Intraspinal cell transplantation for targeting cervical ventral horn in amyotrophic lateral sclerosis and traumatic spinal cord injury

Journal of Visualized Experiments

Volumn , Issue 55, 2011, Pages

  Lepore, Angelo C ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

ALS; Amyotrophic lateral sclerosis; Cell transplantation; Engraftment; Graft; Issue 55; Medicine; Motor neuron; Precursors; SCI; Spinal cord; Spinal cord injury; Stem cells

Indexed keywords

EID: 80053899768     PISSN: 1940087X     EISSN: None     Source Type: Journal    
DOI: 10.3791/3069     Document Type: Article

References (23)

1. Lane, M.A., Fuller, D.D., White, T.E., et al. Respiratory recovery following high cervical hemisection. Trends in neurosciences. 31 (10), 538 (2008).
2. Kaplan, L.M., & Hollander, D. Respiratory dysfunction in amyotrophic lateral sclerosis. Clin. Chest. Med. 15 (4), 675 (1994).
3. Miller, R.G. Rosenberg, J.A., Gelinas, D. F. et al. Practice parameter: the care of the patient with amyotrophic lateral sclerosis (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology: ALS Practice Parameters Task Force. Neurology. 52 (7), 1311-23 (1999).
4. Hiroshi Mitsumoto, David A. Chad, and Erik P. Pioro. Amyotrophic lateral sclerosis. Ed, F.A. Davis, Philadelphia, (1998).
5. Tandan, R. & Bradley, W. G. Amyotrophic leteral sclerosis: Part 2. Etiopathogenesis. Annals of neurology. 18 (3), 419 (1985).
6. Bruijn, L. I., Miller, T. M. and Cleveland, D. W. Unraveling the mechanisms involved in motor neuron degeneration in ALS. Annu Rev Neurosci. 27, 723 (2004).
7. Rosen, D. R. Siddique, T. Patterson, D. et al. Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis. Nature. 362 (6415), 59 (1993).
8. Bruijn, L.I. Becher, M.W., Lee, M.K., et al. ALS-linked SOD1 mutant G85R mediates damage to astrocytes and promotes rapidly progressive disease with SOD1-containing inclusions. Neuron. 18 (2), 327 (1997)
9. Gurney, M.E., Pu, H., Chiu, A.Y., et al. Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation. Science. 264 (5166), 1772-5 (1994)
10. Wong, P. C., Pardo C. A., Borchelt D. R., et al. An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria. Neuron. 14 (6), 1105 (1995).
11. Howland, D. S. Liu, J., She, Y., et al. Focal loss of the glutamate transporter EAAT2 in a transgenic rat model of SOD1 mutant-mediated amyotrophic lateral sclerosis (ALS). Proc Natl Acad Sci U. S. A. 99 (3), 1604 (2002)
12. Nagai, M., Aoki, M., Miyoshi, I., et al. Rats expressing human cytosolic copper-zinc superoxide dismutase transgenes with amyotrophic lateral sclerosis: associated mutations develop motor neuron disease. J. Neurosci. 21 (23), 9246 (2001).
13. McDonald, W., & Becker, D. Spinal cord injury: promising interventions and realistic goals. Am. J. Phys. Med. Rehabi. l82 (10 Suppl), S38 (2003).
14. Sandrow-Feinberg, H. R., Zhukareva, V., Santi, L. et al. PEGylated interferon-beta modulates the acute inflammatory response and recovery when combined with forced exercise following cervical spinal contusion injury. Experimental neurology. 223 (2), 439-51 (2010).
15. Gage, F. H. Mammalian neural stem cells. Science. 287 (5457), 1433 (2000).
16. Lane, M.A. Lee, K. Z., Fuller D. D. et al. Spinal circuitry and respiratory recovery following spinal cord injury. Respiratory physiology & neurobiology. 169 (2), 123 (2009).
17. Lepore, A.C., Rauck, B., Dejea, C. et al. Focal transplantation-based astrocyte replacement is neuroprotective in a model of motor neuron disease. Nature neuroscience. 11 (11), 1294 (2008).
18. Rao, M. S. Multipotent and Restricted Precursors in the Central Nervous System. Anat Rec 257. (4), 137 (1999)
19. Rao, M. S. & Mayer-Proschel, M. Glial- restricted precursors are derived from multipotent neuroepithelial stem cells. Dev Biol. 188 (1), 48 (1997).
20. Suzuki, M., Tork, C., Shelley, B., et al. Sexual dimorphism in disease onset and progression of a rat model of ALS. Sexual dimorphism in disease onset and progression of a rat model of ALS. Amyotroph Lateral Scler. 8 (1), 20 (2007).
21. Lepore, A C., Haenggeli, Gasmi C.M. et al. Intraparenchymal spinal cord delivery of adeno-associated virus IGF-1 is protective in the SOD1G93A model of ALS. Brain research. 1185, 256 (2007).
22. Veldink, J.H., Bar, P.R., Joosten, E.A., et al. Sexual differences in onset of disease and response to exercise in a transgenic model of ALS. Neuromuscul Disord. 13 (9), 737 (2003).
23. Mitsui, T., Shumsky, J. S., Lepore, A. C. et al. Transplantation of Neuronal and Glial Restricted Precursors into Contused Spinal Cord Improves Bladder and Motor Functions, Decreases Thermal Hypersensitivity, and Modifies Intraspinal Circuitry J. Neurosci. 25 (42), 9624 (2005).