLLAGEN; DIMETICONE; GLYCOSAMINOGLYCAN; POLYMER;

ANIMAL CELL; ARTICLE; BIOREACTOR; BIOREACTOR DESIGN; BIOREACTOR EQUIPMENT; BIOSYNTHESIS; CARTILAGE CELL; CELL ADHESION; CELL CULTURE; CONTROLLED STUDY; COW; FINITE ELEMENT ANALYSIS; HIGH THROUGHPUT PERFUSION; HUMAN; MICROBIOREACTOR PLATFORM; NONHUMAN; PERFUSION; PRIORITY JOURNAL; TENSILE STRENGTH; UPREGULATION; WALKING;

ANIMALS; BIOREACTORS; CATTLE; CELL CULTURE TECHNIQUES; CELLS, CULTURED; CHONDROCYTES; COLLAGEN; EQUIPMENT DESIGN; FINITE ELEMENT ANALYSIS; GLYCOSAMINOGLYCANS; HIGH-THROUGHPUT SCREENING ASSAYS; HYDROXYPROLINE; LACTIC ACID; PERFUSION; STRESS, MECHANICAL; TENSILE STRENGTH;

BOVINAE; MAMMALIA;

EID: 80053926857     PISSN: 13872176     EISSN: 15728781     Source Type: Journal    
DOI: 10.1007/s10544-011-9549-z     Document Type: Article

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